More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteins
The first responders of human antiviral immunity are components of the intrinsic immune response that reside within each and every one of our cells. This cell-autonomous arsenal consists of nucleic acid senso... (Source: Retrovirology)
Source: Retrovirology - November 21, 2017 Category: Virology Authors: Guoli Shi, Olivier Schwartz and Alex A. Compton Tags: Review Source Type: research
Genome modification of CXCR4 by Staphylococcus aureus Cas9 renders cells resistance to HIV-1 infection
The CRISPR/Cas9 system has been widely used for genome editing in mammalian cells. CXCR4 is a co-receptor for human immunodeficiency virus type 1 (HIV-1) entry, and loss of CXCR4 function can protect cells from C... (Source: Retrovirology)
Source: Retrovirology - November 15, 2017 Category: Virology Authors: Qiankun Wang, Shuliang Chen, Qiaoqiao Xiao, Zhepeng Liu, Shuai Liu, Panpan Hou, Li Zhou, Wei Hou, Wenzhe Ho, Chunmei Li, Li Wu and Deyin Guo Tags: Research Source Type: research
Increasing the CpG dinucleotide abundance in the HIV-1 genomic RNA inhibits viral replication
The human immunodeficiency virus type 1 (HIV-1) structural protein Gag is necessary and sufficient to form viral particles. In addition to encoding the amino acid sequence for Gag, the underlying RNA sequence ... (Source: Retrovirology)
Source: Retrovirology - November 9, 2017 Category: Virology Authors: Irati Antzin-Anduetza, Charlotte Mahiet, Luke A. Granger, Charlotte Odendall and Chad M. Swanson Tags: Research Source Type: research
The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity
HIV-1 Integrase (IN) interacts with the cellular co-factor LEDGF/p75 and tethers the HIV preintegration complex to the host genome enabling integration. Recently a new class of IN inhibitors was described, th... (Source: Retrovirology)
Source: Retrovirology - November 9, 2017 Category: Virology Authors: C éline Amadori, Yme Ubeles van der Velden, Damien Bonnard, Igor Orlov, Nikki van Bel, Erwann Le Rouzic, Laia Miralles, Julie Brias, Francis Chevreuil, Daniele Spehner, Sophie Chasset, Benoit Ledoussal, Luzia Mayr, François Moreau, Felipe García, José Tags: Research Source Type: research
Correction to: Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells
The authors wish to apologize for an error within the scale bar of the microarray heatmap in Additional File 5 of the supplementary information. Two values were incorrectly displayed on the scale bar (11 inste... (Source: Retrovirology)
Source: Retrovirology - October 18, 2017 Category: Virology Authors: Franziska K. Geis, Melanie Galla, Dirk Hoffmann, Johannes Kuehle, Daniela Zychlinski, Tobias Maetzig, Juliane W. Schott, Adrian Schwarzer, Christine Goffinet, Stephen P. Goff and Axel Schambach Tags: Correction Source Type: research
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain
In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrop... (Source: Retrovirology)
Source: Retrovirology - October 16, 2017 Category: Virology Authors: Eugene L. Asahchop, Oussama Meziane, Manmeet K. Mamik, Wing F. Chan, William G. Branton, Lothar Resch, M. John Gill, Elie Haddad, Jean V. Guimond, Mark A. Wainberg, Glen B. Baker, Eric A. Cohen and Christopher Power Tags: Research Source Type: research
A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies
This study is to investigate whether strong... (Source: Retrovirology)
Source: Retrovirology - October 10, 2017 Category: Virology Authors: Donglai Liu, Chu Wang, Bhavna Hora, Tao Zuo, Nilu Goonetilleke, Michael K. P. Liu, Mark Berrong, Guido Ferrari, Andrew J. McMichael, Tanmoy Bhattacharya, Alan S. Perelson and Feng Gao Tags: Short report Source Type: research
Cellular fatty acid synthase is required for late stages of HIV-1 replication
Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purin... (Source: Retrovirology)
Source: Retrovirology - September 29, 2017 Category: Virology Authors: Manjusha M. Kulkarni, Annette N. Ratcliff, Menakshi Bhat, Yazan Alwarawrah, Philip Hughes, Jesus Arcos, David Loiselle, Jordi B. Torrelles, Nicholas T. Funderburg, Timothy A. Haystead and Jesse J. Kwiek Tags: Research Source Type: research
Unique binding modes for the broad neutralizing activity of single-chain variable fragments (scFv) targeting CD4-induced epitopes
The CD4-induced (CD4i) epitopes in gp120 includes the co-receptor binding site, which are formed and exposed after interaction with CD4. Monoclonal antibodies (mAbs) to the CD4i epitopes exhibit limited neutra... (Source: Retrovirology)
Source: Retrovirology - September 22, 2017 Category: Virology Authors: Kazuki Tanaka, Takeo Kuwata, Muntasir Alam, Gilad Kaplan, Shokichi Takahama, Kristel Paola Ramirez Valdez, Anna Roitburd-Berman, Jonathan M. Gershoni and Shuzo Matsushita Tags: Research Source Type: research
HIV-1 tolerates changes in A-count in a small segment of the pol gene
The HIV-1 RNA genome has a biased nucleotide composition with a surplus of As. Several hypotheses have been put forward to explain this striking phenomenon, but the A-count of the HIV-1 genome has thus far not... (Source: Retrovirology)
Source: Retrovirology - September 5, 2017 Category: Virology Authors: Bep Klaver, Yme van der Velden, Formijn van Hemert, Antoinette C. van der Kuyl and Ben Berkhout Tags: Research Source Type: research
Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8+ T cell responses during acute Friend retrovirus infection
Myeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model,... (Source: Retrovirology)
Source: Retrovirology - August 23, 2017 Category: Virology Authors: Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng, Lieping Chen, Ulf Dittmer and Gennadiy Zelinskyy Tags: Research Source Type: research
Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers
Human endogenous retroviruses (HERVs) comprise approximately 8% of the human genome and while the majority are transcriptionally silent, the most recently integrated HERV, HERV-K (HML-2), remains active. Durin... (Source: Retrovirology)
Source: Retrovirology - August 22, 2017 Category: Virology Authors: Miguel de Mulder, Devi SenGupta, Steven G. Deeks, Jeffrey N. Martin, Christopher D. Pilcher, Frederick M. Hecht, Jonah B. Sacha, Douglas F. Nixon and Henri-Alexandre Michaud Tags: Research Source Type: research
Identification of a homogenous structural basis for oligomerization by retroviral Rev-like proteins
Rev-like proteins are post-transcriptional regulatory proteins found in several retrovirus genera, including lentiviruses, betaretroviruses, and deltaretroviruses. These essential proteins mediate the nuclear ... (Source: Retrovirology)
Source: Retrovirology - August 22, 2017 Category: Virology Authors: Chijioke N. Umunnakwe, Karin S. Dorman, Drena Dobbs and Susan Carpenter Tags: Research Source Type: research
Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration
Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodel... (Source: Retrovirology)
Source: Retrovirology - July 28, 2017 Category: Virology Authors: Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne and Vincent Parissi Tags: Research Source Type: research
Tribute to Mark Wainberg
(Source: Retrovirology)
Source: Retrovirology - June 28, 2017 Category: Virology Authors: Eric J. Arts, Anne Gatignol, Andrew J. Mouland, Chen Liang, Matthias G ötte and Hugo Soudeyns Source Type: research
