Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana
Marijuana ’s putative anti-inflammatory properties may benefit HIV-associated comorbidities. How recreational marijuana use affects gene expression in peripheral blood cells (PBC) among youth with HIV-1 (YWH) i... (Source: Retrovirology)
Source: Retrovirology - May 31, 2022 Category: Virology Authors: Li Yin, Ashok R. Dinasarapu, Samiksha A. Borkar, Kai-Fen Chang, Kristina De Paris, Julie J. Kim-Chang, John W. Sleasman and Maureen M. Goodenow Tags: Research Source Type: research
P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells
P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P-selectin. Recently, PSGL-1 was identif... (Source: Retrovirology)
Source: Retrovirology - May 21, 2022 Category: Virology Authors: Jonathan Burnie, Arvin Tejnarine Persaud, Laxshaginee Thaya, Qingbo Liu, Huiyi Miao, Stephen Grabinsky, Vanessa Norouzi, Paolo Lusso, Vera A. Tang and Christina Guzzo Tags: Research Source Type: research
Simon Litvak (1942 –2022)
(Source: Retrovirology)
Source: Retrovirology - May 19, 2022 Category: Virology Authors: Marcelo L ópez-Lastra, Vincent Parissi and Jean-Luc Darlix Tags: Obituary Source Type: research
No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan
The potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, ... (Source: Retrovirology)
Source: Retrovirology - May 18, 2022 Category: Virology Authors: Meripet Polat Yamanaka, Susumu Saito, Yukiko Hara, Ryosuke Matsuura, Shin-nosuke Takeshima, Kazuyoshi Hosomichi, Yasunobu Matsumoto, Rika A. Furuta, Masami Takei and Yoko Aida Tags: Research Source Type: research
Immunoescape of HIV-1 in Env-EL9 CD8 + T cell response restricted by HLA-B*14:02 in a Non progressor who lost twenty-seven years of HIV-1 control
Long-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease progression for prolonged periods. However, the LTNPs status is temporar... (Source: Retrovirology)
Source: Retrovirology - March 26, 2022 Category: Virology Authors: Ana Moyano, Oscar Blanch-Lombarte, Laura Tarancon-Diez, Nuria Pedre ño-Lopez, Miguel Arenas, Tamara Alvaro, Concepción Casado, Isabel Olivares, Mar Vera, Carmen Rodriguez, Jorge del Romero, Cecilio López-Galíndez, Ezequiel Ruiz-Mateos, Julia G. Prado Tags: Research Source Type: research
Correction to: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
(Source: Retrovirology)
Source: Retrovirology - February 7, 2022 Category: Virology Authors: Melanie M. Hierweger, Michel C. Koch, Ronja V. Kauer, Zolt án Bagó, Anna Oevermann, Giuseppe Bertoni and Torsten Seuberlich Tags: Correction Source Type: research
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
The recent discovery of the role of m6A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is under ... (Source: Retrovirology)
Source: Retrovirology - January 31, 2022 Category: Virology Authors: Sarah N ’Da Konan, Emmanuel Ségéral, Fabienne Bejjani, Maryam Bendoumou, Mélissa Ait Said, Sarah Gallois-Montbrun and Stéphane Emiliani Tags: Research Source Type: research
Bone marrow stromal antigen 2 (BST-2) genetic variants influence expression levels and disease outcome in HIV-1 chronically infected patients
Bone marrow stromal antigen 2 (BST-2) also known as Tetherin (CD317/HM1.24), is a host restriction factor that blocks the release of HIV-1 virions from infected cells. Previous studies reported that BST-2 gene... (Source: Retrovirology)
Source: Retrovirology - January 26, 2022 Category: Virology Authors: Hlelolwenkosi Mlimi, Kewreshini K. Naidoo, Jenniffer Mabuka, Thumbi Ndung ’u and Paradise Madlala Tags: Research Source Type: research
HIV-2/SIV Vpx antagonises NF- κB activation by targeting p65
The NF- κB family of transcription factors and associated signalling pathways are abundant and ubiquitous in human immune responses. Activation of NF-κB transcription factors by viral pathogen-associated molecu... (Source: Retrovirology)
Source: Retrovirology - January 24, 2022 Category: Virology Authors: Douglas L. Fink, James Cai, Matthew V. X. Whelan, Christopher Monit, Carlos Maluquer de Motes, Greg J. Towers and Rebecca P. Sumner Tags: Research Source Type: research
Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda
Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with... (Source: Retrovirology)
Source: Retrovirology - January 15, 2022 Category: Virology Authors: Samira Joussef-Pi ña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Dane Winner, Fred Kyeyune, Keith Chervenak, Bonnie Thiel, Robert Asaad, Curtis Dobrowolski, Benjamin Luttge, Blair Lawley, Cissy M. Kityo, W. Henry Boom, Jonathan Kar Tags: Research Source Type: research
Rotten to the core: antivirals targeting the HIV-1 capsid core
The capsid core of HIV-1 is a large macromolecular assembly that surrounds the viral genome and is an essential component of the infectious virus. In addition to its multiple roles throughout the viral life cy... (Source: Retrovirology)
Source: Retrovirology - December 22, 2021 Category: Virology Authors: William M. McFadden, Alexa A. Snyder, Karen A. Kirby, Philip R. Tedbury, Monika Raj, Zhengqiang Wang and Stefan G. Sarafianos Tags: Review Source Type: research
A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis
The majority of emerging infectious diseases in humans are of animal origin, and many of them are caused by neuropathogenic viruses. Many cases of neurological disease and encephalitis in livestock remain etio... (Source: Retrovirology)
Source: Retrovirology - December 20, 2021 Category: Virology Authors: Melanie M. Hierweger, Michel C. Koch, Ronja V. Kauer, Zolt án Bagó, Anna Oevermann, Giuseppe Bertoni and Torsten Seuberlich Tags: Research Source Type: research
Editing out HIV: application of gene editing technology to achieve functional cure
Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not... (Source: Retrovirology)
Source: Retrovirology - December 18, 2021 Category: Virology Authors: Jingna Xun, Xinyu Zhang, Shuyan Guo, Hongzhou Lu and Jun Chen Tags: Review Source Type: research
Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas
Prototype foamy virus (PFV) is nonpathogenic complex retroviruses that express a transcriptional transactivator Tas, which is essential for the activity of viral long terminal repeat (LTR) promoter and interna... (Source: Retrovirology)
Source: Retrovirology - December 13, 2021 Category: Virology Authors: Peipei Yuan, Jun Yan, Shuang Wang, Yang Guo, Xueyan Xi, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Jochen Bodem and Wanhong Liu Tags: Research Source Type: research
HIV-1 integrase binding to genomic RNA 5 ?-UTR induces local structural changes in vitro and in virio
During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA... (Source: Retrovirology)
Source: Retrovirology - November 22, 2021 Category: Virology Authors: Shuohui Liu, Pratibha C. Koneru, Wen Li, Chathuri Pathirage, Alan N. Engelman, Mamuka Kvaratskhelia and Karin Musier-Forsyth Tags: Research Source Type: research
