Electrophysiological brain signatures for the classification of subjective cognitive decline: towards an individual detection in the preclinical stages of dementia
Alzheimer ’s disease (AD) prevalence is rapidly growing as worldwide populations grow older. Available treatments have failed to slow down disease progression, thus increasing research focus towards early or pr... (Source: Retrovirology)
Source: Retrovirology - June 1, 2019 Category: Virology Authors: David L ópez-Sanz, Ricardo Bruña, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos-Dolado, Fernando Maestú and Stefan Walter Tags: Research Source Type: research
Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer ’s disease: protocol of the BEAT-IT study
Neuropsychiatric symptoms (NPS) are very common in patients with mild cognitive impairment (MCI) and Alzheimer ’s disease (AD) dementia and are associated with various disadvantageous clinical outcomes includin... (Source: Retrovirology)
Source: Retrovirology - May 24, 2019 Category: Virology Authors: Willem S. Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L. van Bruchem, Jeannette A. Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer, Jan J. M. Driesen, Lilian J. H. M. Vroegindeweij Tags: Research Source Type: research
The association of vascular disorders with incident dementia in different age groups
There is increasing evidence that dementia risk associated with vascular disorders is age dependent. Large population-based studies of incident dementia are necessary to further elucidate this effect. Therefor... (Source: Retrovirology)
Source: Retrovirology - May 17, 2019 Category: Virology Authors: Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier and Pieter Jelle Visser Tags: Research Source Type: research
Bovine leukemia virus proviral load is more strongly associated with bovine major histocompatibility complex class II DRB3 polymorphism than with DQA1 polymorphism in Holstein cow in Japan
Bovine leukemia virus (BLV) causes enzootic bovine leukosis and is closely related to the human T-lymphotropic virus. Bovine major histocompatibility complex (BoLAs) are used extensively as markers of disease ... (Source: Retrovirology)
Source: Retrovirology - May 16, 2019 Category: Virology Authors: Shin-nosuke Takeshima, Ayumu Ohno and Yoko Aida Tags: Short report Source Type: research
Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort
The cognitive-functional composite (CFC) was designed to improve the measurement of clinically relevant changes in predementia and early dementia stages. We have previously demonstrated its good test-retest re... (Source: Retrovirology)
Source: Retrovirology - May 15, 2019 Category: Virology Authors: Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, Andr é Aleman, Craig W. Ritchie, Philip Scheltens and Sietske A. M. Sikkes Tags: Research Source Type: research
Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer ’s disease
Several evidences suggest that failure of synaptic function occurs at preclinical stages of Alzheimer ’s disease (AD) preceding neuronal loss and the classical AD pathological hallmarks. Nowadays, there is an u... (Source: Retrovirology)
Source: Retrovirology - May 15, 2019 Category: Virology Authors: Dolores Siedlecki-Wullich, Judit Catal à-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez and Alfredo J. Miñano-Molina Tags: Research Source Type: research
Interaction of HIV-1 integrase with polypyrimidine tract binding protein and associated splicing factor (PSF) and its impact on HIV-1 replication
The different interactions between viral proteins and cellular host proteins are required for efficient replication of HIV-1. Various reports implicated host cellular proteins as a key factor that either inter... (Source: Retrovirology)
Source: Retrovirology - April 29, 2019 Category: Virology Authors: Pooja Yadav, Souvik Sur, Dipen Desai, Smita Kulkarni, Vartika Sharma and Vibha Tandon Tags: Research Source Type: research
Effect of transcription inhibition and generation of suppressive viral non-coding RNAs
