A Radical Reimagining of Fungal Two-Component Regulatory Systems
Trends Microbiol. 2021 Apr 12:S0966-842X(21)00064-0. doi: 10.1016/j.tim.2021.03.005. Online ahead of print.ABSTRACTBacterial two-component regulatory systems (TCSs) mediate signal transduction by transferring phosphoryl groups between sensor kinase and response regulator proteins, sometimes using intermediary histidine-phosphotransferase (Hpt) domains to form multistep phosphorelays. Because (i) almost all known fungal sensor kinases exhibit a domain architecture characteristic of bacterial TCS phosphorelays, (ii) all known fungal Hpts are stand-alone proteins suited to shuttle between cytoplasm and nucleus, and (iii) the ...
Source: Trends in Microbiology - April 15, 2021 Category: Microbiology Authors: Robert B Bourret Emily N Kennedy Clay A Foster Victoria E Sep úlveda William E Goldman Source Type: research

A Radical Reimagining of Fungal Two-Component Regulatory Systems
Trends Microbiol. 2021 Apr 12:S0966-842X(21)00064-0. doi: 10.1016/j.tim.2021.03.005. Online ahead of print.ABSTRACTBacterial two-component regulatory systems (TCSs) mediate signal transduction by transferring phosphoryl groups between sensor kinase and response regulator proteins, sometimes using intermediary histidine-phosphotransferase (Hpt) domains to form multistep phosphorelays. Because (i) almost all known fungal sensor kinases exhibit a domain architecture characteristic of bacterial TCS phosphorelays, (ii) all known fungal Hpts are stand-alone proteins suited to shuttle between cytoplasm and nucleus, and (iii) the ...
Source: Trends in Microbiology - April 15, 2021 Category: Microbiology Authors: Robert B Bourret Emily N Kennedy Clay A Foster Victoria E Sep úlveda William E Goldman Source Type: research

A Radical Reimagining of Fungal Two-Component Regulatory Systems
Trends Microbiol. 2021 Apr 12:S0966-842X(21)00064-0. doi: 10.1016/j.tim.2021.03.005. Online ahead of print.ABSTRACTBacterial two-component regulatory systems (TCSs) mediate signal transduction by transferring phosphoryl groups between sensor kinase and response regulator proteins, sometimes using intermediary histidine-phosphotransferase (Hpt) domains to form multistep phosphorelays. Because (i) almost all known fungal sensor kinases exhibit a domain architecture characteristic of bacterial TCS phosphorelays, (ii) all known fungal Hpts are stand-alone proteins suited to shuttle between cytoplasm and nucleus, and (iii) the ...
Source: Trends in Microbiology - April 15, 2021 Category: Microbiology Authors: Robert B Bourret Emily N Kennedy Clay A Foster Victoria E Sep úlveda William E Goldman Source Type: research

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
Trends Microbiol. 2021 Apr 6:S0966-842X(21)00066-4. doi: 10.1016/j.tim.2021.03.007. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.PMID:33836929 | DOI:10.1016/j.tim.2021.03.007 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 10, 2021 Category: Microbiology Authors: Pramod K Jangir Lois Ogunlana R Craig MacLean Source Type: research

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
Trends Microbiol. 2021 Apr 6:S0966-842X(21)00066-4. doi: 10.1016/j.tim.2021.03.007. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.PMID:33836929 | DOI:10.1016/j.tim.2021.03.007 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 10, 2021 Category: Microbiology Authors: Pramod K Jangir Lois Ogunlana R Craig MacLean Source Type: research

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
Trends Microbiol. 2021 Apr 6:S0966-842X(21)00066-4. doi: 10.1016/j.tim.2021.03.007. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.PMID:33836929 | DOI:10.1016/j.tim.2021.03.007 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 10, 2021 Category: Microbiology Authors: Pramod K Jangir Lois Ogunlana R Craig MacLean Source Type: research

Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
Trends Microbiol. 2021 Apr 6:S0966-842X(21)00066-4. doi: 10.1016/j.tim.2021.03.007. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.PMID:33836929 | DOI:10.1016/j.tim.2021.03.007 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 10, 2021 Category: Microbiology Authors: Pramod K Jangir Lois Ogunlana R Craig MacLean Source Type: research

