Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Stable analogs of 13 ‑hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier
Recently we reported on oxidized derivatives of linoleic acid (LA) that are potential endogenous mediators of chronic pain and itch [1]. Linoleic acid, which is one of the most abundant fatty acids in the skin [2] is designated an “essential fatty acid” since a small amount (0.5% of energy) must be obtained in the diet to form a functional epidermal water barrier and to prevent clinical manifestations of “essential fatty acid deficiency” [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 24, 2021 Category: Biomedical Science Authors: Gregory S. Keyes, Kristen Maiden, Christopher E. Ramsden Source Type: research

Stable analogs of 13-hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier
Recently we reported on oxidized derivatives of linoleic acid (LA) that are potential endogenous mediators of chronic pain and itch [1]. Linoleic acid, which is one of the most abundant fatty acids in the skin [2] is designated an “essential fatty acid” since a small amount (0.5% of energy) must be obtained in the diet to form a functional epidermal water barrier and to prevent clinical manifestations of “essential fatty acid deficiency” [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 24, 2021 Category: Biomedical Science Authors: Gregory S. Keyes, Kristen Maiden, Christopher E. Ramsden Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 1, 2021 Category: Biomedical Science Source Type: research

Blood Fatty Acid Analysis Reveals Similar n-3 Fatty Acid Composition in Non-Pregnant and Pregnant Women and Their Neonates in an Israeli Pilot Study
Maternal nutrition, especially relating to essential fatty acids (EFAs), is an important factor in determining fetal growth and development and in preconditioning adulthood health or disease [1] .Docosahexaenoic (DHA, 20:6 n-3) is the n-3 fatty acid with the highest concentration in the brain and it is critical, together with eicosapentaenoic acid (EPA 20:5 n-3), for the brain growth and functional development of infants and for the maintenance of normal brain [2] . DHA is an important component of neural and retinal membranes where it accumulates rapidly during fetal development [3], whereas EPA, competes with arachidonic...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 30, 2021 Category: Biomedical Science Authors: Alicia Leikin-Frenkel, Aya Mohr –Sasson, Matan Anteby, Michal Kandel-Kfir, Ayelet Harari, Roni Rahav, Yehuda Kamari, Aviv Shaish, Dror Harats, Hofit Cohen, Israel Hendler Source Type: research

Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids
arachidonic acid (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 24, 2021 Category: Biomedical Science Authors: K.M. Bermingham, L. Brennan, R. Segurado, I.J. Gray, R.E. Barron, E.R. Gibney, M.F. Ryan, M.J. Gibney, J.W. Newman, Dr. A.M. O'Sullivan Source Type: research

The effects of a high eicosapentaenoic acid multinutrient supplement on measures of stress, anxiety and depression in young adults: Study protocol for NutriMOOD, a randomised double-blind placebo-controlled trial
apolipoprotein E (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 24, 2021 Category: Biomedical Science Authors: Christos F Kelaiditis, E Leigh Gibson, Simon C Dyall Source Type: research

Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids.
arachidonic acid (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 24, 2021 Category: Biomedical Science Authors: KM Bermingham, L Brennan, R Segurado, IJ Gray, RE Barron, ER Gibney, MF Ryan, MJ Gibney, JW Newman, Dr. AM O'Sullivan Source Type: research

Omega 6 polyunsaturated fatty acids in red blood cell membrane are associated with xerostomia and taste loss in patients with breast cancer
Among cancer treatment side-effects, taste and smell disorders are a well-recognized cause of decreased food intake and/or weight loss and are reported as being one of the most distressing side effects with the consequent loss of their quality of life [1, 2]. Alterations related to treatment are mostly described for radiotherapy in head and neck cancer, where cells and receptors involved in taste and smell senses transduction are damaged, reducing specific receptors or impairing the communication between nerve cells [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 23, 2021 Category: Biomedical Science Authors: J. Am ézaga, G. Ugartemendia, A. Larraioz, N. Bretaña, A. Iruretagoyena, J. Camba, A. Urruticoechea, C. Ferreri, I. Tueros Source Type: research

Omega-3 and Omega-6 Fatty Acids have Distinct Effects on Endothelial Fatty Acid Content and Nitric Oxide Bioavailability
nitric oxide synthase (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 23, 2021 Category: Biomedical Science Authors: Samuel CR Sherratt, Hazem Dawoud, Deepak L Bhatt, Tadeusz Malinski, R Preston Mason Source Type: research

