Open-label, Multicenter, Phase 2 Study of a Food Enriched with Docosahexaenoic Acid in Adults with Sickle Cell Disease
Sickle cell disease (SCD) is a common monogenic disorder that affects over 100,000 people in the United States alone, and millions more worldwide [1]. The disease is generally characterized by red blood cell sickling, episodic vaso-occlusive crises (VOC), and other symptoms associated with pain and inflammation [2]. SCD is an inherited pathology caused by a point mutation of the β-globin gene that results in an abnormal type of hemoglobin, the S variant (HbS) [3]. While the classical paradigm of SCD considers the sickling and polymerization of HbS as the primary cause of its physiological complications, more recent advancements suggest a multifactorial etiology that includ es hemolysis, oxidative stress, and chronic inflammation as additional factors that should be considered [4,5].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: G. Kanakapura, S.K. Bhatnagar, L. Tomlinson, F. Sancilio Tags: Short communication Source Type: research
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