Evaluation of cyclooxygenase oxylipins as potential biomarker for obesity-associated adipose tissue inflammation and type 2 diabetes using targeted multiple reaction monitoring mass spectrometry

Adipose tissue inflammation is a well-observed consequence of obesity and a prologue of the metabolic syndrome (T2D) [1-3]. The underlying molecular mechanisms of obesity-induced adipose tissue inflammation and the subsequent risk of type 2 diabetes (T2D) development are multifactorial but important to detect in an early stage as it is likely that the severity of obesity-associated inflammation relates to T2D onset and related complications. Notably, with already 650 million obese individuals globally [4] there is a high need for clinically validated biomarkers to control this increasing health risk.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research