C-Path launches consortium to support medical product development in sickle cell disease
(Critical Path Institute (C-Path)) C-Path) today announced the launch of the Critical Path for Sickle Cell Disease (CP-SCD) Consortium to support collaboration and regulatory endorsement of new medical product development tools for sickle cell disease. These tools will help to optimize and de-risk clinical trials to increase efficiency in developing and delivering safe, effective treatments for people living with sickle cell disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news

How this Stanford biotech spinout plans to quickly boost gene therapy
The Peninsula startup snared a $45 million Series A round but plans to start a clinical trial in sickle cell disease as early as the first half of next year. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 16, 2020 Category: Biotechnology Authors: Ron Leuty Source Type: news

How this Stanford biotech spinout plans to quickly boost gene therapy
The Peninsula startup snared a $45 million Series A round but plans to start a clinical trial in sickle cell disease as early as the first half of next year. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 16, 2020 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Nigeria: Hypertension, Cancer, HIV Kill 600,000 Nigerians Annually - NCD Alliance
[Vanguard] Worried about the growing trend of hypertension, cancer, HIV, Sickle Cell Disease, and other Non-Communicable Diseases, NCDs, among Nigerians, President of the NCD Alliance Nigeria, Dr. Sonny Kuku, says not less than 60,000 Nigerians die from these diseases annually. (Source: AllAfrica News: HIV-Aids and STDs)
Source: AllAfrica News: HIV-Aids and STDs - September 11, 2020 Category: Infectious Diseases Source Type: news

Improving Health Outcomes for Sickle Cell Disease Care Requires Comprehensive Team-Based Care, New Payment Models, and Addressing Institutional Racism in Health
A new report from the National Academies of Sciences, Engineering, and Medicine provides a blueprint and eight overarching strategies for improving health care for the approximately 100,000 people in the United States living with sickle cell disease (SCD). (Source: News from the National Academies)
Source: News from the National Academies - September 10, 2020 Category: Science Source Type: news

Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease
But no change in opioid use observed for those receiving medical marijuana certification (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 8, 2020 Category: Cancer & Oncology Tags: Family Medicine, Internal Medicine, Oncology, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news

Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease
TUESDAY, Sept. 8, 2020 -- Use of medical marijuana is associated with fewer hospitalizations among patients with sickle cell disease (SCD), according to a study published online Aug. 13 in Blood Advances. Susanna A. Curtis, M.D., from the Yale... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 8, 2020 Category: Pharmaceuticals Source Type: news

September 2020
Battling Bent Blood Cells : Progress in Sickle Cell Disease A Biting Problem : Taming TMJ Troubles Dr. Allison King on Sickle Cell Disease and Learning Communicating Clearly While Wearing a Face Covering Protein May Reverse Age-Related Memory Loss Know the Science (Source: NIH News in Health)
Source: NIH News in Health - September 3, 2020 Category: Consumer Health News Source Type: news

South Africa: UCT Professor's Research Offers Hope of Treatment for Sickle Cell Anaemia
[GroundUp] In a study performed in Cameroon, UCT professor Ambroise Wonkam has identified genetic factors which protect some patients from the effects of sickle cell anemia. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 2, 2020 Category: African Health Source Type: news

UTHSC's Athena Starlard-Davenport awarded NIH grant to study potential sickle cell treatment pathway
UTHSC's Athena Starlard-Davenport, Ph.D. — a junior researcher who is "a woman, a scientist, and an African-American woman scientist at that [which] is very rare" — has been awarded an NIH grant to study a potential sickle cell treatment pathway. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 26, 2020 Category: Biotechnology Authors: Jason Bolton Source Type: news

Africa: UCT Sickle Cell Genetics Study a First for Africa
[UCT] New research investigating the genetic modifiers of long-term survival in individuals with sickle cell anaemia (SCA) reveals a range of possible pathways for novel therapeutic interventions. Professor Ambroise Wonkam, principle investigator and director of Genetic Medicine of African Populations (GeneMAP) in the University of Cape Town's (UCT) Division of Human Genetics, says apart from the study's clinical potential, the fact that it is so deeply rooted in Africa also presents the opportunity for a paradi (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - August 25, 2020 Category: African Health Source Type: news

Adding Sickle Cell Disease To FDA ’s Priority Review Voucher List Of Neglected Tropical Diseases
Sickle cell disease lags behind other neglected diseases in terms of R&D. Adding sickle cell disease to the FDA ’s priority review voucher list of neglected tropical diseases may incentivize drug companies to increase their investment in R&D. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - August 18, 2020 Category: Pharmaceuticals Authors: Joshua Cohen, Contributor Tags: Healthcare /healthcare Innovation /innovation business pharma & Source Type: news

