Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Open-label, Multicenter, Phase 2 Study of a Food Enriched with Docosahexaenoic Acid in Adults with Sickle Cell Disease
Sickle cell disease (SCD) is a common monogenic disorder that affects over 100,000 people in the United States alone, and millions more worldwide [1]. The disease is generally characterized by red blood cell sickling, episodic vaso-occlusive crises (VOC), and other symptoms associated with pain and inflammation [2]. SCD is an inherited pathology caused by a point mutation of the β-globin gene that results in an abnormal type of hemoglobin, the S variant (HbS) [3]. While the classical paradigm of SCD considers the sickling and polymerization of HbS as the primary cause of its physiological complications, more recent advanc...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 7, 2023 Category: Biomedical Science Authors: G. Kanakapura, S.K. Bhatnagar, L. Tomlinson, F. Sancilio Tags: Short communication Source Type: research

Effects of long-chain omega-3 polyunsaturated fatty acids on reducing anxiety and/or depression in adults; A systematic review and meta-analysis of randomised controlled trials
Beck Anxiety Inventory (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 2, 2023 Category: Biomedical Science Authors: Christos F. Kelaiditis, E. Leigh Gibson, Simon C. Dyall Source Type: research

Kinetics of omega-3 fatty acid transfer to milk differs between fatty acids and stage of lactation in dairy cows.
Tissues differ greatly in their FA profile indicating tissue specific uptake and metabolism [1]. This is especially evident with omega-3 (n-3) polyunsaturated FA (PUFA) as they are greatly enriched in some tissues, such as the brain [1]. However, kinetics of n-3 PUFA interorgan trafficking is complex and has not been well studied but may provide unique insight into the metabolism of these essential nutrients. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 30, 2023 Category: Biomedical Science Authors: Natalie L. Urrutia, Michel Baldin, Samantha R. Egolf, Rachel E. Walker, Yun Ying, Michael H. Green, Kevin J. Harvatine Tags: Original research article Source Type: research

Macronutrient composition of term and preterm human milk of different socio economic groups
Human Breast milk (HBM) provides complete nutrition for the infant which contains proteins, carbohydrates, lipids [1], numerous immune substances like antibodies, chemokines, cytokines, growth factors, hormones and immunoglobulins etc. [2]. Proper intake of nutrients in the first year of life is crucial for adequate growth and development of infant and human milk is the sole and essential source of nutrients in the first half of the year [3]. The composition and nutritional profile of milk changes from preterm to term, stages of lactation, and also has diurnal variation [4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 29, 2023 Category: Biomedical Science Authors: Chathyushya K B, Hemalatha R, Ananthan R, J J Babu G, Devraj J P, Santosh Kumar Banjara, Alimelu M, Pradeep Reddy K, Nitasha B, Shiva Prakash M Tags: Original research article Source Type: research

Plasma and rectal mucosal oxylipin levels during aspirin and eicosapentaenoic acid treatment in the seAFOod polyp prevention trial
There is evidence that aspirin and the omega-3 polyunsaturated fatty acid (PUFA) C20:5n-3 eicosapentaenoic acid (EPA) have chemopreventative activity against colorectal cancer (CRC) [1,2]. However, the mechanism(s) of the anti-CRC activity of both agents remains unclear with several cyclooxygenase (COX)-dependent and -independent mechanisms being described, based largely on data from in vitro CRC cell studies and rodent CRC models [1,2]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 23, 2023 Category: Biomedical Science Authors: H Fuller, A D Race, H Fenton, L Burke, A Downing, E A Williams, C J Rees, L C Brown, P M Loadman, M A Hull Tags: Original research article Source Type: research

