Case report: Severe respiratory failure caused by licorice
Licorice, one of the most commonly used herbs, can cause hypokalemia, metabolic alkalosis, and apparent mineralocorticoid excess, also known as pseudoaldosteronism. Herein, we present a case of diaphragmatic dysfunction caused by licorice administration. An 80-year-old woman who had been taking dietary supplements and following a restricted diet for approximately 6 months was brought to the emergency department with impaired consciousness. Chronic respiratory acidosis was observed, and hypertension and hypokalemia became more prominent during hospitalization. History revealed that she was taking herbal medicines containing...
Source: Frontiers in Pharmacology - November 23, 2023 Category: Drugs & Pharmacology Source Type: research
Licochalcone A regulates viral IRES activity to inhibit enterovirus replication
Antiviral Res. 2023 Nov 18:105755. doi: 10.1016/j.antiviral.2023.105755. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is available. Autophagy is a cellular process that targets cytoplasmic proteins or organelles to the lysosomes for degradation. Enteroviruses strategically harness the host aut...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Yu-Ting Chuang Yu-Li Lin Jing-Yi Lin Source Type: research
Licochalcone A regulates viral IRES activity to inhibit enterovirus replication
Antiviral Res. 2023 Nov 18:105755. doi: 10.1016/j.antiviral.2023.105755. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is available. Autophagy is a cellular process that targets cytoplasmic proteins or organelles to the lysosomes for degradation. Enteroviruses strategically harness the host aut...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Yu-Ting Chuang Yu-Li Lin Jing-Yi Lin Source Type: research
Licochalcone A regulates viral IRES activity to inhibit enterovirus replication
Antiviral Res. 2023 Nov 18:105755. doi: 10.1016/j.antiviral.2023.105755. Online ahead of print.ABSTRACTEnterovirus D68 (EV-D68), belonging to the genus Enterovirus of the Picornavirus family, is an emerging pathogen that can cause neurological and respiratory diseases in children. However, there is little understanding of the pathogenesis of EV-D68, and no effective vaccine or drug for the prevention or treatment of the diseases caused by this virus is available. Autophagy is a cellular process that targets cytoplasmic proteins or organelles to the lysosomes for degradation. Enteroviruses strategically harness the host aut...
Source: Antiviral Research - November 20, 2023 Category: Virology Authors: Yu-Ting Chuang Yu-Li Lin Jing-Yi Lin Source Type: research
Tracking the effect of roasting and fermentation on the metabolites of licorice root (Glycyrrhiza glabra L.) using UPLC-MS analysis combined with multivariate statistical analysis
Roasting, honey-roasting and fermentation are the most common pre-processing procedures of licorice roots. They were shown to noticeably change the composition of extracts. In this work, the common alterations... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - November 20, 2023 Category: Complementary Medicine Authors: Sarah S. Takla, Eman Shawky, Yasmin A. Mahgoub and Reham S. Darwish Tags: Research Source Type: research
Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis
Eur J Pharmacol. 2023 Nov 17:176193. doi: 10.1016/j.ejphar.2023.176193. Online ahead of print.ABSTRACTBile acid (BA)-induced apoptosis is a common pathologic feature of cholestatic liver injury. Glycyrrhetinic acid (GA) is the hepatoprotective constituent of licorice. In the present study, the anti-apoptotic potential of GA was investigated in wild type and macrophage-depleted C57BL/6 mice challenged with alpha-naphthyl isothiocyanate (ANIT), and hepatocytes stimulated with Taurocholic acid (TCA) or Tumor necrosis factor alpha (TNF-α). Apoptosis was determined by TUNEL positive cells and expression of executioner caspases...
Source: European Journal of Pharmacology - November 19, 2023 Category: Drugs & Pharmacology Authors: Bin Zou Zhang Shuang Jing Zhao Guochao Song Fengyi Weng Xiaoqing Xu Fengling Li Jingyi Jin Dongming Yan Kai Huang Chenghai Liu Yue Li Furong Qiu Source Type: research
Glycyrrhetinic acid attenuates endoplasmic reticulum stress-induced hepatocyte apoptosis via CHOP/DR5/Caspase 8 pathway in cholestasis
Eur J Pharmacol. 2023 Nov 17:176193. doi: 10.1016/j.ejphar.2023.176193. Online ahead of print.ABSTRACTBile acid (BA)-induced apoptosis is a common pathologic feature of cholestatic liver injury. Glycyrrhetinic acid (GA) is the hepatoprotective constituent of licorice. In the present study, the anti-apoptotic potential of GA was investigated in wild type and macrophage-depleted C57BL/6 mice challenged with alpha-naphthyl isothiocyanate (ANIT), and hepatocytes stimulated with Taurocholic acid (TCA) or Tumor necrosis factor alpha (TNF-α). Apoptosis was determined by TUNEL positive cells and expression of executioner caspases...
