Generation and validation of a highly sensitive bioluminescent HIV-1 reporter vector that simplifies measurement of virus release
The continued persistence of HIV-1 as a public health concern due to the lack of a cure calls for the development of new tools for studying replication of the virus. Here, we used NanoLuc, a small and extremel... (Source: Retrovirology)
Source: Retrovirology - May 19, 2020 Category: Virology Authors: James Kirui and Eric O. Freed Tags: Research Source Type: research
Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors
HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response ... (Source: Retrovirology)
Source: Retrovirology - May 19, 2020 Category: Virology Authors: Tomas Bastys, Vytautas Gapsys, Hauke Walter, Eva Heger, Nadezhda T. Doncheva, Rolf Kaiser, Bert L. de Groot and Olga V. Kalinina Tags: Research Source Type: research
Functional properties and sequence variation of HTLV-1 p13
Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infecti... (Source: Retrovirology)
Source: Retrovirology - May 12, 2020 Category: Virology Authors: Maria Omsland, Micol Silic-Benussi, Ramona Moles, Sarkis Sarkis, Damian F. J. Purcell, David Yurick, Georges Khoury, Donna M. D ’Agostino, Vincenzo Ciminale and Genoveffa Franchini Tags: Review Source Type: research
Identification of the distribution of human endogenous retroviruses K (HML-2) by PCR-based target enrichment sequencing
Human endogenous retroviruses (HERVs), suspected to be transposition-defective, may reshape the transcriptional network of the human genome by regulatory elements distributed in their long terminal repeats (LT... (Source: Retrovirology)
Source: Retrovirology - May 6, 2020 Category: Virology Authors: Bei Xue, Tiansheng Zeng, Lisha Jia, Dongsheng Yang, Stanley L. Lin, Leonardo A. Sechi and David J. Kelvin Tags: Research Source Type: research
The three lives of Pierre Boulanger
(Source: Retrovirology)
Source: Retrovirology - April 30, 2020 Category: Virology Authors: Nathalie Chazal, Hugues de Rocquigny, Philippe Roussel, Serge Bouaziz, Fran çoise Barré-Sinoussi, Jean-François Delfraissy and Jean-Luc Darlix Tags: Obituary Source Type: research
Moving beyond the mousetrap: current and emerging humanized mouse and rat models for investigating prevention and cure strategies against HIV infection and associated pathologies
The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and ... (Source: Retrovirology)
Source: Retrovirology - April 10, 2020 Category: Virology Authors: Yash Agarwal, Cole Beatty, Shivkumar Biradar, Isabella Castronova, Sara Ho, Kevin Melody and Moses Turkle Bility Tags: Review Source Type: research
Benefits and limitations of humanized mice in HIV persistence studies
Significant advances in the treatment of HIV infection have been made in the last three decades. Antiretroviral therapy (ART) is now potent enough to prevent virus replication and stop disease progression. How... (Source: Retrovirology)
Source: Retrovirology - April 6, 2020 Category: Virology Authors: Matthew D. Marsden Tags: Review Source Type: research
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recen... (Source: Retrovirology)
Source: Retrovirology - March 30, 2020 Category: Virology Authors: Nyaradzai Sithole, Claire A. Williams, Truus E. M. Abbink and Andrew M. L. Lever Tags: Research Source Type: research
Arsenic trioxide (As2O3) as a maintenance therapy for adult T cell leukemia/lymphoma
Adult T-cell leukemia-lymphoma (ATL) is an aggressive mature lymphoid proliferation associated with poor prognosis. Standard of care includes chemotherapy and/or the combination of zidovudine and interferon-al... (Source: Retrovirology)
Source: Retrovirology - March 21, 2020 Category: Virology Authors: Ambroise Mar çais, Lucy Cook, Aviva Witkover, Vahid Asnafi, Véronique Avettand-Fenoel, Richard Delarue, Morgane Cheminant, David Sibon, Laurent Frenzel, Hugues de Thé, Charles R. M. Bangham, Ali Bazarbachi, Olivier Hermine and Felipe Suarez Tags: Short report Source Type: research
The challenge of describing the epidemiology of HTLV in the Amazon region of Brazil
HTLV-1 was the first described human retrovirus and was soon found to be associated with severe clinical diseases, including a devastating lymphoma/leukemia and other inflammatory diseases. Although HTLV-2 is ... (Source: Retrovirology)
Source: Retrovirology - February 14, 2020 Category: Virology Authors: Ricardo Ishak, Marlu ísa de Oliveira Guimarães Ishak and Antonio Carlos R. Vallinoto Tags: Review Source Type: research
The KT Jeang Retrovirology Prize 2020: call for nominations
(Source: Retrovirology)
Source: Retrovirology - February 10, 2020 Category: Virology Authors: Susan R. Ross, Johnson Mak and Ariberto Fassati Tags: Editorial Source Type: research
Longitudinal within-host evolution of HIV Nef-mediated CD4, HLA and SERINC5 downregulation activity: a case study
The HIV accessory protein Nef downregulates the viral entry receptor CD4, the Human Leukocyte Antigen (HLA)-A and -B molecules, the Serine incorporator 5 (SERINC5) protein and other molecules from the infected... (Source: Retrovirology)
Source: Retrovirology - January 9, 2020 Category: Virology Authors: Hanwei Sudderuddin, Natalie N. Kinloch, Steven W. Jin, Rachel L. Miller, Bradley R. Jones, Chanson J. Brumme, Jeffrey B. Joy, Mark A. Brockman and Zabrina L. Brumme Tags: Short report Source Type: research
HTLV-1 bZIP factor: the key viral gene for pathogenesis
Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cel... (Source: Retrovirology)
Source: Retrovirology - January 8, 2020 Category: Virology Authors: Masao Matsuoka and Jean-Michel Mesnard Tags: Review Source Type: research
An insight to HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis; evidence from high-throughput data integration and meta-analysis
Human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a progressive disease of the central nervous system that significantly affected spinal cord, nevertheless, the patho... (Source: Retrovirology)
Source: Retrovirology - December 30, 2019 Category: Virology Authors: Sayed-Hamidreza Mozhgani, Mehran Piran, Mohadeseh Zarei-Ghobadi, Mohieddin Jafari, Seyed-Mohammad Jazayeri, Talat Mokhtari-Azad, Majid Teymoori-Rad, Narges Valizadeh, Hamid Farajifard, Mehdi Mirzaie, Azam Khamseh, Houshang Rafatpanah, Seyed-Abdolrahim Rez Tags: Research Source Type: research
HTLV-1 infection of myeloid cells: from transmission to immune alterations
Human T cell leukemia virus type 1 (HTLV-1), the etiological agent of adult T-cell leukemia/lymphoma (ATLL) and the demyelinating neuroinflammatory disease known as HTLV-1-Associated Myelopathy/Tropical Spasti... (Source: Retrovirology)
Source: Retrovirology - December 23, 2019 Category: Virology Authors: Brenda Rocamonde, Auriane Carcone, Renaud Mahieux and H élène Dutartre Tags: Review Source Type: research
