Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas

Prototype foamy virus (PFV) is nonpathogenic complex retroviruses that express a transcriptional transactivator Tas, which is essential for the activity of viral long terminal repeat (LTR) promoter and interna...

Source: Retrovirology - December 13, 2021 Category: Virology Authors: Peipei Yuan, Jun Yan, Shuang Wang, Yang Guo, Xueyan Xi, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Jochen Bodem and Wanhong Liu Tags: Research Source Type: research