Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker
Trends Microbiol. 2023 Dec 21:S0966-842X(23)00334-7. doi: 10.1016/j.tim.2023.11.016. Online ahead of print.ABSTRACTIn recent decades, the presence of flaviviruses of concern for human health in Europe has drastically increased,exacerbated by the effects of climate change - which has allowed the vectors of these viruses to expand into new territories. Co-circulation of West Nile virus (WNV), Usutu virus (USUV), and tick-borne encephalitis virus (TBEV) represents a threat to the European continent, and this is further complicated by the difficulty of obtaining an early and discriminating diagnosis of infection. Moreover, the...
Source: Trends in Microbiology - December 22, 2023 Category: Microbiology Authors: Martina Ceconi Kevin K Ari ën Peter Delputte Source Type: research
Modeling nontuberculous mycobacterial infections in zebrafish
Trends Microbiol. 2023 Dec 21:S0966-842X(23)00329-3. doi: 10.1016/j.tim.2023.11.011. Online ahead of print.ABSTRACTThe incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases. Zebrafish have emerged as an excellent animal model due to genetic amenability and optical transparency during ...
Source: Trends in Microbiology - December 22, 2023 Category: Microbiology Authors: Matt D Johansen Herman P Spaink Stefan H Oehlers Laurent Kremer Source Type: research
Diagnosing arthropod-borne flaviviruses: non-structural protein 1 (NS1) as a biomarker
Trends Microbiol. 2023 Dec 21:S0966-842X(23)00334-7. doi: 10.1016/j.tim.2023.11.016. Online ahead of print.ABSTRACTIn recent decades, the presence of flaviviruses of concern for human health in Europe has drastically increased,exacerbated by the effects of climate change - which has allowed the vectors of these viruses to expand into new territories. Co-circulation of West Nile virus (WNV), Usutu virus (USUV), and tick-borne encephalitis virus (TBEV) represents a threat to the European continent, and this is further complicated by the difficulty of obtaining an early and discriminating diagnosis of infection. Moreover, the...
Source: Trends in Microbiology - December 22, 2023 Category: Microbiology Authors: Martina Ceconi Kevin K Ari ën Peter Delputte Source Type: research
Modeling nontuberculous mycobacterial infections in zebrafish
Trends Microbiol. 2023 Dec 21:S0966-842X(23)00329-3. doi: 10.1016/j.tim.2023.11.011. Online ahead of print.ABSTRACTThe incidence of infections due to nontuberculous mycobacteria (NTM) has increased rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent antimicrobial resistance, NTM infections are particularly difficult to treat with low cure rates. There is an urgent need to understand NTM pathogenesis and to develop novel therapeutic approaches for the treatment of NTM diseases. Zebrafish have emerged as an excellent animal model due to genetic amenability and optical transparency during ...
Source: Trends in Microbiology - December 22, 2023 Category: Microbiology Authors: Matt D Johansen Herman P Spaink Stefan H Oehlers Laurent Kremer Source Type: research
Microbial life in slow and stopped lanes
Trends Microbiol. 2023 Dec 19:S0966-842X(23)00331-1. doi: 10.1016/j.tim.2023.11.014. Online ahead of print.ABSTRACTMicrobes in nature often lack nutrients and face extreme or widely fluctuating temperatures, unlike microbes in growth-optimized settings in laboratories that much of the literature examines. Slowed or suspended lives are the norm for microbes. Studying them is important for understanding the consequences of climate change and for addressing fundamental questions about life: are there limits to how slowly a cell's life can progress, and how long cells can remain viable without self-replicating? Recent studies ...
Source: Trends in Microbiology - December 20, 2023 Category: Microbiology Authors: Rachel M Walker Valeria C Sanabria Hyun Youk Source Type: research
Microbial life in slow and stopped lanes
Trends Microbiol. 2023 Dec 19:S0966-842X(23)00331-1. doi: 10.1016/j.tim.2023.11.014. Online ahead of print.ABSTRACTMicrobes in nature often lack nutrients and face extreme or widely fluctuating temperatures, unlike microbes in growth-optimized settings in laboratories that much of the literature examines. Slowed or suspended lives are the norm for microbes. Studying them is important for understanding the consequences of climate change and for addressing fundamental questions about life: are there limits to how slowly a cell's life can progress, and how long cells can remain viable without self-replicating? Recent studies ...
