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A rapid method for the separation of the phospholipids from the neutral lipids in plasma
It is well-established that different types of dietary fats have different physiological properties with both observational and clinical trials having identified associations between the levels of several specific fatty acids and a number of human diseases, such as inflammatory diseases and cardiovascular diseases [1-3]. Further, there is increasing evidence that the balance between n-6 long chain polyunsaturated fatty acids (LCPUFA), in particular arachidonic acid (AA), and the n-3 LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is particularly important in human health [4], [5]. (Source: Prostaglandin...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 14, 2020 Category: Biomedical Science Authors: Ge Liu, Robert Gibson Source Type: research

Deborah Diersen-Schade: In memoriam (1957 –2020)
On January 3, 2020, the infant nutrition and lipid research community lost one of its lesser known heroes with the passing of Dr Deborah Diersen-Schade, a research scientist who worked tirelessly in her professional life to improve infant nutrition. She blazed a trail in lipid research and skillfully navigated regulatory hurdles to bring formulas with lipid profiles similar to those found in human milk to infants, a legacy of innovation that continues to improve infant health. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 13, 2020 Category: Biomedical Science Authors: Robert Burns, Tom Brenna, Susan Carlson, Margaret Craig-Schmidt Source Type: research

Deborah Diersen-Schade: In Memoriam (1957-2020)
On January 3, 2020, the infant nutrition and lipid research community lost one of its lesser known heroes with the passing of Dr Deborah Diersen-Schade, a research scientist who worked tirelessly in her professional life to improve infant nutrition. She blazed a trail in lipid research and skillfully navigated regulatory hurdles to bring formulas with lipid profiles similar to those found in human milk to infants, a legacy of innovation that continues to improve infant health. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - April 13, 2020 Category: Biomedical Science Authors: Robert Burns, Tom Brenna, Susan Carlson, Margaret Craig-Schmidt Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 31, 2020 Category: Biomedical Science Source Type: research

Fats in maternal and child health: Regional ISSFAL congress in India
The current issue of Prostaglandins, Leukotrienes and Essential Fatty Acids contains peer-reviewed papers presented at the International Symposium on Fats in Maternal and Child Health Nutrition in the context of India, held on 17 –18 September 2018. The symposium was organized as part of regional International Society for the Study of Fatty Acids and Lipids (ISSFAL) congress in collaboration with the ICMR-National Institute of Nutrition, India. The symposium brought together expert researchers with their shared interest a bout the roles of fats in paediatrics, maternal nutrition, fetoplacental nutrition, nutritional neu...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 16, 2020 Category: Biomedical Science Authors: S. Ahamed Ibrahim, Sanjay Basak Tags: Editorial Source Type: research

Fats in maternal & child health: regional ISSFALcongress in India
The current issue of  Prostaglandins, Leukotrienes and Essential Fatty Acids contains peer-reviewed papers presented at the International Symposium on fats in maternal and child health nutrition- in the context of India, held on 17-18 September 2018. The symposium was organized as part of regional International Socie ty for the Study of Fatty Acids and Lipids (ISSFAL) congress in collaboration with the ICMR-National Institute of Nutrition, India. The symposium brought together expert researchers with their shared interest about the roles of fats in paediatrics, maternal nutrition, fetoplacental nutrition, nutri tional ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 16, 2020 Category: Biomedical Science Authors: S. Ahamed Ibrahim, Sanjay Basak Tags: Editorial Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 29, 2020 Category: Biomedical Science Source Type: research

Concentrates of buttermilk and krill oil improve cognition in aged rats
According to the latest Global Burden of Disease, the world population enjoys better overall health [1]. However, the number of years spent with disability is increasing [1]. The reason is that, thanks to better hygiene, diet, and medicine, we live longer. Aging is the most important risk factor for cardiovascular diseases and neurodegeneration, due to declines in cellular function and resistance to stress [2]. Many of the risk factors for age-related pathologies are preventable and include obesity, poor diet, and physical inactivity. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Alba Garc ía-Serrano, Joao Tomé-Carneiro, M. Carmen Crespo, M. Visitación Calvo, Inmaculada Pereda-Pérez, Shishir Baliyan, Emma Burgos-Ramos, Olimpio Montero, Alberto Dávalos, César Venero, Francesco Visioli, Javier Fontecha Tags: Original Research Article Source Type: research

Concentrates of buttermilk and krill oil improve spatial memory in aged rats
According to the latest Global Burden of Disease, the world population enjoys better overall health [1]. However, the number of years spent with disability is increasing [1]. The reason is that, thanks to better hygiene, diet, and medicine, we live longer. Aging is the most important risk factor for cardiovascular diseases and neurodegeneration, due to declines in cellular function and resistance to stress [2]. Many of the risk factors for age-related pathologies are preventable and include obesity, poor diet, and physical inactivity. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Alba Garc ía-Serrano, Joao Tomé-Carneiro, M. Carmen Crespo, M. Visitación Calvo, Inmaculada Pereda-Pérez, Shishir Baliyan, Emma Burgos-Ramos, Olimpio Montero, Alberto Dávalos, César Venero, Francesco Visioli, Javier Fontecha Tags: Original Research Article Source Type: research

LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells
Leukotrienes (LT) are pro-inflammatory lipid mediators derived from arachidonic acid [AA) that are crucial in the immune response to pathogens or danger signals. However, LT also play a role in chronic inflammatory diseases such as asthma and atherosclerosis, and in certain types of cancers [1,2]. Encoded by the ALOX5 gene, 5-lipoxygenase [5-LO) is the key enzyme involved in the bioconversion of AA to LT. Following cell activation, 5-LO catalyzes an oxygenation reaction on the 5th carbon from the carboxyl group resulting in the formation of 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HpETE) [3]. (Source: ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Samuel J Poirier, Luc H Boudreau, Nicolas Flamand, Marc E Surette Tags: Original research article Source Type: research

Changes in behavior and fatty acid composition induced by long-term reduction in murine Δ6-desaturation activity
Among the polyunsaturated fatty acids (PUFAs) that cannot produced ω6 fatty acid linoleic acid (LA) and ω3 fatty acid α-linolenic acid (ALA) play an important role in biological regulation [1,2]. However, ω-6 and ω-3 fatty acids compete with each other because they share a synthetic pathway involving the same desaturation and chain elongation enzymes. A study using Δ6 desaturase (D6D) null mice that were fed artificial milk containing LA and ALA showed an obvious decrease in ARA, EPA, and DHA levels, and impaired growth and development. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Akiko Harauma, Toshiaki Sueyasu, Hisanori Tokuda, Hidemi Yasuda, Yukino Hoshi, Yoshihisa Kaneda, Tomohiro Rogi, Hiroshi Shibata, Manabu T. Nakamura, Toru Moriguchi Tags: Original research article Source Type: research

Maternal dietary fatty acids and their roles in human placental development
Fatty acids carry out many functions throughout the life cycle. Fatty acids are crucial for regulating the architecture, dynamics, phase transitions, and permeability of the cellular membranes. Besides, they are involved in the regulation of membrane ion gates, ion channels, receptors, and cell signaling and gene expression [1-4]. Essential fatty acids (EFAs) belong to the n-6 (omega-6) and n-3 (omega-3) families, starting with the precursors, linoleic acid,18:2n-6 (LA) and alpha-linolenic acid, 18:3n-3 (ALA). (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Asim K. Duttaroy, Sanjay Basak Source Type: research

The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury
Prostaglandin E2 (PGE2) is a major lipid mediator derived from arachidonic acid via the cyclooxygenase (COX/PTGS)/prostaglandin E synthase (PGES/PTGES) pathway and exhibits various activities. In the liver, PGE2 exhibits protective effects against multiple types of liver injury. For example, PGE2 enhances tissue regeneration by promoting the proliferation of hepatocytes in a partial hepatectomy rat model and downregulates the production of inflammatory cytokines, such as TNF α, IL-1β, and IFN-γ, in an ischemia/reperfusion injury mouse model [1,2]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Hiroaki Shimada, Ryota Hashimoto, Aya Aoki, Saya Yamada, Ken-ichi Oba, Atsushi Kawase, Takeo Nakanishi, Masahiro Iwaki Tags: Original research article Source Type: research

Diets with Low n-6:n-3 PUFA Ratio Protects Rats from Fructose-Induced Dyslipidemia and Associated Hepatic Changes: Comparison between 18:3 n-3 and Long-Chain n-3 PUFA
Dietary fructose plays a critical role in the development of metabolic syndrome (MetS), a metabolic disorder defined by the presence of dyslipidemia, insulin resistance, hypertension, and visceral obesity [1]. Hypertriglyceridemia is a critical component of the MetS and contributes to the development and worsening of other MetS components like insulin resistance [2]. Hypertriglyceridemia increases the risk of developing type 2 diabetes and cardiovascular diseases [3]. Fructose consumption elevates the circulatory triglyceride levels in both human subjects and animal models [4, 5]. (Source: Prostaglandins, Leukotrienes and ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Anil Sakamuri, Siva S.V.P. Sakamuri, Suryam Reddy Kona, Sugeedha Jayapal, Ahamed Ibrahim Tags: Original research article Source Type: research

The impact of PUFA on cell responses: caution should be exercised when selecting PUFA concentrations in cell culture
The fatty acid composition of human cells has an impact on many cellular functions [1 –4]. In addition to their role in energy storage in the form of triglycerides (TG), fatty acids are also major components of membrane phospholipids (PL), thus controlling cell membranes fluidity and integrity [5–7]. In particular, polyunsaturated fatty acid (PUFA) from the n-6 and n-3 families s uch as arachidonic acid (AA, 20:4 n-6) and eicosapentaenoic acid (EPA, 20:5 n-3) are important components of cellular membranes that perform signaling functions, can serve as ligands for nuclear receptors and are precursors to lipid mediators ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Maroua Mbarik, Roody S Biam, Philippe-Pierre Robichaud, Marc E. Surette Tags: Original research article Source Type: research