Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder's role in psoriasis treatment
Conclusion: This research has pinpointed lipid metabolism as a key pathway in the treatment of psoriasis with SLBZP. It explores how SLBZP's modulation of gut microbiota and lipid metabolism can alleviate psoriasis, suggesting that balancing gut microbiota may reduce inflammation mediators and offer therapeutic benefits. This underscores lipid metabolism modulation as a potential new strategy in psoriasis treatment.PMID:38425649 | PMC:PMC10904012 | DOI:10.3389/fphar.2024.1362161 (Source: Atherosclerosis)
Source: Atherosclerosis - March 1, 2024 Category: Cardiology Authors: Bin Tang Xuwei Zheng Qianqian Luo Xiong Li Yujie Yang Yang Bi Yonggen Chen Ling Han Haiming Chen Chuanjian Lu Source Type: research
A review of typical biological activities of glycyrrhetinic acid and its derivatives
RSC Adv. 2024 Feb 22;14(10):6557-6597. doi: 10.1039/d3ra08025k. eCollection 2024 Feb 21.ABSTRACTGlycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, exhibits noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial, antiviral, and antioxidant effects. Despite these commendable effects, its further advancement and application, especially in clinical use, have been hindered by its limited druggability, including challenges such as low solubility and bioavailability. To enhance its biological activity and pharmaceutical efficacy, numerous research studies focus on ...
Source: Adv Data - February 23, 2024 Category: Epidemiology Authors: Liang Chen Jingwen Gong Xu Yong Youbin Li Shuojin Wang Source Type: research
Effect of incorporation of “Licorice powder” on storage stability of curd balls at refrigeration temperature
Varsha Vihan, V.P. Singh, Pramila Umaraw, Akhilesh Kumar Verma, Shardanand Verma, Chirag Singh Nutrition & Food Science, Vol. ahead-of-print, No. ahead-of-print, pp.- The purpose of this study is to investigate the impact of integrating “Licorice powder” into curd balls on their storage stability under refrigeration conditions. Through this examination, this study aims to evaluate the potential effects of licorice powder on extending the shelf life, maintaining quality attributes and preserving the overall stability of curd balls when stored at refrigeration temperatures.Licorice powder, in varying quantities (1%,...
Source: Nutrition and Food Science - February 22, 2024 Category: Nutrition Authors: Varsha Vihan V.P. Singh Pramila Umaraw Akhilesh Kumar Verma Shardanand Verma Chirag Singh Source Type: research
18 β-glycyrrhetinic acid suppresses Lewis lung cancer growth through protecting immune cells from ferroptosis
ConclusionThe findings of the present study unraveled a novel mechanism underlying the anti-cancer and immunomodulatory activity of 18 β-GA and support that 18β-GA holds potential to be used as an immune enhancer for lung cancer prevention or treatment. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - February 21, 2024 Category: Cancer & Oncology Source Type: research
Assessing the effectiveness of fenbendazole supramolecular complexes against schistosomiasis, monieziosis and parabronemosis in sheep
This study explores the potential of supramolecular complexes, created through mechanochemical modifications, to address these limitations. The study focuses on two key anthelmintics, praziquantel (PZQ) and fenbendazole (FBZ), employing mechanochemical techniques to enhance their solubility and efficacy. Solid dispersions (SD) of PZQ with polymers and dioctyl sulfosuccine sodium (DSS) and fenbendazole with essential oils licorice extract (ES) and DSS were prepared. The helminthicidal activity of these complexes was assessed through helminthological dissections of sheep infected with Schistosoma turkestanicum, moniesiasis, ...
Source: Experimental Parasitology - February 17, 2024 Category: Parasitology Authors: Firuza Akramova Ulugbek Shakarbaev Dilbar Paluaniyazova Abror Akbarov Salavat Khalikov Alisher Safarov Djalaliddin Azimov Mourad Ben Said Source Type: research
Solid state synthesis of Liquorice-stabilized copper-based nanoparticles: structural and catalytic studies
Chem Biodivers. 2024 Feb 15:e202301794. doi: 10.1002/cbdv.202301794. Online ahead of print.ABSTRACTA large-scale quantity of copper oxalate nanoparticles were successfully obtained via a facile and green solid-state chemical reaction. Copper oxalate nanoparticles were obtained by ball-milling between copper chloride, Liquorice(Glycyrrhiza glabra), and ascorbic acid at ambient conditions. The size and morphology of copper oxalate nanoparticles powder was studied by transmission and scanning electron microscopy. The prepared nanoparticles were semi-spherical in shape and ranged from 5 to 15 nm in size. UV/Vis spectroscopy, F...
Source: Chemistry and Biodiversity - February 15, 2024 Category: Biochemistry Authors: Mai S Maize H Alnassar A M Abou Zeid Wael Eisa Z I Ali Source Type: research
Network pharmacology and gut microbiota insights: unraveling Shenling Baizhu powder ’s role in psoriasis treatment
Conclusion: This research has pinpointed lipid metabolism as a key pathway in the treatment of psoriasis with SLBZP. It explores how SLBZP’s modulation of gut microbiota and lipid metabolism can alleviate psoriasis, suggesting that balancing gut microbiota may reduce inflammation mediators and offer therapeutic benefits. This underscores lipid metabolism modulation as a potential new strategy in psoriasis treatment. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 14, 2024 Category: Drugs & Pharmacology Source Type: research
Licochalcone A induces mitochondria-dependent apoptosis and interacts with venetoclax in acute myeloid leukemia
Eur J Pharmacol. 2024 Feb 11:176418. doi: 10.1016/j.ejphar.2024.176418. Online ahead of print.ABSTRACTThe management of patients with acute myeloid leukemia (AML) remains a challenge because of the complexity and heterogeneity of this malignancy. Despite the recent approval of several novel targeted drugs, resistance seems inevitable, and clinical outcomes are still suboptimal. Increasing evidence supports the use of natural plants as an important source of anti-leukemic therapeutics. Licochalcone A (LCA) is an active flavonoid isolated from the roots of licorice, Glycyrrhiza uralensis Fisch., possessing extensive anti-tum...
