Influence of the amino-terminal sequence on the structure and function of HIV integrase
Antiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful development of ART can be accelerated by accurate structural and biochemical d... (Source: Retrovirology)
Source: Retrovirology - August 31, 2020 Category: Virology Authors: Grant Eilers, Kushol Gupta, Audrey Allen, Jeffrey Zhou, Young Hwang, Michael B. Cory, Frederic D. Bushman and Gregory Van Duyne Tags: Research Source Type: research
Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma
Adult T-cell leukemia lymphoma (ATLL) is a chemotherapy-resistant malignancy with a median survival of less than one year that will afflict between one hundred thousand and one million individuals worldwide wh... (Source: Retrovirology)
Source: Retrovirology - August 28, 2020 Category: Virology Authors: Daniel A. Rauch, Sydney L. Olson, John C. Harding, Hemalatha Sundaramoorthi, Youngsoo Kim, Tianyuan Zhou, A. Robert MacLeod, Grant Challen and Lee Ratner Tags: Research Source Type: research
Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting: a collaborative study for performance evaluation of diagnostic assays in Japan
The reliable diagnosis of human T-cell leukemia virus type 1 (HTLV-1) infection is important, particularly as it can be vertically transmitted by breast feeding mothers to their infants. However, current diagn... (Source: Retrovirology)
Source: Retrovirology - August 24, 2020 Category: Virology Authors: Kazu Okuma, Madoka Kuramitsu, Toshihiro Niwa, Tomokuni Taniguchi, Yumiko Masaki, Gohzoh Ueda, Chieko Matsumoto, Rieko Sobata, Yasuko Sagara, Hitomi Nakamura, Masahiro Satake, Kiyonori Miura, Naoki Fuchi, Hideaki Masuzaki, Akihiko Okayama, Kazumi Umeki & h Tags: Research Source Type: research
Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection
Alternative splicing is a key step in Human Immunodeficiency Virus type 1 (HIV-1) replication that is tightly regulated both temporally and spatially. More than 50 different transcripts can be generated from a... (Source: Retrovirology)
Source: Retrovirology - August 17, 2020 Category: Virology Authors: Nam Nguyen Quang, Sophie Goudey, Emmanuel S égéral, Ammara Mohammad, Sophie Lemoine, Corinne Blugeon, Margaux Versapuech, Jean-Christophe Paillart, Clarisse Berlioz-Torrent, Stéphane Emiliani and Sarah Gallois-Montbrun Tags: Research Source Type: research
Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection
HIV-1 infects a wide range of CD4+ T cells with different phenotypic properties and differing expression levels of entry coreceptors. We sought to determine the viral tropism of subtype C (C-HIV) Envelope (Env) c... (Source: Retrovirology)
Source: Retrovirology - August 6, 2020 Category: Virology Authors: Matthew J. Gartner, Paul R. Gorry, Carolin Tumpach, Jingling Zhou, Ashanti Dantanarayana, J. Judy Chang, Thomas A. Angelovich, Paula Ellenberg, Annemarie E. Laumaea, Molati Nonyane, Penny L. Moore, Sharon R. Lewin, Melissa J. Churchill, Jacqueline K. Flyn Tags: Research Source Type: research
Correction to: LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
An amendment to this paper has been published and can be accessed via the original article. (Source: Retrovirology)
Source: Retrovirology - July 29, 2020 Category: Virology Authors: Belete Ayele Desimmie, Rik Schrijvers, Jonas Demeulemeester, Doortje Borrenberghs, Caroline Weydert, Wannes Thys, Sofie Vets, Barbara Van Remoortel, Johan Hofkens, Jan De Rijck, Jelle Hendrix, Norbert Bannert, Rik Gijsbers, Frauke Christ and Zeger Debyser Tags: Correction Source Type: research
Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
An amendment to this paper has been published and can be accessed via the original article. (Source: Retrovirology)
Source: Retrovirology - July 29, 2020 Category: Virology Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Igor Paron, Jan De Rijck, Jan Mast, Norbert Bannert, Rik Gijsbers, Frauke Christ and Zeger Debyser Tags: Correction Source Type: research
The KT Jeang Retrovirology prize 2020: Tatyana Golovkina
(Source: Retrovirology)