Analysis of Fatty Acid composition and Sensitivity to Dietary n-3 PUFA Intervention of Mouse n-3 PUFA-Enriched Tissues/Organs
It is well known that fatty acids, as an important component of the plasma membrane, are involved in modulating cell function and fate. Docosahexaenoic acid (DHA; C22:6 n3) and eicosapentaenoic acid (EPA; C20:5 n3) are the major n-3 polyunsaturated fatty acids (PUFAs), and their function has received a lot of attention [1]. The brain has an abundance of DHA and arachidonic acid (AA; C20:4 n6) selectively esterified into the sn-2 position of phospholipids, as well as low levels of other PUFAs, such as linoleic acid (LA; C18:2 n6), α-linolenic acid (ALA; C18:3 n3), and EPA [2,3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 22, 2023 Category: Biomedical Science Authors: Hui Zhang, Yannan He, Chunyan Song, Zhenglong Chai, Chundi Liu, Shuben Sun, Qiuhan Huang, Canxia He, Xiaohong Zhang, Yuping Zhou, Feng Zhao Tags: Original research article Source Type: research

Sex Differences in Hippocampal-dependent Memory and the Hippocampal Lipidome in Adolescent Rats Raised on Diets With or Without DHA
Docosahexaenoic acid (DHA, 22:6n-3) is necessary for the optimal development of the central nervous system and spatial memory [1 –3]. In North America, intakes of DHA by pregnant women have been estimated to be under 100 mg/d [4,5] while there are several advisories from expert groups and associations recommending an intake of 200 mg/d of DHA during pregnancy and lactation [6–8]. There is also a recent recommendation for an intake of 1000mg/d of DHA during pregnancy to reduce premature birth by the International Society for the Study of Fatty Acids and Lipids [9]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 22, 2023 Category: Biomedical Science Authors: Daniel M. Lamontagne-Kam, Saeideh Davari, Juan J Aristizabal-Henao, Seungjae Cho, Dan Chalil, John G. Mielke, Ken D. Stark Tags: Original research article Source Type: research

Lower Omega-3 Status Associated with Higher Erythrocyte Distribution Width and Neutrophil-Lymphocyte Ratio in UK Biobank Cohort
A complete blood count is a routine component of medical exams that provides comprehensive hematologic information. Using standardized reference ranges, healthy individuals can be distinguished from those with nutrient deficiencies, infections, tissue damage, and inflammation. In addition to basic information provided by hemoglobin, hematocrit, and platelet and white blood cell counts, the red blood cell distribution width (RDW) is routinely used to diagnose anemias [1] and may be useful to assess overall wellness [2]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 15, 2023 Category: Biomedical Science Authors: Michael I. McBurney, Nathan L. Tintle, William S. Harris Tags: Original research article Source Type: research

Dietary omega-3 fatty acid deficiency from pre-pregnancy to lactation affects expression of genes involved in hippocampal neurogenesis of the offspring
For optimal growth, the fetal brain requires maternal long-chain polyunsaturated fatty acids (LCPUFAs) via the placenta and breast milk in utero and postnatally, respectively [1 –3]. Maternal PUFAs support fetal growth and brain development [4,5]. Maternal PUFAs are important for the overall development of the fetus, including lactating mammary gland [6]. The mammary gland is an active lipid synthetic organ that secretes many milk lipids during the 20-d lactation cycle in mice. Its development is comparable between humans and rodents. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 11, 2023 Category: Biomedical Science Authors: Vilasagaram Srinivas, Saikanth Varma, Suryam Reddy Kona, Ahamed Ibrahim, Asim K Duttaroy, Sanjay Basak Tags: Original research article Source Type: research