Psychosocial and clinical risk factors associated with substance use in observational cohort of patients with sickle cell disease - Wilson JD, Lanzkron S, Pecker LH, Bediako SM, Han D, Beach MC.
BACKGROUND: Patients with sickle cell disease (SCD) experience high rates of chronic pain, and have a high burden of mental health comorbidities shown to negatively influence health. There is limited research on substance use among individuals with SCD. ... (Source: SafetyLit)
Source: SafetyLit - August 14, 2020 Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news

Heel-prick blood test could predict type 1 diabetes in children
Heel-prick tests are already used in Britain to check for nine rare but serious conditions, including cystic fibrosis and sickle cell disease. Scientists are pushing for diabetes to be added. (Source: the Mail online | Health)
Source: the Mail online | Health - August 10, 2020 Category: Consumer Health News Source Type: news

Gut Microbiome Translates Stress Into Sickle Cell Crises
July 30, 2020—(BRONX, NY)—A new study shows how chronic psychological stress leads to painful vessel-clogging episodes—the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible ways to prevent them. The research was conducted by scientists atAlbert Einstein College of Medicine and published online today inImmunity. (Source: Einstein News)
Source: Einstein News - July 30, 2020 Category: Universities & Medical Training Source Type: news

Gut microbiome translates stress into sickle cell crises
(Albert Einstein College of Medicine) A new study shows how chronic psychological stress leads to painful vessel-clogging episodes--the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations. The findings, made in mice, show that the gut microbiome plays a key role in triggering those episodes and reveals possible ways to prevent them. The research was conducted by scientists at Albert Einstein College of Medicine and published online today in Immunity. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 30, 2020 Category: International Medicine & Public Health Source Type: news

Vaporized cannabis may reduce sickle cell disease pain, study finds
Inhaled cannabis did not significantly reduce pain in hospitalized patients with sickle cell disease who also were treated with prescription opioid pain relievers, a study published Friday by JAMA Network Open found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 17, 2020 Category: Consumer Health News Source Type: news

Cannabis shows potential for mitigating sickle cell disease pain
(University of California - Irvine) Cannabis appears to be a safe and potentially effective treatment for the chronic pain that afflicts people with sickle cell disease, according to a new clinical trial co-led by University of California, Irvine researcher Kalpna Gupta and Dr. Donald Abrams of UC San Francisco. The findings appear in JAMA Network Open. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 17, 2020 Category: International Medicine & Public Health Source Type: news

Umbilical cord blood successfully treats rare genetic disorders in largest study to date
(University of Pittsburgh) Infusing umbilical cord blood - a readily available source of stem cells - safely and effectively treated 44 children born with various non-cancerous genetic disorders, including sickle cell, thalassemia, Hunter syndrome, Krabbe disease, MLD, and an array of immune deficiencies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 14, 2020 Category: International Medicine & Public Health Source Type: news

Sickle Cell & COVID: What You Need to Know
COVID-19 can cause severe inflammation and lung injury. And that can have a greater impact on people with sickle cell disease, a group of inherited red blood cell disorders. (Source: WebMD Health)
Source: WebMD Health - July 13, 2020 Category: Consumer Health News Source Type: news

What People With Sickle Cell Disease Need to Know About COVID-19
MONDAY, July 13, 2020 -- People with sickle cell disease are at increased risk for severe complications from COVID-19, an expert says. " Many patients experience a pain crisis, also known as a vaso-occlusive crisis, early in COVID-19 infection... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 13, 2020 Category: General Medicine Source Type: news

What People With Sickle Cell Disease Need to Know About COVID-19
Title: What People With Sickle Cell Disease Need to Know About COVID-19Category: Health NewsCreated: 7/13/2020 12:00:00 AMLast Editorial Review: 7/13/2020 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - July 13, 2020 Category: Anesthesiology Source Type: news

This Startup Might Finally Cure Sickle Cell Disease —After A Century Of Racist Neglect
The painful blood disorder, which mostly affects Black people, is just one of thousands of rare diseases that could be cured by Beam Therapeutics' revolutionary gene editing technology. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - July 10, 2020 Category: Pharmaceuticals Authors: Katie Jennings, Forbes Staff Tags: Healthcare /healthcare Innovation /innovation Science /science Business /business Leadership /leadership Forbes Daily Cover Stories /daily-cover-stories Editors' Pick editors-pick Source Type: news

Sickle Cell Disease May Not Worsen COVID-19 Prognosis Sickle Cell Disease May Not Worsen COVID-19 Prognosis
Sickle cell disease does not appear to worsen the prognosis of COVID-19, at least not in younger patients, although vaso-occlusive crisis is common with the infection, researchers in France report.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - July 7, 2020 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Researchers discover improved treatment for children with sickle cell anemia
(Indiana University School of Medicine) A team of international researchers has learned that dose escalation of hydroxyurea treatment for children in Uganda with sickle cell anemia is more effective and has similar side effects than a lower fixed dose of the same drug. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2020 Category: International Medicine & Public Health Source Type: news

