Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Supplemental dietary oils rich in oleic acid or linoleic acid attenuate egg yolk and tissue n-3 polyunsaturated fatty acid contents in laying hens co-fed oils enriched in either stearidonic acid or α-linolenic acid1
Based on early trials of fish consumption and omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation, dietary very long-chain (VLC;>20C) n-3 PUFA are generally considered to be beneficial for cardiovascular (CDV) health in humans [1 –3]. Although there is little disagreement that dietary VLC n-3 PUFA exert a large, dose-dependent lowering effect on circulating levels of triglycerides, with small effects on low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) concentrations, the oral adm inistration of n-3 PUFA differing in either composition or dose has more recently been ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 6, 2021 Category: Biomedical Science Authors: Robert G. Elkin, Ahmed S.A. El-Zenary, Rebecca Bomberger, Kevin J. Harvatine Source Type: research

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Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 1, 2021 Category: Biomedical Science Source Type: research

Acute catabolism of leukocyte lipid bodies: characterization of a nordihydroguaiaretic acid (NDGA)-induced proteasomal-dependent model
This work was supported by Conselho Nacional de Desenvolvimento Cient ífico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 13, 2021 Category: Biomedical Science Authors: Maria N. de Lira, Lukas Bolini, Nat ália RT Amorim, Hercules A Silva-Souza, Bruno L Diaz, Claudio Canetti, Pedro M Persechini, Christianne Bandeira-Melo Source Type: research

Virtual Non-Compliance with Omega-3 Treatment Results in Null Effects: The RANGER study
“Omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) levels at baseline and post-intervention should be assessed and reported in future research to evaluate the efficacy of n-3 LCPUFA supplementation.” [1] This is an official statement from the International Society for the Study of Fatty Acids and Lipids (ISSFAL) by de Groot and Meyers that is entitled, “The importance of measuring blood omega-3 long chain polyunsaturated fatty acid levels in research.” A recent paper from Marriott et al. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 6, 2021 Category: Biomedical Science Authors: William S. Harris, Daniel T. Johnston Source Type: research

Addition of EP2 agonists to an FP agonist additively and synergistically modulates adipogenesis and the physical properties of 3D 3T3-L1 sphenoids
Prostaglandins (PGs) bind to specific G-protein coupled receptors (GPCRs) on target cells, thus initiating a series of intracellular effects. Of the major metabolites of cyclooxygenase (COX) enzymes, PGE2, PGF2 α and PGI2 are the most abundant PGs [1, 2]. Although it is well known that both EP2 and FP receptors are co-expressed in the same cells, both receptors regulate intracellular signaling in different manners. EP2 receptors couple to Gαs, resulting in an increase in cAMP levels, and FP receptors cou ple to Gαq resulting in the release of inositol-1,4,5-triphosphate (IP) and dialcylglycerol (DAG) [2-5]. (Source: Pro...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 3, 2021 Category: Biomedical Science Authors: Yosuke Ida, Megumi Watanabe, Araya Umetsu, Hiroshi Ohguro, Fumihito Hikage Source Type: research

Gestational Diabetes Mellitus Decreased Umbilical Cord Blood Polyunsaturated Fatty Acids: A Meta-analysis of Observational Studies
Gestational diabetes mellitus (GDM)1 refers to the impairment of glucose tolerance that is initially diagnosed during pregnancy [1]. The risk of developing metabolic diseases is reportedly higher in infants born to mothers with GDM as compared to that in infants born to mothers without GDM [2]. GDM seriously affects the health of mothers and their offspring [3], with emerging evidence indicating that GDM contributes towards neurodevelopmental disorders [4] and cognitive impairment in their offspring [5]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 2, 2021 Category: Biomedical Science Authors: Yu Hai-Tao, Guo Zhi-Heng, Chen Yi-Ru, Li Yue-Ting, Zhang Hai-Ying, Liu Ya-Juan, Xie Lin Source Type: research

Evidence of Multiple Hepatic Mechanisms to Mobilize Docosahexaenoic Acid into Dam Plasma during Pregnancy in chow-fed Sprague Dawley Rats
Docosahexaenoic acid (DHA, 22:6n-3) is necessary for optimal brain development [1, 2]. Several authoritative groups have recommended increasing fish intake during pregnancy [3-5] to provide approximately 200mg/d DHA. Global assessments of DHA intake and DHA blood status indicate that most populations consume less than these recommendations [6, 7]. Mean intakes of DHA of North American women during pregnancy have been reported to range between 62-82 mg/d with over 90% of these women consuming less than 200mg/d [3, 7, 8]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 28, 2021 Category: Biomedical Science Authors: Dan Chalil, Juan J. Aristizabal-Henao, Alan Chalil, Ken D. Stark Source Type: research

Endogenous ω-3 fatty acids in Fat-1 mice attenuated depression-like behaviors, spatial memory impairment and relevant changes induced by olfactory bulbectomy
The etiology of depression is heterogeneous and multifactorial. Dysfunction of brain limbic system may play a crucial role in the onset and development of depression. Olfactory bulbectomy (OB)-induced depression model is based the lesion of the limbic system, such as frontal cortex, amygdala and hippocampus, which can induce serious of behavioral, neuroendocrine, neurotransmitter and immune changes. For example, rodent OB model exhibits hyperactivity in novel or stressful environments, anhedonic, memory impairment [1-3], hypercortisonism, and deficiency of serotonin and noradrenaline systems, which are similar to those obs...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 23, 2021 Category: Biomedical Science Authors: Minqing Gu, Xiaohong Li, Ling Yan, Yongping Zhang, Longen Yang, Shurui Li, Cai Song Source Type: research

