Fucoidan-based nanoparticles: Preparations and applications
Int J Biol Macromol. 2022 Jul 13:S0141-8130(22)01498-2. doi: 10.1016/j.ijbiomac.2022.07.068. Online ahead of print.ABSTRACTNanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles have been synthesized using microwave, emulsion, solvent evaporation, green synthesis, polyelectrolyte self-assembly, precipitation, and ultrasonication...
Source: International Journal of Biological Macromolecules - July 16, 2022 Category: Biochemistry Authors: Jayachandran Venkatesan Sesha Subramanian Murugan Gi Hun Seong Source Type: research
Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice
In this study a low molecular weight fucoidan (LMWF) was obtained from Saccharina japonica and its effect on the cerebrovascular damage in db/db mice was investigated. Results were shown after LMWF treatment, the degree of cerebrovascular damage, the number of apoptotic neuronal cells and the inflammation were all decreased in db/db mice. Moreover, LMWF could up-regulates CD34 and VEGFA expression in db/db mice brain, and the subintestinal vessel angiogenesis in zebrafish was also promoted by LMWF. Moreover, the lumen formation of HUVEC endothelial cells was rescued by LMWF which was destroyed in high glucose treated endot...
Source: International Journal of Biological Macromolecules - July 16, 2022 Category: Biochemistry Authors: Zhi Li Ning Wu Jing Wang Yang Yue Lihua Geng Quanbin Zhang Source Type: research
Fucoidan-based nanoparticles: Preparations and applications
Int J Biol Macromol. 2022 Jul 13:S0141-8130(22)01498-2. doi: 10.1016/j.ijbiomac.2022.07.068. Online ahead of print.ABSTRACTNanoparticle-based therapy has gained much attention in the pharmaceutical industry. Fucoidan is a sulfated polysaccharide naturally derived from marine brown algae and is widely used for medical applications. We explore preparation of fucoidan-based nanoparticles and their biomedical applications in the current review. The fucoidan-based nanoparticles have been synthesized using microwave, emulsion, solvent evaporation, green synthesis, polyelectrolyte self-assembly, precipitation, and ultrasonication...
Source: International Journal of Biological Macromolecules - July 16, 2022 Category: Biochemistry Authors: Jayachandran Venkatesan Sesha Subramanian Murugan Gi Hun Seong Source Type: research
Low molecular weight fucoidan alleviates cerebrovascular damage by promoting angiogenesis in type 2 diabetes mice
In this study a low molecular weight fucoidan (LMWF) was obtained from Saccharina japonica and its effect on the cerebrovascular damage in db/db mice was investigated. Results were shown after LMWF treatment, the degree of cerebrovascular damage, the number of apoptotic neuronal cells and the inflammation were all decreased in db/db mice. Moreover, LMWF could up-regulates CD34 and VEGFA expression in db/db mice brain, and the subintestinal vessel angiogenesis in zebrafish was also promoted by LMWF. Moreover, the lumen formation of HUVEC endothelial cells was rescued by LMWF which was destroyed in high glucose treated endot...
Source: International Journal of Biological Macromolecules - July 16, 2022 Category: Biochemistry Authors: Zhi Li Ning Wu Jing Wang Yang Yue Lihua Geng Quanbin Zhang Source Type: research
Fucoxanthin Inactivates the PI3K/Akt Signaling Pathway to Mediate Malignant Biological Behaviors of Non-Small Cell Lung Cancer
In conclusion, FX inhibits malignant biological behaviors of NSCLC by suppressing the phosphorylation of both PI3K and AKT, and subsequently inactivating PI3K/AKT signaling pathway.PMID:35838029 | DOI:10.1080/01635581.2022.2091149 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - July 15, 2022 Category: Cancer & Oncology Authors: Xuehong Fang Yuzhen Zhu Taomin Zhang Qian Li Lvhua Fan Xiaodan Li Daishun Jiang Jie Lin Liyi Zou Jianwei Ren Zunnan Huang Hua Ye Yi Liu Source Type: research
Fucoxanthin Inactivates the PI3K/Akt Signaling Pathway to Mediate Malignant Biological Behaviors of Non-Small Cell Lung Cancer
In conclusion, FX inhibits malignant biological behaviors of NSCLC by suppressing the phosphorylation of both PI3K and AKT, and subsequently inactivating PI3K/AKT signaling pathway.PMID:35838029 | DOI:10.1080/01635581.2022.2091149 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - July 15, 2022 Category: Cancer & Oncology Authors: Xuehong Fang Yuzhen Zhu Taomin Zhang Qian Li Lvhua Fan Xiaodan Li Daishun Jiang Jie Lin Liyi Zou Jianwei Ren Zunnan Huang Hua Ye Yi Liu Source Type: research
Fucoxanthin Inactivates the PI3K/Akt Signaling Pathway to Mediate Malignant Biological Behaviors of Non-Small Cell Lung Cancer
In conclusion, FX inhibits malignant biological behaviors of NSCLC by suppressing the phosphorylation of both PI3K and AKT, and subsequently inactivating PI3K/AKT signaling pathway.PMID:35838029 | DOI:10.1080/01635581.2022.2091149 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - July 15, 2022 Category: Cancer & Oncology Authors: Xuehong Fang Yuzhen Zhu Taomin Zhang Qian Li Lvhua Fan Xiaodan Li Daishun Jiang Jie Lin Liyi Zou Jianwei Ren Zunnan Huang Hua Ye Yi Liu Source Type: research
Fucoxanthin Inactivates the PI3K/Akt Signaling Pathway to Mediate Malignant Biological Behaviors of Non-Small Cell Lung Cancer
In conclusion, FX inhibits malignant biological behaviors of NSCLC by suppressing the phosphorylation of both PI3K and AKT, and subsequently inactivating PI3K/AKT signaling pathway.PMID:35838029 | DOI:10.1080/01635581.2022.2091149 (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - July 15, 2022 Category: Cancer & Oncology Authors: Xuehong Fang Yuzhen Zhu Taomin Zhang Qian Li Lvhua Fan Xiaodan Li Daishun Jiang Jie Lin Liyi Zou Jianwei Ren Zunnan Huang Hua Ye Yi Liu Source Type: research
Lipoxygenase pathway in brown algae: The biosynthesis of novel oxylipins 'ectocarpins' by hydroperoxide bicyclase CYP5164A3 of Ectocarpus siliculosus
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jul 11:159205. doi: 10.1016/j.bbalip.2022.159205. Online ahead of print.ABSTRACTThe sequence encoding the CYP5164A3 of the brown alga Ectocarpus siliculosus (Stramenopiles, SAR) was heterologously expressed in E. coli cells. The resulting recombinant CYP74 clan-related protein CYP5164A3 possessed a selective activity towards the α-linolenic acid 13(S)-hydroperoxide (13-HPOTE) and eicosapentaenoic acid 15(S)-hydroperoxide (15-HPEPE). The major products were the heterobicyclic oxylipins. For instance, the 13-HPOTE was converted into plasmodiophorols A, B, and C formed at about...
