The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses
The induction of HIV-1-specific antibodies that can neutralize a broad number of isolates is a major goal of HIV-1 vaccination strategies. However, to date no candidate HIV-1 vaccine has successfully elicited ... (Source: Retrovirology)
Source: Retrovirology - August 6, 2018 Category: Virology Authors: Eirini Moysi, Constantinos Petrovas and Richard A. Koup Tags: Review Source Type: research
Poly- and autoreactivity of HIV-1 bNAbs: implications for vaccine design
A central puzzle in HIV-1 research is the inability of vaccination or even infection to reliably elicit humoral responses against broadly neutralizing epitopes in the HIV-1 envelope protein. In infected indivi... (Source: Retrovirology)
Source: Retrovirology - July 28, 2018 Category: Virology Authors: Joel Finney and Garnett Kelsoe Tags: Review Source Type: research
Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?
The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantl... (Source: Retrovirology)
Source: Retrovirology - July 28, 2018 Category: Virology Authors: Harini Subbaraman, Merle Schanz and Alexandra Trkola Tags: Review Source Type: research
HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at the contact site forms the virological synapse. Additional cellular processes, such as nanotubes, filopodia, virus a... (Source: Retrovirology)
Source: Retrovirology - July 28, 2018 Category: Virology Authors: J érémy Dufloo, Timothée Bruel and Olivier Schwartz Tags: Review Source Type: research
Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail
HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41. The cleaved, native, trimeric form of Envs expose... (Source: Retrovirology)
Source: Retrovirology - July 20, 2018 Category: Virology Authors: Sweety Samal, Supratik Das, Saikat Boliar, Huma Qureshi, Tripti Shrivastava, Naresh Kumar, Sandeep Goswami, Manish Bansal and Bimal K. Chakrabarti Tags: Research Source Type: research
Myricetin antagonizes semen-derived enhancer of viral infection (SEVI) formation and influences its infection-enhancing activity
Semen is a critical vector for human immunodeficiency virus (HIV) sexual transmission and harbors seminal amyloid fibrils that can markedly enhance HIV infection. Semen-derived enhancer of viral infection (SEV... (Source: Retrovirology)
Source: Retrovirology - July 16, 2018 Category: Virology Authors: Ruxia Ren, Shuwen Yin, Baolong Lai, Lingzhen Ma, Jiayong Wen, Xuanxuan Zhang, Fangyuan Lai, Shuwen Liu and Lin Li Tags: Research Source Type: research
The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag
Nuclear localization of Gag is a property shared by many retroviruses and retrotransposons. The importance of this stage for retroviral replication is still unknown, but studies on the Rous Sarcoma virus indic... (Source: Retrovirology)
Source: Retrovirology - July 11, 2018 Category: Virology Authors: Joris Paris, Jo ëlle Tobaly-Tapiero, Marie-Lou Giron, Julien Burlaud-Gaillard, Florence Buseyne, Philippe Roingeard, Pascale Lesage, Alessia Zamborlini and Ali Saïb Tags: Research Source Type: research
Quantitation of the latent HIV-1 reservoir from the sequence diversity in viral outgrowth assays
The ability of HIV-1 to integrate into the genomes of quiescent host immune cells, establishing a long-lived latent viral reservoir (LVR), is the primary obstacle to curing these infections. Quantitative viral... (Source: Retrovirology)
Source: Retrovirology - July 5, 2018 Category: Virology Authors: Art F. Y. Poon, Jessica L. Prodger, Briana A. Lynch, Jun Lai, Steven J. Reynolds, Jingo Kasule, Adam A. Capoferri, Susanna L. Lamers, Christopher W. Rodriguez, Daniel Bruno, Stephen F. Porcella, Craig Martens, Thomas C. Quinn and Andrew D. Redd Tags: Research Source Type: research
Global phosphoproteomics of CCR5-tropic HIV-1 signaling reveals reprogramming of cellular protein production pathways and identifies p70-S6K1 and MK2 as HIV-responsive kinases required for optimal infection of CD4+ T cells
Viral reprogramming of host cells enhances replication and is initiated by viral interaction with the cell surface. Upon human immunodeficiency virus (HIV) binding to CD4+ T cells, a signal transduction cascad... (Source: Retrovirology)
Source: Retrovirology - July 3, 2018 Category: Virology Authors: Danica D. Wiredja, Caroline O. Tabler, Daniela M. Schlatzer, Ming Li, Mark R. Chance and John C. Tilton Tags: Research Source Type: research
CD8+ T cells specific for conserved, cross-reactive Gag epitopes with strong ability to suppress HIV-1 replication
Development of AIDS vaccines for effective prevention of circulating HIV-1 is required, but no trial has demonstrated definitive effects on the prevention. Several recent T-cell vaccine trials showed no protec... (Source: Retrovirology)
Source: Retrovirology - July 3, 2018 Category: Virology Authors: Hayato Murakoshi, Chengcheng Zou, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tom áš Hanke and Masafumi Takiguchi Tags: Research Source Type: research
Reticuloendotheliosis virus and avian leukosis virus subgroup J synergistically increase the accumulation of exosomal miRNAs
Co-infection with avian leukosis virus subgroup J and reticuloendotheliosis virus induces synergistic pathogenic effects and increases mortality. However, the role of exosomal miRNAs in the molecular mechanism... (Source: Retrovirology)
Source: Retrovirology - July 3, 2018 Category: Virology Authors: Defang Zhou, Jingwen Xue, Shuhai He, Xusheng Du, Jing Zhou, Chengui Li, Libo Huang, Venugopal Nair, Yongxiu Yao and Ziqiang Cheng Tags: Research Source Type: research
The KT Jeang Retrovirology prize 2018: Eric Freed
(Source: Retrovirology)
Source: Retrovirology - July 2, 2018 Category: Virology Tags: Editorial Source Type: research
The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level
The ability of human immunodeficiency virus type 1 (HIV-1) to form a stable viral reservoir is the major obstacle to an HIV-1 cure and post-transcriptional events contribute to the maintenance of viral latency... (Source: Retrovirology)
Source: Retrovirology - June 28, 2018 Category: Virology Authors: Shringar Rao, Raquel Amorim, Meijuan Niu, Abdelkrim Temzi and Andrew J. Mouland Tags: Research Source Type: research
Super-resolution fluorescence microscopy studies of human immunodeficiency virus
Super-resolution fluorescence microscopy combines the ability to observe biological processes beyond the diffraction limit of conventional light microscopy with all advantages of the fluorescence readout such ... (Source: Retrovirology)
Source: Retrovirology - June 8, 2018 Category: Virology Authors: Jakub Chojnacki and Christian Eggeling Tags: Review Source Type: research
Obituary: Remembering Professor David Cooper
(Source: Retrovirology)
Source: Retrovirology - May 24, 2018 Category: Virology Authors: Stuart Turville and Anthony Kelleher Tags: Obituary Source Type: research
