Formulation of a thermo-sensitive hydro-gel for ulcerative colitis treatment
Bioinformation. 2022 Oct 31;18(10):925-937. doi: 10.6026/97320630018925. eCollection 2022.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes chronic intestinal inflammation in gastrointestinal (GI) tract, mainly in innermost lining of colonic mucosa. In any of the UC drug therapy regimens, maintaining remission is challenging and about 20-40% of patients don't respond to conventional UC medications, namely, amino salicylates, steroids and immunosuppressive drugs. These agents can weaken the patient's immune system thus enhancing the risk of infectious diseases. Therefore, in our explo...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Deepa Sathesh K Sathesh Kumar Velmurugan Devadasan Sujatha Kuppusamy Source Type: research
Formulation of a thermo-sensitive hydro-gel for ulcerative colitis treatment
Bioinformation. 2022 Oct 31;18(10):925-937. doi: 10.6026/97320630018925. eCollection 2022.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes chronic intestinal inflammation in gastrointestinal (GI) tract, mainly in innermost lining of colonic mucosa. In any of the UC drug therapy regimens, maintaining remission is challenging and about 20-40% of patients don't respond to conventional UC medications, namely, amino salicylates, steroids and immunosuppressive drugs. These agents can weaken the patient's immune system thus enhancing the risk of infectious diseases. Therefore, in our explo...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Deepa Sathesh K Sathesh Kumar Velmurugan Devadasan Sujatha Kuppusamy Source Type: research
Formulation of a thermo-sensitive hydro-gel for ulcerative colitis treatment
Bioinformation. 2022 Oct 31;18(10):925-937. doi: 10.6026/97320630018925. eCollection 2022.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes chronic intestinal inflammation in gastrointestinal (GI) tract, mainly in innermost lining of colonic mucosa. In any of the UC drug therapy regimens, maintaining remission is challenging and about 20-40% of patients don't respond to conventional UC medications, namely, amino salicylates, steroids and immunosuppressive drugs. These agents can weaken the patient's immune system thus enhancing the risk of infectious diseases. Therefore, in our explo...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Deepa Sathesh K Sathesh Kumar Velmurugan Devadasan Sujatha Kuppusamy Source Type: research
Formulation of a thermo-sensitive hydro-gel for ulcerative colitis treatment
Bioinformation. 2022 Oct 31;18(10):925-937. doi: 10.6026/97320630018925. eCollection 2022.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes chronic intestinal inflammation in gastrointestinal (GI) tract, mainly in innermost lining of colonic mucosa. In any of the UC drug therapy regimens, maintaining remission is challenging and about 20-40% of patients don't respond to conventional UC medications, namely, amino salicylates, steroids and immunosuppressive drugs. These agents can weaken the patient's immune system thus enhancing the risk of infectious diseases. Therefore, in our explo...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Deepa Sathesh K Sathesh Kumar Velmurugan Devadasan Sujatha Kuppusamy Source Type: research
Formulation of a thermo-sensitive hydro-gel for ulcerative colitis treatment
Bioinformation. 2022 Oct 31;18(10):925-937. doi: 10.6026/97320630018925. eCollection 2022.ABSTRACTUlcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes chronic intestinal inflammation in gastrointestinal (GI) tract, mainly in innermost lining of colonic mucosa. In any of the UC drug therapy regimens, maintaining remission is challenging and about 20-40% of patients don't respond to conventional UC medications, namely, amino salicylates, steroids and immunosuppressive drugs. These agents can weaken the patient's immune system thus enhancing the risk of infectious diseases. Therefore, in our explo...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Deepa Sathesh K Sathesh Kumar Velmurugan Devadasan Sujatha Kuppusamy Source Type: research
The role of microbial biofilms in range shifts of marine habitat-forming organisms
Trends Microbiol. 2023 Aug 25:S0966-842X(23)00228-7. doi: 10.1016/j.tim.2023.07.015. Online ahead of print.ABSTRACTMarine species, such as corals and kelp, are responding to climate change by altering their distributions. Microbial biofilms underpin key processes that affect the establishment, maintenance, and function of these dominant habitat-formers. Climate-mediated changes to microbial biofilms can therefore strongly influence species' range shifts. Here, we review emerging research on the interactions between benthic biofilms and habitat-formers and identify two key areas of interaction where climate change can impac...
