Holistically assessing the quality consistency of compound liquorice tablets from similarities of both all chemical fingerprints and the integrated dissolution curves by systematically quantified fingerprint method
In this study, a chromatographic and dissolution-based quality analysis method was proposed, which effectively overcomes the shortcomings of previous analytical methods and provides a scientific analytical method for the quality control of natural drugs.PMID:37302351 | DOI:10.1016/j.talanta.2023.124774 (Source: Talanta)
Source: Talanta - June 11, 2023 Category: Chemistry Authors: Ming Cai Qian Zhang Lili Lan Wanyang Sun Hong Zhang Guoxiang Sun Source Type: research
Holistically assessing the quality consistency of compound liquorice tablets from similarities of both all chemical fingerprints and the integrated dissolution curves by systematically quantified fingerprint method
In this study, a chromatographic and dissolution-based quality analysis method was proposed, which effectively overcomes the shortcomings of previous analytical methods and provides a scientific analytical method for the quality control of natural drugs.PMID:37302351 | DOI:10.1016/j.talanta.2023.124774 (Source: Talanta)
Source: Talanta - June 11, 2023 Category: Chemistry Authors: Ming Cai Qian Zhang Lili Lan Wanyang Sun Hong Zhang Guoxiang Sun Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 May 30. doi: 10.1007/s12012-023-09795-5. Online ahead of print.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiomyocytes ...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 May 30. doi: 10.1007/s12012-023-09795-5. Online ahead of print.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiomyocytes ...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 May 30. doi: 10.1007/s12012-023-09795-5. Online ahead of print.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiomyocytes ...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 May 30. doi: 10.1007/s12012-023-09795-5. Online ahead of print.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiomyocytes ...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 May 30. doi: 10.1007/s12012-023-09795-5. Online ahead of print.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiomyocytes ...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
