Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages
Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing ... (Source: Retrovirology)
Source: Retrovirology - October 26, 2019 Category: Virology Authors: Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M. Mansky, Raymond F. Schinazi and Baek Kim Tags: Research Source Type: research
Isolation of the Arawete and Asurini Indians keeps the tribes free from HTLV infection during 36 years of follow-up
Arawete and Asurini Indian tribes were revisited after a 36-year follow-up in search of HTLV infections. 46 persons (23 from each tribe) were tested for HTLV-1/2 antibodies and viral DNA. None were positive; t... (Source: Retrovirology)
Source: Retrovirology - October 22, 2019 Category: Virology Authors: Antonio C. R. Vallinoto, Mateus I. Otake, Paulo V. N. R. Sousa, Felipe T. Lopes, Eliene R. P. Sacuena, Maria A. F. Queiroz, Greice L. C. Costa, Marlu ísa O. G. Ishak, Izaura M. V. Cayres-Vallinoto, João F. Guerreiro and Ricardo Ishak Tags: Correspondence Source Type: research
Characterization of resistance to a potent d-peptide HIV entry inhibitor
PIE12-trimer is a highly potent d-peptide HIV-1 entry inhibitor that broadly targets group M isolates. It specifically binds the three identical conserved hydrophobic pockets at the base of the gp41 N-trimer with... (Source: Retrovirology)
Source: Retrovirology - October 22, 2019 Category: Virology Authors: Amanda R. Smith, Matthew T. Weinstock, Amanda E. Siglin, Frank G. Whitby, J. Nicholas Francis, Christopher P. Hill, Debra M. Eckert, Michael J. Root and Michael S. Kay Tags: Research Source Type: research
BLV: lessons on vaccine development
Vaccination against retroviruses is a challenge because of their ability to stably integrate into the host genome, undergo long-term latency in a proportion of infected cells and thereby escape immune response... (Source: Retrovirology)
Source: Retrovirology - October 7, 2019 Category: Virology Authors: Alejandro Abdala, Irene Alvarez, H élène Brossel, Luis Calvinho, Hugo Carignano, Lautaro Franco, Hélène Gazon, Christelle Gillissen, Malik Hamaidia, Clotilde Hoyos, Jean-Rock Jacques, Thomas Joris, Florent Laval, Marcos Petersen, Florent Porquet, Nata Tags: Review Source Type: research
Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors
Of the members of the primate T cell lymphotropic virus (PTLV) family, only the human T-cell leukemia virus type-1 (HTLV-1) causes disease in humans —as the etiological agent of adult T-cell leukemia/lymphoma (... (Source: Retrovirology)
Source: Retrovirology - September 6, 2019 Category: Virology Authors: Robert Harrod Tags: Review Source Type: research
The KT Jeang Prize 2019: Reuben S. Harris
(Source: Retrovirology)
Source: Retrovirology - August 29, 2019 Category: Virology Tags: Editorial Source Type: research
Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other inflammatory diseases. There is no diseas... (Source: Retrovirology)
Source: Retrovirology - August 22, 2019 Category: Virology Authors: Mari Kannagi, Atsuhiko Hasegawa, Yoshiko Nagano, Shuichi Kimpara and Youko Suehiro Tags: Review Source Type: research
A trip down memory lane with Retrovirology
(Source: Retrovirology)
Source: Retrovirology - August 21, 2019 Category: Virology Authors: Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia-Martinez, D. Margolis, Monique Nijhuis, Leslie Parent, Klaus Strebel, Fran çois Venter, Frank Kirchhoff, Andrew Lever, Susan Ross and Johnson Mak Tags: Editorial Source Type: research
Comparative virology of HTLV-1 and HTLV-2
Human T cell leukemia virus type 1 (HTLV-1) was the first discovered human retrovirus and the etiologic agent of adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Shortly aft... (Source: Retrovirology)
Source: Retrovirology - August 7, 2019 Category: Virology Authors: Michael P. Martinez, Jacob Al-Saleem and Patrick L. Green Tags: Review Source Type: research
Correction to: CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice
Following publication of their article [1], the authors realized that they inadvertently omitted the contribution of Dr. Li Wu (Ohio State University) who commented on the manuscript at the early stage of the ... (Source: Retrovirology)
Source: Retrovirology - July 23, 2019 Category: Virology Authors: Qiaoqiao Xiao, Shuliang Chen, Qiankun Wang, Zhepeng Liu, Shuai Liu, Huan Deng, Wei Hou, Dongcheng Wu, Yong Xiong, Jiafu Li and Deyin Guo Tags: Correction Source Type: research
On the generation of the MSD- Ѱ class of defective HIV proviruses
Antiretroviral therapy (ART) can effectively suppress ongoing HIV replication and block disease progression, but the infection is never cured due to the persistence of a small pool of latently infected cells h... (Source: Retrovirology)
Source: Retrovirology - July 11, 2019 Category: Virology Authors: Atze T. Das, Alexander O. Pasternak and Ben Berkhout Tags: Correspondence Source Type: research
The autophagy protein ATG9A promotes HIV-1 infectivity
Nef is a multifunctional accessory protein encoded by HIV-1, HIV-2 and SIV that plays critical roles in viral pathogenesis, contributing to viral replication, assembly, budding, infectivity and immune evasion,... (Source: Retrovirology)
Source: Retrovirology - July 3, 2019 Category: Virology Authors: Elodie Mailler, Abdul A. Waheed, Sang-Yoon Park, David C. Gershlick, Eric O. Freed and Juan S. Bonifacino Tags: Research Source Type: research
NNRTI-induced HIV-1 protease-mediated cytotoxicity induces rapid death of CD4 T cells during productive infection and latency reversal
Current efforts towards HIV-1 eradication focus on the reactivation and elimination of the latent viral reservoir, so-called shock and kill therapy. However, work from several groups indicates that infected ce... (Source: Retrovirology)
Source: Retrovirology - June 26, 2019 Category: Virology Authors: Benjamin Trinit é, Hongtao Zhang and David N. Levy Tags: Research Source Type: research
Fused in sarcoma silences HIV gene transcription and maintains viral latency through suppressing AFF4 gene activation
The human immunodeficiency virus (HIV) cell reservoir is currently a main obstacle towards complete eradication of the virus. This infected pool is refractory to anti-viral therapy and harbors integrated provi... (Source: Retrovirology)
Source: Retrovirology - June 25, 2019 Category: Virology Authors: Simona Krasnopolsky, Lital Marom, Rachel A. Victor, Alona Kuzmina, Jacob C. Schwartz, Koh Fujinaga and Ran Taube Tags: Research Source Type: research
CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice
The chemokine receptor CCR5, which belongs to the superfamily of G protein-coupled receptors, is the major co-receptor for HIV-1 entry. Individuals with a homozygous CCR5 Δ32 mutation have a long lasting and incre... (Source: Retrovirology)
Source: Retrovirology - June 11, 2019 Category: Virology Authors: Qiaoqiao Xiao, Shuliang Chen, Qiankun Wang, Zhepeng Liu, Shuai Liu, Huan Deng, Wei Hou, Dongcheng Wu, Yong Xiong, Jiafu Li and Deyin Guo Tags: Research Source Type: research
