Prostaglandins, Leukotrienes and Essential Fatty Acids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The effect of a 6-month Ketogenic Medium-Chain Triglyceride Supplement on Plasma Cardiometabolic and Inflammatory Markers in Mild Cognitive Impairment.
Mild cognitive impairment (MCI) is a major risk factor for Alzheimer's disease (AD) with an reported annualized conversion rate ranging from 5-17% per person-year [1] depending on the MCI subtypes and the presence of the APOE4 allele [2]. By definition, cognitive decline in MCI does not significantly affect daily functioning but does involve below normal results in at least one cognitive domain compared to healthy age-matched older people. MCI is often accompanied by metabolic abnormalities such as insulin resistance and comorbidities such as dyslipidemia and hypertension [3, 4]. (Source: Prostaglandins, Leukotrienes and E...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 23, 2020 Category: Biomedical Science Authors: Étienne Myette-Côté, Valérie St-Pierre, Sandrine Beaulieu, Christian-Alexandre Castellano, Mélanie Fortier, Mélanie Plourde, Christian Bocti, Tamas Fulop, Stephen C. Cunnane Source Type: research

Feeding regulation by oleoylethanolamide synthesized from dietary oleic acid
Fatty acid ethanolamides (FAEs), lipid mediators in both plant and animal tissues, are involved in a variety of biological functions. Among the members of the FAE family, arachidonoylethanolamide (anandamide) is known to serve as an endogenous ligand for cannabinoid receptors, and plays important roles in neuroprotection, hypotension, pain relief, and feeding stimulation [1-3]. Other members of the FAE family, such as oleoylethanolamide (OEA; Fig. 1) and palmitoylethanolamide (PEA), are not ligands of cannabinoid receptors but are instead involved in specific biological effects through receptors such as GPR119, peroxisome ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 21, 2020 Category: Biomedical Science Authors: Miki Igarashi, Kensuke Iwasa, Keisuke Yoshikawa Source Type: research

Deletion of the Gene Encoding Prostamide/Prostaglandin F synthase Reveals an Important Role in Regulating Intraocular Pressure
The prostaglandin F2 α (PGF2α) analogs are established as first line therapies for treating glaucoma. The selective FP receptor agonists were designed by virtue of the need to attenuate the ocular side effects produced by the naturally occurring prostanoid PGF2α [1-3]. Similarly, bimatoprost is an analog of PGF2α et hanolamide (prostamide F2α) [4, 5]. Both PGF2α and prostamide F2α are the products of identical biosynthetic pathways but differ with respect to their cyclo-oxygenase substrate. Thus, arachidonic acid is the primary precursor for PGF2α, whereas prostamide F2α is biosynthesized from the naturall y occur...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 21, 2020 Category: Biomedical Science Authors: Jacques A Bertrand, David F Woodward, Joseph M Sherwood, Alice Spenlehauer, Cristoforo Silvestri, Fabiana Piscitelli, Vincenzo Di Marzo, Maya Yamazaki, Kenji Sakimura, Yoko Inoue, Kikuko Watanabe, Darryl R Overby Source Type: research

The effect of polyunsaturated fatty acid deficiency on allergic response in ovalbumin-immunized mice
This study examined the effect of a PUFA-deficient diet on food-allergy symptoms in ovalbumin (OVA)-immunized mice. The exacerbation of immune responses after OVA-sensitization was not observed in mice fed a PUFA-deficient diet. There were no differences in serum PUFA levels between OVA-immunized and non-immunized mice fed a PUFA-deficient diet. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 20, 2020 Category: Biomedical Science Authors: Yuri Hayashi, Yuka Yokomizo, Yoko Fujiwara, Ikuyo Ichi Source Type: research

Lipids in the origin of intracellular detail and speciation in the Cambrian epoch and the significance of the last double bond of docosahexaenoic acid in cell signaling.
Our hypothesis starts with events which took place with the oxidative metabolism in the Vendian-Cambrian epochs with the appearance for the first time, of intracellular detail in living systems and the origin of vision, the nervous system and the brain. For the first 2.5 to 3 billion years of living systems on the planet life systems were largely anaerobic; converting sunlight into carbohydrates and proteins. There is no fossil evidence of intracellular detail during that period. After billions of years, atmospheric oxygen from photosynthesis and water photolysis increased in concentration to breach the Pasteur Point, at w...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 19, 2020 Category: Biomedical Science Authors: Michael A. Crawford, Walter F. Schmidt, C. Leigh Broadhurst, Yiqun Wang Source Type: research

In vitro dissolution behaviour and absorption in humans of a novel mixed L-lysine salt formulation of EPA and DHA
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are available in oily formulations containing either their triacylglycerols, ethyl-esters, phospholipids or free fatty acids. Recently, a L-lysine salt formulation of (carboxylic) EPA and DHA became available (Lys-FFA), offering favourable stability and technical properties. Lys-FFA showed complete dissolution in vitro under simulated gastric (12hr) and intestinal (3hr) conditions, supporting the hypothesis that it will release free fatty acids in the upper GI tract. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 19, 2020 Category: Biomedical Science Authors: Koen Manusama, Michiel Balvers, Marlies Diepeveen-de Bruin, Laura Headley, Roberta Bosi, Michael Schwarm, Renger Witkamp Source Type: research

