Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer via STING-TBK1-IRF3 pathway
In this study, a novel fucoidan MF4 was extracted from Fucus vesiculosus and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose in a molar ratio of 12.3: 4.9: 1.1: 1.0: 1.1, with an average molecular weight of 67.7 kDa. Notably, MF4 demonstrated suppression of LLC tumor growth in vivo. RNA-sequencing analysis revealed that MF4 enhanced the expression of type I interferon-associated downstream genes in macrophages. Furthermore, MF4 increased the levels of phosphorylated TBK1 a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Chuanqin Shi Shihua Zhao Liyan Mi Deying Niu Fanwen Hu Wenwei Han Bing Li Source Type: research
Fucoidan MF4 from Fucus vesiculosus inhibits Lewis lung cancer via STING-TBK1-IRF3 pathway
In this study, a novel fucoidan MF4 was extracted from Fucus vesiculosus and isolated using Q-Sepharose fast-flow ion-exchange chromatography. The physicochemical properties of MF4 were characterized. MF4 is primarily composed of fucose, xylose, galactose, glucose, and mannose in a molar ratio of 12.3: 4.9: 1.1: 1.0: 1.1, with an average molecular weight of 67.7 kDa. Notably, MF4 demonstrated suppression of LLC tumor growth in vivo. RNA-sequencing analysis revealed that MF4 enhanced the expression of type I interferon-associated downstream genes in macrophages. Furthermore, MF4 increased the levels of phosphorylated TBK1 a...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Chuanqin Shi Shihua Zhao Liyan Mi Deying Niu Fanwen Hu Wenwei Han Bing Li Source Type: research
The oldest mysticete in the Northern Hemisphere
Curr Biol. 2024 Mar 19:S0960-9822(24)00308-7. doi: 10.1016/j.cub.2024.03.011. Online ahead of print.ABSTRACTExtant baleen whales (Mysticeti) uniquely use keratinous baleen for filter-feeding and lack dentition, but the fossil record clearly shows that "toothed" baleen whales first appeared in the Late Eocene.1 Globally, only two Eocene mysticetes have been found, and both are from the Southern Hemisphere: Mystacodon selenensis from Peru, 36.4 mega-annum (Ma) ago1,2 and Llanocetus denticrenatus from Antarctica, 34.2 Ma ago.3,4 Based on a partial skull from the lower part of the Lincoln Creek Formation in Washington State, U...
Source: Current Biology - March 29, 2024 Category: Biology Authors: Cheng-Hsiu Tsai James L Goedert Robert W Boessenecker Source Type: research
Repeated co-option of HMG-box genes for sex determination in brown algae and animals | Science
Identification of the brown algal master sex factor reveals that animals and seaweeds have converged on male sex determination. (Source: Science: Current Issue)
Source: Science: Current Issue - March 22, 2024 Category: Science Source Type: research
Sensors, Vol. 24, Pages 1971: Enhancing Sun-Dried Kelp Detection: Introducing K-YOLO, a Lightweight Model with Improved Precision and Recall
Tao Jiang
Kelp, often referred to as a “sea vegetable”, holds substantial economic significance. Currently, the drying process for kelp in China primarily relies on outdoor sun-drying methods. Detecting kelp in the field presents challenges arising from issues such as overlapping and obstruction. To address these challenges, this study introduces a lightweight model, K-YOLOv5, specifically designed for the precise detection of sun-dried kelp. YOLOv5-n serves as the base model, with several enhancements implemented in this study: the addition of a detection head incorporating an upsampling la...
Source: Sensors - March 20, 2024 Category: Biotechnology Authors: Zhefei Xiao Ye Zhu Yang Hong Tiantian Ma Tao Jiang Tags: Article Source Type: research
Copay
I surrender this portion. I pay it the way I imagine the ancient Greeks paid their tithes to stone all-seeing Zeus: half a body of cow, half my daily lot, anointed in oil, smoldering or charred. Will you remember me by the increments of what I owed you? I will remember you by the way you taught me to recognize the sun behind my dark life: butter light, kelp light, spinner and canary light. Cloud- hide-metal light. I can close my eyes and your office lamp is shedding its petals into your lap, as if a hundred sunflowers bowed their heads to your hands. (Source: JAMA)
Source: JAMA - March 19, 2024 Category: General Medicine Source Type: research
Phloroglucinol Enhances Anagen Signaling and Alleviates H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Oxidative Stress in Human Dermal Papilla Cells
In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylat...
Source: Journal of Microbiology and Biotechnology - March 13, 2024 Category: Biotechnology Authors: Seokmuk Park Ye Jin Lim Hee Su Kim Hee-Jae Shin Ji-Seon Kim Jae Nam Lee Jae Ho Lee Seunghee Bae Source Type: research
Phloroglucinol Enhances Anagen Signaling and Alleviates H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Oxidative Stress in Human Dermal Papilla Cells
In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylat...
Source: Journal of Microbiology and Biotechnology - March 13, 2024 Category: Biotechnology Authors: Seokmuk Park Ye Jin Lim Hee Su Kim Hee-Jae Shin Ji-Seon Kim Jae Nam Lee Jae Ho Lee Seunghee Bae Source Type: research
Phloroglucinol Enhances Anagen Signaling and Alleviates H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Oxidative Stress in Human Dermal Papilla Cells
In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylat...