Enhancing Microbial Pollutant Degradation by Integrating Eco-Evolutionary Principles with Environmental Biotechnology
Trends Microbiol. 2021 Mar 31:S0966-842X(21)00061-5. doi: 10.1016/j.tim.2021.03.002. Online ahead of print.ABSTRACTEnvironmental accumulation of anthropogenic pollutants is a pressing global issue. The biodegradation of these pollutants by microbes is an emerging field but is hampered by inefficient degradation rates and a limited knowledge of potential enzymes and pathways. Here, we advocate the view that significant progress can be achieved by harnessing artificial community selection for a desired biological process, an approach that makes use of eco-evolutionary principles. The selected communities can either be direct...
Source: Trends in Microbiology - April 4, 2021 Category: Microbiology Authors: Erik Borchert Katrin Hammerschmidt Ute Hentschel Peter Deines Source Type: research

Enhancing Microbial Pollutant Degradation by Integrating Eco-Evolutionary Principles with Environmental Biotechnology
Trends Microbiol. 2021 Mar 31:S0966-842X(21)00061-5. doi: 10.1016/j.tim.2021.03.002. Online ahead of print.ABSTRACTEnvironmental accumulation of anthropogenic pollutants is a pressing global issue. The biodegradation of these pollutants by microbes is an emerging field but is hampered by inefficient degradation rates and a limited knowledge of potential enzymes and pathways. Here, we advocate the view that significant progress can be achieved by harnessing artificial community selection for a desired biological process, an approach that makes use of eco-evolutionary principles. The selected communities can either be direct...
Source: Trends in Microbiology - April 4, 2021 Category: Microbiology Authors: Erik Borchert Katrin Hammerschmidt Ute Hentschel Peter Deines Source Type: research

Enhancing Microbial Pollutant Degradation by Integrating Eco-Evolutionary Principles with Environmental Biotechnology
Trends Microbiol. 2021 Mar 31:S0966-842X(21)00061-5. doi: 10.1016/j.tim.2021.03.002. Online ahead of print.ABSTRACTEnvironmental accumulation of anthropogenic pollutants is a pressing global issue. The biodegradation of these pollutants by microbes is an emerging field but is hampered by inefficient degradation rates and a limited knowledge of potential enzymes and pathways. Here, we advocate the view that significant progress can be achieved by harnessing artificial community selection for a desired biological process, an approach that makes use of eco-evolutionary principles. The selected communities can either be direct...
Source: Trends in Microbiology - April 4, 2021 Category: Microbiology Authors: Erik Borchert Katrin Hammerschmidt Ute Hentschel Peter Deines Source Type: research

Enhancing Microbial Pollutant Degradation by Integrating Eco-Evolutionary Principles with Environmental Biotechnology
Trends Microbiol. 2021 Mar 31:S0966-842X(21)00061-5. doi: 10.1016/j.tim.2021.03.002. Online ahead of print.ABSTRACTEnvironmental accumulation of anthropogenic pollutants is a pressing global issue. The biodegradation of these pollutants by microbes is an emerging field but is hampered by inefficient degradation rates and a limited knowledge of potential enzymes and pathways. Here, we advocate the view that significant progress can be achieved by harnessing artificial community selection for a desired biological process, an approach that makes use of eco-evolutionary principles. The selected communities can either be direct...
Source: Trends in Microbiology - April 4, 2021 Category: Microbiology Authors: Erik Borchert Katrin Hammerschmidt Ute Hentschel Peter Deines Source Type: research

Enhancing Microbial Pollutant Degradation by Integrating Eco-Evolutionary Principles with Environmental Biotechnology
Trends Microbiol. 2021 Mar 31:S0966-842X(21)00061-5. doi: 10.1016/j.tim.2021.03.002. Online ahead of print.ABSTRACTEnvironmental accumulation of anthropogenic pollutants is a pressing global issue. The biodegradation of these pollutants by microbes is an emerging field but is hampered by inefficient degradation rates and a limited knowledge of potential enzymes and pathways. Here, we advocate the view that significant progress can be achieved by harnessing artificial community selection for a desired biological process, an approach that makes use of eco-evolutionary principles. The selected communities can either be direct...
Source: Trends in Microbiology - April 4, 2021 Category: Microbiology Authors: Erik Borchert Katrin Hammerschmidt Ute Hentschel Peter Deines Source Type: research

