Moths and magnets could save lives
(Rice University) Rice University bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 13, 2018 Category: Cancer & Oncology Source Type: news

Eyeing faster path for sickle cell drug, Peninsula biotech plots expansion — for a higher price
Less than a year after moving into one of South San Francisco's new biotech real estate developments, Global Blood Therapeutics Inc. will be moving again, nearly tripling its space as it shifts operations just a few yards away. Like any biotech company looking to move digs in a tight real estate market, Global Blood will pay top dollar to do so. Even as real estate developers add millions of square feet in South San Francisco alone, it is being snatched up quickly by large pharmaceutical companies… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 8, 2018 Category: American Health Authors: Ron Leuty Source Type: news

Eyeing faster path for sickle cell drug, Peninsula biotech plots expansion — for a higher price
Less than a year after moving into one of South San Francisco's new biotech real estate developments, Global Blood Therapeutics Inc. will be moving again, nearly tripling its space as it shifts operations just a few yards away. Like any biotech company looking to move digs in a tight real estate market, Global Blood will pay top dollar to do so. Even as real estate developers add millions of square feet in South San Francisco alone, it is being snatched up quickly by large pharmaceutical companies… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 8, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

Sickle Cell Trait Linked to Venous, Renal Complications Sickle Cell Trait Linked to Venous, Renal Complications
People who carry sickle cell trait (SCT) are at increased risk of pulmonary embolism (PE) and chronic kidney disease (CKD), according to the first-ever systematic review to look at clinical outcomes associated with the trait.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - November 1, 2018 Category: Intensive Care Tags: Hematology-Oncology News Source Type: news

Systematic review study supports that sickle cell trait increases risk for some health conditions
(Source: NHGRI Homepage Highlights)
Source: NHGRI Homepage Highlights - October 30, 2018 Category: Genetics & Stem Cells Source Type: news

FDA Approves New DNA-Based Test to Verify Blood Compatibility
FRIDAY, Oct. 12, 2018 -- The U.S. Food and Drug Administration has approved the ID CORE XT DNA-based test to help doctors verify blood compatibility before a transfusion. Patients who need repeated transfusions, such as those with sickle cell... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 12, 2018 Category: Pharmaceuticals Source Type: news

New DNA-Based Test Approved to Help Verify Blood Compatibility
FRIDAY, Oct. 12, 2018 -- The U.S. Food and Drug Administration has approved the ID CORE XT DNA-based test to help doctors verify blood compatibility before a transfusion. People who need repeated transfusions, such as those with sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 12, 2018 Category: General Medicine Source Type: news

FDA lifts hold on CRISPR, Vertex sickle cell trial
CRISPR Therapeutics and Vertex Pharmaceuticals announced that the U.S. FDA has lifted the clinical hold and accepted the Investigational New Drug application for a new treatment for sickle cell disease. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - October 11, 2018 Category: Pharmaceuticals Source Type: news

NHS calls on 40,000 black people to sign up as blood and organ donors
Davinia Caballero, 33, from Brixton in London, needed a transplant after her kidneys were damaged by sickle cell disease. She said she was 'lucky' her brother was able to donate his kidney. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2018 Category: Consumer Health News Source Type: news

Tinchy Stryder gives blood to raise sickle cell awareness
The rapper has donated his blood for the first time to help the fight against sickle cell disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - October 2, 2018 Category: Consumer Health News Source Type: news

Sickle Cell in the ED: Old Therapies, New Strategies
(MedPage Today) -- With treatments unchanged in decades, docs seek to improve delivery (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - October 2, 2018 Category: Hematology Source Type: news

