Stable analogs of 13 ‑hydroxy-9,10-trans-epoxy-(11E)-octadecenoate (13,9-HEL), an oxidized derivative of linoleic acid implicated in the epidermal skin barrier

Recently we reported on oxidized derivatives of linoleic acid (LA) that are potential endogenous mediators of chronic pain and itch [1]. Linoleic acid, which is one of the most abundant fatty acids in the skin [2] is designated an “essential fatty acid” since a small amount (0.5% of energy) must be obtained in the diet to form a functional epidermal water barrier and to prevent clinical manifestations of “essential fatty acid deficiency” [3].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research