Chemosynthesis: a neglected foundation of marine ecology and biogeochemistry: (Trends in Microbiology, Published online January 30, 2024)
Trends Microbiol. 2024 Feb 21:S0966-842X(24)00045-3. doi: 10.1016/j.tim.2024.02.005. Online ahead of print.NO ABSTRACTPMID:38383220 | DOI:10.1016/j.tim.2024.02.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - February 21, 2024 Category: Microbiology Authors: Francesco Ricci Chris Greening Source Type: research
Deciphering Fc-effector functions against SARS-CoV-2
Trends Microbiol. 2024 Feb 15:S0966-842X(24)00005-2. doi: 10.1016/j.tim.2024.01.005. Online ahead of print.ABSTRACTMajor efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, thes...
Source: Trends in Microbiology - February 16, 2024 Category: Microbiology Authors: Guillaume Beaudoin-Bussi ères Andr és Finzi Source Type: research
Deciphering Fc-effector functions against SARS-CoV-2
Trends Microbiol. 2024 Feb 15:S0966-842X(24)00005-2. doi: 10.1016/j.tim.2024.01.005. Online ahead of print.ABSTRACTMajor efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, thes...
Source: Trends in Microbiology - February 16, 2024 Category: Microbiology Authors: Guillaume Beaudoin-Bussi ères Andr és Finzi Source Type: research
Deciphering Fc-effector functions against SARS-CoV-2
Trends Microbiol. 2024 Feb 15:S0966-842X(24)00005-2. doi: 10.1016/j.tim.2024.01.005. Online ahead of print.ABSTRACTMajor efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, thes...
Source: Trends in Microbiology - February 16, 2024 Category: Microbiology Authors: Guillaume Beaudoin-Bussi ères Andr és Finzi Source Type: research
Deciphering Fc-effector functions against SARS-CoV-2
Trends Microbiol. 2024 Feb 15:S0966-842X(24)00005-2. doi: 10.1016/j.tim.2024.01.005. Online ahead of print.ABSTRACTMajor efforts were deployed to study the antibody response against SARS-CoV-2. Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of infections, vaccinations, and breakthrough infections. Antibodies, however, are pleiotropic proteins that have many functions in addition to neutralization. These include Fc-effector functions such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP). Although important to combat viral infections, thes...
Source: Trends in Microbiology - February 16, 2024 Category: Microbiology Authors: Guillaume Beaudoin-Bussi ères Andr és Finzi Source Type: research
How does evolution work in superabundant microbes?
Trends Microbiol. 2024 Feb 14:S0966-842X(24)00024-6. doi: 10.1016/j.tim.2024.01.009. Online ahead of print.ABSTRACTMarine phytoplankton play crucial roles in the Earth's ecological, chemical, and geological processes. They are responsible for about half of global primary production and drive the ocean biological carbon pump. Understanding how plankton species may adapt to the Earth's rapidly changing environments is evidently an urgent priority. This problem requires evolutionary genetic approaches as evolution occurs at the level of allele frequency change within populations driven by genetic drift and natural selection (...
Source: Trends in Microbiology - February 15, 2024 Category: Microbiology Authors: Dmitry A Filatov Mark Kirkpatrick Source Type: research
Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery
Trends Microbiol. 2024 Feb 14:S0966-842X(24)00008-8. doi: 10.1016/j.tim.2024.01.008. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the stressful and nutritionally constrained environments in these cells. Exploiting these adaptations for drug discovery has revealed that perturbing cAMP signaling can restrict Mtb growth in macrophages. Specifically, compounds that agonize or stimulate the bacterial enzyme, Rv1625c/Cya, induce cAMP synthesis and this interferes with the ability of Mtb to metabolize cholesterol. In murine tuberculosis (TB) infection models, Rv1...
Source: Trends in Microbiology - February 15, 2024 Category: Microbiology Authors: Dipak Kathayat Brian C VanderVen Source Type: research
How does evolution work in superabundant microbes?
Trends Microbiol. 2024 Feb 14:S0966-842X(24)00024-6. doi: 10.1016/j.tim.2024.01.009. Online ahead of print.ABSTRACTMarine phytoplankton play crucial roles in the Earth's ecological, chemical, and geological processes. They are responsible for about half of global primary production and drive the ocean biological carbon pump. Understanding how plankton species may adapt to the Earth's rapidly changing environments is evidently an urgent priority. This problem requires evolutionary genetic approaches as evolution occurs at the level of allele frequency change within populations driven by genetic drift and natural selection (...
Source: Trends in Microbiology - February 15, 2024 Category: Microbiology Authors: Dmitry A Filatov Mark Kirkpatrick Source Type: research
Exploiting cAMP signaling in Mycobacterium tuberculosis for drug discovery
Trends Microbiol. 2024 Feb 14:S0966-842X(24)00008-8. doi: 10.1016/j.tim.2024.01.008. Online ahead of print.ABSTRACTMycobacterium tuberculosis (Mtb) replicates within host macrophages by adapting to the stressful and nutritionally constrained environments in these cells. Exploiting these adaptations for drug discovery has revealed that perturbing cAMP signaling can restrict Mtb growth in macrophages. Specifically, compounds that agonize or stimulate the bacterial enzyme, Rv1625c/Cya, induce cAMP synthesis and this interferes with the ability of Mtb to metabolize cholesterol. In murine tuberculosis (TB) infection models, Rv1...