What Causes Hyperkalemia?
Discussion Potassium (K+) is an alkali metal (Group 1 of periodic table with Hydrogen, Lithium and Sodium) with an anatomic number of 19. Its chemical symbol K, comes from the medieval Latin, kalium which means potash (mainly potassium carbonate or potassium hydroxide), the substance it was first isolated from. Potassium is an important cation and it mainly resides in the intracellular fluid with only a small amount in the extracellular fluid. Potassium regulates cell volume, pH and enzyme functions. Hyperkalemia is defined as a potassium level> 5.5 mEq/L in children and> 6.0 mEq/L in newborns. Hyperkalemia incre...
Source: PediatricEducation.org - September 24, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Decades later, man meets the UCLA doctor who saved his life
It ’s 1970 and 10-month-old Maurice Elias lay in a hospital bed in the pediatric intensive care unit dangerously malnourished, at just 14 pounds, and with a severe infection in his mouth. The antibiotics that doctors at UCLA had been using to treat Maurice, who had been born without a functional immu ne system, were no longer working.The only way Maurice was going to survive was a bone marrow transplant.“If we couldn't find a way to give Maurice a working immune system, he was going to die. And the only way to do so was with a risky transplant that could be fatal, too,” said Dr. Richard Stiehm, the UCLA d...
Source: UCLA Newsroom: Health Sciences - September 19, 2018 Category: Universities & Medical Training Source Type: news

NIH launches initiative to accelerate genetic therapies to cure sickle cell disease
Effort will take advantage of the latest genetic discoveries and technological advances. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - September 13, 2018 Category: American Health Source Type: news

How sickled red blood cells stick to blood vessels
(Massachusetts Institute of Technology) An MIT study describes how sickled red blood cells get stuck in tiny blood vessels of patients with sickle-cell disease. The findings may help researchers predict more accurately when such a vaso-occlusive pain crisis might occur. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 3, 2018 Category: International Medicine & Public Health Source Type: news

CRISPR Gene Editing Fixes Muscular Dystrophy in Dogs. Are Humans Next?
The powerful gene editing technology CRISPR is one small step closer to treating a human disease. In a new paper published in Science, researchers led by Eric Olson, professor and chair of molecular biology at UT Southwestern Medical Center, reported that he and his team successfully used CRISPR to correct the genetic defect responsible for Duchenne muscular dystrophy in four beagles bred with the disease-causing gene. It’s the first use of CRISPR to treat muscular dystrophy in a large animal. (Previous studies had tested the technology on rodents.) In varying degrees, the genetic therapy halted the muscle degradatio...
Source: TIME: Health - August 30, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Genetics healthytime Source Type: news

Mount Sinai receives NIH Grant to study use of inhaled corticosteroids for sickle cell treatment
(The Mount Sinai Hospital / Mount Sinai School of Medicine) The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a $4 million grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease (SCD) in individuals who do not have asthma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 13, 2018 Category: International Medicine & Public Health Source Type: news

Treatments for cancer and sickle cell disease deplete germ cells in young boys
(European Society of Human Reproduction and Embryology) Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, the treatment for sickle cell disease results in complete destruction of all their germ cells, which are called spermatogonia. The study is published in Human Reproduction and is the first to describe the effects of these treatments on spermatogonial quantity (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 24, 2018 Category: International Medicine & Public Health Source Type: news

L-Glutamine Benefit Patients With Sickle Cell Disease L-Glutamine Benefit Patients With Sickle Cell Disease
For people with sickle cell disease, oral twice-daily L-glutamine reduces hospitalization and trims the number of sickle cell crises compared with placebo, whether or not they are also receiving hydroxyurea, according to details of the key test that resulted in U.S. approval of the treatment just over a year ago.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

& lt;small & gt;L & lt;/small & gt; - Glutamine Reduces Number of Pain Crises in Sickle Cell Disease
Significantly fewer pain crises, hospitalizations compared with those receiving placebo (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 19, 2018 Category: Cancer & Oncology Tags: Oncology, Pediatrics, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease
THURSDAY, July 19, 2018 -- For patients with sickle cell-related pain, those receiving oral therapy with L-glutamine have a lower median number of pain crises, according to a study published in the July 19 issue of the New England Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 19, 2018 Category: Pharmaceuticals Source Type: news

