Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response ...

Source: Retrovirology - May 19, 2020 Category: Virology Authors: Tomas Bastys, Vytautas Gapsys, Hauke Walter, Eva Heger, Nadezhda T. Doncheva, Rolf Kaiser, Bert L. de Groot and Olga V. Kalinina Tags: Research Source Type: research