Crosslink cleaving enzymes: the smart autolysins that remodel the bacterial cell wall
Trends Microbiol. 2023 Dec 9:S0966-842X(23)00322-0. doi: 10.1016/j.tim.2023.11.004. Online ahead of print.ABSTRACTPeptidoglycan (PG) is a protective mesh-like polymer in bacterial cell walls that enables their survival in almost every ecological niche. PG is formed by crosslinking of several glycan strands through short peptides, conferring a characteristic structure and elasticity, distinguishing it from other polymeric exoskeletons. The significance of PG crosslink formation has been known for decades, as some of the most widely used antibiotics, namely β-lactams, target the enzymes that catalyze this step. However, the...
Source: Trends in Microbiology - December 10, 2023 Category: Microbiology Authors: Vaidehi Rajguru Stuti Chatterjee Shambhavi Garde Manjula Reddy Source Type: research
Crosslink cleaving enzymes: the smart autolysins that remodel the bacterial cell wall
Trends Microbiol. 2023 Dec 9:S0966-842X(23)00322-0. doi: 10.1016/j.tim.2023.11.004. Online ahead of print.ABSTRACTPeptidoglycan (PG) is a protective mesh-like polymer in bacterial cell walls that enables their survival in almost every ecological niche. PG is formed by crosslinking of several glycan strands through short peptides, conferring a characteristic structure and elasticity, distinguishing it from other polymeric exoskeletons. The significance of PG crosslink formation has been known for decades, as some of the most widely used antibiotics, namely β-lactams, target the enzymes that catalyze this step. However, the...
Source: Trends in Microbiology - December 10, 2023 Category: Microbiology Authors: Vaidehi Rajguru Stuti Chatterjee Shambhavi Garde Manjula Reddy Source Type: research
Crosslink cleaving enzymes: the smart autolysins that remodel the bacterial cell wall
Trends Microbiol. 2023 Dec 9:S0966-842X(23)00322-0. doi: 10.1016/j.tim.2023.11.004. Online ahead of print.ABSTRACTPeptidoglycan (PG) is a protective mesh-like polymer in bacterial cell walls that enables their survival in almost every ecological niche. PG is formed by crosslinking of several glycan strands through short peptides, conferring a characteristic structure and elasticity, distinguishing it from other polymeric exoskeletons. The significance of PG crosslink formation has been known for decades, as some of the most widely used antibiotics, namely β-lactams, target the enzymes that catalyze this step. However, the...
Source: Trends in Microbiology - December 10, 2023 Category: Microbiology Authors: Vaidehi Rajguru Stuti Chatterjee Shambhavi Garde Manjula Reddy Source Type: research
Microbes guide corals looking to find a home
Trends Microbiol. 2023 Dec 8:S0966-842X(23)00335-9. doi: 10.1016/j.tim.2023.11.017. Online ahead of print.ABSTRACTCoral reefs are facing unprecedented anthropogenic pressures impacting critical processes such as recruitment of juvenile corals. Through larval choice assays and co-occurrence network analyses, a recent study by Turnlund et al. identified microbial taxa within reef biofilms that positively correlate and therefore have potential key roles in inducing coral settlement.PMID:38071163 | DOI:10.1016/j.tim.2023.11.017 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 9, 2023 Category: Microbiology Authors: David G Bourne Yui Sato Hillary A Smith Source Type: research
A review on the use of prebiotics in ulcerative colitis
Trends Microbiol. 2023 Dec 7:S0966-842X(23)00325-6. doi: 10.1016/j.tim.2023.11.007. Online ahead of print.ABSTRACTThe gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes and Bifidobacterium in the colon, and an increase in sulfate-reducing bacteria. Prebiotics are dietary substrates which are selectively metabolised by the human colonic microbiota to confer health benefits to the host. This review explores our current understanding of the potential benefits of prebiotics on various clinical,...
Source: Trends in Microbiology - December 8, 2023 Category: Microbiology Authors: James M Kennedy Aminda De Silva Gemma E Walton Glenn R Gibson Source Type: research
Microbe of the month: Pseudomonas aeruginosa
Trends Microbiol. 2023 Dec 7:S0966-842X(23)00324-4. doi: 10.1016/j.tim.2023.11.005. Online ahead of print.NO ABSTRACTPMID:38065787 | DOI:10.1016/j.tim.2023.11.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 8, 2023 Category: Microbiology Authors: Tino Krell Miguel A Matilla Source Type: research
A review on the use of prebiotics in ulcerative colitis
Trends Microbiol. 2023 Dec 7:S0966-842X(23)00325-6. doi: 10.1016/j.tim.2023.11.007. Online ahead of print.ABSTRACTThe gut microbiome in the inflammatory bowel disease, ulcerative colitis (UC), is different to that of healthy controls. Patients with UC have relative reductions in abundance of Firmicutes and Bifidobacterium in the colon, and an increase in sulfate-reducing bacteria. Prebiotics are dietary substrates which are selectively metabolised by the human colonic microbiota to confer health benefits to the host. This review explores our current understanding of the potential benefits of prebiotics on various clinical,...