Myxococcus xanthus
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00065-2. doi: 10.1016/j.tim.2021.03.006. Online ahead of print.NO ABSTRACTPMID:33795155 | DOI:10.1016/j.tim.2021.03.006 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Michiel Vos Source Type: research

Likelihood of amyloid formation in COVID-19-induced ARDS
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00067-6. doi: 10.1016/j.tim.2021.03.008. Online ahead of print.ABSTRACTSevere coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation occurring due to protein homeostasis disruption can be one of the complications associated with COVID-19-induced-ARDS.PMID:33795156 | DOI:10.1016/j.tim.2021.03.008 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Nabodita Sinha Ashwani K Thakur Source Type: research

Myxococcus xanthus
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00065-2. doi: 10.1016/j.tim.2021.03.006. Online ahead of print.NO ABSTRACTPMID:33795155 | DOI:10.1016/j.tim.2021.03.006 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Michiel Vos Source Type: research

Likelihood of amyloid formation in COVID-19-induced ARDS
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00067-6. doi: 10.1016/j.tim.2021.03.008. Online ahead of print.ABSTRACTSevere coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation occurring due to protein homeostasis disruption can be one of the complications associated with COVID-19-induced-ARDS.PMID:33795156 | DOI:10.1016/j.tim.2021.03.008 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Nabodita Sinha Ashwani K Thakur Source Type: research

Myxococcus xanthus
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00065-2. doi: 10.1016/j.tim.2021.03.006. Online ahead of print.NO ABSTRACTPMID:33795155 | DOI:10.1016/j.tim.2021.03.006 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Michiel Vos Source Type: research

Likelihood of amyloid formation in COVID-19-induced ARDS
Trends Microbiol. 2021 Mar 29:S0966-842X(21)00067-6. doi: 10.1016/j.tim.2021.03.008. Online ahead of print.ABSTRACTSevere coronavirus disease 2019 (COVID-19) infection leads to multifactorial acute respiratory distress syndrome (ARDS), with little therapeutic success. The pathophysiology associated with ARDS or post-ARDS is not yet well understood. We hypothesize that amyloid formation occurring due to protein homeostasis disruption can be one of the complications associated with COVID-19-induced-ARDS.PMID:33795156 | DOI:10.1016/j.tim.2021.03.008 (Source: Trends in Microbiology)
Source: Trends in Microbiology - April 2, 2021 Category: Microbiology Authors: Nabodita Sinha Ashwani K Thakur Source Type: research

Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
Trends Microbiol. 2021 Mar 14:S0966-842X(21)00063-9. doi: 10.1016/j.tim.2021.03.004. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with increased disease severity and poor clinical outcomes in diabetic patients compared with their nondiabetic counterparts. Diabetes/hyperglycemia-triggered endothelial dysfunction and hyperactive inflammatory and immune responses are correlated to twofold to threefold higher intensive care hospitalizations and more than twice the mortality among diabetic coronavirus disease 2019 (COVID-19) patients. While comorbidities such as o...
Source: Trends in Microbiology - March 31, 2021 Category: Microbiology Authors: Samson Mathews Samuel Elizabeth Varghese Dietrich B üsselberg Source Type: research

Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
Trends Microbiol. 2021 Mar 14:S0966-842X(21)00063-9. doi: 10.1016/j.tim.2021.03.004. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections present with increased disease severity and poor clinical outcomes in diabetic patients compared with their nondiabetic counterparts. Diabetes/hyperglycemia-triggered endothelial dysfunction and hyperactive inflammatory and immune responses are correlated to twofold to threefold higher intensive care hospitalizations and more than twice the mortality among diabetic coronavirus disease 2019 (COVID-19) patients. While comorbidities such as o...
Source: Trends in Microbiology - March 31, 2021 Category: Microbiology Authors: Samson Mathews Samuel Elizabeth Varghese Dietrich B üsselberg Source Type: research

