Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection
To determine if individuals, from HIV-1 serodiscordant couple cohorts from Rwanda and Zambia, who become HIV-positive have a distinct inflammatory biomarker profile compared to individuals who remain HIV-negat... (Source: Retrovirology)
Source: Retrovirology - March 17, 2021 Category: Virology Authors: Samantha McInally, Kristin Wall, Tianwei Yu, Rabindra Tirouvanziam, William Kilembe, Jill Gilmour, Susan A. Allen and Eric Hunter Tags: Research Source Type: research
Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread
The Human T-cell Lymphotropic Virus Type-1 (HTLV-1) is a blood-borne pathogen and etiological agent of Adult T-cell Leukemia/Lymphoma (ATLL) and HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/T... (Source: Retrovirology)
Source: Retrovirology - February 23, 2021 Category: Virology Authors: Daniel O. Pinto, Sarah Al Sharif, Gifty Mensah, Maria Cowen, Pooja Khatkar, James Erickson, Heather Branscome, Thomas Lattanze, Catherine DeMarino, Farhang Alem, Ruben Magni, Weidong Zhou, Sandrine Alais, H élène Dutartre, Nazira El-Hage, Renaud Mahieux Tags: Research Source Type: research
Correction to: Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection
An amendment to this paper has been published and can be accessed via the original article. (Source: Retrovirology)
Source: Retrovirology - February 22, 2021 Category: Virology Authors: Lloyd Einsiedel, Fabian Chiong, Hubertus Jersmann and Graham P. Taylor Tags: Correction Source Type: research
Vpx enhances innate immune responses independently of SAMHD1 during HIV-1 infection
The genomes of HIV-2 and some SIV strains contain the accessory gene vpx, which carries out several functions during infection, including the downregulation of SAMHD1. Vpx is also commonly used in experiments to ... (Source: Retrovirology)
Source: Retrovirology - February 9, 2021 Category: Virology Authors: Oya Cing öz, Nicolas D. Arnow, Mireia Puig Torrents and Norbert Bannert Tags: Research Source Type: research
Seroprevalence of human T-lymphotropic virus infection among blood donors in China: a first nationwide survey
In this study, a multi-center nationwide serological survey was desig... (Source: Retrovirology)
Source: Retrovirology - January 7, 2021 Category: Virology Authors: Le Chang, Shanhai Ou, Zhengang Shan, Faming Zhu, Huimin Ji, Xia Rong, Fei Guo, Xinyi Jiang, Huizhen Sun, Ying Yan and Lunan Wang Tags: Research Source Type: research
Modulation of BRD4 in HIV epigenetic regulation: implications for finding an HIV cure
Following reverse transcription, HIV viral DNA is integrated into host cell genomes and establishes a stable latent infection, which has posed a major obstacle for obtaining a cure for HIV. HIV proviral transc... (Source: Retrovirology)
Source: Retrovirology - January 7, 2021 Category: Virology Authors: Edrous Alamer, Chaojie Zhong, Renee Hajnik, Lynn Soong and Haitao Hu Tags: Review Source Type: research
Human T-cell leukaemia virus type 1 associated pulmonary disease: clinical and pathological features of an under-recognised complication of HTLV-1 infection
The lung is one of several organs that can be affected by HTLV-1 mediated inflammation. Pulmonary inflammation associated with HTLV-1 infection involves the interstitium, airways and alveoli, resulting in seve... (Source: Retrovirology)
Source: Retrovirology - January 6, 2021 Category: Virology Authors: Lloyd Einsiedel, Fabian Chiong, Hubertus Jersmann and Graham P. Taylor Tags: Review Source Type: research
Inconsistent reversal of HIV-1 latency ex vivo by antigens of HIV-1, CMV, and other infectious agents
A reservoir of replication-competent but latent virus is the main obstacle to a cure for HIV-1 infection. Much of this reservoir resides in memory CD4 T cells. We hypothesized that these cells can be reactivat... (Source: Retrovirology)