Source: Trends in Microbiology - December 8, 2023 Category: Microbiology Authors: James M Kennedy Aminda De Silva Gemma E Walton Glenn R Gibson Source Type: research
Microbe of the month: Pseudomonas aeruginosa
Trends Microbiol. 2023 Dec 7:S0966-842X(23)00324-4. doi: 10.1016/j.tim.2023.11.005. Online ahead of print.NO ABSTRACTPMID:38065787 | DOI:10.1016/j.tim.2023.11.005 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 8, 2023 Category: Microbiology Authors: Tino Krell Miguel A Matilla Source Type: research
Unveiling strain-level dynamics in probiotic activity
Trends Microbiol. 2023 Dec 5:S0966-842X(23)00327-X. doi: 10.1016/j.tim.2023.11.009. Online ahead of print.ABSTRACTDivergent gene content among distinct probiotic strains contributes to varied or conflicting clinical efficacies. Zhang et al. unveils a novel bacterial gene signature, particularly the abfA gene cluster, offering a promising avenue for screening probiotics and advancing our understanding of strain-level activities in the context of gastrointestinal health.PMID:38057167 | DOI:10.1016/j.tim.2023.11.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 6, 2023 Category: Microbiology Authors: Jiang Chang Yuwei Wu Hao Wu Source Type: research
Unveiling strain-level dynamics in probiotic activity
Trends Microbiol. 2023 Dec 5:S0966-842X(23)00327-X. doi: 10.1016/j.tim.2023.11.009. Online ahead of print.ABSTRACTDivergent gene content among distinct probiotic strains contributes to varied or conflicting clinical efficacies. Zhang et al. unveils a novel bacterial gene signature, particularly the abfA gene cluster, offering a promising avenue for screening probiotics and advancing our understanding of strain-level activities in the context of gastrointestinal health.PMID:38057167 | DOI:10.1016/j.tim.2023.11.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 6, 2023 Category: Microbiology Authors: Jiang Chang Yuwei Wu Hao Wu Source Type: research
Unveiling strain-level dynamics in probiotic activity
Trends Microbiol. 2023 Dec 5:S0966-842X(23)00327-X. doi: 10.1016/j.tim.2023.11.009. Online ahead of print.ABSTRACTDivergent gene content among distinct probiotic strains contributes to varied or conflicting clinical efficacies. Zhang et al. unveils a novel bacterial gene signature, particularly the abfA gene cluster, offering a promising avenue for screening probiotics and advancing our understanding of strain-level activities in the context of gastrointestinal health.PMID:38057167 | DOI:10.1016/j.tim.2023.11.009 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 6, 2023 Category: Microbiology Authors: Jiang Chang Yuwei Wu Hao Wu Source Type: research
Colonization factors of human and animal-specific enterotoxigenic Escherichia coli (ETEC)
Trends Microbiol. 2023 Dec 4:S0966-842X(23)00319-0. doi: 10.1016/j.tim.2023.11.001. Online ahead of print.ABSTRACTColonization factors (CFs) are major virulence factors of enterotoxigenic Escherichia coli (ETEC). This pathogen is among the most common causes of bacterial diarrhea in children in low- and middle-income countries, travelers, and livestock. CFs are major candidate antigens in vaccines under development as preventive measures against ETEC infections in humans and livestock. Recent molecular studies have indicated that newly identified CFs on human ETEC are closely related to animal ETEC CFs. Increased knowledge...
Source: Trends in Microbiology - December 5, 2023 Category: Microbiology Authors: Astrid von Mentzer Ann-Mari Svennerholm Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
SNAREs: a double-edged sword for intravacuolar bacterial pathogens within host cells
Trends Microbiol. 2023 Nov 30:S0966-842X(23)00320-7. doi: 10.1016/j.tim.2023.11.002. Online ahead of print.ABSTRACTIn the tug-of-war between host and pathogen, both evolve to combat each other's defence arsenals. Intracellular phagosomal bacteria have developed strategies to modify the vacuolar niche to suit their requirements best. Conversely, the host tries to target the pathogen-containing vacuoles towards the degradative pathways. The host cells use a robust system through intracellular trafficking to maintain homeostasis inside the cellular milieu. In parallel, intracellular bacterial pathogens have coevolved with the...
Source: Trends in Microbiology - December 1, 2023 Category: Microbiology Authors: Ritika Chatterjee Subba Rao Gangi Setty Dipshikha Chakravortty Source Type: research
