Disparities in Olfactory Dysfunction in African Americans
CONCLUSION: On both tests of olfaction, AA performed worse than Whites and a greater proportion of AA were considered hyposmic compared to Whites. This is a discrepancy with self-reported olfaction, which showed no difference between Whites and AA. AA performed significantly worse than their White counterparts on several scents, with possible implications regarding cultural appropriateness of scents used in olfactory testing.PMID:38235801 | DOI:10.1177/00034894231222693 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - January 18, 2024 Category: ENT & OMF Authors: Nicholas J Choi Kevin J Sykes Mark Villwock Jennifer Villwock Source Type: research
Licorice (Glycyrrhiza Glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects [Corrigendum]
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - January 16, 2024 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Regulating microsomal triglyceride transfer protein with natural products for the treatment of hyperlipidaemia
This study explores a novel approach by screening natural products to identify plant extracts that down-regulate MTP gene expression, aiming to reduce hyperlipidaemia with fewer side effects. Modulating MTP expression, rather than direct inhibition, offers a promising avenue for lowering plasma lipids and mitigating cardiovascular risk. Various plant extracts were examined for their potential as MTP down-regulators, with Liquorice root and Pomegranate rind extracts demonstrating the highest efficacy. Additionally, the study assessed the total phenolic content of these extracts, revealing their -antioxidant capacity. This r...
Source: Natural Product Research - January 5, 2024 Category: Biochemistry Authors: Miral O Sabry Mohamed S Sedeek Sawsan M El-Sonbaty Marwa Y Issa Soheir M El Zalabani Source Type: research
Regulating microsomal triglyceride transfer protein with natural products for the treatment of hyperlipidaemia
This study explores a novel approach by screening natural products to identify plant extracts that down-regulate MTP gene expression, aiming to reduce hyperlipidaemia with fewer side effects. Modulating MTP expression, rather than direct inhibition, offers a promising avenue for lowering plasma lipids and mitigating cardiovascular risk. Various plant extracts were examined for their potential as MTP down-regulators, with Liquorice root and Pomegranate rind extracts demonstrating the highest efficacy. Additionally, the study assessed the total phenolic content of these extracts, revealing their -antioxidant capacity. This r...
Source: Natural Product Research - January 5, 2024 Category: Biochemistry Authors: Miral O Sabry Mohamed S Sedeek Sawsan M El-Sonbaty Marwa Y Issa Soheir M El Zalabani Source Type: research
Regulating microsomal triglyceride transfer protein with natural products for the treatment of hyperlipidaemia
This study explores a novel approach by screening natural products to identify plant extracts that down-regulate MTP gene expression, aiming to reduce hyperlipidaemia with fewer side effects. Modulating MTP expression, rather than direct inhibition, offers a promising avenue for lowering plasma lipids and mitigating cardiovascular risk. Various plant extracts were examined for their potential as MTP down-regulators, with Liquorice root and Pomegranate rind extracts demonstrating the highest efficacy. Additionally, the study assessed the total phenolic content of these extracts, revealing their -antioxidant capacity. This r...
Source: Natural Product Research - January 5, 2024 Category: Biochemistry Authors: Miral O Sabry Mohamed S Sedeek Sawsan M El-Sonbaty Marwa Y Issa Soheir M El Zalabani Source Type: research
Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus
J Pers Med. 2023 Nov 24;13(12):1639. doi: 10.3390/jpm13121639.ABSTRACTHuman papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrr...
Source: Cancer Control - December 23, 2023 Category: Cancer & Oncology Authors: Victoria Bravo Mar ía Serrano Alfonso Duque Juan Ferragud Pluvio J Coronado Source Type: research
Chalcones from plants cause toxicity by inhibiting human and rat 11 β-hydroxysteroid dehydrogenase 2: 3D-quantitative structure-activity relationship (3D-QSAR) and in silico docking analysis
In conclusion, many chalcones inhibit human and rat 11β-HSD2, possibly causing side effects and there is structure-dependent and species-dependent inhibition on 11β-HSD2.PMID:38141941 | DOI:10.1016/j.fct.2023.114415 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - December 23, 2023 Category: Food Science Authors: Hang Lin Ming Su Chao Wen Yunbing Tang Huitao Li Yandan Wu Ren-Shan Ge Xing-Wang Li Han Lin Source Type: research
Effects of the antimicrobial glabridin on membrane integrity and stress response activation in Listeria monocytogenes
In this study, we aimed to investigate the mode of action of glabridin using a combined phenotypic and proteomic approach on Listeria monocytogenes. Fluorescence and transmission electron microscopy of cells exposed to glabridin showed membrane permeabilization upon treatment with lethal concentrations of glabridin. Comparative proteomics analysis of control cells and cells exposed to sub-lethal concentrations of glabridin showed upregulation of proteins related to the two-component systems LiaSR and VirRS, confirming cell envelope damage during glabridin treatment. Additional upregulation of SigmaB regulon members signifi...
