A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors

Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1...

Source: Retrovirology - April 9, 2021 Category: Virology Authors: Dibya Ghimire, Yuvraj KC, Uddhav Timilsina, Kriti Goel, T. J. Nitz, Carl T. Wild and Ritu Gaur Tags: Research Source Type: research