Spatial technologies to strengthen traditional testing for SARS-CoV-2
Trends Microbiol. 2021 Mar 14:S0966-842X(21)00062-7. doi: 10.1016/j.tim.2021.03.003. Online ahead of print.ABSTRACTAdvanced spatial and digital technologies may help us to take fuller advantage of limited testing resources to monitor the infection status of a large population in a cost-effective manner. Moreover, they may provide additional evidence to supplement results of nucleic acid testing (NAT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to decrease false-negative and false-positive rates.PMID:33775546 | PMC:PMC7955912 | DOI:10.1016/j.tim.2021.03.003 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 29, 2021 Category: Microbiology Authors: Shujuan Yang Xiongfeng Pan Peibin Zeng Peng Jia Source Type: research

Spatial technologies to strengthen traditional testing for SARS-CoV-2
Trends Microbiol. 2021 Mar 14:S0966-842X(21)00062-7. doi: 10.1016/j.tim.2021.03.003. Online ahead of print.ABSTRACTAdvanced spatial and digital technologies may help us to take fuller advantage of limited testing resources to monitor the infection status of a large population in a cost-effective manner. Moreover, they may provide additional evidence to supplement results of nucleic acid testing (NAT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to decrease false-negative and false-positive rates.PMID:33775546 | DOI:10.1016/j.tim.2021.03.003 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 29, 2021 Category: Microbiology Authors: Shujuan Yang Xiongfeng Pan Peibin Zeng Peng Jia Source Type: research

Spatial technologies to strengthen traditional testing for SARS-CoV-2
Trends Microbiol. 2021 Mar 14:S0966-842X(21)00062-7. doi: 10.1016/j.tim.2021.03.003. Online ahead of print.ABSTRACTAdvanced spatial and digital technologies may help us to take fuller advantage of limited testing resources to monitor the infection status of a large population in a cost-effective manner. Moreover, they may provide additional evidence to supplement results of nucleic acid testing (NAT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to decrease false-negative and false-positive rates.PMID:33775546 | DOI:10.1016/j.tim.2021.03.003 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 29, 2021 Category: Microbiology Authors: Shujuan Yang Xiongfeng Pan Peibin Zeng Peng Jia Source Type: research

Interferon system deficiencies exacerbating severe pandemic virus infections
Trends Microbiol. 2021 Mar 20:S0966-842X(21)00060-3. doi: 10.1016/j.tim.2021.03.001. Online ahead of print.ABSTRACTPandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and se...
Source: Trends in Microbiology - March 24, 2021 Category: Microbiology Authors: Silke Stertz Benjamin G Hale Source Type: research

Interferon system deficiencies exacerbating severe pandemic virus infections
Trends Microbiol. 2021 Mar 20:S0966-842X(21)00060-3. doi: 10.1016/j.tim.2021.03.001. Online ahead of print.ABSTRACTPandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and se...
Source: Trends in Microbiology - March 24, 2021 Category: Microbiology Authors: Silke Stertz Benjamin G Hale Source Type: research

Interferon system deficiencies exacerbating severe pandemic virus infections
Trends Microbiol. 2021 Mar 20:S0966-842X(21)00060-3. doi: 10.1016/j.tim.2021.03.001. Online ahead of print.ABSTRACTPandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and se...
Source: Trends in Microbiology - March 24, 2021 Category: Microbiology Authors: Silke Stertz Benjamin G Hale Source Type: research

Interferon system deficiencies exacerbating severe pandemic virus infections
Trends Microbiol. 2021 Mar 20:S0966-842X(21)00060-3. doi: 10.1016/j.tim.2021.03.001. Online ahead of print.ABSTRACTPandemics are caused by novel pathogens to which pre-existing antibody immunity is lacking. Under these circumstances, the body must rely on innate interferon-mediated defenses to limit pathogen replication and allow development of critical humoral protection. Here, we highlight studies on disease susceptibility during H1N1 influenza and COVID-19 (SARS-CoV-2) pandemics. An emerging concept is that genetic and non-genetic deficiencies in interferon system components lead to uncontrolled virus replication and se...
Source: Trends in Microbiology - March 24, 2021 Category: Microbiology Authors: Silke Stertz Benjamin G Hale Source Type: research