Source: Journal of Microbiology and Biotechnology - March 13, 2024 Category: Biotechnology Authors: Seokmuk Park Ye Jin Lim Hee Su Kim Hee-Jae Shin Ji-Seon Kim Jae Nam Lee Jae Ho Lee Seunghee Bae Source Type: research
Phloroglucinol Enhances Anagen Signaling and Alleviates H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Oxidative Stress in Human Dermal Papilla Cells
In this study, we investigated the therapeutic potential of PG for improving hair loss. A non-cytotoxic concentration of PG increased anagen-inductive genes and transcriptional activities of β-Catenin. Since several anagen-inductive genes are regulated by β-Catenin, further experiments were performed to elucidate the molecular mechanism by which PG upregulates anagen signaling. Various biochemical analyses revealed that PG upregulated β-Catenin signaling without affecting the expression of Wnt. In particular, PG elevated the phosphorylation of protein kinase B (AKT), leading to an increase in the inhibitory phosphorylat...
Source: Journal of Microbiology and Biotechnology - March 13, 2024 Category: Biotechnology Authors: Seokmuk Park Ye Jin Lim Hee Su Kim Hee-Jae Shin Ji-Seon Kim Jae Nam Lee Jae Ho Lee Seunghee Bae Source Type: research
Highly crystalline cellulose microparticles from dealginated seaweed waste ameliorate high fat-sugar diet-induced hyperlipidemia in mice by modulating gut microbiota
Int J Biol Macromol. 2024 Feb 27:130485. doi: 10.1016/j.ijbiomac.2024.130485. Online ahead of print.ABSTRACTThe effects of seaweed cellulose (SC) on high fat-sugar diet (HFSD)-induced glucolipid metabolism disorders in mice and potential mechanisms were investigated. SC was isolated from dealginated residues of giant kelp (Macrocystis pyrifera), with a crystallinity index of 85.51 % and an average particle size of 678.2 nm. Administering SC to C57BL/6 mice at 250 or 500 mg/kg BW/day via intragastric gavage for six weeks apparently inhibited the development of HFSD-induced obesity, dyslipidemia, insulin resistance, oxidativ...
Source: International Journal of Biological Macromolecules - February 29, 2024 Category: Biochemistry Authors: Shiying Tang Xiuyu Dong Yueyun Ma Hui Zhou Yunhai He Dandan Ren Xiang Li Yidi Cai Qiukuan Wang Long Wu Source Type: research
Alginate-encapsulated biochar as an effective soil ameliorant for reducing Pb phytoavailability to lettuce (Lactuca sativa L.)
Environ Sci Pollut Res Int. 2024 Feb 27. doi: 10.1007/s11356-024-32594-6. Online ahead of print.ABSTRACTThe alginate-biochar formulation for metal removal from aquatic environments has been widely tried but its use for lowering phytoavailability of metals in the soil-crop continuum is limited. Biochar has been increasingly used as a soil amendment due to its potential for soil carbon sequestration and sorption capacity. Handling of powdery biochar as a soil top-dressing material is, however, cumbersome and vulnerable to loss by water and wind. In this experiment, biochar powder, which was pyrolyzed from oak trees, was enca...
Source: Environmental Science and Pollution Research International - February 27, 2024 Category: Environmental Health Authors: Hyuck Soo Kim Yeon Kyu Lee Byung Jun Park Ji Eun Lee Seok Soon Jeong Kwon Rae Kim Sung Chul Kim M B Kirkham Jae E Yang Kye-Hoon Kim Jung-Hwan Yoon Source Type: research
Algal evolution: A touch of brown in a Paleozoic sea of greens and reds
Curr Biol. 2024 Feb 26;34(4):R150-R152. doi: 10.1016/j.cub.2024.01.028.ABSTRACTPrevious molecular clock studies indicated a Mesozoic origin for the brown algae (Phaeophyceae). New research based on phylogenetic evidence challenges this notion and provides novel insights into the origin and diversification of brown algae, which includes multiple transitions within the group from isogamy to oogamy (and back again!).PMID:38412826 | DOI:10.1016/j.cub.2024.01.028 (Source: Current Biology)
Source: Current Biology - February 27, 2024 Category: Biology Authors: Olivier De Clerck Steven T LoDuca Source Type: research
Alginate-encapsulated biochar as an effective soil ameliorant for reducing Pb phytoavailability to lettuce (Lactuca sativa L.)
Environ Sci Pollut Res Int. 2024 Feb 27. doi: 10.1007/s11356-024-32594-6. Online ahead of print.ABSTRACTThe alginate-biochar formulation for metal removal from aquatic environments has been widely tried but its use for lowering phytoavailability of metals in the soil-crop continuum is limited. Biochar has been increasingly used as a soil amendment due to its potential for soil carbon sequestration and sorption capacity. Handling of powdery biochar as a soil top-dressing material is, however, cumbersome and vulnerable to loss by water and wind. In this experiment, biochar powder, which was pyrolyzed from oak trees, was enca...
Source: Environmental Science and Pollution Research International - February 27, 2024 Category: Environmental Health Authors: Hyuck Soo Kim Yeon Kyu Lee Byung Jun Park Ji Eun Lee Seok Soon Jeong Kwon Rae Kim Sung Chul Kim M B Kirkham Jae E Yang Kye-Hoon Kim Jung-Hwan Yoon Source Type: research
Algal evolution: A touch of brown in a Paleozoic sea of greens and reds
Curr Biol. 2024 Feb 26;34(4):R150-R152. doi: 10.1016/j.cub.2024.01.028.ABSTRACTPrevious molecular clock studies indicated a Mesozoic origin for the brown algae (Phaeophyceae). New research based on phylogenetic evidence challenges this notion and provides novel insights into the origin and diversification of brown algae, which includes multiple transitions within the group from isogamy to oogamy (and back again!).PMID:38412826 | DOI:10.1016/j.cub.2024.01.028 (Source: Current Biology)
Source: Current Biology - February 27, 2024 Category: Biology Authors: Olivier De Clerck Steven T LoDuca Source Type: research
