Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effect of parenteral lipid emulsion on preterm infant PUFAs and their downstream metabolites
Intravenous lipid emulsions form an important component of parenteral nutrition for infants unable to tolerate full enteral feeds, by providing essential fatty acids and a low volume energy source. Parenteral lipid emulsions available for use in preterm infants contain the essential polyunsaturated fatty acids (PUFAs) linoleic acid (LA, omega-6) and α-linolenic acid (ALA, omega-3). Some lipid preparations also contain long chain polyunsaturated fatty acids (LCPUFAs) including the omega-6 LCPUFA arachidonic acid (AA), and the omega-3 LCPUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) [1]. (Source: Prostagla...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Hiroki Suganuma, Carmel T Collins, Andrew J McPhee, Shalem Leemaqz, Ge Liu, Chad C Andersen, Dennis Bonney, Robert A Gibson Source Type: research

Effect of fasting status and other pre-analytical variables on quantitation of long-chain fatty acids in red blood cells
As a source of energy, constituents of membranes and precursors to numerous bioactive molecules, long-chain fatty acids (LCFAs) play essential roles in health maintenance and outcomes [1]. Insufficient intake or the inability to absorb LCFAs from the diet can cause a number of health problems, such as dermatitis, liver and immune system dysfunction, or impaired growth in children. Factors contributing to development of fatty acid deficiencies include genetic disorders such as cystic fibrosis and inborn errors of metabolism, receiving parenteral nutrition, or severe malabsorption [2,3,4,5]. (Source: Prostaglandins, Leukotri...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: BK. Lozier, RN. Kim, LM. Zuromski, E. Kish-Trier, I. De Biase, T. Yuzyuk Source Type: research

Fish oil supplementation enhances colon recovery after experimental colitis
Inflammatory bowel disease (IBD) including Crohn's disease and ulcerative colitis is an immunological disease of the gastrointestinal tract (GI). IBD patients experience periods of clinical remission and relapsing active phase, with severe clinical symptoms such as rectal bleeding, abdominal pain, fever, and diarrhea that significantly impoverish the quality of life [1]. IBD pathogenesis provokes disturbances in the GI physiology with relevant disorders of the intestinal mucus whose role is to protect mucosal cells from luminal microorganisms and also from alterations in the inflammatory background of the GI tissues that w...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Igor Pedroso Soares, Bruna A.C. Oliveira, Suelen C.S. Baal, Lucelia Donatti, Max Ingberman, Breno C.B. Beir ão, Marcia H. Appel, Luiz C. Fernandes Source Type: research

Regulative effect of maternal serum fatty acid-binding protein 4 on insulin resistance and the development of gestational diabetes mellitus
Gestational diabetes mellitus (GDM) is a severe pregnancy syndrome affecting 9.8% –25.5% of the pregnant women worldwide [1]. For normal pregnant women, during pregnancy, the insulin sensitivity significantly decreases, and glucose production increases to ensure the fetal energy supply [2]. However, in GDM patients, insufficient insulin production caused by pancreatic β cell d ysfunction, is a main cause of insulin resistance [2a], leading to disturbed metabolism. Women with a history of GDM have higher risks of developing obesity, type 2 diabetes mellitus (T2DM) and cardiovascular diseases [3]. (Source: Prostaglandins,...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Bide Duan, Yuan Li, Kun Dong, Yuan Sun, Airong Ma, Xiuzhi Yang Source Type: research

Assessment of polyunsaturated fatty acids: A self-report and biomarker assessment with a racially and ethnically diverse sample of women
Polyunsaturated fatty acids (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Reigada LC, Storch B, Alku D, Hazeltine DB, Heppelmann PG, Polokowski AR Source Type: research

Long chain omega-3 fatty acids and their oxidized metabolites are associated with reduced prostate tumor growth
Effects of long chain polyunsaturated fatty acids (LC-PUFA) from omega-3 ( ω-3) on prostate cancer incidence and progression is controversial. A positive association between high plasma level of LC-ω-3PUFA and prostate cancer risk have been reported in some observational studies in humans [1, 2]. In contrast, fats derived marine products were indirectly associated with a lower incidence of prostate cancer in Inuit populations [3, 4]. A reduction of the ratio ω-3/ω-6 LC-PUFA in the prostate has been correlated with the increased incidence of prostate cancer in comparison to a benign hyperplasia control group [5]. (Sourc...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Jean-Fran çois Bilodeau, Nikunj Gevariya, Jessica Larose, Karine Robitaille, Jérôme Roy, Camille Oger, Jean-Marie Galano, Alain Bergeron, Thierry Durand, Yves Fradet, Pierre Julien, Associate Professor Vincent Fradet Source Type: research

Differences in erythrocyte phospholipid membrane long-chain polyunsaturated fatty acids and the prevalence of fatty acid desaturase genotype among African Americans and European Americans.
African Americans have a higher burden of chronic diseases [1, 2, 3]. The cause of these disparities are not fully known but likely due to a combination of environmental, genetic, socioeconomic and cultural factors. Another possible contributing factor could be related to higher levels of arachidonic acid and other omega-6 polyunsaturated fatty acids (n-6 PUFAs), which have been associated with inflammation and chronic diseases including diabetes and several cancers [4 –7]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: SB Rifkin, MJ Shrubsole, Q Cai, WE Smalley, RM Ness, LL Swift, G Milne, W Zheng, HJ Murff Source Type: research