Source: Retrovirology - July 20, 2020 Category: Virology Tags: Editorial Source Type: research
M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms
HIV-1 promotes the formation of tunneling nanotubes (TNTs) that connect distant cells, aiding cell-to-cell viral transmission between macrophages. Our recent study suggests that the cellular protein M-Sec play... (Source: Retrovirology)
Source: Retrovirology - July 10, 2020 Category: Virology Authors: Sameh Lotfi, Hesham Nasser, Osamu Noyori, Masateru Hiyoshi, Hiroaki Takeuchi, Yoshio Koyanagi and Shinya Suzu Tags: Research Source Type: research
Variations in Trim5 α and Cyclophilin A genes among HIV-1 elite controllers and non controllers in Uganda: a laboratory-based cross-sectional study
Tripartite Motif Containing 5 alpha (TRIM5 α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV caps... (Source: Retrovirology)
Source: Retrovirology - July 6, 2020 Category: Virology Authors: Sharon Bright Amanya, Brian Nyiro, Francis Waswa, Bonniface Obura, Rebecca Nakaziba, Eva Nabulime, Ashaba Fred Katabazi, Rose Nabatanzi, Alice Bayiyana, Gerald Mboowa, Alex Kayongo, Misaki Wayengera and Obondo J. Sande Tags: Research Source Type: research
HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses
Heterosexual transmission remains the main route of HIV-1 transmission and female genital tract (FGT) inflammation increases the risk of infection. However, the mechanism(s) by which inflammation facilitates i... (Source: Retrovirology)
Source: Retrovirology - July 2, 2020 Category: Virology Authors: Evelyn Ngwa Lumngwena, Simon Metenou, Lindi Masson, Claudia Cicala, James Arthos and Zenda Woodman Tags: Research Source Type: research
Increased expression of CDKN1A/p21 in HIV-1 controllers is correlated with upregulation of ZC3H12A/MCPIP1
Some multifunctional cellular proteins, as the monocyte chemotactic protein-induced protein 1 (ZC3H12A/MCPIP1) and the cyclin-dependent kinase inhibitor CDKN1A/p21, are able to modulate the cellular susceptibi... (Source: Retrovirology)
Source: Retrovirology - July 2, 2020 Category: Virology Authors: Suwellen S. D. de Azevedo, Marcelo Ribeiro-Alves, Fernanda H. C ôrtes, Edson Delatorre, Lucia Spangenberg, Hugo Naya, Leonardo N. Seito, Brenda Hoagland, Beatriz Grinsztejn, Valdilea G. Veloso, Mariza G. Morgado, Thiago Moreno L. Souza and Gonzalo Bello Tags: Research Source Type: research
MxB impedes the NUP358-mediated HIV-1 pre-integration complex nuclear import and viral replication cooperatively with CPSF6
The human myxovirus resistance 2 (Mx2/MxB) protein was originally found to regulate cytoplasmic-nuclear transport but was recently reported to restrict HIV-1 replication by binding to HIV-1 capsid (CA), preven... (Source: Retrovirology)
Source: Retrovirology - June 29, 2020 Category: Virology Authors: Linlin Xie, Lang Chen, Chaojie Zhong, Ting Yu, Zhao Ju, Meirong Wang, Hairong Xiong, Yan Zeng, Jianhua Wang, Haitao Hu, Wei Hou and Yong Feng Tags: Research Source Type: research
Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques
Simian T-cell leukemia virus type 1 (STLV-1) is disseminated among various non-human primate species and is closely related to human T-cell leukemia virus type 1 (HTLV-1), the causative agent of adult T-cell l... (Source: Retrovirology)
Source: Retrovirology - June 23, 2020 Category: Virology Authors: Megumi Murata, Jun-ichirou Yasunaga, Ayaka Washizaki, Yohei Seki, Madoka Kuramitsu, Wei Keat Tan, Anna Hu, Kazu Okuma, Isao Hamaguchi, Takuo Mizukami, Masao Matsuoka and Hirofumi Akari Tags: Research Source Type: research
Comparison of pathological clotting using haematological, functional and morphological investigations in HIV-positive and HIV-negative patients with deep vein thrombosis
Patients infected with the human immunodeficiency virus (HIV) are more prone to systemic inflammation and pathological clotting, and many may develop deep vein thrombosis (DVT) as a result of this dysregulated... (Source: Retrovirology)
Source: Retrovirology - June 22, 2020 Category: Virology Authors: Brandon S. Jackson, Julien Nunes Goncalves and Etheresia Pretorius Tags: Research Source Type: research
