LPS induces ALOX5 promoter activation and 5-lipoxygenase expression in human monocytic cells

Leukotrienes (LT) are pro-inflammatory lipid mediators derived from arachidonic acid [AA) that are crucial in the immune response to pathogens or danger signals. However, LT also play a role in chronic inflammatory diseases such as asthma and atherosclerosis, and in certain types of cancers [1,2]. Encoded by the ALOX5 gene, 5-lipoxygenase [5-LO) is the key enzyme involved in the bioconversion of AA to LT. Following cell activation, 5-LO catalyzes an oxygenation reaction on the 5th carbon from the carboxyl group resulting in the formation of 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid (5-HpETE) [3].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - February 20, 2020 Category: Biomedical Science Authors: Samuel J Poirier, Luc H Boudreau, Nicolas Flamand, Marc E Surette Tags: Original research article Source Type: research