Source: European Journal of Pharmacology - November 19, 2023 Category: Drugs & Pharmacology Authors: Bin Zou Zhang Shuang Jing Zhao Guochao Song Fengyi Weng Xiaoqing Xu Fengling Li Jingyi Jin Dongming Yan Kai Huang Chenghai Liu Yue Li Furong Qiu Source Type: research
Fabrication and characterization of curcumin-loaded nanoparticles using licorice protein isolate from Radix Glycyrrhizae
Int J Biol Macromol. 2023 Nov 17:128235. doi: 10.1016/j.ijbiomac.2023.128235. Online ahead of print.ABSTRACTLicorice was widely used in food and herbal medicine. In its extract industry, a substantial amount of licorice protein was produced and discarded as waste. Herein, we extracted Licorice Protein Isolate (LPI) and explored its potential as a curcumin nanocarrier. Using a pH-driven method, we fabricated LPI-curcumin nanoparticles with diameters ranging from 129.30 ± 3.21 nm to 75.03 ± 1.19 nm, depending on the LPI/curcumin molar ratio. The formation of LPI-curcumin nanoparticles was primarily driven by hydrophobic in...
Source: International Journal of Biological Macromolecules - November 19, 2023 Category: Biochemistry Authors: Huiqin Wang Binbin Song Jianwu Zhou Guanzhen Gao Yanan Ding Xiangyu Meng Lijing Ke Wei Ding Suyun Zhang Tianbao Chen Pingfan Rao Source Type: research
Licorice flavonoid alleviates gastric ulcers by producing changes in gut microbiota and promoting mucus cell regeneration
In this study, we manifested that LF increased the viability of human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored gastric mucosal barrier in GU rats. After LF therapy, the EtOH-induced gut dysbiosis was partly modulated, and short-chain fatty acids (SCFAs) like butyric acid, propionic acid, and valeric acid were found in higher concentrations. We discovered that the majority of genera that increased in the GU group had a negative correlation with SCFAs in the intestinal tract. In addition, LF-upregulated SCFAs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Yufan Wu Yinglin Guo Tairun Huang Dehao Huang Li Liu Chunyan Shen Cuiping Jiang Zhuxian Wang Hongkai Chen Peiyi Liang Yi Hu Zeying Zheng Tao Liang Dan Zhai Hongxia Zhu Qiang Liu Source Type: research
Licorice flavonoid alleviates gastric ulcers by producing changes in gut microbiota and promoting mucus cell regeneration
In this study, we manifested that LF increased the viability of human gastric mucosal epithelial (GES-1) cells, attenuated ethanol (EtOH)-induced manifestations, reduced histological injury, suppressed inflammation, and restored gastric mucosal barrier in GU rats. After LF therapy, the EtOH-induced gut dysbiosis was partly modulated, and short-chain fatty acids (SCFAs) like butyric acid, propionic acid, and valeric acid were found in higher concentrations. We discovered that the majority of genera that increased in the GU group had a negative correlation with SCFAs in the intestinal tract. In addition, LF-upregulated SCFAs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 12, 2023 Category: Drugs & Pharmacology Authors: Yufan Wu Yinglin Guo Tairun Huang Dehao Huang Li Liu Chunyan Shen Cuiping Jiang Zhuxian Wang Hongkai Chen Peiyi Liang Yi Hu Zeying Zheng Tao Liang Dan Zhai Hongxia Zhu Qiang Liu Source Type: research
Fermentation improves antioxidant capacity and γ-aminobutyric acid content of Ganmai Dazao Decoction by lactic acid bacteria
DiscussionAmong the top 30 differential metabolites with VIP values, the content of five functional substances increased significantly. Our results showed that lactic acid bacteria fermentation of Ganmai Dazao Decoction improves its antioxidant effects and that fermentation of Ganmai Dazao Decoction with lactic acid bacteria is an innovative approach that improves the health-promoting ingredients of Ganmai Dazao Decoction. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 2, 2023 Category: Microbiology Source Type: research
Inactivated vaccine with glycyrrhizic acid adjuvant elicits potent innate and adaptive immune responses against foot-and-mouth disease
ConclusionCollectively, glycyrrhizic acid could have utility as a novel vaccine adjuvant that can address the limitations of commercialized FMD vaccines by inducing potent innate and adaptive immune responses. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - October 31, 2023 Category: Microbiology Source Type: research
Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management
This study suggests that further experimental investigations can be conducted on Ginkgolide A and Licorice glycoside D2 to explore their potential therapeutic applications for AD.PMID:37886145 | PMC:PMC10599677 | DOI:10.6026/97320630019565 (Source: Bioinformation)
Source: Bioinformation - October 27, 2023 Category: Bioinformatics Authors: Israa J Hakeem Source Type: research
Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management
This study suggests that further experimental investigations can be conducted on Ginkgolide A and Licorice glycoside D2 to explore their potential therapeutic applications for AD.PMID:37886145 | PMC:PMC10599677 | DOI:10.6026/97320630019565 (Source: Bioinformation)
Source: Bioinformation - October 27, 2023 Category: Bioinformatics Authors: Israa J Hakeem Source Type: research
Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management
This study suggests that further experimental investigations can be conducted on Ginkgolide A and Licorice glycoside D2 to explore their potential therapeutic applications for AD.PMID:37886145 | PMC:PMC10599677 | DOI:10.6026/97320630019565 (Source: Bioinformation)
Source: Bioinformation - October 27, 2023 Category: Bioinformatics Authors: Israa J Hakeem Source Type: research