HIV-1 patients receiving combination antiretroviral therapy (cART) survive infection but require life-long adherence at high expense. In chronic cART-treated patients with undetectable viral titers, cell-assoc... (Source: Retrovirology)
Source: Retrovirology - April 29, 2019 Category: Virology Authors: Daniel O. Pinto, Tristan A. Scott, Catherine DeMarino, Michelle L. Pleet, Thy T. Vo, Mohammed Saifuddin, Dmytro Kovalskyy, James Erickson, Maria Cowen, Robert A. Barclay, Chen Zeng, Marc S. Weinberg and Fatah Kashanchi Tags: Research Source Type: research
Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A
Efficient HIV-1 replication depends on interaction of the viral capsid with the host protein cyclophilin A (CypA). CypA, a peptidylprolyl isomerase, binds to an exposed loop in the viral CA protein via the enz... (Source: Retrovirology)
Source: Retrovirology - April 4, 2019 Category: Virology Authors: Wang Peng, Jiong Shi, Chantal L. M árquez, Derrick Lau, James Walsh, K. M. Rifat Faysal, Chang H. Byeon, In-Ja L. Byeon, Christopher Aiken and Till Böcking Tags: Research Source Type: research
Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo
Reverse transcription (RT) of HIV and SIV is initiated by the binding of the acceptor stem of tRNALys3 to the primer binding site (PBS) of the viral RNA genome. Previous studies have suggested that this tRNALys3 ... (Source: Retrovirology)
Source: Retrovirology - April 4, 2019 Category: Virology Authors: Christine M. Fennessey, Celine Camus, Taina T. Immonen, Carolyn Reid, Frank Maldarelli, Jeffrey D. Lifson and Brandon F. Keele Tags: Research Source Type: research
Impact of LEDGIN treatment during virus production on residual HIV-1 transcription
Persistence of latent, replication-competent provirus is the main impediment towards the cure of HIV infection. One of the critical questions concerning HIV latency is the role of integration site selection in... (Source: Retrovirology)
Source: Retrovirology - April 2, 2019 Category: Virology Authors: Gerlinde Vansant, Lenard S. Vranckx, Irena Zurnic, Dominique Van Looveren, Paulien Van de Velde, Christopher Nobles, Rik Gijsbers, Frauke Christ and Zeger Debyser Tags: Research Source Type: research
Analysis of herpes simplex type 1 gB, gD, and gH/gL on production of infectious HIV-1: HSV-1 gD restricts HIV-1 by exclusion of HIV-1 Env from maturing viral particles
In this study, we analyzed if the four HSV-1 glycoproteins (gD, gB, and gH/gL), which are the minimum glycop... (Source: Retrovirology)
Source: Retrovirology - April 2, 2019 Category: Virology Authors: Sachith Polpitiya Arachchige, Wyatt Henke, Maria Kalamvoki and Edward B. Stephens Tags: Research Source Type: research
Obituary: Jonas Blomberg (1944 –2019)
(Source: Retrovirology)
Source: Retrovirology - March 14, 2019 Category: Virology Authors: Patrik Medstrand and Patric Jern Tags: Obituary Source Type: research
Origin and recent expansion of an endogenous gammaretroviral lineage in domestic and wild canids
Vertebrate genomes contain a record of retroviruses that invaded the germlines of ancestral hosts and are passed to offspring as endogenous retroviruses (ERVs). ERVs can impact host function since they contain... (Source: Retrovirology)
Source: Retrovirology - March 7, 2019 Category: Virology Authors: Julia V. Halo, Amanda L. Pendleton, Abigail S. Jarosz, Robert J. Gifford, Malika L. Day and Jeffrey M. Kidd Tags: Research Source Type: research
Hypericin-photodynamic therapy inhibits the growth of adult T-cell leukemia cells through induction of apoptosis and suppression of viral transcription
Adult T-cell leukemia (ATL) is an aggressive neoplasm caused by human T-cell leukemia virus type 1 (HTLV-1). ATL carries a poor prognosis due to chemotherapy resistance. Thus, it is urgent to develop new treat... (Source: Retrovirology)
Source: Retrovirology - February 19, 2019 Category: Virology Authors: Lingling Xu, Xueqing Zhang, Wenzhao Cheng, Yong Wang, Kaining Yi, Zhilong Wang, Yiling Zhang, Linxiang Shao and Tiejun Zhao Tags: Research Source Type: research