Source: Cell Research - December 21, 2023 Category: Cytology Authors: Alberto Bombelli Carla Araya-Cloutier Sjef Boeren Jean-Paul Vincken Tjakko Abee Heidy M W den Besten Source Type: research
Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment
Colloids Surf B Biointerfaces. 2023 Dec 9;234:113703. doi: 10.1016/j.colsurfb.2023.113703. Online ahead of print.ABSTRACTThe management of coronavirus necessitates that medicines are available, reasonably priced, and easy to administer. The work aimed at formulating and characterizing remdesivir and licorice extract nanoemulsions and comparing their efficacy against coronavirus for further subcutaneous injection. First, the solubility of remdesivir was determined in different oils, surfactants, and co-surfactants to choose the optimal nanoemulsion components. Nanoemulsions were optimized concerning surfactant: co-surfactan...
Source: Colloids and Surfaces - December 14, 2023 Category: Biotechnology Authors: Al Zahraa G Al Ashmawy Gehan F Balata Source Type: research
Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment
Colloids Surf B Biointerfaces. 2023 Dec 9;234:113703. doi: 10.1016/j.colsurfb.2023.113703. Online ahead of print.ABSTRACTThe management of coronavirus necessitates that medicines are available, reasonably priced, and easy to administer. The work aimed at formulating and characterizing remdesivir and licorice extract nanoemulsions and comparing their efficacy against coronavirus for further subcutaneous injection. First, the solubility of remdesivir was determined in different oils, surfactants, and co-surfactants to choose the optimal nanoemulsion components. Nanoemulsions were optimized concerning surfactant: co-surfactan...
Source: Colloids and Surfaces - December 14, 2023 Category: Biotechnology Authors: Al Zahraa G Al Ashmawy Gehan F Balata Source Type: research
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production
CONCLUSION: Glab is a specific inhibitor of the cGAS-STING signaling pathway and may be used in the clinical therapy of cGAS-STING pathway-mediated autoimmune diseases.PMID:38066431 | DOI:10.1186/s10020-023-00754-y (Source: Molecular Medicine)
Source: Molecular Medicine - December 8, 2023 Category: Molecular Biology Authors: Jincai Wen Wenqing Mu Hui Li Yulu Yan Xiaoyan Zhan Wei Luo Zhongxia Wang Wen Kan Jia Zhao Siwen Hui Ping He Shuanglin Qin Yingjie Xu Ping Zhang Xiaohe Xiao Guang Xu Zhaofang Bai Source Type: research
Iranian Traditional Medicine (ITM) and Natural Remedies for Treatment of the Common Cold and Flu
Rev Recent Clin Trials. 2023 Dec 1. doi: 10.2174/0115748871275500231127065053. Online ahead of print.ABSTRACTTraditional Iranian medicine is usually used for both prevention and relief of cold and flu symptoms in China, Iran, and many other Asian countries all over the world. There are 4 kinds of influenza viruses. Unlike type B, which may cause seasonal epidemics, type A viruses can cause pandemics, and influenza C may lead to mild human infection with little public health effects. A literature review was done by using multiple databases such as ISI Web of knowledge, PubMed, Science Direct and Google Scholar. The most not...
Source: Reviews on Recent Clinical Trials - December 4, 2023 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Iranian Traditional Medicine (ITM) and Natural Remedies for Treatment of the Common Cold and Flu
Rev Recent Clin Trials. 2023 Dec 1. doi: 10.2174/0115748871275500231127065053. Online ahead of print.ABSTRACTTraditional Iranian medicine is usually used for both prevention and relief of cold and flu symptoms in China, Iran, and many other Asian countries all over the world. There are 4 kinds of influenza viruses. Unlike type B, which may cause seasonal epidemics, type A viruses can cause pandemics, and influenza C may lead to mild human infection with little public health effects. A literature review was done by using multiple databases such as ISI Web of knowledge, PubMed, Science Direct and Google Scholar. The most not...
Source: Reviews on Recent Clinical Trials - December 4, 2023 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Iranian Traditional Medicine (ITM) and Natural Remedies for Treatment of the Common Cold and Flu
Rev Recent Clin Trials. 2023 Dec 1. doi: 10.2174/0115748871275500231127065053. Online ahead of print.ABSTRACTTraditional Iranian medicine is usually used for both prevention and relief of cold and flu symptoms in China, Iran, and many other Asian countries all over the world. There are 4 kinds of influenza viruses. Unlike type B, which may cause seasonal epidemics, type A viruses can cause pandemics, and influenza C may lead to mild human infection with little public health effects. A literature review was done by using multiple databases such as ISI Web of knowledge, PubMed, Science Direct and Google Scholar. The most not...
Source: Reviews on Recent Clinical Trials - December 4, 2023 Category: Cancer & Oncology Authors: Mohamad Hesam Shahrajabian Wenli Sun Source Type: research
Potential Targets and Mechanisms of Bitter Almond-Licorice for COVID-19 Treatment Based on Network Pharmacology and Molecular Docking
CONCLUSION: The bitter almond-licorice could be used to treat COVID-19 by inhibiting inflammatory responses and regulating cellular stress. This work is based on data mining and molecular docking, and the findings need to be interpreted with caution.</P>.PMID:38018195 | DOI:10.2174/0113816128265009231102063840 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 29, 2023 Category: Drugs & Pharmacology Authors: Qiwei Hong Xinyue Shang Yanan Wu Zhenlin Nie Bangshun He Source Type: research
