The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection because they are the source o... (Source: Retrovirology)
Source: Retrovirology - April 5, 2024 Category: Virology Authors: Uri Mbonye and Jonathan Karn Tags: Review Source Type: research
MicroRNAs and long non-coding RNAs during transcriptional regulation and latency of HIV and HTLV
Human immunodeficiency virus (HIV) and human T cell leukemia virus (HTLV) have replicative and latent stages of infection. The status of the viruses is dependent on the cells that harbour them and on different... (Source: Retrovirology)
Source: Retrovirology - February 29, 2024 Category: Virology Authors: Sergio P. Alpuche-Lazcano, Robert J. Scarborough and Anne Gatignol Tags: Review Source Type: research
HERVK-mediated regulation of neighboring genes: implications for breast cancer prognosis
Human endogenous retroviruses (HERVs) are the remnants of ancient retroviral infections integrated into the human genome. Although most HERVs are silenced or rendered inactive by various regulatory mechanisms,... (Source: Retrovirology)
Source: Retrovirology - February 22, 2024 Category: Virology Authors: Boying Liang, Tengyue Yan, Huilin Wei, Die Zhang, Lanxiang Li, Zengjing Liu, Wen Li, Yuluan Zhang, Nili Jiang, Qiuxia Meng, Guiyang Jiang, Yanling Hu and Jing Leng Tags: Research Source Type: research
Endogenous feline leukemia virus long terminal repeat integration site diversity is highly variable in related and unrelated domestic cats
Endogenous retroviruses (ERV) are indicators of vertebrate evolutionary history and play important roles as homeostatic regulators. ERV long terminal repeat (LTR) elements may act as cis-activating promoters o... (Source: Retrovirology)
Source: Retrovirology - February 12, 2024 Category: Virology Authors: Elliott S. Chiu, Coby A. McDonald, Roderick B. Gagne, Henry Dunkleberger, Matthew Moxcey and Sue VandeWoude Tags: Research Source Type: research
The HIV-1 gag p6: a promising target for therapeutic intervention
The p6 domain of the Gag precursors (Gag p6) in human immunodeficiency virus type 1 (HIV-1) plays multifunctional roles in the viral life cycle. It utilizes the endosomal sorting complex required for transport... (Source: Retrovirology)
Source: Retrovirology - January 23, 2024 Category: Virology Authors: Xiaowei Chen and Xiao Wang Tags: Review Source Type: research
The chemokine receptor CCR5: multi-faceted hook for HIV-1
Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by interacting with G protein-coupled cell surface receptors (GPC... (Source: Retrovirology)
Source: Retrovirology - January 23, 2024 Category: Virology Authors: Natacha Faivre, Christel Verollet and Fabrice Dumas Tags: Review Source Type: research
The KT Jeang retrovirology prize 2023: Thumbi Ndung ’u
(Source: Retrovirology)
Source: Retrovirology - October 18, 2023 Category: Virology Authors: Thumbi Ndung ’u Tags: Editorial Source Type: research
Murine leukemia virus (MLV) P50 protein induces cell transformation via transcriptional regulatory function
The murine leukemia virus (MLV) has been a powerful model of pathogenesis for the discovery of genes involved in cancer. Its splice donor (SD ’)-associated retroelement (SDARE) is important for infectivity and ... (Source: Retrovirology)
Source: Retrovirology - September 12, 2023 Category: Virology Authors: Charbel Akkawi, Jerome Feuillard, Felipe Leon Diaz, Khalid Belkhir, Nelly Godefroy, Jean-Marie Peloponese, Marylene Mougel and Sebastien Laine Tags: Research Source Type: research
Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor
Human immunodeficiency virus (HIV) and other lentiviruses adapt to new hosts by evolving to evade host-specific innate immune proteins that differ in sequence and often viral recognition between host species. ... (Source: Retrovirology)
Source: Retrovirology - August 22, 2023 Category: Virology Authors: Joy Twentyman, Anthony Khalifeh, Abby L. Felton, Michael Emerman and Molly Ohainle Tags: Research Source Type: research
Analysis of PERV-C superinfection resistance using HA-tagged viruses
Using pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still a zoonotic risk associated with xenotransplantation, and the potential... (Source: Retrovirology)
Source: Retrovirology - August 21, 2023 Category: Virology Authors: Merle Flecks, Nicole Fischer, Jacomina Krijnse Locker, Ralf R. T önjes and Antonia W. Godehardt Tags: Research Source Type: research
Transmitted/founder SHIV.D replicates in the brain, causes neuropathogenesis, and persists on combination antiretroviral therapy in rhesus macaques
A biologically relevant non-human primate (NHP) model of HIV persistence in the central nervous system (CNS) is necessary. Most current NHP/SIV models of HIV infection fail to recapitulate viral persistence in... (Source: Retrovirology)
Source: Retrovirology - August 10, 2023 Category: Virology Authors: Rachel M. Podgorski, Jake A. Robinson, Mandy D. Smith, Suvadip Mallick, Huaqing Zhao, Ronald S. Veazey, Dennis L. Kolson, Katharine J. Bar and Tricia H. Burdo Tags: Brief Report Source Type: research
Correction to: DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
(Source: Retrovirology)
Source: Retrovirology - July 11, 2023 Category: Virology Authors: Mar ía José Lista, AnneCaroline Jousset, Mingpan Cheng, Violaine SaintAndré, Elouan Perrot, Melissa Rodrigues, Carmelo Di Primo, Danielle Gadelle, Elenia Toccafondi, Emmanuel Segeral, Clarisse BerliozTorrent, Stéphane Emiliani, JeanLouis Mergny and Ma Tags: Correction Source Type: research
A complex network of transcription factors and epigenetic regulators involved in bovine leukemia virus transcriptional regulation
Bovine Leukemia Virus (BLV) is the etiological agent of enzootic bovine leukosis, a disease characterized by the neoplastic proliferation of B cells in cattle. While most European countries have introduced eff... (Source: Retrovirology)
Source: Retrovirology - June 2, 2023 Category: Virology Authors: Estelle Plant, Maxime Bellefroid and Carine Van Lint Tags: Review Source Type: research
DNA topoisomerase 1 represses HIV-1 promoter activity through its interaction with a guanine quadruplex present in the LTR sequence
Once integrated in the genome of infected cells, HIV-1 provirus is transcribed by the cellular transcription machinery. This process is regulated by both viral and cellular factors, which are necessary for an ... (Source: Retrovirology)
Source: Retrovirology - May 30, 2023 Category: Virology Authors: Mar ía José Lista, Anne-Caroline Jousset, Mingpan Cheng, Violaine Saint-André, Elouan Perrot, Melissa Rodrigues, Carmelo Di Primo, Danielle Gadelle, Elenia Toccafondi, Emmanuel Segeral, Clarisse Berlioz-Torrent, Stéphane Emiliani, Jean-Louis Mergny an Tags: Review Source Type: research
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Neutralizing antibodies (NAbs) protect against HIV-1 acquisition in animal models and show promise in treatment of infection. They act by binding to the viral envelope glycoprotein (Env), thereby blocking its ... (Source: Retrovirology)
Source: Retrovirology - May 27, 2023 Category: Virology Authors: Philippe Colin, Rajesh P. Ringe, Anila Yasmeen, Gabriel Ozorowski, Thomas J. Ketas, Wen-Hsin Lee, Andrew B. Ward, John P. Moore and P. J. Klasse Tags: Research Source Type: research
