Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs
Cardiovasc Toxicol. 2023 Jun;23(5-6):207-217. doi: 10.1007/s12012-023-09795-5. Epub 2023 May 30.ABSTRACTLicorice has been traditionally prescribed for palpitation, whereas its overdose has caused lethal arrhythmias including torsade de pointes. Licorice contains glycyrrhizic acid of ≥ 2% (w/w), which is hydrolyzed to glycyrrhetinic acid (GRA) in the intestine. Since their cardiac electropharmacological properties are not fully understood, we assessed them to ask mechanism of licorice-induced torsade de pointes. GRA at 0.1, 1 and 10 μg/mL was cumulatively applied to the human induced pluripotent stem cell-derived cardiom...
Source: Cardiovascular Toxicology - May 30, 2023 Category: Cardiology Authors: Hiroko Izumi-Nakaseko Koki Chiba Ai Goto Ryuichi Kambayashi Akio Matsumoto Yoshinori Takei Shinichi Kawai Atsushi Sugiyama Source Type: research
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway
Int Immunopharmacol. 2023 May 26;120:110371. doi: 10.1016/j.intimp.2023.110371. Online ahead of print.ABSTRACTParticulate matter (PM) is a major environmental pollutant that contributes considerably to deaths worldwide. The pathogenesis of PM-induced lung injury (PILI) is far from elucidated and warrants effective intervention. An effective component of licorice, glycyrrhizin (GL), has been the subject of much research due to its anti-inflammatory and anti-oxidative capabilities. Although preventive properties of GL are well-known, the precise mechanism of GL in PILI has not yet been investigated. A mouse model of PILI was...
Source: International Immunopharmacology - May 28, 2023 Category: Allergy & Immunology Authors: Qiangqiang Shi Yao Qian Beibei Wang Li Liu Yang Chen Chengshui Chen Lanfang Feng Junjie Chen Nian Dong Source Type: research
Licochalcone A inhibits the assembly function of β-barrel assembly machinery in Escherichia coli
Biochem Biophys Res Commun. 2023 May 22;668:90-95. doi: 10.1016/j.bbrc.2023.05.083. Online ahead of print.ABSTRACTAntimicrobial resistance (AMR) crisis urges the development of new antibiotics. In the present work, we for the first time used bio-affinity ultrafiltration combined with HPLC-MS (UF-HPLC-MS) to examine the interaction between the outer membrane β-barrel proteins and natural products. Our results showed that natural product licochalcone A from licorice interacts with BamA and BamD with the enrichment factor of 6.38 ± 1.46 and 4.80 ± 1.23, respectively. The interaction was further confirmed by use of biacore ...
Source: Biochemical and Biophysical Research communications - May 28, 2023 Category: Biochemistry Authors: Liangwan Wei Zhe Wang Yindi Chu Kun Cai Wei Li Piying Huang Youcai Qin Dailin Liu Xiaocui Zhuang Mingquan Guo Xinbo Song Enguo Fan Source Type: research
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway
Int Immunopharmacol. 2023 May 26;120:110371. doi: 10.1016/j.intimp.2023.110371. Online ahead of print.ABSTRACTParticulate matter (PM) is a major environmental pollutant that contributes considerably to deaths worldwide. The pathogenesis of PM-induced lung injury (PILI) is far from elucidated and warrants effective intervention. An effective component of licorice, glycyrrhizin (GL), has been the subject of much research due to its anti-inflammatory and anti-oxidative capabilities. Although preventive properties of GL are well-known, the precise mechanism of GL in PILI has not yet been investigated. A mouse model of PILI was...
Source: International Immunopharmacology - May 28, 2023 Category: Allergy & Immunology Authors: Qiangqiang Shi Yao Qian Beibei Wang Li Liu Yang Chen Chengshui Chen Lanfang Feng Junjie Chen Nian Dong Source Type: research