Source: Trends in Microbiology - August 26, 2023 Category: Microbiology Authors: Christopher Cooney Brigitte Sommer Ezequiel M Marzinelli Will F Figueira Source Type: research
The role of microbial biofilms in range shifts of marine habitat-forming organisms
Trends Microbiol. 2023 Aug 25:S0966-842X(23)00228-7. doi: 10.1016/j.tim.2023.07.015. Online ahead of print.ABSTRACTMarine species, such as corals and kelp, are responding to climate change by altering their distributions. Microbial biofilms underpin key processes that affect the establishment, maintenance, and function of these dominant habitat-formers. Climate-mediated changes to microbial biofilms can therefore strongly influence species' range shifts. Here, we review emerging research on the interactions between benthic biofilms and habitat-formers and identify two key areas of interaction where climate change can impac...
Source: Trends in Microbiology - August 26, 2023 Category: Microbiology Authors: Christopher Cooney Brigitte Sommer Ezequiel M Marzinelli Will F Figueira Source Type: research
Mercury exposure in Antarctic seabirds: Assessing the influence of trophic position and migration patterns
This study investigated total mercury (THg) concentrations in feathers and eggs of resident and migratory Antarctic seabirds. Stable isotope data (δ15N, δ13C, and δ34S) were employed to ascertain the key factors influencing the exposure of these species to Hg. We gathered feathers and eggs from three resident species - Adélie, Gentoo, and Chinstrap penguins, as well as five migratory species - Snowy Sheathbill, Antarctic Tern, Southern Giant Petrel, Kelp Gull, and South Polar Skua. These samples were collected from Admiralty Bay, King George Island, in the Antarctica Peninsula. For all species, THg concentrations were ...
Source: Chemosphere - August 23, 2023 Category: Chemistry Authors: J A G Padilha J Souza-Kasprzyk M Pinzoni G Prohaska W Espejo A Leite S Santos L S T Cunha E S Costa A R Pess ôa J P M Torres G Lepoint K Das P R Dorneles Source Type: research
Mercury exposure in Antarctic seabirds: Assessing the influence of trophic position and migration patterns
This study investigated total mercury (THg) concentrations in feathers and eggs of resident and migratory Antarctic seabirds. Stable isotope data (δ15N, δ13C, and δ34S) were employed to ascertain the key factors influencing the exposure of these species to Hg. We gathered feathers and eggs from three resident species - Adélie, Gentoo, and Chinstrap penguins, as well as five migratory species - Snowy Sheathbill, Antarctic Tern, Southern Giant Petrel, Kelp Gull, and South Polar Skua. These samples were collected from Admiralty Bay, King George Island, in the Antarctica Peninsula. For all species, THg concentrations were ...
Source: Chemosphere - August 23, 2023 Category: Chemistry Authors: J A G Padilha J Souza-Kasprzyk M Pinzoni G Prohaska W Espejo A Leite S Santos L S T Cunha E S Costa A R Pess ôa J P M Torres G Lepoint K Das P R Dorneles Source Type: research
Mercury exposure in Antarctic seabirds: Assessing the influence of trophic position and migration patterns
This study investigated total mercury (THg) concentrations in feathers and eggs of resident and migratory Antarctic seabirds. Stable isotope data (δ15N, δ13C, and δ34S) were employed to ascertain the key factors influencing the exposure of these species to Hg. We gathered feathers and eggs from three resident species - Adélie, Gentoo, and Chinstrap penguins, as well as five migratory species - Snowy Sheathbill, Antarctic Tern, Southern Giant Petrel, Kelp Gull, and South Polar Skua. These samples were collected from Admiralty Bay, King George Island, in the Antarctica Peninsula. For all species, THg concentrations were ...
Source: Chemosphere - August 23, 2023 Category: Chemistry Authors: J A G Padilha J Souza-Kasprzyk M Pinzoni G Prohaska W Espejo A Leite S Santos L S T Cunha E S Costa A R Pess ôa J P M Torres G Lepoint K Das P R Dorneles Source Type: research
Mercury exposure in Antarctic seabirds: Assessing the influence of trophic position and migration patterns
This study investigated total mercury (THg) concentrations in feathers and eggs of resident and migratory Antarctic seabirds. Stable isotope data (δ15N, δ13C, and δ34S) were employed to ascertain the key factors influencing the exposure of these species to Hg. We gathered feathers and eggs from three resident species - Adélie, Gentoo, and Chinstrap penguins, as well as five migratory species - Snowy Sheathbill, Antarctic Tern, Southern Giant Petrel, Kelp Gull, and South Polar Skua. These samples were collected from Admiralty Bay, King George Island, in the Antarctica Peninsula. For all species, THg concentrations were ...