Source: Trends in Microbiology - February 15, 2024 Category: Microbiology Authors: Dipak Kathayat Brian C VanderVen Source Type: research
Broadening oncological boundaries: the intratumoral microbiota
Trends Microbiol. 2024 Feb 2:S0966-842X(24)00007-6. doi: 10.1016/j.tim.2024.01.007. Online ahead of print.ABSTRACTThe microbiota of solid tumors was identified >100 years ago; however, heterogeneous composition and diversity have been revealed only recently. Growing evidence has suggested that several functional mechanisms of the intratumoral microbiota affect tumorigenesis and progression, suggesting that the intratumoral microbiota is a promising biomarker for multiple cancers. The low biomass of the intratumoral microbiota poses a major challenge to related research, thus necessitating the use of a multiple-modality ...
Source: Trends in Microbiology - February 3, 2024 Category: Microbiology Authors: Ying-Qi Lu Han Qiao Xi-Rong Tan Na Liu Source Type: research
The energetic costs of cellular complexity in evolution
Trends Microbiol. 2024 Feb 1:S0966-842X(24)00003-9. doi: 10.1016/j.tim.2024.01.003. Online ahead of print.ABSTRACTThe evolutionary history of cells has been marked by drastic increases in complexity. Some hypothesize that such cellular complexification requires a massive energy flux as the origin of new features is hypothetically more energetically costly than their evolutionary maintenance. However, it remains unclear how increases in cellular complexity demand more energy. I propose that the early evolution of new genes with weak functions imposes higher energetic costs by overexpression before their functions are evolut...
Source: Trends in Microbiology - February 2, 2024 Category: Microbiology Authors: Sergio A Mu ñoz-Gómez Source Type: research
Chemosynthesis: a neglected foundation of marine ecology and biogeochemistry
Trends Microbiol. 2024 Jan 17:S0966-842X(23)00332-3. doi: 10.1016/j.tim.2023.11.013. Online ahead of print.ABSTRACTChemosynthesis is a metabolic process that transfers carbon to the biosphere using reduced compounds. It is well recognised that chemosynthesis occurs in much of the ocean, but it is often thought to be a negligible process compared to photosynthesis. Here we propose that chemosynthesis is the underlying process governing primary production in much of the ocean and suggest that it extends to a much wider range of compounds, microorganisms, and ecosystems than previously thought. In turn, this process has had a...
Source: Trends in Microbiology - January 31, 2024 Category: Microbiology Authors: Francesco Ricci Chris Greening Source Type: research
Deep-sea microbial genetic resources: new frontiers for bioprospecting
Trends Microbiol. 2024 Jan 29:S0966-842X(24)00002-7. doi: 10.1016/j.tim.2024.01.002. Online ahead of print.ABSTRACTDeep-sea ecosystems are home to a diverse community of microorganisms. These microbes are not only fundamental to ecological processes but also a treasure trove of natural products and enzymes with significant scientific and industrial applications. This forum focuses on the vast diversity of deep-sea microbes and their potential for bioprospecting. It also discusses threats posed by climate change and deep-sea mining to deep-sea microbial genetic resources, and proposes future research directions.PMID:3829087...
Source: Trends in Microbiology - January 30, 2024 Category: Microbiology Authors: Chuwen Zhang Yongyi Peng Xinyue Liu Jieni Wang Xiyang Dong Source Type: research
Starvation helps transition to abundance - a ferrosome story
Trends Microbiol. 2024 Jan 27:S0966-842X(24)00006-4. doi: 10.1016/j.tim.2024.01.006. Online ahead of print.ABSTRACTIron is an essential nutrient for bacterial pathogenesis. In their study, Skaar and colleagues (Pi et al.) discovered and determined the detailed structure of ferrosomes within Clostridioides difficile, the iron-storage organelles that form under iron-limited conditions in anticipation of future iron overload.PMID:38281864 | DOI:10.1016/j.tim.2024.01.006 (Source: Trends in Microbiology)
Source: Trends in Microbiology - January 28, 2024 Category: Microbiology Authors: Subham Mridha Michael C Abt Source Type: research
HIV-1-induced translocation of CPSF6 to biomolecular condensates
Trends Microbiol. 2024 Jan 23:S0966-842X(24)00001-5. doi: 10.1016/j.tim.2024.01.001. Online ahead of print.ABSTRACTCleavage and polyadenylation specificity factor subunit 6 (CPSF6, also known as CFIm68) is a 68 kDa component of the mammalian cleavage factor I (CFIm) complex that modulates mRNA alternative polyadenylation (APA) and determines 3' untranslated region (UTR) length, an important gene expression control mechanism. CPSF6 directly interacts with the HIV-1 core during infection, suggesting involvement in HIV-1 replication. Here, we review the contributions of CPSF6 to every stage of the HIV-1 replication cycle. Rec...
Source: Trends in Microbiology - January 24, 2024 Category: Microbiology Authors: Katarzyna Bialas Felipe Diaz-Griffero Source Type: research