Development of Phylodynamic Methods for Bacterial Pathogens
Trends Microbiol. 2021 Mar 15:S0966-842X(21)00044-5. doi: 10.1016/j.tim.2021.02.008. Online ahead of print.ABSTRACTPhylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay ...
Source: Trends in Microbiology - March 19, 2021 Category: Microbiology Authors: Danielle J Ingle Benjamin P Howden Sebastian Duchene Source Type: research

Development of Phylodynamic Methods for Bacterial Pathogens
Trends Microbiol. 2021 Mar 15:S0966-842X(21)00044-5. doi: 10.1016/j.tim.2021.02.008. Online ahead of print.ABSTRACTPhylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay ...
Source: Trends in Microbiology - March 19, 2021 Category: Microbiology Authors: Danielle J Ingle Benjamin P Howden Sebastian Duchene Source Type: research

Development of Phylodynamic Methods for Bacterial Pathogens
Trends Microbiol. 2021 Mar 15:S0966-842X(21)00044-5. doi: 10.1016/j.tim.2021.02.008. Online ahead of print.ABSTRACTPhylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay ...
Source: Trends in Microbiology - March 19, 2021 Category: Microbiology Authors: Danielle J Ingle Benjamin P Howden Sebastian Duchene Source Type: research

Development of Phylodynamic Methods for Bacterial Pathogens
Trends Microbiol. 2021 Mar 15:S0966-842X(21)00044-5. doi: 10.1016/j.tim.2021.02.008. Online ahead of print.ABSTRACTPhylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay ...
Source: Trends in Microbiology - March 19, 2021 Category: Microbiology Authors: Danielle J Ingle Benjamin P Howden Sebastian Duchene Source Type: research

Development of Phylodynamic Methods for Bacterial Pathogens
Trends Microbiol. 2021 Mar 15:S0966-842X(21)00044-5. doi: 10.1016/j.tim.2021.02.008. Online ahead of print.ABSTRACTPhylodynamic methods have been essential to understand the interplay between the evolution and epidemiology of infectious diseases. To date, the field has centered on viruses. Bacterial pathogens are seldom analyzed under such phylodynamic frameworks, due to their complex genome evolution and, until recently, a paucity of whole-genome sequence data sets with rich associated metadata. We posit that the increasing availability of bacterial genomes and epidemiological data means that the field is now ripe to lay ...
Source: Trends in Microbiology - March 19, 2021 Category: Microbiology Authors: Danielle J Ingle Benjamin P Howden Sebastian Duchene Source Type: research

Live and Wet Markets: Food Access versus the Risk of Disease Emergence
Trends Microbiol. 2021 Mar 9:S0966-842X(21)00043-3. doi: 10.1016/j.tim.2021.02.007. Online ahead of print.ABSTRACTEmerging zoonotic diseases exert a significant burden on human health and have considerable socioeconomic impact worldwide. In Asia, live animals as well as animal products are commonly sold in informal markets. The interaction of humans, live domestic animals for sale, food products, and wild and scavenging animals, creates a risk for emerging infectious diseases. Such markets have been in the spotlight as sources of zoonotic viruses, for example, avian influenza viruses and coronaviruses, Here, we bring data ...
Source: Trends in Microbiology - March 13, 2021 Category: Microbiology Authors: Mahmoud M Naguib Ruiyun Li Jiaxin Ling Delia Grace Hung Nguyen-Viet Johanna F Lindahl Source Type: research

