Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli
Biochem Biophys Res Commun. 2023 May 22;668:90-95. doi: 10.1016/j.bbrc.2023.05.083. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) crisis urges the development of new antibiotics. In the present work, we for the first time used bio-affinity ultrafiltration combined with HPLC-MS (UF-HPLC-MS) to examine the interaction between the outer membrane β-barrel proteins and natural products. Our results showed that natural product licochalcone A from licorice interacts with BamA and BamD with the enrichment factor of 6.38 ± 1.46 and 4.80 ± 1.23, respectively. The interaction was further confirmed by use of biacore ...
Source: Biochemical and Biophysical Research communications - May 28, 2023 Category: Biochemistry Authors: Liangwan Wei Zhe Wang Yindi Chu Kun Cai Wei Li Piying Huang Youcai Qin Dailin Liu Xiaocui Zhuang Mingquan Guo Xinbo Song Enguo Fan Source Type: research
A Review of the Antiviral Activities of Glycyrrhizic Acid, Glycyrrhetinic Acid and Glycyrrhetinic Acid Monoglucuronide
Pharmaceuticals (Basel). 2023 Apr 23;16(5):641. doi: 10.3390/ph16050641.ABSTRACTLicorice, a natural medicine derived from the roots and rhizomes of Glycyrrhiza species, possesses a wide range of therapeutic applications, including antiviral properties. Glycyrrhizic acid (GL) and glycyrrhetinic acid (GA) are the most important active ingredients in licorice. Glycyrrhetinic acid 3-O-mono-β-d-glucuronide (GAMG) is the active metabolite of GL. GL and its metabolites have a wide range of antiviral activities against viruses, such as, the hepatitis virus, herpes virus and severe acute respiratory syndrome coronavirus 2 (SARS-Co...
Source: Herpes - May 27, 2023 Category: Infectious Diseases Authors: Jiawei Zuo Tao Meng Yuanyuan Wang Wenjian Tang Source Type: research
A Review of the Antiviral Activities of Glycyrrhizic Acid, Glycyrrhetinic Acid and Glycyrrhetinic Acid Monoglucuronide
Pharmaceuticals (Basel). 2023 Apr 23;16(5):641. doi: 10.3390/ph16050641.ABSTRACTLicorice, a natural medicine derived from the roots and rhizomes of Glycyrrhiza species, possesses a wide range of therapeutic applications, including antiviral properties. Glycyrrhizic acid (GL) and glycyrrhetinic acid (GA) are the most important active ingredients in licorice. Glycyrrhetinic acid 3-O-mono-β-d-glucuronide (GAMG) is the active metabolite of GL. GL and its metabolites have a wide range of antiviral activities against viruses, such as, the hepatitis virus, herpes virus and severe acute respiratory syndrome coronavirus 2 (SARS-Co...
Source: Herpes - May 27, 2023 Category: Infectious Diseases Authors: Jiawei Zuo Tao Meng Yuanyuan Wang Wenjian Tang Source Type: research
PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer's disease effect of licorice stem flavonoids
Aging (Albany NY). 2023 Feb 22;15. doi: 10.18632/aging.204536. Online ahead of print.ABSTRACTActive ingredients were screened by TCMSP and swissADME, meanwhile, PharmMapper combined with UniProt database was used to predict the active ingredient target information, GeneCard database was employed to obtain Alzheimer's disease (AD)-related genes, Cytoscapes 3.7.2 software was utilized to map the active ingredient-target effect. Besides, Cytoscapes 3.7.2 software Bisogenet and Cyto NCA plug-in combined with STRING platform were utilized to map the protein-protein interaction (PPI) network, DAVID was employed for GO annotation...
Source: Aging - May 11, 2023 Category: Biomedical Science Authors: Hongyan Pei Lei He Meiling Shi Xiangjuan Guo Weijia Chen Jianming Li Zhongmei He Rui Du Source Type: research
PI3K-Akt signaling pathway based on network pharmacology for the anti-Alzheimer's disease effect of licorice stem flavonoids
Aging (Albany NY). 2023 Feb 22;15. doi: 10.18632/aging.204536. Online ahead of print.ABSTRACTActive ingredients were screened by TCMSP and swissADME, meanwhile, PharmMapper combined with UniProt database was used to predict the active ingredient target information, GeneCard database was employed to obtain Alzheimer's disease (AD)-related genes, Cytoscapes 3.7.2 software was utilized to map the active ingredient-target effect. Besides, Cytoscapes 3.7.2 software Bisogenet and Cyto NCA plug-in combined with STRING platform were utilized to map the protein-protein interaction (PPI) network, DAVID was employed for GO annotation...
Source: Aging - May 11, 2023 Category: Biomedical Science Authors: Hongyan Pei Lei He Meiling Shi Xiangjuan Guo Weijia Chen Jianming Li Zhongmei He Rui Du Source Type: research
