Impact of HIV-1 CRF55_01B infection on the evolution of CD4 count and plasma HIV RNA load in men who have sex with men prior to antiretroviral therapy
This study aimed... (Source: Retrovirology)
Source: Retrovirology - August 16, 2021 Category: Virology Authors: Lan Wei, Hao Li, Xing Lv, Chenli Zheng, Guilian Li, Zhengrong Yang, Lin Chen, Xiaoxu Han, Huachun Zou, Yanxiao Gao, Jinquan Cheng, Hui Wang and Jin Zhao Tags: Research Source Type: research
Addressing an HIV cure in LMIC
HIV-1 persists in infected individuals despite years of antiretroviral therapy (ART), due to the formation of a stable and long-lived latent viral reservoir. Early ART can reduce the latent reservoir and is as... (Source: Retrovirology)
Source: Retrovirology - August 3, 2021 Category: Virology Authors: Sherazaan D. Ismail, Joshua Pankrac, Emmanuel Ndashimye, Jessica L. Prodger, Melissa-Rose Abrahams, Jamie F. S. Mann, Andrew D. Redd and Eric J. Arts Tags: Review Source Type: research
A novel class III endogenous retrovirus with a class I envelope gene in African frogs with an intact genome and developmentally regulated transcripts in Xenopus tropicalis
Retroviruses exist as exogenous infectious agents and as endogenous retroviruses (ERVs) integrated into host chromosomes. Such endogenous retroviruses (ERVs) are grouped into three classes roughly correspondin... (Source: Retrovirology)
Source: Retrovirology - July 14, 2021 Category: Virology Authors: Venkat R. K. Yedavalli, Akash Patil, Janay Parrish and Christine A. Kozak Tags: Research Source Type: research
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection
Microtubules (MTs) form a filamentous array that provide both structural support and a coordinated system for the movement and organization of macromolecular cargos within the cell. As such, they play a critic... (Source: Retrovirology)
Source: Retrovirology - July 6, 2021 Category: Virology Authors: Mojgan H. Naghavi Tags: Review Source Type: research
Interview with a Retrovirologist: Sebla B. Kutluay in conversation with Carol Carter
(Source: Retrovirology)
Source: Retrovirology - July 1, 2021 Category: Virology Authors: Carol Carter and Sebla B. Kutluay Tags: Commentary Source Type: research
Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
HIV remains one of the most important health issues worldwide, with almost 40 million people living with HIV. Although patients develop antibodies against the virus, its high mutation rate allows evasion of im... (Source: Retrovirology)
Source: Retrovirology - June 28, 2021 Category: Virology Authors: Catherine M. Moore, Melanie Grandits, Clemens Gr ünwald-Gruber, Friedrich Altmann, Maria Kotouckova, Audrey Y.-H. Teh and Julian K.-C. Ma Tags: Research Source Type: research
HIVIntact: a python-based tool for HIV-1 genome intactness inference
The characterisation of the HIV-1 reservoir, which consists of replication-competent integrated proviruses that persist on antiretroviral therapy (ART), is made difficult by the rarity of intact proviruses rel... (Source: Retrovirology)
Source: Retrovirology - June 27, 2021 Category: Virology Authors: Imogen A. Wright, Michael J. Bale, Wei Shao, Wei-Shau Hu, John M. Coffin, Gert U. Van Zyl and Mary F. Kearney Tags: Short report Source Type: research
Heterologous avian system for quantitative analysis of Syncytin-1 interaction with ASCT2 receptor
Human Syncytin-1 is a placentally-expressed cell surface glycoprotein of retroviral origin. After interaction with ASCT2, its cellular receptor, Syncytin-1 triggers cell –cell fusion and formation of a multinuc... (Source: Retrovirology)