Source: Trends in Microbiology - December 20, 2023 Category: Microbiology Authors: Rachel M Walker Valeria C Sanabria Hyun Youk Source Type: research
Microbial life in slow and stopped lanes
Trends Microbiol. 2023 Dec 19:S0966-842X(23)00331-1. doi: 10.1016/j.tim.2023.11.014. Online ahead of print.ABSTRACTMicrobes in nature often lack nutrients and face extreme or widely fluctuating temperatures, unlike microbes in growth-optimized settings in laboratories that much of the literature examines. Slowed or suspended lives are the norm for microbes. Studying them is important for understanding the consequences of climate change and for addressing fundamental questions about life: are there limits to how slowly a cell's life can progress, and how long cells can remain viable without self-replicating? Recent studies ...
Source: Trends in Microbiology - December 20, 2023 Category: Microbiology Authors: Rachel M Walker Valeria C Sanabria Hyun Youk Source Type: research
A brief history of metal recruitment in protozoan predation
Trends Microbiol. 2023 Dec 15:S0966-842X(23)00326-8. doi: 10.1016/j.tim.2023.11.008. Online ahead of print.ABSTRACTMetals and metalloids are used as weapons for predatory feeding by unicellular eukaryotes on prokaryotes. This review emphasizes the role of metal(loid) bioavailability over the course of Earth's history, coupled with eukaryogenesis and the evolution of the mitochondrion to trace the emergence and use of the metal(loid) prey-killing phagosome as a feeding strategy. Members of the genera Acanthamoeba and Dictyostelium use metals such as zinc (Zn) and copper (Cu), and possibly metalloids, to kill their bacterial...
Source: Trends in Microbiology - December 16, 2023 Category: Microbiology Authors: Yanshuang Yu Yuan-Ping Li Kexin Ren Xiuli Hao Ernest Chi Fru Regin R ønn Windell L Rivera Karsten Becker Renwei Feng Jun Yang Christopher Rensing Source Type: research
A brief history of metal recruitment in protozoan predation
Trends Microbiol. 2023 Dec 15:S0966-842X(23)00326-8. doi: 10.1016/j.tim.2023.11.008. Online ahead of print.ABSTRACTMetals and metalloids are used as weapons for predatory feeding by unicellular eukaryotes on prokaryotes. This review emphasizes the role of metal(loid) bioavailability over the course of Earth's history, coupled with eukaryogenesis and the evolution of the mitochondrion to trace the emergence and use of the metal(loid) prey-killing phagosome as a feeding strategy. Members of the genera Acanthamoeba and Dictyostelium use metals such as zinc (Zn) and copper (Cu), and possibly metalloids, to kill their bacterial...
Source: Trends in Microbiology - December 16, 2023 Category: Microbiology Authors: Yanshuang Yu Yuan-Ping Li Kexin Ren Xiuli Hao Ernest Chi Fru Regin R ønn Windell L Rivera Karsten Becker Renwei Feng Jun Yang Christopher Rensing Source Type: research
A brief history of metal recruitment in protozoan predation
Trends Microbiol. 2023 Dec 15:S0966-842X(23)00326-8. doi: 10.1016/j.tim.2023.11.008. Online ahead of print.ABSTRACTMetals and metalloids are used as weapons for predatory feeding by unicellular eukaryotes on prokaryotes. This review emphasizes the role of metal(loid) bioavailability over the course of Earth's history, coupled with eukaryogenesis and the evolution of the mitochondrion to trace the emergence and use of the metal(loid) prey-killing phagosome as a feeding strategy. Members of the genera Acanthamoeba and Dictyostelium use metals such as zinc (Zn) and copper (Cu), and possibly metalloids, to kill their bacterial...
