Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
