Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC)
Trends Microbiol. 2023 Dec 4:S0966-842X(23)00319-0. doi: 10.1016/j.tim.2023.11.001. Online ahead of print.ABSTRACTColonization factors (CFs) are major virulence factors of enterotoxigenic Escherichia coli (ETEC). This pathogen is among the most common causes of bacterial diarrhea in children in low- and middle-income countries, travelers, and livestock. CFs are major candidate antigens in vaccines under development as preventive measures against ETEC infections in humans and livestock. Recent molecular studies have indicated that newly identified CFs on human ETEC are closely related to animal ETEC CFs. Increased knowledge...
Source: Trends in Microbiology - December 5, 2023 Category: Microbiology Authors: Astrid von Mentzer Ann-Mari Svennerholm Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
Plasmid-mediated colistin-resistance genes: mcr
Trends Microbiol. 2023 Nov 25:S0966-842X(23)00295-0. doi: 10.1016/j.tim.2023.10.006. Online ahead of print.ABSTRACTColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we...
Source: Trends in Microbiology - November 26, 2023 Category: Microbiology Authors: Jian-Hua Liu Yi-Yun Liu Ying-Bo Shen Jun Yang Timothy R Walsh Yang Wang Jianzhong Shen Source Type: research
Plasmid-mediated colistin-resistance genes: mcr
Trends Microbiol. 2023 Nov 25:S0966-842X(23)00295-0. doi: 10.1016/j.tim.2023.10.006. Online ahead of print.ABSTRACTColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we...
Source: Trends in Microbiology - November 26, 2023 Category: Microbiology Authors: Jian-Hua Liu Yi-Yun Liu Ying-Bo Shen Jun Yang Timothy R Walsh Yang Wang Jianzhong Shen Source Type: research
Plasmid-mediated colistin-resistance genes: mcr
Trends Microbiol. 2023 Nov 25:S0966-842X(23)00295-0. doi: 10.1016/j.tim.2023.10.006. Online ahead of print.ABSTRACTColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we...
Source: Trends in Microbiology - November 26, 2023 Category: Microbiology Authors: Jian-Hua Liu Yi-Yun Liu Ying-Bo Shen Jun Yang Timothy R Walsh Yang Wang Jianzhong Shen Source Type: research
Plasmid-mediated colistin-resistance genes: mcr
Trends Microbiol. 2023 Nov 25:S0966-842X(23)00295-0. doi: 10.1016/j.tim.2023.10.006. Online ahead of print.ABSTRACTColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we...
Source: Trends in Microbiology - November 26, 2023 Category: Microbiology Authors: Jian-Hua Liu Yi-Yun Liu Ying-Bo Shen Jun Yang Timothy R Walsh Yang Wang Jianzhong Shen Source Type: research
Plasmid-mediated colistin-resistance genes: mcr
Trends Microbiol. 2023 Nov 25:S0966-842X(23)00295-0. doi: 10.1016/j.tim.2023.10.006. Online ahead of print.ABSTRACTColistin is regarded as a last-line drug against serious infections caused by multidrug-resistant Gram-negative bacterial pathogens. Therefore, the emergence of mobile colistin resistance (mcr) genes has attracted global concern and led to policy changes for the use of colistin in food animals across many countries. Currently, the distribution, function, mechanism of action, transmission vehicles, origin of mcr, and new treatment strategies against MCR-producing pathogens have been extensively studied. Here we...
Source: Trends in Microbiology - November 26, 2023 Category: Microbiology Authors: Jian-Hua Liu Yi-Yun Liu Ying-Bo Shen Jun Yang Timothy R Walsh Yang Wang Jianzhong Shen Source Type: research
Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens
Trends Microbiol. 2023 Nov 18:S0966-842X(23)00300-1. doi: 10.1016/j.tim.2023.10.011. Online ahead of print.ABSTRACTInvasive fungal infections pose a major threat to human health. Bacterial and protozoan pathogens secrete protein effectors that overcome innate immune barriers to promote microbial colonization, yet few such molecules have been identified in human fungal pathogens. Recent studies have begun to reveal these long-sought effectors and have illuminated how they subvert key cellular pathways, including apoptosis, myeloid cell polarization, Toll-like receptor signaling, and phagosome action. Thus, despite lacking t...