Effect of omega-6 Linoleic Acid on Neurobehavioral Development in Caenorhabditis elegans
Linoleic acid (LA, C18H32O2, 18:2, n-6), which cannot be synthesized by humans, is supplied by vegetable oils such as corn, sunflower, and soybean and peanut oils, and is essential for normal growth and development at 1 to 2% of daily energy requirements [1]. Omega-6 polyunsaturated fatty acids (PUFAs) including LA facilitate the protection of the brain and stabilization of neuronal membrane [2], which is required for normal growth and brain development [3]. Nevertheless, a few correlative clinical reports have revealed that excess LA intake potentiates influence of brain development, as LA is a precursor of oxidized linol...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 2, 2023 Category: Biomedical Science Authors: Tun-Chieh Chen, Wen-Li Hsu, Ching-Ying Wu, Yun-Ru Lai, How-Ran Chao, Chu-Huang Chen, Ming-Hsien Tsai Tags: Original research article Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 1, 2023 Category: Biomedical Science Source Type: research

Phospholipase A2 enzymes differently impact PUFA release and oxylipin formation ex vivo in rat hearts
Phospholipase A2 (PLA2) is a superfamily of enzymes involved in the hydrolysis of membrane phospholipids [1,2]. The polyunsaturated fatty acids (PUFA) released by PLA2 can then be converted by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes into oxylipins. These bioactive lipid mediators are involved in important physiological and pathophysiological cardiovascular functions, such as regulation of vascular tone, inflammation, cardiac function, and blood coagulation [3 –11]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 28, 2023 Category: Biomedical Science Authors: Anne Manson, Tanja Winter, Harold M. Aukema Tags: Original research article Source Type: research

Krill oil supplementation's effect on school grades in typically developing adolescents
The effects of long-chain polyunsaturated fatty acids (LCPUFA) on physical health, mental health and cognitive outcomes has been investigated intensely (for reviews see among others [1 –3]). LCPUFAs such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are involved in a vast array of processes in the human body such as signal transduction, inflammation, blood-brain barrier integration and neuronal membrane fluidity [4,5]. Considering these functions, DHA and EPA hav e been hypothesised to be important for brain functioning, and it might not come as a surprise that there are a multitude of studies investigati...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 27, 2023 Category: Biomedical Science Authors: Inge S.M. van der Wurff, Clemens von Schacky, Trygve Bergeland, Maurice P. Zeegers, Paul A. Kirschner, Renate H.M. de Groot Tags: Original research article Source Type: research

The Potential Effects of Polyunsaturated ω-3 Fatty Acids on Spinal Cord Injury: A Systematic Review & Meta-Analysis of Preclinical Evidence
Spinal cord injury (SCI) is a devastating neurological impairment affecting between 250,000 and 500,000 people worldwide each year [1]. Around 90% of SCI patients are left with permanent disabilities that include the loss of motor and sensory function below the level of injury. SCI patients often develop other secondary complications including autonomic/bladder/bowel dysfunctions, neuropathic pain, pressure ulcers and urinary tract infections [2,3]. While there is currently no effective treatment available for SCI, there are promising preclinical studies that have examined the efficacies of the long chain polyunsaturated Ï...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 27, 2023 Category: Biomedical Science Authors: W.A.C. MacIntosh-Smith, A. Abdallah, C.J. Cunningham Tags: Original research article Source Type: research

Impact of dietary n-3 polyunsaturated fatty acid intake during the perinatal and post-weaning periods on the phospholipid and ganglioside composition of olfactory tissues
Polyunsaturated fatty acids (PUFAs) from the n-6 and n-3 families are essential for the development and normal growth of mammals. In addition to energy production through β-oxidation, PUFAs from these two series play crucial roles in the structure and function of cell membranes and the regulation of numerous signaling pathways. Linoleic acid (LA; 18:2n-6) and α-linolenic acid (ALA; 18:3n-3) are precursors for the long-chain n-6 and n-3 PUFAs, respectively. They can not be synthesized by mammals and must be provided by the diet. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 25, 2023 Category: Biomedical Science Authors: Spiro Khoury, Vanessa Soubeyre, St éphanie Cabaret, Stéphane Grégoire, Esther Mézière, Elodie Masson, Xavier Grosmaitre, Lionel Bretillon, Olivier Berdeaux, Niyazi Acar, Anne Marie Le Bon Tags: Original research article Source Type: research