Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Leukotrienes, a potential target for Covid-19
Repositioning of clinically approved drugs that may reduce the severity, hospitalization events, and time of recovery from SARS-CoV2 infection is a global health priority. Clinical reports of drug effects and lung pathology are providing insight into the pathogenesis of Covid-19, and comparison of these findings with our knowledge of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) can be used to develop rational hypotheses to prioritize clinical studies of available therapeutics. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - September 15, 2020 Category: Biomedical Science Authors: Francesca Citron, Luigi Perelli, Angela K. Deem, Giannicola Genovese, Andrea Viale Source Type: research

Acyl-CoA Synthetases as regulators of brain phospholipid acyl-chain diversity
Fatty acids are critical substrates for numerous metabolic processes, have high potential for energy production, and serve as the foundation for cellular membrane hydrophobic regions. Across the body, the distribution and metabolic fate of fatty acids are highly differential. Metabolically, fatty acid fate can be placed into three major categories: oxidation for energy, storage as triacylglycerol, and use for phospholipid synthesis and remodeling. While the oxidation and storage of fatty acids are the main metabolic fates for certain cell types or in response to feeding/fasting conditions, the use of fatty acids for incorp...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - September 14, 2020 Category: Biomedical Science Authors: Regina Fernandez Fernandez, Jessica M Ellis Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 28, 2020 Category: Biomedical Science Source Type: research

Role of oxylipins generated from dietary PUFAs in the modulation of endothelial cell function
Endothelial cells (ECs), which line the inner surface of blood vessels, are more than a barrier separating the blood from the surrounding tissues, since they also participate in the regulation of key vascular functions, including vascular tone, inflammation, and vessel formation. Dietary fatty acids (FAs) have been known to positively or negatively impact EC function [1, 2], however, the exact mechanisms are largely unknown. Oxylipins, a family of oxygenated lipid mediators generated from polyunsaturated FAs (PUFAs), have been shown to modulate endothelial function [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 17, 2020 Category: Biomedical Science Authors: Youjia Du, Carla G. Taylor, Harold M. Aukema, Peter Zahradka Source Type: research

Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients
Pulmonary hypertension (PH) is characterized by a progressive increase in mean pulmonary artery pressure (mPAP>20 mmHg) and vascular resistance due to sustained pulmonary artery vasoconstriction [1, 2]. The clinical classification of PH is intended to categorize multiple clinical conditions into five groups. Depending on this classification, PH Group-III is defined as PH due to lung diseases and/or hypoxia. Common lung diseases associated with PH are chronic obstructive pulmonary disease (COPD), interstitial lung disease and combined pulmonary fibrosis and emphysema [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 4, 2020 Category: Biomedical Science Authors: Gulsev Ozen, Yasmine Amgoud, Heba Abdelazeem, Salma Mani, Chabha Benyahia, Amel Bouhadoun, Alexy Tran-Dinh, Yves Castier, Alice Guyard, Dan Longrois, Adam M. Silverstein, Xavier Norel Source Type: research

Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population
Polyunsaturated fatty acids (PUFAs) are an important component of the brain. These molecules, especially long-chain PUFAs (C>20) (LC-PUFAs), are found as constituents of the cell membrane. Besides, they can affect cognitive development and modulate several processes within the brain, such as neuroinflammation [1-3]. In neuronal cells, these molecules can modulate inflammation through pro-inflammatory and/or anti-inflammatory mediators such as eicosanoids and specialized pro-resolving mediators [3, 4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 3, 2020 Category: Biomedical Science Authors: Souha HAMMOUDA, Imen GHZAIEL, Sonia HAMMAMI, Samia YOUNES MHENNI, Slim SAMET, Mohamed HAMMAMI, Amira ZARROUK Source Type: research

Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry
Adipose tissue inflammation is a well-observed consequence of obesity and a prologue of the metabolic syndrome (T2D) [1-3]. The underlying molecular mechanisms of obesity-induced adipose tissue inflammation and the subsequent risk of type 2 diabetes (T2D) development are multifactorial but important to detect in an early stage as it is likely that the severity of obesity-associated inflammation relates to T2D onset and related complications. Notably, with already 650 million obese individuals globally [4] there is a high need for clinically validated biomarkers to control this increasing health risk. (Source: Prostaglandin...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 25, 2020 Category: Biomedical Science Authors: Roel Tans, Rieke Bande, Arno van Rooij, Billy J. Molloy, Rinke Stienstra, Cees J. Tack, Ron A. Wevers, Hans J.C.T. Wessels, Jolein Gloerich, Alain J. van Gool Source Type: research

