Role of oxylipins generated from dietary PUFAs in the modulation of endothelial cell function

Endothelial cells (ECs), which line the inner surface of blood vessels, are more than a barrier separating the blood from the surrounding tissues, since they also participate in the regulation of key vascular functions, including vascular tone, inflammation, and vessel formation. Dietary fatty acids (FAs) have been known to positively or negatively impact EC function [1, 2], however, the exact mechanisms are largely unknown. Oxylipins, a family of oxygenated lipid mediators generated from polyunsaturated FAs (PUFAs), have been shown to modulate endothelial function [3].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 17, 2020 Category: Biomedical Science Authors: Youjia Du, Carla G. Taylor, Harold M. Aukema, Peter Zahradka Source Type: research