A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver
Antimicrob Agents Chemother. 2024 Mar 22:e0091523. doi: 10.1128/aac.00915-23. Online ahead of print.ABSTRACTPrimaquine is the mainstream antimalarial drug to prevent Plasmodium vivax relapses. However, this drug can induce hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Nanostructure formulations of primaquine loaded with D-galactose were used as a strategy to target the drug to the liver and decrease the hemolytic risks. Nanoemulsion (NE-Pq) and nanochitosan (NQ-Pq) formulations of primaquine diphosphate containing D-galactose were prepared and characterized by their physicochemistry properties. P...
Source: Antimicrobial Agents and Chemotherapy - March 22, 2024 Category: Microbiology Authors: F Gomes A C Ribeiro G S Sanches H S Borges L A U Takahashi C T Daniel-Ribeiro A C Tedesco J W L Nascimento L J M Carvalho Source Type: research
A new malaria vaccination tool based on replication-competent Plasmodium falciparum parasites
EMBO Mol Med. 2024 Mar 21. doi: 10.1038/s44321-024-00056-8. Online ahead of print.NO ABSTRACTPMID:38514792 | DOI:10.1038/s44321-024-00056-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Diana Moita Miguel Prud êncio Source Type: research
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of < em > Plasmodial < /em > cysteine protease inhibitors for the treatment of malaria
RSC Med Chem. 2024 Feb 1;15(3):1022-1037. doi: 10.1039/d3md00490b. eCollection 2024 Mar 20.ABSTRACTMalaria eradication is still a global challenge due to the lack of a broadly effective vaccine and the emergence of drug resistance to most of the currently available drugs as part of the mainline artemisinin-based combination therapy. A variety of experimental approaches are quite successful in identifying and synthesizing new promising pharmacophore hybrids with distinct mechanisms of action. Based on our recent findings, the current study demonstrates the reinvestigation of a series of diphenylmethylpiperazine and pyrazine...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Hari Madhav G Srinivas Reddy Zeba Rizvi Ehtesham Jameel Tarosh S Patel Abdur Rahman Vikas Yadav Sadaf Fatima Fatima Heyat Kavita Pal Amisha Minju-Op Naidu Subbarao Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research
Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy
Ann Pharm Fr. 2024 Mar 20:S0003-4509(24)00040-3. doi: 10.1016/j.pharma.2024.03.005. Online ahead of print.ABSTRACTMalaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to ...
Source: Annales Pharmaceutiques Francaises - March 22, 2024 Category: Drugs & Pharmacology Authors: Anamika Jain Rajeev Sharma Laxmikant Gautam Priya Shrivastava Kamalinder K Singh S P Vyas Source Type: research
Prevalence and Genetic Diversity of Simian Malaria in Wild Macaque Populations Across Thailand: Implications for Human Health
This study aims to address several research questions, including the prevalence and distribution of simian malaria in these two Thai wild macaque species, variations in infection between different macaque species and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well as two locations in Vietnam and Myanmar. We employed quantitative real-time PCR targeting the Plasmodium genus-specific 18S ribosomal RNA (rRNA) gene to detect malaria infection, with a limit of detection set at 1,21...
Source: Acta Tropica - March 22, 2024 Category: Infectious Diseases Authors: Kriangkrai Karnchaisri Nicholas P J Day Arjen M Dondorp Suchinda Malaivijitnond Mallika Imwong Source Type: research
Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo
CONCLUSION: This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.PMID:38519039 | DOI:10.1055/s-0044-1782182 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Hongmei Zhu Richard L Auten Augustus Richard Whorton Stanley Nicholas Mason Cheryl B Bock Gary T Kucera Zachary T Kelleher Aaron T Vose Tim J McMahon Source Type: research
A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver
Antimicrob Agents Chemother. 2024 Mar 22:e0091523. doi: 10.1128/aac.00915-23. Online ahead of print.ABSTRACTPrimaquine is the mainstream antimalarial drug to prevent Plasmodium vivax relapses. However, this drug can induce hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Nanostructure formulations of primaquine loaded with D-galactose were used as a strategy to target the drug to the liver and decrease the hemolytic risks. Nanoemulsion (NE-Pq) and nanochitosan (NQ-Pq) formulations of primaquine diphosphate containing D-galactose were prepared and characterized by their physicochemistry properties. P...
