In search of pulmonary hypertension treatments: Effect of 17 β-estradiol on PGI2 pathway in human pulmonary artery

Pulmonary hypertension (PH) is characterized by a progressive increase in resting mean pulmonary arterial pressure (mPAP ≥ 20 mmHg) at the time of cardiac catheterization. This elevation is associated with increased pulmonary vascular resistance due to sustained pulmonary arterial vasoconstriction. [1, 2]. The chest imaging and the electrocardiogram support hypertrophy of the pulmonary arteries, abnormalities of the pulmonary parenchyma in relation to respiratory diseases, and an enlargement of the right heart [3].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - August 9, 2021 Category: Biomedical Science Authors: Yasmine Amgoud, Amira Senbel, Amel Bouhadoun, Heba Abdelazeem, Gulsev Ozen, Ines Savan é, Hasanga D Manikpurage, Salma Mani, Alexy Tran-Dinh, Yves Castier, Alice Guyard, Dan Longrois, Adam M. Silverstein, Dr. Xavier Norel Source Type: research