Associations of Umbilical Cord Fatty Acid Profiles and Desaturase Enzyme Indices with Birth Weight for Gestational Age in Japanese Infants
The rate of low-birth-weight infants who are less than 2500 g reached 9.6% in 2010 in Japan [1], which is high among Organisation for Economic Co-operation and Development (OECD) countries [2]. Factors related to low-birth-weight infants include preterm birth and intrauterine growth retardation. Intrauterine growth retardation can also refer to infants born full-term but small for gestational age (SGA). Epidemiological studies have shown that SGA infants have a high risk of lifestyle diseases [3]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 17, 2020 Category: Biomedical Science Authors: Azusa MATSUMOTO, Terue KAWABATA, Yasuo KAGAWA, Kumiko SHOJI, Fumiko KIMURA, Teruo MIYAZAWA, Nozomi TATSUTA, Takahiro ARIMA, Nobuo YAEGASHI, Kunihiko NAKAI Source Type: research

Associations between red blood cells fatty acids, desaturases indices and metabolism of Platelet Activating Factor in healthy volunteers
arachidonic acid (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 17, 2020 Category: Biomedical Science Authors: E. Fragopoulou, P Detopoulou, E. Alepoudea, T. Nomikos, N. Kalogeropoulos, S. Antonopoulou Source Type: research

Regulation of the cytochrome P450 epoxyeicosanoid pathway is associated with distinct histologic features in pediatric non-alcoholic fatty liver disease
arachidonic acid (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 16, 2020 Category: Biomedical Science Authors: Laura Kalveram, Wolf-Hagen Schunck, Michael Rothe, Birgit Rudolph, Christoph Loddenkemper, Hermann-Georg Holzh ütter, Stephan Henning, Philip Bufler, Marten Schulz, David Meierhofer, Ingrid W. Zhang, Karsten H. Weylandt, Susanna Wiegand, Christian A. Hud Source Type: research

Palmitic Acid Methyl Ester Inhibits Cardiac Arrest-Induced Neuroinflammation and Mitochondrial Dysfunction
We previously discovered that palmitic acid methyl ester (PAME) is a potent vasodilator released from the sympathetic ganglion with vasoactive properties. Post-treatment with PAME can enhance cortical cerebral blood flow and functional learning and memory, while inhibiting neuronal cell death in the CA1 region of the hippocampus under pathological conditions (i.e. cerebral ischemia). Since mechanisms underlying PAME-mediated neuroprotection remain unclear, we investigated the possible neuroprotective mechanisms of PAME after 6 min of asphyxia cardiac arrest (ACA, an animal model of global cerebral ischemia). (Source: Prost...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 16, 2020 Category: Biomedical Science Authors: Celeste Yin-Chieh Wu, Alexandre Couto e Silva, Cristiane T. Citadin, Garrett A. Clemons, Christina H Acosta, Brianne A Knox, Mychal S. Grames, Krista M Rodgers, Reggie Hui-Chao Lee, Hung Wen Lin Source Type: research

Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with major depressive disorder and chronic inflammation
AA (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 4, 2020 Category: Biomedical Science Authors: Stefania Lamon-Fava, Jisun So, David Mischoulon, Thomas R. Ziegler, Boadie W. Dunlop, Becky Kinkead, Pamela J. Schettler, Andrew A. Nierenberg, Jennifer C. Felger, Krishna Rao Maddipati, Maurizio Fava, Mark Hyman Rapaport Source Type: research

Editorial Board
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Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - December 1, 2020 Category: Biomedical Science Source Type: research

Altered Tissue Specialized Pro-Resolving Mediators in Chronic Rhinosinusitis
Small-subunit ribosomal ribonucleic acid gene (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 25, 2020 Category: Biomedical Science Authors: Thad W. Vickery, Michael Armstrong, Jennifer M. Kofonow, Charles E. Robertson, Miranda E. Kroehl, Nichole A. Reisdorph, Vijay R. Ramakrishnan, Daniel N. Frank Source Type: research

Prostaglandins as potential targets for the treatment of polycystic kidney disease
Polycystic kidney disease (PKD) encompasses a group of disorders characterized by the proliferation of fluid-filled renal cysts. These cysts cause progressive damage to the normal renal parenchyma, which ultimately leads to progressive renal failure. The most common form of PKD and the most common monogenetic cause of any renal disease is autosomal dominant PKD (ADPKD), which in the past was referred to as adult PKD, since renal failure typically occurs later in life. Another form of the disease, which is much less common but more severe, is autosomal recessive PKD that affects the pediatric population. (Source: Prostaglan...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 25, 2020 Category: Biomedical Science Authors: Harold M. Aukema Source Type: research

The role of peripheral fatty acids as biomarkers for Alzheimer's disease and brain inflammation
Alzheimer's disease (AD) is one of the leading causes of dementia worldwide and it is seen frequently in the elderly. AD is characterized by amyloid beta (Ab) plaques burden, neurofibrillary tangles, neuroinflammation and neuronal loss with memory impairment being one of the first signs of the disease [1, 2]. Some people experience mild cognitive impairment (MCI) which is often considered a transition phase from normal aging to AD, and subjects diagnosed with MCI have an increased risk of developing AD. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 19, 2020 Category: Biomedical Science Authors: Giulia Cisbani, Richard P. Bazinet Source Type: research