Source: Biochimica et Biophysica Acta - July 14, 2022 Category: Biochemistry Authors: Yana Y Toporkova Elena O Smirnova Lucia S Mukhtarova Alexander N Grechkin Source Type: research
Lipoxygenase pathway in brown algae: The biosynthesis of novel oxylipins 'ectocarpins' by hydroperoxide bicyclase CYP5164A3 of Ectocarpus siliculosus
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jul 11:159205. doi: 10.1016/j.bbalip.2022.159205. Online ahead of print.ABSTRACTThe sequence encoding the CYP5164A3 of the brown alga Ectocarpus siliculosus (Stramenopiles, SAR) was heterologously expressed in E. coli cells. The resulting recombinant CYP74 clan-related protein CYP5164A3 possessed a selective activity towards the α-linolenic acid 13(S)-hydroperoxide (13-HPOTE) and eicosapentaenoic acid 15(S)-hydroperoxide (15-HPEPE). The major products were the heterobicyclic oxylipins. For instance, the 13-HPOTE was converted into plasmodiophorols A, B, and C formed at about...
Source: Mol Biol Cell - July 14, 2022 Category: Molecular Biology Authors: Yana Y Toporkova Elena O Smirnova Lucia S Mukhtarova Alexander N Grechkin Source Type: research
Lipoxygenase pathway in brown algae: The biosynthesis of novel oxylipins 'ectocarpins' by hydroperoxide bicyclase CYP5164A3 of Ectocarpus siliculosus
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jul 11:159205. doi: 10.1016/j.bbalip.2022.159205. Online ahead of print.ABSTRACTThe sequence encoding the CYP5164A3 of the brown alga Ectocarpus siliculosus (Stramenopiles, SAR) was heterologously expressed in E. coli cells. The resulting recombinant CYP74 clan-related protein CYP5164A3 possessed a selective activity towards the α-linolenic acid 13(S)-hydroperoxide (13-HPOTE) and eicosapentaenoic acid 15(S)-hydroperoxide (15-HPEPE). The major products were the heterobicyclic oxylipins. For instance, the 13-HPOTE was converted into plasmodiophorols A, B, and C formed at about...
Source: Biochimica et Biophysica Acta - July 14, 2022 Category: Biochemistry Authors: Yana Y Toporkova Elena O Smirnova Lucia S Mukhtarova Alexander N Grechkin Source Type: research
Transcriptional responses in Ecklonia cava to short-term exposure to polycyclic aromatic hydrocarbons
ConclusionThis study demonstrated the discovery of DEGs inE. cava that may be impacted by environmental PAHs, as well as predicted how the transcript levels would affect physiology and metabolism. Such results will contribute to a better understanding of how seaweed reacts to pollution. (Source: Molecular and Cellular Toxicology)
Source: Molecular and Cellular Toxicology - July 11, 2022 Category: Cytology Source Type: research
Multifunctional Enzyme with Endoglucanase and Alginase/Glucuronan Lyase Activities from Bacterium Cellulophaga lytica
AbstractCellulophaga lytica is a Gram-negative aerobic bacterium in the genome of which there are many genes encoding polysaccharide degrading enzymes. One of the enzymes named ClGP contains a glycoside hydrolase domain from the GH5 family and a polysaccharide lyase domain from the PL31 family. The enzyme also contains the TAT signaling peptide and the TIGR04183 domain that indicates extracellular nature of the enzyme. Phylogenetic analysis has shown that the enzymes most closely related to ClGP and containing all four domains (TAT, GH5, PL31, TIGR04183) are widespread among bacterial species belonging to theFlavobacteriac...
Source: Biochemistry (Moscow) - July 1, 2022 Category: Biochemistry Source Type: research
High graphitic porous carbon prepared via K2FeO4-assisted KOH activation for supercapacitors
New J. Chem., 2022, Accepted Manuscript DOI: 10.1039/D2NJ02150A, PaperYongtao Tan, Jining Ren, XiaoMing Li, Lijun He, Cheng-Meng Chen, Haibo Li The high graphitic porous carbon was prepared derived from kelp biomass using KOH as the main activated agent with K2FeO4 as the assisted activated agent for supercapacitors. The K2FeO4 mass... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - June 13, 2022 Category: Chemistry Authors: Yongtao Tan Source Type: research