Source: Trends in Microbiology - November 20, 2023 Category: Microbiology Authors: Michael J Boucher Hiten D Madhani Source Type: research
Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens
Trends Microbiol. 2023 Nov 18:S0966-842X(23)00300-1. doi: 10.1016/j.tim.2023.10.011. Online ahead of print.ABSTRACTInvasive fungal infections pose a major threat to human health. Bacterial and protozoan pathogens secrete protein effectors that overcome innate immune barriers to promote microbial colonization, yet few such molecules have been identified in human fungal pathogens. Recent studies have begun to reveal these long-sought effectors and have illuminated how they subvert key cellular pathways, including apoptosis, myeloid cell polarization, Toll-like receptor signaling, and phagosome action. Thus, despite lacking t...
Source: Trends in Microbiology - November 20, 2023 Category: Microbiology Authors: Michael J Boucher Hiten D Madhani Source Type: research
Convergent evolution of innate immune-modulating effectors in invasive fungal pathogens
Trends Microbiol. 2023 Nov 18:S0966-842X(23)00300-1. doi: 10.1016/j.tim.2023.10.011. Online ahead of print.ABSTRACTInvasive fungal infections pose a major threat to human health. Bacterial and protozoan pathogens secrete protein effectors that overcome innate immune barriers to promote microbial colonization, yet few such molecules have been identified in human fungal pathogens. Recent studies have begun to reveal these long-sought effectors and have illuminated how they subvert key cellular pathways, including apoptosis, myeloid cell polarization, Toll-like receptor signaling, and phagosome action. Thus, despite lacking t...
Source: Trends in Microbiology - November 20, 2023 Category: Microbiology Authors: Michael J Boucher Hiten D Madhani Source Type: research
Enhancing agroecosystem nitrogen management: microbial insights for improved nitrification inhibition
Trends Microbiol. 2023 Nov 14:S0966-842X(23)00298-6. doi: 10.1016/j.tim.2023.10.009. Online ahead of print.ABSTRACTNitrification is a key microbial process in the nitrogen (N) cycle that converts ammonia to nitrate. Excessive nitrification, typically occurring in agroecosystems, has negative environmental impacts, including eutrophication and greenhouse gas emissions. Nitrification inhibitors (NIs) are widely used to manage N in agricultural systems by reducing nitrification rates and improving N use efficiency. However, the effectiveness of NIs can vary depending on the soil conditions, which, in turn, affect the microbia...
Source: Trends in Microbiology - November 16, 2023 Category: Microbiology Authors: Fabian Beeckman Laure Annetta Mario Corrochano-Monsalve Tom Beeckman Hans Motte Source Type: research
Enhancing agroecosystem nitrogen management: microbial insights for improved nitrification inhibition
Trends Microbiol. 2023 Nov 14:S0966-842X(23)00298-6. doi: 10.1016/j.tim.2023.10.009. Online ahead of print.ABSTRACTNitrification is a key microbial process in the nitrogen (N) cycle that converts ammonia to nitrate. Excessive nitrification, typically occurring in agroecosystems, has negative environmental impacts, including eutrophication and greenhouse gas emissions. Nitrification inhibitors (NIs) are widely used to manage N in agricultural systems by reducing nitrification rates and improving N use efficiency. However, the effectiveness of NIs can vary depending on the soil conditions, which, in turn, affect the microbia...
Source: Trends in Microbiology - November 16, 2023 Category: Microbiology Authors: Fabian Beeckman Laure Annetta Mario Corrochano-Monsalve Tom Beeckman Hans Motte Source Type: research