Feeding mice a diet high in oxidized linoleic acid metabolites does not alter liver oxylipin concentrations
Alpha-linoleic acid; (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 23, 2021 Category: Biomedical Science Authors: Nuanyi Liang, Marie Hennebelle, Susanne Gaul, Casey D Johnson, Zhichao Zhang, Irina A Kirpich, Craig J McClain, Ariel E Feldstein, Christopher E Ramsden, Ameer Y Taha Source Type: research

The aromatase inhibitor letrozole restores FADS2 function in ER+ MCF7 human breast cancer cells ✰
DNA amplification is a common mechanism leading to oncogenic activation in cancers [1 –3]. Several oncogenes map to the human chromosome 11q13 (HSA 11q13), established as among the most frequently amplified genomic regions in a number of human cancers, including breast cancer (BC) [2, 4–8]. The 11q13 region is amplified in 15–20% of BC and comprises multiple amplicons highly va riable in size, spanning several Mb of DNA from 11q12.2 to 11q14.1 [9–14]. 11q13 amplification in BC is associated with estrogen receptor (ER) expression, resistance to hormone therapy and poor prognosis [5, 14–17]. (Source: Prostaglandins...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 15, 2021 Category: Biomedical Science Authors: Hui Gyu Park, Jae Hun Kim, Andrew N. Dancer, Kumar S. Kothapalli, J. Thomas Brenna Source Type: research

The aromatase inhibitor letrozole restores FADS2 function in ER+ MCF7 human breast cancer cells
DNA amplification is a common mechanism leading to oncogenic activation in cancers [1-3]. Several oncogenes map to the human chromosome 11q13 (HSA 11q13), established as among the most frequently amplified genomic regions in a number of human cancers, including breast cancer (BC) [2, 4-8]. The 11q13 region is amplified in 15 –20% of BC and comprises multiple amplicons highly variable in size, spanning several Mb of DNA from 11q12.2 to 11q14.1 [9-14]. 11q13 amplification in BC is associated with estrogen receptor (ER) expression, resistance to hormone therapy and poor prognosis [5, 14-17]. (Source: Prostaglandins, Leukotr...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 15, 2021 Category: Biomedical Science Authors: Hui Gyu Park, Jae Hun Kim, Andrew N. Dancer, Kumar S. Kothapalli, J. Thomas Brenna Source Type: research

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Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 8, 2021 Category: Biomedical Science Source Type: research

The major endocannabinoid anandamide (AEA) induces apoptosis of human granulosa cells
Folliculogenesis is a cyclic, dynamic, and highly organised process, defined by the growth and development of follicles that culminates with the generation of a competent oocyte. Oocyte quality is crucial for reproductive success and greatly depends on the interaction with the surrounding granulosa cells (GCs). This dialogue is mediated by a large variety of molecular markers, such as hormones, cytokines and growth factors [1]. The GCs have also a pivotal role after ovulation in the formation of the corpus luteum, by providing the hormonal support for embryo implantation [2]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 8, 2021 Category: Biomedical Science Authors: L. Costa, B. Moreia-Pinto, E. Felgueira, A. Ribeiro, I. Rebelo, B.M. Fonseca Source Type: research

Profiling the expression of fatty acid-binding proteins and fatty acid transporters in mouse microglia and assessing their role in docosahexaenoic acid-d5 uptake
Neuroinflammation is the biochemical and cellular response of the central nervous system (CNS) to injury and infection, and it has been reported to contribute to the pathology of some neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and motor neuron disease (MND) [1]. Neuroinflammation is mediated by the production of proinflammatory cytokines, chemokines, reactive oxygen species (ROS), and secondary messengers by resident CNS cells, such as astrocytes, peripherally derived immune cells, and microglia [1]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 26, 2021 Category: Biomedical Science Authors: Y.L. Low, Y. Pan, J.L. Short, J.A. Nicolazzo Source Type: research

Beneficial effect of long-chain n-3 polyunsaturated fatty acid supplementation on tuberculosis in mice
Tuberculosis (TB) is an infectious disease characterized by exaggerated and progressive inflammation, lung pathology and tissue damage [1]. Controlling this excessive inflammation may lead to improved TB outcomes [2]. Therefore, anti-inflammatory and inflammation-resolving treatments have been suggested as host-directed therapy (HDT) in TB patients [2]. Dietary polyunsaturated fatty acid (PUFA) consumption alters membrane phospholipid fatty acid (FA) composition of cells that play a role in immune and inflammatory responses in a time- and dose-dependent manner, which affects the pro-inflammatory and inflammation-resolving ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 26, 2021 Category: Biomedical Science Authors: Arista Nienaber, Mumin Ozturk, Robin C Dolman, Lizelle Zandberg, Frank EA Hayford, Frank Brombacher, Renee Blaauw, Cornelius M Smuts, Suraj P Parihar, Linda Malan Source Type: research