Live and Wet Markets: Food Access versus the Risk of Disease Emergence
Trends Microbiol. 2021 Mar 9:S0966-842X(21)00043-3. doi: 10.1016/j.tim.2021.02.007. Online ahead of print.ABSTRACTEmerging zoonotic diseases exert a significant burden on human health and have considerable socioeconomic impact worldwide. In Asia, live animals as well as animal products are commonly sold in informal markets. The interaction of humans, live domestic animals for sale, food products, and wild and scavenging animals, creates a risk for emerging infectious diseases. Such markets have been in the spotlight as sources of zoonotic viruses, for example, avian influenza viruses and coronaviruses, Here, we bring data ...
Source: Trends in Microbiology - March 13, 2021 Category: Microbiology Authors: Mahmoud M Naguib Ruiyun Li Jiaxin Ling Delia Grace Hung Nguyen-Viet Johanna F Lindahl Source Type: research

Live and Wet Markets: Food Access versus the Risk of Disease Emergence
Trends Microbiol. 2021 Mar 9:S0966-842X(21)00043-3. doi: 10.1016/j.tim.2021.02.007. Online ahead of print.ABSTRACTEmerging zoonotic diseases exert a significant burden on human health and have considerable socioeconomic impact worldwide. In Asia, live animals as well as animal products are commonly sold in informal markets. The interaction of humans, live domestic animals for sale, food products, and wild and scavenging animals, creates a risk for emerging infectious diseases. Such markets have been in the spotlight as sources of zoonotic viruses, for example, avian influenza viruses and coronaviruses, Here, we bring data ...
Source: Trends in Microbiology - March 13, 2021 Category: Microbiology Authors: Mahmoud M Naguib Ruiyun Li Jiaxin Ling Delia Grace Hung Nguyen-Viet Johanna F Lindahl Source Type: research

Live and Wet Markets: Food Access versus the Risk of Disease Emergence
Trends Microbiol. 2021 Mar 9:S0966-842X(21)00043-3. doi: 10.1016/j.tim.2021.02.007. Online ahead of print.ABSTRACTEmerging zoonotic diseases exert a significant burden on human health and have considerable socioeconomic impact worldwide. In Asia, live animals as well as animal products are commonly sold in informal markets. The interaction of humans, live domestic animals for sale, food products, and wild and scavenging animals, creates a risk for emerging infectious diseases. Such markets have been in the spotlight as sources of zoonotic viruses, for example, avian influenza viruses and coronaviruses, Here, we bring data ...
Source: Trends in Microbiology - March 13, 2021 Category: Microbiology Authors: Mahmoud M Naguib Ruiyun Li Jiaxin Ling Delia Grace Hung Nguyen-Viet Johanna F Lindahl Source Type: research

The Emerging Role of Iron Acquisition in Biofilm-Associated Infections
Trends Microbiol. 2021 Mar 8:S0966-842X(21)00045-7. doi: 10.1016/j.tim.2021.02.009. Online ahead of print.ABSTRACTA possible association between iron and biofilm formation has been explored for a long time. Here, we focus on major recent advances that shed light on the mechanisms behind this relationship and discuss how siderophore-mediated iron acquisition may impact the virulence of important nosocomial pathogens.PMID:33707049 | DOI:10.1016/j.tim.2021.02.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 12, 2021 Category: Microbiology Authors: Fernando Oliveira Holger Rohde Manuel Vilanova Nuno Cerca Source Type: research

The Emerging Role of Iron Acquisition in Biofilm-Associated Infections
Trends Microbiol. 2021 Mar 8:S0966-842X(21)00045-7. doi: 10.1016/j.tim.2021.02.009. Online ahead of print.ABSTRACTA possible association between iron and biofilm formation has been explored for a long time. Here, we focus on major recent advances that shed light on the mechanisms behind this relationship and discuss how siderophore-mediated iron acquisition may impact the virulence of important nosocomial pathogens.PMID:33707049 | DOI:10.1016/j.tim.2021.02.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 12, 2021 Category: Microbiology Authors: Fernando Oliveira Holger Rohde Manuel Vilanova Nuno Cerca Source Type: research