Metabolic syndrome in postmenopausal women is associated with lower erythrocyte PUFA/MUFA and n-3/n-6 ratio: A case-control study
Female cardiovascular risk is currently a major health concerns. Women after menopause are more prone to changes in lipid metabolism, and so to cardiovascular disease [1,2]. The prevalence of metabolic syndrome (MetS) in postmenopausal women is thus higher than in other population groups [3,4]. Moreover, MetS and postmenopausal status are independent factors associated with an increased risk of cardiovascular disease. It is important to identify the genetic and nutritional determinants of lipid abnormalities in postmenopausal women, so as to be able to modify factors affecting the occurrence of MetS in this group, and in t...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 25, 2020 Category: Biomedical Science Authors: Agata Muzsik, Henryk H. Jele ń, Agata Chmurzynska Source Type: research

Abnormal n-6 fatty acid metabolism in cystic fibrosis contributes to pulmonary symptoms
Cystic fibrosis (CF) is a metabolic recessive hereditary disease with the most common mutation, dF508, identified at chromosome 7 in the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) [1]. To date, roughly 2000 mutations have been identified; however, less than a tenth of those are associated with a clinical CF phenotype. The distribution of mutations varies in different ethnic populations and combinations with frequent complex alleles further influencing the phenotype [2,3,4]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 25, 2020 Category: Biomedical Science Authors: Craig E. Wheelock, Birgitta Strandvik Source Type: research

Evaluation of cyclo-oxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry
Adipose tissue inflammation is a well-observed consequence of obesity and a prologue of the metabolic syndrome (T2D) [1-3]. The underlying molecular mechanisms of obesity-induced adipose tissue inflammation and the subsequent risk of type 2 diabetes (T2D) development are multifactorial but important to detect in an early stage as it is likely that the severity of obesity-associated inflammation relates to T2D onset and related complications. Notably, with already 650 million obese individuals globally [4] there is a high need for clinically validated biomarkers to control this increasing health risk. (Source: Prostaglandin...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 25, 2020 Category: Biomedical Science Authors: Roel Tans, Rieke Bande, Arno van Rooij, Billy J. Molloy, Rinke Stienstra, Cees J. Tack, Ron A. Wevers, Hans J.C.T. Wessels, Jolein Gloerich, Alain J. van Gool Source Type: research

Editorial Board
(Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 13, 2020 Category: Biomedical Science Source Type: research

DHA-enriched fish oil reduces insulin resistance in overweight and obese adults
Percent body fat (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - June 12, 2020 Category: Biomedical Science Authors: KA Abbott, TL Burrows, S Acharya, RN Thota, ML Garg Source Type: research

Evolution of breast milk fatty acids in Spanish mothers after one year of uninterrupted lactation
Health benefits of breastfeeding for mother and baby are substantial and widely recognized worldwide. Hence, human milk has been described as the gold standard of infant nutrition [1]. Breastfeeding is acknowledged as a biological process since it is firmly rooted in our mammalian identity and it is essential to the survival of mammalian species [2]. This practice protects the neonate from malnutrition or even infectious diseases, potentially caused by contaminated water used to prepare breast milk substitutes in developing countries. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 29, 2020 Category: Biomedical Science Authors: R. Barreiro, P. Regal, O. L ópez-Racamonde, A. Cepeda, C. Fente Source Type: research

ATP-Binding Cassette Transporter C4 is a Prostaglandin D2 Exporter in HMC-1 cells
ATP-binding cassette transporter C4 (ABCC4) functions as an efflux pump for certain antiviral drugs (adefovir) and anticancer drugs (methotrexate), which contributes to chemotherapy resistance [1]. In addition to functioning as a multidrug resistance-associated protein, ABCC4 is thought to mediate intra- and intercellular signalling by export of cyclic adenosine monophosphate (cAMP) and some bioactive lipid mediators [2-5]. Our research group and others have reported that ABCC4 transports certain prostaglandins (PGs) as high affinity substrates [4-7]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - May 28, 2020 Category: Biomedical Science Authors: Nobuaki Tanaka, Junya Kawai, Noriyasu Hirasawa, Nariyasu Mano, Hiroaki Yamaguchi Source Type: research