Source: Trends in Microbiology - December 16, 2023 Category: Microbiology Authors: Yanshuang Yu Yuan-Ping Li Kexin Ren Xiuli Hao Ernest Chi Fru Regin R ønn Windell L Rivera Karsten Becker Renwei Feng Jun Yang Christopher Rensing Source Type: research
Exploring the antibiotic potential of cultured 'unculturable' bacteria
Trends Microbiol. 2023 Dec 14:S0966-842X(23)00330-X. doi: 10.1016/j.tim.2023.11.012. Online ahead of print.ABSTRACTIn response to the severe global antibiotic resistance crisis, this forum delves into 'unculturable' bacteria, believed to be a promising source of novel antibiotics. We propose remarkable drug discovery strategies that leverage these bacteria's diversity, aspiring to transform resistance management. The urgent call for new antibiotics accentuates the essentiality of further research.PMID:38102034 | DOI:10.1016/j.tim.2023.11.012 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 15, 2023 Category: Microbiology Authors: Xiaozhao Wang Zixin Deng Jiangtao Gao Source Type: research
The protist cultural renaissance
Trends Microbiol. 2023 Dec 14:S0966-842X(23)00328-1. doi: 10.1016/j.tim.2023.11.010. Online ahead of print.ABSTRACTProtists are key players in the biosphere. Here, we provide a perspective on integrating protist culturing with omics approaches, imaging, and high-throughput single-cell manipulation strategies, concluding with actions required for a successful return of the golden age of protist culturing.PMID:38102035 | DOI:10.1016/j.tim.2023.11.010 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 15, 2023 Category: Microbiology Authors: Javier Del Campo Maria Carlos-Oliveira Ivan Čepička Elisabeth Hehenberger Ale š Horák Anna Karnkowska Martin Kolisko Enrique Lara Julius Luke š Tom áš Pánek Kasia Piwosz Daniel J Richter Pavel Škaloud Robert Sutak Jan Tachezy Vladim ír Hampl Source Type: research
Pseudomonas aeruginosa's adaptive trajectory: diverse origins, convergent paths
Trends Microbiol. 2023 Dec 14:S0966-842X(23)00337-2. doi: 10.1016/j.tim.2023.12.002. Online ahead of print.ABSTRACTDoes genetic background contribute to populations following the same or divergent adaptive trajectories? A recent study by Filipow et al. evolved multiple genetically distinct Pseudomonas aeruginosa strains to an artificial cystic fibrosis lung sputum media. The strains adapted at different rates but converged on similar phenotypes despite their initial diversity.PMID:38102036 | DOI:10.1016/j.tim.2023.12.002 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 15, 2023 Category: Microbiology Authors: Tiffany B Taylor Matthew J Shepherd James S Horton Source Type: research
Exploring the antibiotic potential of cultured 'unculturable' bacteria
Trends Microbiol. 2023 Dec 14:S0966-842X(23)00330-X. doi: 10.1016/j.tim.2023.11.012. Online ahead of print.ABSTRACTIn response to the severe global antibiotic resistance crisis, this forum delves into 'unculturable' bacteria, believed to be a promising source of novel antibiotics. We propose remarkable drug discovery strategies that leverage these bacteria's diversity, aspiring to transform resistance management. The urgent call for new antibiotics accentuates the essentiality of further research.PMID:38102034 | DOI:10.1016/j.tim.2023.11.012 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 15, 2023 Category: Microbiology Authors: Xiaozhao Wang Zixin Deng Jiangtao Gao Source Type: research
The protist cultural renaissance
Trends Microbiol. 2023 Dec 14:S0966-842X(23)00328-1. doi: 10.1016/j.tim.2023.11.010. Online ahead of print.ABSTRACTProtists are key players in the biosphere. Here, we provide a perspective on integrating protist culturing with omics approaches, imaging, and high-throughput single-cell manipulation strategies, concluding with actions required for a successful return of the golden age of protist culturing.PMID:38102035 | DOI:10.1016/j.tim.2023.11.010 (Source: Trends in Microbiology)
Source: Trends in Microbiology - December 15, 2023 Category: Microbiology Authors: Javier Del Campo Maria Carlos-Oliveira Ivan Čepička Elisabeth Hehenberger Ale š Horák Anna Karnkowska Martin Kolisko Enrique Lara Julius Luke š Tom áš Pánek Kasia Piwosz Daniel J Richter Pavel Škaloud Robert Sutak Jan Tachezy Vladim ír Hampl Source Type: research