The Emerging Role of Iron Acquisition in Biofilm-Associated Infections
Trends Microbiol. 2021 Mar 8:S0966-842X(21)00045-7. doi: 10.1016/j.tim.2021.02.009. Online ahead of print.ABSTRACTA possible association between iron and biofilm formation has been explored for a long time. Here, we focus on major recent advances that shed light on the mechanisms behind this relationship and discuss how siderophore-mediated iron acquisition may impact the virulence of important nosocomial pathogens.PMID:33707049 | DOI:10.1016/j.tim.2021.02.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - March 12, 2021 Category: Microbiology Authors: Fernando Oliveira Holger Rohde Manuel Vilanova Nuno Cerca Source Type: research

Selective Autophagy Receptors in Antiviral Defense
Trends Microbiol. 2021 Mar 4:S0966-842X(21)00042-1. doi: 10.1016/j.tim.2021.02.006. Online ahead of print.ABSTRACTAutophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes and route them to elongating autophagic membranes, a process referred to as selective autophagy. Besides contributing to cell homeostasis, selective autophagy constitutes an important cell-autonomous defense mechanism against virus...
Source: Trends in Microbiology - March 8, 2021 Category: Microbiology Authors: Christophe Viret R émi Duclaux-Loras St éphane Nancey Aurore Rozi ères Mathias Faure Source Type: research

Selective Autophagy Receptors in Antiviral Defense
Trends Microbiol. 2021 Mar 4:S0966-842X(21)00042-1. doi: 10.1016/j.tim.2021.02.006. Online ahead of print.ABSTRACTAutophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes and route them to elongating autophagic membranes, a process referred to as selective autophagy. Besides contributing to cell homeostasis, selective autophagy constitutes an important cell-autonomous defense mechanism against virus...
Source: Trends in Microbiology - March 8, 2021 Category: Microbiology Authors: Christophe Viret R émi Duclaux-Loras St éphane Nancey Aurore Rozi ères Mathias Faure Source Type: research

Selective Autophagy Receptors in Antiviral Defense
Trends Microbiol. 2021 Mar 4:S0966-842X(21)00042-1. doi: 10.1016/j.tim.2021.02.006. Online ahead of print.ABSTRACTAutophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes and route them to elongating autophagic membranes, a process referred to as selective autophagy. Besides contributing to cell homeostasis, selective autophagy constitutes an important cell-autonomous defense mechanism against virus...
Source: Trends in Microbiology - March 8, 2021 Category: Microbiology Authors: Christophe Viret R émi Duclaux-Loras St éphane Nancey Aurore Rozi ères Mathias Faure Source Type: research

Microbial Regulation of Host Physiology by Short-chain Fatty Acids
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00035-4. doi: 10.1016/j.tim.2021.02.001. Online ahead of print.ABSTRACTOur ancestral diet consisted of much more nondigestible fiber than that of many societies today. Thus, from an evolutionary perspective the human genome and its physiological and nutritional requirements are not well aligned to modern dietary habits. Fiber reaching the colon is anaerobically fermented by the gut bacteria, which produce short-chain fatty acids (SCFAs) as metabolic by-products. SCFAs play a role in intestinal homeostasis, helping to explain why changes in the microbiota can contribute to the path...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Bart van der Hee Jerry M Wells Source Type: research

Evolution of Microbiota-Host Associations: The Microbe's Perspective
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00041-X. doi: 10.1016/j.tim.2021.02.005. Online ahead of print.ABSTRACTMicrobiota-host associations are ubiquitous in nature. They are often studied using a host-centered view, while microbes are assumed to have coevolved with hosts or colonize hosts as nonadapted entities. Both assumptions are often incorrect. Instead, many host-associated microbes are adapted to a biphasic life cycle in which they alternate between noncoadapted hosts and a free-living phase. Full appreciation of microbiota-host symbiosis thus needs to consider how microbes optimize fitness across this life cycle...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Nancy Obeng Florence Bansept Michael Sieber Arne Traulsen Hinrich Schulenburg Source Type: research