Supplement May Ease the Pain of Sickle Cell Disease
Title: Supplement May Ease the Pain of Sickle Cell DiseaseCategory: Health NewsCreated: 7/18/2018 12:00:00 AMLast Editorial Review: 7/19/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - July 19, 2018 Category: Anesthesiology Source Type: news

Balance control is impaired in adults with sickle cell anaemia - Silva PO, Ferreira AS, Lima CMA, Guimar ães FS, Lopes AJ.
BACKGROUND: Musculoskeletal involvement and cerebrovascular disease are common in sickle cell anaemia (SCA). These changes are potentially important factors that modify the control of balance in this population. OBJECTIVE: To assess balance control... (Source: SafetyLit)
Source: SafetyLit - July 19, 2018 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain–focused CRISPR-Cas9–based genetic screen with a newly optimized single-guide RNA scaffold. The screen uncovered the heme-regulated inhibitor HRI (also known as EIF2AK1), an erythroid-specific kinase that controls protein translation, as an HbF repressor. HRI depletion markedly increased HbF production in a specific manner and reduce...
Source: ScienceNOW - July 19, 2018 Category: Science Authors: Grevet, J. D., Lan, X., Hamagami, N., Edwards, C. R., Sankaranarayanan, L., Ji, X., Bhardwaj, S. K., Face, C. J., Posocco, D. F., Abdulmalik, O., Keller, C. A., Giardine, B., Sidoli, S., Garcia, B. A., Chou, S. T., Liebhaber, S. A., Hardison, R. C., Shi, Tags: Medicine, Diseases, Molecular Biology reports Source Type: news

Supplement May Ease Sickle Cell Pain
Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell patients' number of acute pain crises by 25 percent compared with a placebo, researchers have found. (Source: WebMD Health)
Source: WebMD Health - July 18, 2018 Category: Consumer Health News Source Type: news

Endari (L-Glutamine) Supplement May Ease the Pain of Sickle Cell Disease
WEDNESDAY, July 18, 2018 -- An FDA-approved supplement reduces episodes of severe pain in people with sickle cell disease, a new clinical trial shows. Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 18, 2018 Category: General Medicine Source Type: news

Supplement May Ease the Pain of Sickle Cell Disease
WEDNESDAY, July 18, 2018 -- An FDA-approved supplement reduces episodes of severe pain in people with sickle cell disease, a new clinical trial shows. Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 18, 2018 Category: General Medicine Source Type: news

It ’s easy to host a blood drive at your business
Every two seconds — that’s how often someone in the U.S. needs blood. And, according to the American Red Cross – Ohio Buckeye Region, approximately 500 donations are needed each day in Central Ohio. Blood is needed for routine surgeries, chemotherapy, the treatment of chronic illnesses like sickle cell disease and in saving lives after a traumatic event— one car accident victim can require as many as 100 pints of blood. But despite advancements made in modern medicine, we can’t manufacture… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 1, 2018 Category: Pharmaceuticals Authors: Nationwide Source Type: news

It ’s easy to host a blood drive at your business
Every two seconds — that’s how often someone in the U.S. needs blood. And, according to the American Red Cross – Ohio Buckeye Region, approximately 500 donations are needed each day in Central Ohio. Blood is needed for routine surgeries, chemotherapy, the treatment of chronic illnesses like sickle cell disease and in saving lives after a traumatic event— one car accident victim can require as many as 100 pints of blood. But despite advancements made in modern medicine, we can’t manufacture… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 1, 2018 Category: Biotechnology Authors: Nationwide Source Type: news

