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Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
Oncol Rep. 2023 Dec;50(6):214. doi: 10.3892/or.2023.8651. Epub 2023 Oct 20.ABSTRACTLung squamous cell carcinoma (LSCC) is a highly heterogeneous malignancy with high mortality and few therapeutic options. Licochalcone A (LCA, PubChem ID: 5318998) is a chalcone extracted from licorice and possesses anticancer and anti‑inflammatory activities. The present study aimed to elucidate the anticancer effect of LCA on LSCC and explore the conceivable molecular mechanism. MTT assay revealed that LCA significantly inhibited the proliferation of LSCC cells with less cytotoxicity towards human bronchial epithelial cells. 5‑ethynyl�...
Source: Oncology Reports - October 20, 2023 Category: Cancer & Oncology Authors: Xiaoli Fan Guoqiang Guan Juan Wang Meihua Jin Liming Wang Xiaoqun Duan Source Type: research

Determination of ochratoxin A in licorice extract based on modified immunoaffinity column clean-up and HPLC analysis
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Source: Food Additives and Contaminants Part A - October 20, 2023 Category: Food Science Authors: Zhentao TangFang FangTingting LouBakhetgul ManatbaiCheng PengZhiguo GongJinlin Guoa State Key Laboratory of Southwestern Chinese Medicine Resources, School of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu, Chinab Technolo Source Type: research

Liquiritin targeting Th17 cells differentiation and abnormal proliferation of keratinocytes alleviates psoriasis via NF- κB and AP-1 pathway
Phytother Res. 2023 Oct 17. doi: 10.1002/ptr.8038. Online ahead of print.ABSTRACTPsoriasis is a common immune-mediated inflammatory skin disease, caused by disturbed interactions between keratinocytes and immune cells. Chinese medicine shows potential clinical application for its treatment. Liquiritin is a flavone compound extracted from licorice and shows potential antitussive, antioxidant and antiinflammatory effects, and therefore may have potential as a psoriasis therapeutic. The aim of this work was to examine the possible roles that liquiritin may have in treating psoriasis. HaCaT cells were stimulated by TNF-α with...
Source: Cell Research - October 18, 2023 Category: Cytology Authors: Dandan Guo Qianqian Wang Aifang Li Shuxuan Li Baiyan Wang Yalan Li Juan Yuan Tao Guo Shuying Feng Source Type: research

Efficacy and safety of licorice (Glycyrrhiza glabra) in moderately ill patients with COVID-19: a randomized controlled trial
In this study, 60 patients with confirmed COVID-19 were randomly assigned in a 1:1 ratio to receive licorice (at a dose of 760 mg three times a day for seven days) or control groups. The primary outcomes were SPO2, body temperature, and respiratory rate (RR) after the end of the intervention. The findings indicated that SPO2, body temperature, and RR had no significant difference between the groups at the end of the intervention. However, CRP and ALT improved in the licorice group toward the baseline. The number of patients with worse prognoses, LOS, mortality, and the incidence of adverse events were not different betwe...
Source: Inflammopharmacology - October 17, 2023 Category: Drugs & Pharmacology Source Type: research

STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota
Bioinformation. 2023 Apr 30;19(4):499-501. doi: 10.6026/97320630019499. eCollection 2023.ABSTRACTGlycyrrhizin is present in the root extract of the licorice plant used for various conditions, including gastric ulcers. Therefore, it is of interest to document the STITCH enabled molecular interaction of glycrhizzin with peri-implant microbiota. The peri implant pathogens includes Aggregatibacter actinomycetemcomitans (D7S-1), Centipeda periodontii, Campylobacter gracilisi, Fusobacterium nucleatumi, Slackia exigua, Prevotella intermedia, Tannerella forsythia, Staphylococcus aureus, Bacteroides fragilis, and Bacteroides fragil...
Source: Bioinformation - October 12, 2023 Category: Bioinformatics Authors: Karthickraj Selladurai Sahana Selvaganesh Vishnu Priya Veeraraghavan Thiyaneswaran Nesappan Rajalakshmanan Eswaramoorthy Source Type: research

Molecules, Vol. 28, Pages 7042: Multi-Omics Elucidates Difference in Accumulation of Bioactive Constituents in Licorice (Glycyrrhiza uralensis) under Drought Stress
ntian Xie Licorice is a frequently applied herb with potential edible and medicinal value based on various flavonoids and triterpenes. However, studies on detailed flavonoid and triterpene metabolism and the molecular basis of their biosynthesis in licorice are very limited, especially under drought conditions. In the present study, we carried out transcriptome, proteome, and metabolome experiments. To ultimately combine three omics for analysis, we performed a bioinformatics comparison, integrating transcriptome data and proteome data through a Cloud platform, along with a simplified biosynthesis of primary flavonoids...
Source: Molecules - October 12, 2023 Category: Chemistry Authors: Chengcheng Wang Dawei Wu Liying Jiang Xunhong Liu Tiantian Xie Tags: Article Source Type: research

Fabrication of green composite hand knitted silk mesh reinforced with silk hydrogel
Int J Biol Macromol. 2023 Oct 6:127284. doi: 10.1016/j.ijbiomac.2023.127284. Online ahead of print.ABSTRACTSoft tissue defects like hernia and post-surgical fistula formation can be resolved with modern biomaterials in the form of meshes without post-operative complications. In the present study hand knitted silk meshes were surface coated with regenerated silk fibroin hydrogel and pure natural extracts. Two phytochemicals (Licorice extract (LE) and Bearberry extract (BE)) and the two honeybee products (royal jelly (RJ) and honey (HE)) were incorporated separately to induce antibacterial, anti-inflammatory, and wound heali...
Source: International Journal of Biological Macromolecules - October 8, 2023 Category: Biochemistry Authors: Natasha Bokhari Asif Ali Abida Yasmeen Hamad Khalid Sher Zaman Safi Faiza Sharif Source Type: research

Molecules, Vol. 28, Pages 6966: Pharmacological Mechanisms and Adjuvant Properties of Licorice Glycyrrhiza in Treating Gastric Cancer
i Nan Ling Yuan Licorice is a remarkable traditional Chinese medicine obtained from the dried root and rhizomes of the Glycyrrhiza genus, and t has been utilized in China for many centuries. It consists of more than 300 compounds that are mainly divided into triterpene saponins, flavonoids, polysaccharides, and phenolic components. The active compounds of licorice have been found to possess multiple biological activities, including antitumor, anti-inflammatory, antiviral, antimicrobial, immunoregulatory, cardioprotective, and neuroprotective functions. In addition to providing a brief overview of licorice&rsq...
Source: Molecules - October 7, 2023 Category: Chemistry Authors: Joanna Japhet Tibenda Yuhua Du Shicong Huang Guoqing Chen Na Ning Wenjing Liu Mengyi Ye Yi Nan Ling Yuan Tags: Review Source Type: research