HTLV-1 CTCF-binding site is dispensable for in vitro immortalization and persistent infection in vivo
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia/lymphoma (ATL) and the neurological disorder HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The... (Source: Retrovirology)
Source: Retrovirology - December 21, 2019 Category: Virology Authors: Michael P. Martinez, Xiaogang Cheng, Ancy Joseph, Jacob Al-Saleem, Amanda R. Panfil, Marilly Palettas, Wessel P. Dirksen, Lee Ratner and Patrick L. Green Tags: Research Source Type: research
p30 protein: a critical regulator of HTLV-1 viral latency and host immunity
The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the severity of the health conditions associated with the virus impress the great need f... (Source: Retrovirology)
Source: Retrovirology - December 18, 2019 Category: Virology Authors: Ramona Moles, Sarkis Sarkis, Veronica Galli, Maria Omsland, Damian F. J. Purcell, David Yurick, Georges Khoury, Cynthia A. Pise-Masison and Genoveffa Franchini Tags: Review Source Type: research
Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence
The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo ’s group, is the etiologic agent of both cancer and inflammatory diseases. Despite approximately 40 years of investigation... (Source: Retrovirology)
Source: Retrovirology - December 18, 2019 Category: Virology Authors: Sarkis Sarkis, Veronica Galli, Ramona Moles, David Yurick, Georges Khoury, Damian F. J. Purcell, Genoveffa Franchini and Cynthia A. Pise-Masison Tags: Review Source Type: research
HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA
The HERV-K (HML-2) viruses are the youngest of the human endogenous retroviruses. They are present as several almost complete proviral copies and numerous fragments in the human genome. Many HERV-K proviruses ... (Source: Retrovirology)
Source: Retrovirology - December 16, 2019 Category: Virology Authors: Laurie R. Gray, Rachel E. Jackson, Patrick E. H. Jackson, Stefan Bekiranov, David Rekosh and Marie-Louise Hammarskj öld Tags: Research Source Type: research
STLV-1 as a model for studying HTLV-1 infection
Few years after HTLV-1 identification and isolation in humans, STLV-1, its simian counterpart, was discovered. It then became clear that STLV-1 is present almost in all simian species. Subsequent molecular epi... (Source: Retrovirology)
Source: Retrovirology - December 16, 2019 Category: Virology Authors: Brice J égado, Fatah Kashanchi, Hélène Dutartre and Renaud Mahieux Tags: Review Source Type: research
HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP
Human T cell leukaemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases such as adult T-cell leukaemia/lymphoma and HTLV-1 associated myelopathy/tropical spastic paraparesis. In contrast to... (Source: Retrovirology)
Source: Retrovirology - December 16, 2019 Category: Virology Authors: Paola Miyazato, Misaki Matsuo, Benjy J. Y. Tan, Michiyo Tokunaga, Hiroo Katsuya, Saiful Islam, Jumpei Ito, Yasuhiro Murakawa and Yorifumi Satou Tags: Research Source Type: research
Molecular epidemiology, genetic variability and evolution of HTLV-1 with special emphasis on African genotypes
Human T cell leukemia virus (HTLV-1) is an oncoretrovirus that infects at least 10 million people worldwide. HTLV-1 exhibits a remarkable genetic stability, however, viral strains have been classified in sever... (Source: Retrovirology)
Source: Retrovirology - December 16, 2019 Category: Virology Authors: Philippe V. Afonso, Olivier Cassar and Antoine Gessain Tags: Review Source Type: research
Mutations of Glu560 within HIV-1 Envelope Glycoprotein N-terminal heptad repeat region contribute to resistance to peptide inhibitors of virus entry
Peptides corresponding to N- and C-terminal heptad repeat regions (HR1 and HR2, respectively) of gp41 can inhibit HIV-1 infection in a dominant negative manner by interfering with refolding of the viral HR1 an... (Source: Retrovirology)
Source: Retrovirology - December 3, 2019 Category: Virology Authors: Chen Yuan, Jia-Ye Wang, Hai-Jiao Zhao, Yan Li, Di Li, Hong Ling and Min Zhuang Tags: Research Source Type: research
Cardiovascular disease risk in an urban African population: a cross-sectional analysis on the role of HIV and antiretroviral treatment
This study investigated to what extent HI... (Source: Retrovirology)
Source: Retrovirology - December 3, 2019 Category: Virology Authors: Alinda G. Vos, Klariska Hoeve, Roos E. Barth, Joyce Peper, Michelle Moorhouse, Nigel J. Crowther, Willem D. F. Venter, Diederick E. Grobbee, Michiel L. Bots and Kerstin Klipstein-Grobusch Tags: Research Source Type: research
Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1
Immunity against pathogens evolved through complex mechanisms that only for sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and adaptive immunity are strongly intertwined... (Source: Retrovirology)
Source: Retrovirology - November 29, 2019 Category: Virology Authors: Greta Forlani, Mariam Shallak, Elise Ramia, Alessandra Tedeschi and Roberto S. Accolla Tags: Review Source Type: research
Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately 10 –20 million people worldwide. While the majority of infected people are asymptomatic carriers of HTLV-1, only 4% of ... (Source: Retrovirology)
Source: Retrovirology - November 29, 2019 Category: Virology Authors: Yoshimi Enose-Akahata and Steven Jacobson Tags: Review Source Type: research
Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species
The Deltaretrovirus genus of retroviruses (family Retroviridae) includes the human T cell leukemia viruses and bovine leukemia virus (BLV). Relatively little is known about the biology and evolution of these viru... (Source: Retrovirology)
Source: Retrovirology - November 27, 2019 Category: Virology Authors: Tom áš Hron, Daniel Elleder and Robert J. Gifford Tags: Short report Source Type: research
Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency
HIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-inf... (Source: Retrovirology)
Source: Retrovirology - November 11, 2019 Category: Virology Authors: Sushama Telwatte, Sara Mor ón-López, Dvir Aran, Peggy Kim, Christine Hsieh, Sunil Joshi, Mauricio Montano, Warner C. Greene, Atul J. Butte, Joseph K. Wong and Steven A. Yukl Tags: Research Source Type: research
Engineering and characterising a novel, highly potent bispecific antibody iMab-CAP256 that targets HIV-1
The existing repertoire of HIV-1 patient derived broadly neutralising antibodies (bNAbs) that target the HIV-1 envelope glycoprotein (Env) present numerous and exciting opportunities for immune-based therapeut... (Source: Retrovirology)
Source: Retrovirology - November 8, 2019 Category: Virology Authors: Tumelo Moshoette, Stuart Alvaro Ali, Maria Antonia Papathanasopoulos and Mark Andrew Killick Tags: Short report Source Type: research
NHEJ pathway is involved in post-integrational DNA repair due to Ku70 binding to HIV-1 integrase
HIV-1 integration results in genomic DNA gaps that are repaired by cellular DNA repair pathways. This step of the lentiviral life cycle remains poorly understood despite its crucial importance for successful r... (Source: Retrovirology)
Source: Retrovirology - November 6, 2019 Category: Virology Authors: Ekaterina Knyazhanskaya, Andrey Anisenko, Olga Shadrina, Anastasia Kalinina, Timofei Zatsepin, Arthur Zalevsky, Dmitriy Mazurov and Marina Gottikh Tags: Research Source Type: research