Source: Antimicrobial Agents and Chemotherapy - March 22, 2024 Category: Microbiology Authors: F Gomes A C Ribeiro G S Sanches H S Borges L A U Takahashi C T Daniel-Ribeiro A C Tedesco J W L Nascimento L J M Carvalho Source Type: research
A new malaria vaccination tool based on replication-competent Plasmodium falciparum parasites
EMBO Mol Med. 2024 Mar 21. doi: 10.1038/s44321-024-00056-8. Online ahead of print.NO ABSTRACTPMID:38514792 | DOI:10.1038/s44321-024-00056-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Diana Moita Miguel Prud êncio Source Type: research
Plasmodium falciparum heat shock proteins as anti-malarial drug targets: An update
Cell Stress Chaperones. 2024 Mar 20:S1355-8145(24)00059-2. doi: 10.1016/j.cstres.2024.03.007. Online ahead of print.ABSTRACTGlobal efforts to eradicate malaria are threatened by multiple factors, particularly the emergence of anti-malarial drug resistant strains of Plasmodium falciparum. Heat shock proteins (HSPs), particularly P. falciparum HSPs (PfHSPs), represent promising drug targets due to their essential roles in parasite survival and virulence across the various life cycle stages. Despite structural similarities between human and malarial HSPs posing challenges, there is substantial evidence for subtle differences ...
Source: Cell Stress and Chaperones - March 22, 2024 Category: Cytology Authors: Tanveer Ahmad Bushra A Alhammadi Shaikha Y Almaazmi Sahar Arafa Gregory L Blatch Tanima Dutta Jason E Gestwicki Robert A Keyzers Addmore Shonhai Harpreet Singh Source Type: research
Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy
Ann Pharm Fr. 2024 Mar 20:S0003-4509(24)00040-3. doi: 10.1016/j.pharma.2024.03.005. Online ahead of print.ABSTRACTMalaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to ...
Source: Annales Pharmaceutiques Francaises - March 22, 2024 Category: Drugs & Pharmacology Authors: Anamika Jain Rajeev Sharma Laxmikant Gautam Priya Shrivastava Kamalinder K Singh S P Vyas Source Type: research
Prevalence and Genetic Diversity of Simian Malaria in Wild Macaque Populations Across Thailand: Implications for Human Health
This study aims to address several research questions, including the prevalence and distribution of simian malaria in these two Thai wild macaque species, variations in infection between different macaque species and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well as two locations in Vietnam and Myanmar. We employed quantitative real-time PCR targeting the Plasmodium genus-specific 18S ribosomal RNA (rRNA) gene to detect malaria infection, with a limit of detection set at 1,21...
Source: Acta Tropica - March 22, 2024 Category: Infectious Diseases Authors: Kriangkrai Karnchaisri Nicholas P J Day Arjen M Dondorp Suchinda Malaivijitnond Mallika Imwong Source Type: research
A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver
Antimicrob Agents Chemother. 2024 Mar 22:e0091523. doi: 10.1128/aac.00915-23. Online ahead of print.ABSTRACTPrimaquine is the mainstream antimalarial drug to prevent Plasmodium vivax relapses. However, this drug can induce hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Nanostructure formulations of primaquine loaded with D-galactose were used as a strategy to target the drug to the liver and decrease the hemolytic risks. Nanoemulsion (NE-Pq) and nanochitosan (NQ-Pq) formulations of primaquine diphosphate containing D-galactose were prepared and characterized by their physicochemistry properties. P...
Source: Antimicrobial Agents and Chemotherapy - March 22, 2024 Category: Microbiology Authors: F Gomes A C Ribeiro G S Sanches H S Borges L A U Takahashi C T Daniel-Ribeiro A C Tedesco J W L Nascimento L J M Carvalho Source Type: research
Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy
Ann Pharm Fr. 2024 Mar 20:S0003-4509(24)00040-3. doi: 10.1016/j.pharma.2024.03.005. Online ahead of print.ABSTRACTMalaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to ...
Source: Annales Pharmaceutiques Francaises - March 22, 2024 Category: Drugs & Pharmacology Authors: Anamika Jain Rajeev Sharma Laxmikant Gautam Priya Shrivastava Kamalinder K Singh S P Vyas Source Type: research
Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo
CONCLUSION: This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.PMID:38519039 | DOI:10.1055/s-0044-1782182 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Hongmei Zhu Richard L Auten Augustus Richard Whorton Stanley Nicholas Mason Cheryl B Bock Gary T Kucera Zachary T Kelleher Aaron T Vose Tim J McMahon Source Type: research
Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy
Ann Pharm Fr. 2024 Mar 20:S0003-4509(24)00040-3. doi: 10.1016/j.pharma.2024.03.005. Online ahead of print.ABSTRACTMalaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to ...
Source: Annales Pharmaceutiques Francaises - March 22, 2024 Category: Drugs & Pharmacology Authors: Anamika Jain Rajeev Sharma Laxmikant Gautam Priya Shrivastava Kamalinder K Singh S P Vyas Source Type: research