The effects of perioperative dexamethasone on eicosanoids and mediators of inflammation resolution: A sub-study of the PADDAG trial
Dexamethasone is frequently used during surgery for the prevention and treatment of perioperative nausea and vomiting. [1] There is evidence that glucocorticoids such as dexamethasone may induce hyperglycaemia [2] and that acute hyperglycaemia may impair immune function and wound healing after surgery [3]. However, in our recent trial, we showed that compared with placebo, dexamethasone 4mg or 8mg did not induce greater hyperglycaemia in nondiabetic and well controlled diabetic patients[4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 16, 2021 Category: Biomedical Science Authors: Professor Anne Barden, Michael Phillips, Sujata Shinde, Tomas Corcoran, Trevor A Mori Source Type: research

In search of pulmonary hypertension treatments: Effect of 17 β-estradiol on PGI2 pathway in human pulmonary artery
Pulmonary hypertension (PH) is characterized by a progressive increase in resting mean pulmonary arterial pressure (mPAP ≥ 20 mmHg) at the time of cardiac catheterization. This elevation is associated with increased pulmonary vascular resistance due to sustained pulmonary arterial vasoconstriction. [1, 2]. The chest imaging and the electrocardiogram support hypertrophy of the pulmonary arteries, abnormalities of the pulmonary parenchyma in relation to respiratory diseases, and an enlargement of the right heart [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 9, 2021 Category: Biomedical Science Authors: Yasmine Amgoud, Amira Senbel, Amel Bouhadoun, Heba Abdelazeem, Gulsev Ozen, Ines Savan é, Hasanga D Manikpurage, Salma Mani, Alexy Tran-Dinh, Yves Castier, Alice Guyard, Dan Longrois, Adam M. Silverstein, Dr. Xavier Norel Source Type: research

The association between a Fatty Acid Binding Protein 1 (FABP1) gene polymorphism and serum lipid abnormalities in the MASHAD cohort study
Dyslipidemia is a common risk factor for cardiovascular disease (CVD) [1, 2]. A fasted lipid profile characterized by increased fasting serum total cholesterol (TC), triglycerides (TGs), or low serum high-density lipoprotein (HDL) levels are associated with an increased risk of CVD [3]; environmental and genetic factors both affect the levels of serum lipid concentrations [4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 7, 2021 Category: Biomedical Science Authors: Mohsen Valizadeh, Maliheh Aghasizadeh, Mohsen Nemati, Mohammad Hashemi, Seyed Hamid Aghaei, Reza Zare-Feyzabadi, Habibollah Esmaily, Hamideh Ghazizdaeh, Reza Sahebi, Najmeh Ahangari, Gordon. A Ferns, Alireza Pasdar, Majid Ghayour-Mobarhan Source Type: research

Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: involvement of μ-opioid receptor and 5-HT transporter
Tramadol enhanced the PGD2-induced release and mRNA expression of osteoprotegerin in osteoblast-like MC3T3-E1 cells. Naloxone reduced the amplification by tramadol of the PGD2-stimulated osteoprotegerin release. Not reboxetine but fluvoxamine and sertraline upregulated the PGD2-induced osteoprotegerin release, which was further amplified by morphine. Tramadol enhanced PGD2-stimulated phosphorylation of p38 MAP kinase and SAPK/JNK, but not p44/p42 MAP kinase. Both SB203580 and SP600125 suppressed the tramadol effect to enhance the PGD2-stimulated osteoprotegerin release. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 7, 2021 Category: Biomedical Science Authors: Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida Tags: Research article Source Type: research

New β-ketophosphonates for the synthesis of prostaglandin analogues. 1. Phosphonates with a bicyclo[3.3.0]octene scaffold spaced by a methylene group from the β-ketone
The big family of prostaglandins (PGs) and prostaglandin (PG) analogs with different biological activities was obtained by modifying the α-side chain, the ω-side chain or both side chains in the molecule. Generally, the modifications of the ω-side chain have led to the most interesting biological activities of the PG analogs [1-2] and the researches in this direction were most extensive. In the total stereo-controlled Corey synthe sis of natural PGs and PG analogs, the ω-side chain is introduced by an E-selective Horner-Emmons-Wadsworth (HEW) olefination of an aldehyde with a δ-lactone (1), γ-lactone (2) and cyclopen...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 7, 2021 Category: Biomedical Science Authors: Comstantin T ănase, Miron Theodor Căproiu, Constantin Drăghici Source Type: research