Family travels 7,500 miles to save son ’s life with treatment developed at UCLA
When he was born in September 2015, Hussein El Kerdi looked like a healthy baby boy. No one knew that his immune cells lacked an important enzyme. But the absence of that enzyme would profoundly change the El Kerdi family ’s life, sending them on a journey from their small hometown in Lebanon to UCLA. Their one goal: to save Hussein’s life.When Hussein was three months old, a physician in Beirut diagnosed Hussein with a life-threatening immune disorder called adenosine deaminase-deficient severe combined immunodeficiency, also known as ADA-SCID or bubble baby disease.The disorder is caused by a genetic mutation...
Source: UCLA Newsroom: Health Sciences - June 28, 2018 Category: Universities & Medical Training Source Type: news

GBT's drug meets trial goal, investors skeptical of speedy approval
(Reuters) - Global Blood Therapeutics Inc's sickle cell disease treatment met the main goal of a late-stage trial, but scepticism over whether the drug would get an accelerated review from health regulators pushed its shares down 12 percent. (Source: Reuters: Health)
Source: Reuters: Health - June 27, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Global Blood Therapeutics' sickle cell disease drug succeeds in trial
(Reuters) - Global Blood Therapeutics Inc said on Wednesday its experimental drug met the main goal of a late-stage trial testing it in patients with sickle cell disease. (Source: Reuters: Health)
Source: Reuters: Health - June 27, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Cameroon:World Sickle Cell Day - CERAC Communes With Patients
[Cameroon Tribune] This was during an event to donate gifts to patients at the Chantal Biya Foundation yesterday in Yaounde. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 21, 2018 Category: African Health Source Type: news

Uganda:Sickle Cell Disease - "Break the Silence, Let's Care"
[Observer] On June 19, Uganda joined the rest of the world to commemorate the World Sickle Cell Day under the theme "Break the Silence, Let's Care". (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:World Sickle Cell Day - Know the Facts
[Guardian] In Nigeria, over 150,000 children are born annually with symptomatic sickle cell anaemia, 1-in-4 people are healthy carriers of the disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:Sickle Cell - Emir of Gwandu Calls for Test Before Marriage
[Leadership] The emir of Gwandu in Kebbi and chairman Kebbi State council of chiefs, Alhaji Muhammadu Iliyasu Bashar has called on couples to go for blood screening in order to know their genotype before marriage . (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:Sickle Cell Day - Governor Urges Speedy Deployment of Improved Disease Management Options
[This Day] Edo State Governor, Mr. Godwin Obaseki, has called for increased sensitisation on the choices that lead to the increased cases of sickle cell incidence in society, noting that his government would continue to support sufferers of the health condition by creating the right environment for management of the genetic disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:World Sickle Cell Day - Why Disease Remains Endemic in Nigeria
[Premium Times] As Nigeria joins the rest of the world today to celebrate World Sickle Cell Awareness Day, thousands of the country's citizens are still under the clutches of the deadly disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

AHA: New Insights Into Sickle Cell and Stroke Risk
TUESDAY, June 19, 2018 (American Heart Association) -- Sickle cell disease increases the risk of stroke for African Americans -- but recent research shows carrying the genetic trait for sickle cell doesn't. It's a new layer on the study and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 19, 2018 Category: General Medicine Source Type: news

New Drugs Promise Hope This World Sickle Cell Day
This year brings a bit of good news regarding the drug pipeline for sickle cell disease, but pain management is a growing problem. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 19, 2018 Category: Pharmaceuticals Authors: Judy Stone, Contributor Source Type: news

Uganda:Home Care for Children With Sickle Cell Disease
[Monitor] Being in and out of hospital is one of the worst experiences parents of children with sickle cell suffer. However, parents should never tire from being in hospital because any slight laziness can lead to death. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 18, 2018 Category: African Health Source Type: news

Study finds music therapy brings effective pain relief for sickle cell patients
(University Hospitals Cleveland Medical Center) In a randomized controlled trial, patients with sickle cell disease were assigned to one of three 20-minute conditions: a session with a music therapist, an iPod to listen to pre-selected music themselves, or no music at all. While passively listening to music improved mood, music therapy had a significantly stronger impact on aiding in pain management for patients actively engaged with a music therapist. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 13, 2018 Category: Cancer & Oncology Source Type: news