Source: Retrovirology - November 23, 2020 Category: Virology Authors: Thomas Vollbrecht, Aaron O. Angerstein, Bryson Menke, Nikesh M. Kumar, Michelli Faria de Oliveira, Douglas D. Richman and John C. Guatelli Tags: Research Source Type: research
Comparative analysis of human microglial models for studies of HIV replication and pathogenesis
HIV associated neurocognitive disorders cause significant morbidity and mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of fundamental mechanisms underlying HIV inf... (Source: Retrovirology)
Source: Retrovirology - November 19, 2020 Category: Virology Authors: Mohammad A. Rai, Jason Hammonds, Mario Pujato, Christopher Mayhew, Krishna Roskin and Paul Spearman Tags: Research Source Type: research
Koala retrovirus diversity, transmissibility, and disease associations
Koalas are infected with the koala retrovirus (KoRV) that exists as exogenous or endogenous viruses. KoRV is genetically diverse with co-infection with up to ten envelope subtypes (A-J) possible; KoRV-A is the... (Source: Retrovirology)
Source: Retrovirology - October 2, 2020 Category: Virology Authors: HaoQiang Zheng, Yi Pan, Shaohua Tang, Geoffrey W. Pye, Cynthia K. Stadler, Larry Vogelnest, Kimberly Vinette Herrin, Bruce A. Rideout and William M. Switzer Tags: Research Source Type: research
Increased HIV-1 pretreatment drug resistance with consistent clade homogeneity among ART-naive HIV-1 infected individuals in Ethiopia
The development of pretreatment drug resistance (PDR) is becoming an obstacle to the success of antiretroviral therapy (ART). Besides, data from developing settings including Ethiopia is still limited. Therefo... (Source: Retrovirology)
Source: Retrovirology - September 29, 2020 Category: Virology Authors: Mulugeta Kiros, Dawit Hailu Alemayehu, Eleni Geberekidan, Adane Mihret, Melanie Maier, Woldaregay Erku Abegaz and Andargachew Mulu Tags: Research Source Type: research
HIV and the tuberculosis “set point”: how HIV impairs alveolar macrophage responses to tuberculosis and sets the stage for progressive disease
As HIV has fueled a global resurgence of tuberculosis over the last several decades, there is a growing awareness that HIV-mediated impairments in both innate and adaptive immunity contribute to the heightened... (Source: Retrovirology)
Source: Retrovirology - September 23, 2020 Category: Virology Authors: Sara C. Auld and Bashar S. Staitieh Tags: Review Source Type: research
Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration
A protein exhibiting more than one biochemical function is termed a moonlighting protein. Glycolytic enzymes are typical moonlighting proteins, and these enzymes control the infection of various viruses. Previ... (Source: Retrovirology)
Source: Retrovirology - September 11, 2020 Category: Virology Authors: Naoki Kishimoto, Kengo Yamamoto, Nozomi Iga, Chie Kirihara, Towa Abe, Nobutoki Takamune and Shogo Misumi Tags: Research Source Type: research
A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF- κB activity in T-cells
Human T-cell leukemia virus type 1 (HTLV-1) infects primarily CD4+ T-lymphocytes and evoques severe diseases, predominantly Adult T-Cell Leukemia/ Lymphoma (ATL/L) and HTLV-1-associated Myelopathy/ Tropical Spast... (Source: Retrovirology)
Source: Retrovirology - September 10, 2020 Category: Virology Authors: Sebastian Millen, Lina Meretuk, Tim G öttlicher, Sarah Schmitt, Bernhard Fleckenstein and Andrea K. Thoma-Kress Tags: Research Source Type: research
HLA-B*35 as a new marker for susceptibility to human T-cell lymphotropic virus type 1 (HTLV-1) Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) in patients living in Argentina
Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV associated myelopathy/ Tropical Spastic Paraparesis (HAM/TSP) and Adult T cell leukemia/lymphoma (ATLL), in around 2 –5% of the i... (Source: Retrovirology)
Source: Retrovirology - September 3, 2020 Category: Virology Authors: Paula Benencio, Sindy A. Fraile Gonzalez, Nicol ás Ducasa, Kimberly Page, Carolina A. Berini and Mirna M. Biglione Tags: Research Source Type: research