Effect of parenteral lipid emulsion on preterm infant PUFAs and their downstream metabolites.
Intravenous lipid emulsions form an important component of parenteral nutrition for infants unable to tolerate full enteral feeds, by providing essential fatty acids and a low volume energy source. Parenteral lipid emulsions available for use in preterm infants contain the essential polyunsaturated fatty acids (PUFAs) linoleic acid (LA, omega-6) and α-linolenic acid (ALA, omega-3). Some lipid preparations also contain long chain polyunsaturated fatty acids (LCPUFAs) including the omega-6 LCPUFA arachidonic acid (AA), and the omega-3 LCPUFAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) [1]. (Source: Prostagla...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 18, 2020 Category: Biomedical Science Authors: Hiroki Suganuma, Carmel T Collins, Andrew J McPhee, Shalem Leemaqz, Ge Liu, Chad C Andersen, Dennis Bonney, Robert A Gibson Source Type: research

Exploring the role of LC-PUFA metabolism in pregnancy complications
Maternal nutritional status during pregnancy influences pregnancy outcomes. In pregnancy, the nutritional demand of the mother and fetus increases and a balanced nutrition is important for their well-being [1 –3]. Emerging evidence suggests that inadequate nutritional status contributes to pregnancy complications like preeclampsia and gestational diabetes mellitus (GDM) and downregulates fetal growth leading to adverse birth outcomes like low birth weights and preterm births [4–6]. Maternal nutrition al deficiency during pregnancy may lead to long-term effects increasing the risk of cardiovascular and neurodevelopmenta...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Aditi A. Godhamgaonkar, Nisha S. Wadhwani, Sadhana R. Joshi Source Type: research

Dietary supplementation with docosahexaenoic acid rich fish oil increases circulating levels of testosterone in overweight and obese men
Percent body fat (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Kylie Abbott, Tracy L Burrows, Shamasunder Acharya, Rohith N Thota, Manohar L Garg Source Type: research

Higher Omega-3 Index is Associated with More Rapid Heart Rate Recovery in Healthy Men and Women
Omega-3 Index (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Stephen W. Farrell, Laura F. DeFina, Nathan Tintle, Carolyn E. Barlow, David Leonard, William L. Haskell, Jarett D. Berry, Benjamin L. Willis, Andjelka Pavlovic, William S. Harris Source Type: research

The influence of DHA supplementation during pregnancy on language development across childhood: follow-up of a randomised controlled trial
Docosahexaenoic acid (DHA, 22:6n −3) is an omega-3 long chain polyunsaturated fatty acid that is concentrated in neural tissues, and is actively accumulated in the fetal brain during pregnancy [1,2]. The rapid growth period of the brain during the last trimester of pregnancy is matched by a peak in the accumulation of DHA in neur al tissues, contributing to the hypothesis that prenatal DHA exposure is crucial for supporting brain development [1,2]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: N.R. Gawlik, M. Makrides, L. Kettler, L.N. Yelland, S. Leemaqz, J.F. Gould Source Type: research

In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma
ALA, 18:3n-3 (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Nicola Zamai, Colin H. Cortie, Eleanor M. Jarvie, Christopher C. Onyiaodike, Amaal Alrehaili, Monique Francois, Dilys J. Freeman, Barbara J. Meyer Source Type: research

Prostaglandin F2 α in vitro can affect basic inflammatory parameters of mesenchymal stem cells and slight modulating some of their immunomodulatory properties
Mesenchymal stem cells  (MSCs), the major stem cells for cell therapy, have been studied for more than a decade including investigations into their mechanisms of immunoregulatory modulation. The immunomodulatory role of MSCs is well established; MSCs are able to regulate cells involved in adaptive and innate immune resp onses [1], including T and B lymphocytes, natural killer cells, monocytes, macrophages, dendritic cells, and neutrophils [2,3]. These immunomodulatory properties could be used in maintenance of peripheral tolerance, transplantation tolerance, and autoimmunity. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Andressa Cristina Antunes Santos, Talita Sartori, Primavera Borelli, Ricardo Ambrosio Fock Source Type: research

Effect of one year krill oil supplementation on depressive symptoms and self-esteem of Dutch adolescents: a randomized controlled trial.
According to the World Health Organisation approximately 322 million people (4.4 % of the world population) are affected by depression [1]. Whilst relatively uncommon in childhood (prevalence in the 6-12 months prior to assessment of 0.4-2.5%) [2], depression prevalence increases sharply during adolescence [3], with approximately 14-25% of adolescents experience at least one episode of depression before the age of 18 years [4]. Adolescent depression has serious social, mental and physical consequences, there is an increased risk of reoccurrence of depression, increased risk of anxiety, and increased risk of suicide compare...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 12, 2020 Category: Biomedical Science Authors: Dr. ISM van der Wurff, C von Schacky, T Bergeland, R. Leontjevas, MP Zeegers, PA Kirschner, RHM de Groot Source Type: research