Microbial Regulation of Host Physiology by Short-chain Fatty Acids
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00035-4. doi: 10.1016/j.tim.2021.02.001. Online ahead of print.ABSTRACTOur ancestral diet consisted of much more nondigestible fiber than that of many societies today. Thus, from an evolutionary perspective the human genome and its physiological and nutritional requirements are not well aligned to modern dietary habits. Fiber reaching the colon is anaerobically fermented by the gut bacteria, which produce short-chain fatty acids (SCFAs) as metabolic by-products. SCFAs play a role in intestinal homeostasis, helping to explain why changes in the microbiota can contribute to the path...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Bart van der Hee Jerry M Wells Source Type: research

Evolution of Microbiota-Host Associations: The Microbe's Perspective
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00041-X. doi: 10.1016/j.tim.2021.02.005. Online ahead of print.ABSTRACTMicrobiota-host associations are ubiquitous in nature. They are often studied using a host-centered view, while microbes are assumed to have coevolved with hosts or colonize hosts as nonadapted entities. Both assumptions are often incorrect. Instead, many host-associated microbes are adapted to a biphasic life cycle in which they alternate between noncoadapted hosts and a free-living phase. Full appreciation of microbiota-host symbiosis thus needs to consider how microbes optimize fitness across this life cycle...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Nancy Obeng Florence Bansept Michael Sieber Arne Traulsen Hinrich Schulenburg Source Type: research

Microbial Regulation of Host Physiology by Short-chain Fatty Acids
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00035-4. doi: 10.1016/j.tim.2021.02.001. Online ahead of print.ABSTRACTOur ancestral diet consisted of much more nondigestible fiber than that of many societies today. Thus, from an evolutionary perspective the human genome and its physiological and nutritional requirements are not well aligned to modern dietary habits. Fiber reaching the colon is anaerobically fermented by the gut bacteria, which produce short-chain fatty acids (SCFAs) as metabolic by-products. SCFAs play a role in intestinal homeostasis, helping to explain why changes in the microbiota can contribute to the path...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Bart van der Hee Jerry M Wells Source Type: research

Evolution of Microbiota-Host Associations: The Microbe's Perspective
Trends Microbiol. 2021 Mar 2:S0966-842X(21)00041-X. doi: 10.1016/j.tim.2021.02.005. Online ahead of print.ABSTRACTMicrobiota-host associations are ubiquitous in nature. They are often studied using a host-centered view, while microbes are assumed to have coevolved with hosts or colonize hosts as nonadapted entities. Both assumptions are often incorrect. Instead, many host-associated microbes are adapted to a biphasic life cycle in which they alternate between noncoadapted hosts and a free-living phase. Full appreciation of microbiota-host symbiosis thus needs to consider how microbes optimize fitness across this life cycle...
Source: Trends in Microbiology - March 6, 2021 Category: Microbiology Authors: Nancy Obeng Florence Bansept Michael Sieber Arne Traulsen Hinrich Schulenburg Source Type: research

High-Specificity Local and Global c-di-GMP Signaling
Trends Microbiol. 2021 Feb 24:S0966-842X(21)00037-8. doi: 10.1016/j.tim.2021.02.003. Online ahead of print.ABSTRACTThe striking multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins in many bacteria has brought second messenger signaling back onto the agenda of contemporary microbiology. How can several signaling pathways act in parallel in a specific manner if all of them use the same diffusible second messenger present at a certain global cellular concentration? Recent research has now shown that bacteria achieve this by flexibly combining modes of local and global c-di-GMP signaling...
Source: Trends in Microbiology - February 28, 2021 Category: Microbiology Authors: Regine Hengge Source Type: research

High-Specificity Local and Global c-di-GMP Signaling
Trends Microbiol. 2021 Feb 24:S0966-842X(21)00037-8. doi: 10.1016/j.tim.2021.02.003. Online ahead of print.ABSTRACTThe striking multiplicity, signal input diversity, and output specificity of c-di-GMP signaling proteins in many bacteria has brought second messenger signaling back onto the agenda of contemporary microbiology. How can several signaling pathways act in parallel in a specific manner if all of them use the same diffusible second messenger present at a certain global cellular concentration? Recent research has now shown that bacteria achieve this by flexibly combining modes of local and global c-di-GMP signaling...
Source: Trends in Microbiology - February 28, 2021 Category: Microbiology Authors: Regine Hengge Source Type: research