The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1)
Viroporins are virally encoded ion channels involved in virus assembly and release. Human immunodeficiency virus type 1 (HIV-1) and influenza A virus encode for viroporins. The human coronavirus SARS-CoV-2 enc... (Source: Retrovirology)
Source: Retrovirology - November 19, 2022 Category: Virology Authors: Wyatt Henke, Hope Waisner, Sachith Polpitiya Arachchige, Maria Kalamvoki and Edward Stephens Tags: Research Source Type: research
Visualization of clonal expansion after massive depletion of cells carrying the bovine leukemia virus (BLV) integration sites during the course of disease progression in a BLV naturally-infected cow: a case report
Bovine leukemia virus (BLV) infects cattle, integrates into host DNA as a provirus, and induces malignant B-cell lymphoma. Previous studies have addressed the impact of proviral integration of BLV on BLV-induc... (Source: Retrovirology)
Source: Retrovirology - November 3, 2022 Category: Virology Authors: Susumu Saito, Kazuyoshi Hosomichi, Meripet Polat Yamanaka, Tetsuya Mizutani, Shin-nosuke Takeshima and Yoko Aida Tags: Brief Report Source Type: research
HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819
TASOR, a component of the HUSH repressor epigenetic complex, and SAMHD1, a cellular triphosphohydrolase (dNTPase), are both anti-HIV proteins antagonized by HIV-2/SIVsmm Viral protein X. As a result, the same ... (Source: Retrovirology)
Source: Retrovirology - October 29, 2022 Category: Virology Authors: Virginie Vauthier, Ang élique Lasserre, Marina Morel, Margaux Versapuech, Clarisse Berlioz-Torrent, Alessia Zamborlini, Florence Margottin-Goguet and Roy Matkovic Tags: Research Source Type: research
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved for use in treatment-na ïve individuals living with HIV; these ... (Source: Retrovirology)
Source: Retrovirology - October 22, 2022 Category: Virology Authors: Alexa Vyain Zhao, Rustin D. Crutchley, Rakesh Chowdary Guduru, Kathy Ton, Tammie Lam and Amy Cheng Min Tags: Review Source Type: research
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infectio... (Source: Retrovirology)
Source: Retrovirology - September 16, 2022 Category: Virology Authors: Junru Cui, Mesfin Meshesha, Natela Churgulia, Christian Merlo, Edward Fuchs, Jennifer Breakey, Joyce Jones and James T. Stivers Tags: Research Source Type: research
The KT Jeang Retrovirology prize 2022: Florence Margottin-Goguet
(Source: Retrovirology)
Source: Retrovirology - September 6, 2022 Category: Virology Tags: Editorial Source Type: research
The key amino acid sites 199 –205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A
Avian leukosis virus (ALV) is an infectious retrovirus, that mainly causes various forms of tumours, immunosuppression, a decreased egg production rate and slow weight gain in poultry. ALV consists of 11 subgr... (Source: Retrovirology)
Source: Retrovirology - August 24, 2022 Category: Virology Authors: Jian Chen, Jinqun Li, Xinyi Dong, Ming Liao and Weisheng Cao Tags: Research Source Type: research
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency
The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 replication. Control is mediated in part thr... (Source: Retrovirology)
Source: Retrovirology - August 19, 2022 Category: Virology Authors: Subha Dahal, Kiera Clayton, Terek Been, Rapha ële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta, Kayluz Frias Boligan, Furkan Guvenc, Fariha Rahman, Donald Branch, Brendan Bell, Ben Tags: Research Source Type: research
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and a... (Source: Retrovirology)
Source: Retrovirology - August 10, 2022 Category: Virology Authors: Jenna Kropp Schmidt, Matthew R. Reynolds, Thaddeus G. Golos and Igor I. Slukvin Tags: Review Source Type: research
Two lymphoid cell lines potently silence unintegrated HIV-1 DNAs
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing o... (Source: Retrovirology)
Source: Retrovirology - July 9, 2022 Category: Virology Authors: Franziska K. Geis, Demetra P. Kelenis and Stephen P. Goff Tags: Brief Report Source Type: research
Innate immune regulation in HIV latency models
Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to bec... (Source: Retrovirology)
Source: Retrovirology - July 8, 2022 Category: Virology Authors: Rebecca M. Olson, Germ án Gornalusse, Leanne S. Whitmore, Dan Newhouse, Jennifer Tisoncik-Go, Elise Smith, Christina Ochsenbauer, Florian Hladik and Michael Gale Jr Tags: Research Source Type: research
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan
(Source: Retrovirology)
Source: Retrovirology - July 4, 2022 Category: Virology Authors: Hung Fan and Wibke Bayer Tags: Comment Source Type: research
Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome landscape. There are example... (Source: Retrovirology)
Source: Retrovirology - June 28, 2022 Category: Virology Authors: Jeffrey Kuniholm, Carolyn Coote and Andrew J. Henderson Tags: Review Source Type: research
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, reactivation of the virus from latently infected cell reservoirs is a major challenge tow... (Source: Retrovirology)
Source: Retrovirology - June 22, 2022 Category: Virology Authors: Lendel Correia da Costa, Larissa Maciel Bomfim, Uilla Victoria Torres Dittz, Camila de Almeida Velozo, Rodrigo Delvecchio da Cunha and Amilcar Tanuri Tags: Research Source Type: research
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome
Human endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that became incorporated into the germline DNA and evolutionarily fixed in the human genome. HERVs can be... (Source: Retrovirology)
Source: Retrovirology - June 8, 2022 Category: Virology Authors: Lei Jia, Mengying Liu, Caiqin Yang, Hanping Li, Yongjian Liu, Jingwan Han, Xiuli Zhai, Xiaolin Wang, Tianyi Li, Jingyun Li, Bohan Zhang, Changyuan Yu and Lin Li Tags: Research Source Type: research