Source: European Journal of Pharmacology - February 13, 2024 Category: Drugs & Pharmacology Authors: Youhong Li Mengting Zhao Ye Lin Xia Jiang Lili Jin Peipei Ye Ying Lu Renzhi Pei Lei Jiang Source Type: research
The effect of Jian Gan powder on the proliferation, migration and polarization of macrophages and relative mechanism
CONCLUSIONS: JGP effectively suppressed the cellular function of RAW264.7 cells by down-regulating the IL-6/STAT3 signaling pathway and modulating macrophage M1/M2 polarization. These findings provide valuable theoretical and experimental basis for considering the potential clinical application of JGP in the treatment of immune-mediated liver injury in clinical practice.PMID:38327157 | PMC:PMC10854435 | DOI:10.1080/13880209.2024.2309864 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 8, 2024 Category: Drugs & Pharmacology Authors: Kun Li Xue Zheng Jian Zhang Zhanpeng Yan Yu Ji Fei Ge Fangshi Zhu Source Type: research
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis
Eur J Pharmacol. 2024 Feb 3;967:176365. doi: 10.1016/j.ejphar.2024.176365. Online ahead of print.ABSTRACTGlycyrrhizic acid (GA), one of the major active components derived from licorice root, exerts liver-protecting activity. Its molecular mechanisms of action, however, remain not completely understood. The angiotensin (Ang) converting enzyme (ACE) 2/Ang-(1-7)/Mas axis, regulated by ACE2 through converting Ang II into Ang-(1-7) to activate Mas receptor, counteracts the pro-inflammatory and pro-steatotic effects of the ACE/Ang II/Ang II receptor type 1 (AT1) axis. Here, it was found that pretreatment with GA suppressed LPS/...
Source: European Journal of Pharmacology - February 5, 2024 Category: Drugs & Pharmacology Authors: Longyue Zhou Shankang Chen Yuanyi Wei Yihui Sun Yifan Yang Bingqi Lin Yuhao Li Chunxia Wang Source Type: research
Improving the geographical origin classification of Radix Glycyrrhizae (licorice) through hyperspectral imaging assisted with U-Net fine structure recognition
Analyst, 2024, Accepted Manuscript DOI: 10.1039/D3AN02064A, PaperHui Zhang, YiXia Pan, Yuan Chen, Hongxu Zhang, Jianhui Xie, Xingchu Gong, Jieqiang Zhu, Jizhong Yan Radix Glycyrrhizae (licorice) is extensively employed in traditional Chinese medicine, and serves as a crucial raw material in industries such as food and cosmetics. The quality of licorice from different... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - January 27, 2024 Category: Chemistry Authors: Hui Zhang Source Type: research
Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways
Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known as Liquorice, is a widely used plant containing bioactive c... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 27, 2024 Category: Complementary Medicine Authors: Rui Zhang, Aiminuer Asikaer, Qi Chen, Fang Wang, Junjie Lan, Yang Liu, Linfang Hu, Huaye Zhao and Hongtao Duan Tags: Research Source Type: research
Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders
CONCLUSION: Considering the positive effects of herbal formulations in VH management, further research on novel herbal and/or herbal/chemical preparations is warranted.PMID:38258770 | DOI:10.2174/0113892010261502231102040149 (Source: Current Pharmaceutical Biotechnology)
Source: Current Pharmaceutical Biotechnology - January 23, 2024 Category: Biotechnology Authors: Naser-Aldin Lashgari Nazanin Momeni Roudsari Saeideh Momtaz Faezeh Niazi Shahraki Nadia Zandi Benyamin Pazoki Mohammad Hosein Farzaei Mehdi Ghasemi Mohammad Abdollahi Amir Hossein Abdolghaffari Source Type: research
A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial
CONCLUSIONS: We found licorice to be more potent than previously known, with significant increases in BP, after a daily intake of only 100 mg GA. Thus, the safe limit of intake of this substance might need to be reconsidered. This trial was registered at clinicaltrials.gov as NCT05661721 (https://clinicaltrials.gov/study/NCT05661721).PMID:38246526 | DOI:10.1016/j.ajcnut.2024.01.011 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - January 21, 2024 Category: Nutrition Authors: Peder Af Geijerstam Annelie Joelsson Karin R ådholm Fredrik H Nystr öm Source Type: research
A low dose of daily licorice intake affects renin, aldosterone, and home blood pressure in a randomized crossover trial
CONCLUSIONS: We found licorice to be more potent than previously known, with significant increases in BP, after a daily intake of only 100 mg GA. Thus, the safe limit of intake of this substance might need to be reconsidered. This trial was registered at clinicaltrials.gov as NCT05661721 (https://clinicaltrials.gov/study/NCT05661721).PMID:38246526 | DOI:10.1016/j.ajcnut.2024.01.011 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - January 21, 2024 Category: Nutrition Authors: Peder Af Geijerstam Annelie Joelsson Karin R ådholm Fredrik H Nystr öm Source Type: research
