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Characterisation of the merozoite thrombospondin related anonymous protein (MTRAP) of Plasmodium berghei as a transmission-blocking antigen
CONCLUSION: Our results indicate that antibodies to PbMTRAP may reduce but are not sufficient to completely block transmission.PMID:38537036 | PMC:PMC10959096 | DOI:10.1590/0074-02760230217 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - March 27, 2024 Category: Infectious Diseases Authors: Xiomara Alexandra Gait án Juliana Calit Irina Dobrescu Maris é Solórzano Ramos Alba Marina Gimenez Daniel Youssef Bargieri Source Type: research

Child Health and Infection with Low Density (CHILD) malaria: a protocol for a randomised controlled trial to assess the long-term health and socioeconomic impacts of testing and treating low-density malaria infection among children in Tanzania
Introduction As malaria declines, low-density malaria infections (LMIs) represent an increasing proportion of infections and may have negative impacts on child health and cognition, necessitating development of targeted and effective solutions. This trial assesses the health, cognitive and socioeconomic impact of two strategies for detecting and treating LMI in a low transmission setting. Methods and analysis The study is a 3-arm open-label individually randomised controlled trial enrolling 600 children aged 6 months to 10 years in Bagamoyo district, Tanzania. Children are randomised to one of three arms: active case dete...
Source: BMJ Open - March 27, 2024 Category: General Medicine Authors: Jebiwott, S., Gutapaka, N., Sumari, D., Loss, G., Athuman, T., Nyandele, J. P., Cummins, H., Chemba, M., Benjamin-Chung, J., Gangar, P., Wu, X., Smith, J., Chen, I., Dorsey, G., Fink, G., Olotu, A., Hsiang, M. Tags: Open access, Global health Source Type: research

Whole transcriptomic analysis reveals overexpression of salivary gland and cuticular proteins genes in insecticide-resistant Anopheles arabiensis from Western Kenya
Effective vector control is key to malaria prevention. However, this is now compromised by increased insecticide resistance due to continued reliance on insecticide-based control interventions. In Kenya, we ha... (Source: BMC Genomics)
Source: BMC Genomics - March 27, 2024 Category: Genetics & Stem Cells Authors: Diana Omoke, Lucy Mackenzie Impoinvil, Dieunel Derilus, Stephen Okeyo, Helga Saizonou, Nicola Mulder, Nsa Dada, Audrey Lenhart, Luc Djogb énou and Eric Ochomo Tags: Research Source Type: research

A systematic review: is Anopheles vagus a species complex?
Anopheles vagus (subgenus Cellia) has been identified as a vector for malaria, filariasis, and Japanese encephalitis in Asia. Sporozoites of Plasmodium falciparum and Plasmodium vivax have been found in this zoop... (Source: Malaria Journal)
Source: Malaria Journal - March 27, 2024 Category: Infectious Diseases Authors: Dalilah Dalilah, Din Syafruddin, Irsan Saleh, Ahmad Ghiffari, Leo Vernadesly, Lepa Syahrani, Irdayanti Irdayanti and Chairil Anwar Tags: Review Source Type: research

An evaluation of LLIN physical integrity and population attitudes towards net use, care and handling during the Magude project in southern Mozambique
The Magude Project assessed the feasibility of eliminating malaria in Magude district, a low transmission setting in southern Mozambique, using a package of interventions, including long-lasting insecticidal n... (Source: Malaria Journal)
Source: Malaria Journal - March 27, 2024 Category: Infectious Diseases Authors: Celso Alafo, Lucia Fernandez Montoya, Helena Mart í-Soler, Mara Máquina, Arlindo Malheia, Charfudin Sacoor, Ana Paula Abílio, Dulcisaria Marrenjo, Nelson Cuamba, Beatriz Galatas, Pedro Aide, Francisco Saúte and Krijn P. Paaijmans Tags: Research Source Type: research

Implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda: stakeholder engagement meeting report
A Stakeholder engagement meeting on the implementation of post-discharge malaria chemoprevention (PDMC) in Benin, Kenya, Malawi, and Uganda was held in Nairobi, Kenya, on 27 September 2023. Representatives fro... (Source: Malaria Journal)
Source: Malaria Journal - March 27, 2024 Category: Infectious Diseases Authors: Jenny Hill Tags: Meeting Report Source Type: research

Evaluating Malaria Rapid Diagnostic Tests and Microscopy for Detecting Plasmodium Infection and Status of Plasmodium falciparum Histidine-Rich Protein 2/3 Gene Deletions in Southeastern Nigeria
Am J Trop Med Hyg. 2024 Mar 26:tpmd230690. doi: 10.4269/ajtmh.23-0690. Online ahead of print.ABSTRACTDelays in malaria diagnosis increase treatment failures and deaths. In endemic regions, standard diagnostic methods are microscopy and malaria rapid diagnostic tests (mRDTs) detecting Plasmodium falciparum histidine-rich protein 2/3 (PFHRP2/PFHRP3), but gene deletions can allow certain parasites to remain undetected. We enlisted a cohort comprising 207 symptomatic individuals, encompassing both children and adults, at a hospital in Nnewi, Nigeria. The prevalence of parasites was determined using a highly sensitive, species-...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Moses Ikegbunam Maike Maurer Harrison Abone Dorothy Ezeagwuna Thaisa Lucas Sandri Charles Esimone Olusola Ojurongbe Tamirat Gebru Woldearegai Andrea Kreidenweiss Jana Held Rolf Fendel Source Type: research