Plasma and rectal mucosal oxylipin levels during aspirin and eicosapentaenoic acid treatment in the seAFOod polyp prevention trial

There is evidence that aspirin and the omega-3 polyunsaturated fatty acid (PUFA) C20:5n-3 eicosapentaenoic acid (EPA) have chemopreventative activity against colorectal cancer (CRC) [1,2]. However, the mechanism(s) of the anti-CRC activity of both agents remains unclear with several cyclooxygenase (COX)-dependent and -independent mechanisms being described, based largely on data from in vitro CRC cell studies and rodent CRC models [1,2].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 23, 2023 Category: Biomedical Science Authors: H Fuller, A D Race, H Fenton, L Burke, A Downing, E A Williams, C J Rees, L C Brown, P M Loadman, M A Hull Tags: Original research article Source Type: research