Cameroon:Labelled Sorcerers, Children With Sickle-Cell Disease Face Death
[Thomson Reuters Foundation] Douala -"I killed my child because he was going to die anyway. Before, he was suffering greatly. Now he is at peace." (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 1, 2018 Category: African Health Source Type: news

FDA halts Vertex, CRISPR sickle-cell trial
CRISPR Therapeutics and Vertex Pharmaceuticals announced that the U.S. FDA has placed a clinical hold on the new-drug application for a drug used for the treatment of sickle-cell disease. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - June 1, 2018 Category: Pharmaceuticals Source Type: news

CRISPR, Vertex say FDA puts brakes on upcoming gene editing trial
Cambridge startup CRISPR Therapeutics and Boston-based Vertex Pharmaceuticals said on Wednesday that the FDA has put on hold a highly anticipated upcoming trial of their experimental gene editing drug for sickle cell disease. CRISPR (Nasdaq: CRISPR) and Vertex (Nasdaq: VRTX) announced after markets closed on Wednesday that the FDA had halted the upcoming trial, which hasn't started yet. The companies sought approval in April to begin the early-stage study in humans; it would be one of the first… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 31, 2018 Category: American Health Authors: Max Stendahl Source Type: news

CRISPR, Vertex say FDA puts brakes on upcoming gene editing trial
Cambridge startup CRISPR Therapeutics and Boston-based Vertex Pharmaceuticals said on Wednesday that the FDA has put on hold a highly anticipated upcoming trial of their experimental gene editing drug for sickle cell disease. CRISPR (Nasdaq: CRISPR) and Vertex (Nasdaq: VRTX) announced after markets closed on Wednesday that the FDA had halted the upcoming trial, which hasn't started yet. The companies sought approval in April to begin the early-stage study in humans; it would be one of the first… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 31, 2018 Category: Biotechnology Authors: Max Stendahl Source Type: news

Research, for Whom?
We presented this finding to the health minister, who praised our work and announced that the government would set up a tribal medical research centre in Gadchiroli. Eventually, though, the centre was set up in Pune (where there are no tribals) because researchers and doctors did not want to come to Gadchiroli.Disappointed, we approached the tribal leaders in the villages and requested them to put some pressure on the government to bring the centre to Gadchiroli. Their response took us unawares: “Doctor, this is your disease, not ours,” they said. “Did we ever tell you that we need help for this?” t...
Source: IPS Inter Press Service - Health - May 16, 2018 Category: International Medicine & Public Health Authors: Abhay Bang Tags: Asia-Pacific Development & Aid Headlines Health Poverty & SDGs Source Type: news

Uganda:Church to Subject Couples to Mandatory Sickle Cell Testing
[Monitor] Masaka -In a bid to end the sickle cell disease burden in families, West Buganda Diocese has made it a requirement for couples intending to marry in Church to be subjected to mandatory sickle cell tests. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 14, 2018 Category: African Health Source Type: news

St. Jude to combat ‘unacceptable’ sickle cell death rate
Because she is a physician, Dr. Glenda Newell-Harris, national president of The Links Foundation Inc. and The Links Inc. said the organization's $1 million award to St. Jude Children's Research Hospital for sickle cell research was even more special to her. "Health is my passion," the Oakland, California-based internist said. "So to be able to be a part of an organization that is willing to acknowledge and recognize the importance of us continuing to be at the forefront of helping to promote research,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 4, 2018 Category: Pharmaceuticals Authors: Elle Perry Source Type: news

Debut novelist reveals how sickle cell disease inspired her book
Debut novelist Adebayo Ayobami reveals how sickle cell disease inspired her book. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 30, 2018 Category: Consumer Health News Source Type: news