Source: Retrovirology - June 22, 2021 Category: Virology Authors: Kry štof Štafl, Martin Trávníček, Dana Kučerová, Ľubomíra Pecnová, Veronika Krchlíková, Eliška Gáliková, Volodymyr Stepanets, Jiří Hejnar and Kateřina Trejbalová Tags: Research Source Type: research
Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse
Humanized mice have become an important workhorse model for HIV research. Advances that enabled development of a human immune system in immune deficient mouse strains have aided new basic research in HIV patho... (Source: Retrovirology)
Source: Retrovirology - June 16, 2021 Category: Virology Authors: Janice J. Endsley, Matthew B. Huante, Kubra F. Naqvi, Benjamin B. Gelman and Mark A. Endsley Tags: Review Source Type: research
Humanized Mice for Infectious and Neurodegenerative disorders
Humanized mice model human disease and as such are used commonly for research studies of infectious, degenerative and cancer disorders. Recent models also reflect hematopoiesis, natural immunity, neurobiology,... (Source: Retrovirology)
Source: Retrovirology - June 5, 2021 Category: Virology Authors: Prasanta K. Dash, Santhi Gorantla, Larisa Poluektova, Mahmudul Hasan, Emiko Waight, Chen Zhang, Milica Markovic, Benson Edagwa, Jatin Machhi, Katherine E. Olson, Xinglong Wang, R. Lee Mosley, Bhavesh Kevadiya and Howard E. Gendelman Tags: Review Source Type: research
Neutralization diversity of HIV-1 Indian subtype C envelopes obtained from cross sectional and followed up individuals against broadly neutralizing monoclonal antibodies having distinct gp120 specificities
The potential use of the broadly neutralizing monoclonal antibodies (bnAbs) towards prophylaxis and treatment to HIV-1 is currently being explored. While a number of promising bnAbs have been discovered and a ... (Source: Retrovirology)
Source: Retrovirology - May 14, 2021 Category: Virology Authors: Ranajoy Mullick, Jyoti Sutar, Nitin Hingankar, Suprit Deshpande, Madhuri Thakar, Seema Sahay, Rajesh P. Ringe, Sampurna Mukhopadhyay, Ajit Patil, Shubhangi Bichare, Kailapuri G. Murugavel, Aylur K. Srikrishnan, Rajat Goyal, Devin Sok and Jayanta Bhattacha Tags: Research Source Type: research
Subtype-specific differences in Gag-protease replication capacity of HIV-1 isolates from East and West Africa
The HIV-1 epidemic in sub-Saharan Africa is heterogeneous with diverse unevenly distributed subtypes and regional differences in prevalence. Subtype-specific differences in disease progression rate and transmi... (Source: Retrovirology)
Source: Retrovirology - May 5, 2021 Category: Virology Authors: Omotayo Farinre, Kamini Gounder, Tarylee Reddy, Marcel Tongo, Jonathan Hare, Beth Chaplin, Jill Gilmour, Phyllis Kanki, Jaclyn K. Mann and Thumbi Ndung ’u Tags: Research Source Type: research
Falling fowl of the chicken reference genome: pitfalls of studying polymorphic endogenous retroviruses
High quality reference genomes have facilitated the study of endogenous retroviruses (ERVs). However, there are an increasing number of published works which assume the ERVs in reference genomes are universal;... (Source: Retrovirology)
Source: Retrovirology - April 20, 2021 Category: Virology Authors: Andrew S. Mason Tags: Correspondence Source Type: research
A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1... (Source: Retrovirology)
Source: Retrovirology - April 9, 2021 Category: Virology Authors: Dibya Ghimire, Yuvraj KC, Uddhav Timilsina, Kriti Goel, T. J. Nitz, Carl T. Wild and Ritu Gaur Tags: Research Source Type: research
Memoriam for Renaud Mahieux
(Source: Retrovirology)
Source: Retrovirology - March 17, 2021 Category: Virology Authors: Fatah Kashanchi, Ali Bazarbachi and Antoine Gessain Tags: Obituary Source Type: research