Source: Chemosphere - August 23, 2023 Category: Chemistry Authors: J A G Padilha J Souza-Kasprzyk M Pinzoni G Prohaska W Espejo A Leite S Santos L S T Cunha E S Costa A R Pess ôa J P M Torres G Lepoint K Das P R Dorneles Source Type: research
Identification of the Seaweed Metabolites as Potential Anti-tubercular Agents Against Human Pantothenate synthetase: An In Silico Approach
In this study, we have modeled binding modes of selected known anti-tubercular compounds and different solvent extract against pantothenate synthase using advanced docking program AutoDock 4.2 tool. In our current study, in silico experiments were carried out to determine if fucoidan, κ-carrageenan, and ulvan sulfated polysaccharides could be a potential target against PANc (pantothenate synthetase), with the goal of identifying potential inhibitors as anti-TB leads targeting PANc for further wet lab validation. Two bioactive compounds were docked to the Mtb pantothenate synthetase protein binding site, with docking score...
Source: Current Microbiology - August 14, 2023 Category: Microbiology Authors: Mary Shamya Arokia Rajan Rajasekar Thirunavukkarasu Jerrine Joseph Gangaraj Karyath Palliyath Kanagasabai Somarathinam Gugan Kothandan Kumaran Subaramaniyan Riaz Ullah Rajaian Pushpabai Rajesh Source Type: research
Identification of the Seaweed Metabolites as Potential Anti-tubercular Agents Against Human Pantothenate synthetase: An In Silico Approach
In this study, we have modeled binding modes of selected known anti-tubercular compounds and different solvent extract against pantothenate synthase using advanced docking program AutoDock 4.2 tool. In our current study, in silico experiments were carried out to determine if fucoidan, κ-carrageenan, and ulvan sulfated polysaccharides could be a potential target against PANc (pantothenate synthetase), with the goal of identifying potential inhibitors as anti-TB leads targeting PANc for further wet lab validation. Two bioactive compounds were docked to the Mtb pantothenate synthetase protein binding site, with docking score...
Source: Current Microbiology - August 14, 2023 Category: Microbiology Authors: Mary Shamya Arokia Rajan Rajasekar Thirunavukkarasu Jerrine Joseph Gangaraj Karyath Palliyath Kanagasabai Somarathinam Gugan Kothandan Kumaran Subaramaniyan Riaz Ullah Rajaian Pushpabai Rajesh Source Type: research
Identification of the Seaweed Metabolites as Potential Anti-tubercular Agents Against Human Pantothenate synthetase: An In Silico Approach
In this study, we have modeled binding modes of selected known anti-tubercular compounds and different solvent extract against pantothenate synthase using advanced docking program AutoDock 4.2 tool. In our current study, in silico experiments were carried out to determine if fucoidan, κ-carrageenan, and ulvan sulfated polysaccharides could be a potential target against PANc (pantothenate synthetase), with the goal of identifying potential inhibitors as anti-TB leads targeting PANc for further wet lab validation. Two bioactive compounds were docked to the Mtb pantothenate synthetase protein binding site, with docking score...
Source: Current Microbiology - August 14, 2023 Category: Microbiology Authors: Mary Shamya Arokia Rajan Rajasekar Thirunavukkarasu Jerrine Joseph Gangaraj Karyath Palliyath Kanagasabai Somarathinam Gugan Kothandan Kumaran Subaramaniyan Riaz Ullah Rajaian Pushpabai Rajesh Source Type: research
Marine heatwave temperatures enhance larval performance but are meditated by paternal thermal history and inter-individual differences in the purple sea urchin, Strongylocentrotus purpuratus
Marine heatwave (MHW) events, characterized by periods of anomalous temperatures, are an increasingly prevalent threat to coastal marine ecosystems. Given the seasonal phenology of MHWs, the full extent of their biological consequences may depend on how these thermal stress events align with an organism’s reproductive cycle. In organisms with more complex life cycles (e.g., many marine invertebrate species) the alignment of adult and larval environments may be an important factor determining offspring success, setting the stage for MHW events to influence reproduction and development in situ. Here, the influence of MHW-l...
Source: Frontiers in Physiology - August 4, 2023 Category: Physiology Source Type: research