Researchers find best way to treat children with sickle cell anemia in sub-Saharan Africa
(Indiana University) A team of international researchers has learned that dose escalation of hydroxyurea treatment for children in Uganda with sickle cell anemia is more effective and has similar side effects than a lower fixed dose of the same drug. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2020 Category: International Medicine & Public Health Source Type: news

Best way found to treat children with sickle cell anemia in sub-Saharan Africa
(Cincinnati Children's Hospital Medical Center) A team of international researchers has learned that dose escalation of hydroxyurea treatment for children in Uganda with sickle cell anemia is more effective and has similar side effects than a lower fixed dose of the same drug. They report in the New England Journal of Medicine that the clinical research milestone removes a major barrier to broadly expand the use of hydroxyurea in low-resource regions like sub-Saharan Africa. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - June 24, 2020 Category: Infectious Diseases Source Type: news

First patient to use CRISPR to treat sickle cell disease says the technology is alleviating symptoms
Mother-of-four Victoria Gray, 34, of Forest, Mississippi, says the controversial gene-editing tool CRISPR has helped alleviate her of severe bouts of pain due to sickle cell disease. (Source: the Mail online | Health)
Source: the Mail online | Health - June 23, 2020 Category: Consumer Health News Source Type: news

A Year In, 1st Patient To Get Gene Editing For Sickle Cell Disease Is Thriving
Since receiving a landmark treatment with the gene-editing tool CRISPR, a sickle cell patient has the strength to care for herself and her children — while navigating the pandemic.(Image credit: Victoria Gray) (Source: NPR Health and Science)
Source: NPR Health and Science - June 23, 2020 Category: Consumer Health News Authors: Rob Stein Source Type: news

Kenya: Sickle Cell Disease Patients At Higher Risk of Severe COVID-19
[Capital FM] Nairobi -Patients with sickle-cell disease (SCD) face a higher risk of contracting and suffering severe COVID-19 due to their low immunity resulting from the blood disorder, the health ministry warned on Thursday . (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 22, 2020 Category: African Health Source Type: news

Nigeria: Stakeholders Advocate 'Newborn Screening' for Sickle Cell Disorder in Nigeria
[This Day] In commemoration of the annual World Sickle Cell Day, the coalition of Sickle Cell Disorder (SCD) nongovernmental organisations have tasked the legislative arm of government to implement the 'Newborn Screening' procedure policy in order to tackle the burden of the disease in Nigeria. (Source: AllAfrica News: Pregnancy and Childbirth)
Source: AllAfrica News: Pregnancy and Childbirth - June 18, 2020 Category: OBGYN Source Type: news

Global Blood Therapeutics to seek to expand label for sickle cell treatment
Global Blood Therapeutics Inc said on Monday it plans to ask U.S. regulators to greenlight the use of its sickle cell treatment, Oxbryta, in children aged 4 to 11, expanding on an earlier approval for patients 12 and over. (Source: Reuters: Health)
Source: Reuters: Health - June 8, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Sickle Cell Crisis
Sickle Cell Disease (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - June 8, 2020 Category: General Medicine Source Type: news

Can a drug developed for sickle cell anemia mitigate lung damage in patients with COVID-19?
(University of California - Davis Health) Scientists around the globe are working to identify approved and investigational drugs that can be repurposed to treat COVID-19. The senicapoc study will assess whether the drug can prevent SARS and lung damage and reduce days spent on a ventilator. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 12, 2020 Category: Infectious Diseases Source Type: news

Cardiovascular Manifestations of Sickle Cell Disease Cardiovascular Manifestations of Sickle Cell Disease
This article provides an updated review of recent advances in the pathophysiology, diagnosis, and management of cardiac manifestations of sickle cell disease.European Heart Journal (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - May 6, 2020 Category: Intensive Care Tags: Cardiology Journal Article Source Type: news

Chronic medical conditions may place youth at an increased risk for anxiety disorders
(Elsevier) Youth who report one of the seven chronic medical conditions (CMCs), including asthma, congenital heart disease, diabetes, epilepsy, inflammatory bowel disease, juvenile idiopathic arthritis, and sickle cell disease, are often diagnosed with an anxiety disorder. A new systematic review in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, examines the prevalence of anxiety disorders and the impact of anxiety on disease-related outcomes for children and adolescents with CMCs. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 4, 2020 Category: International Medicine & Public Health Source Type: news

Rice wins fed grant to advance sickle cell disease therapy
(Rice University) Rice University bioengineer Gang Bao wins a federal grant to advance research into a cure for sickle cell disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 24, 2020 Category: International Medicine & Public Health Source Type: news

EHA and TIF on How COVID-19 Affects Thalassemia and SCD Patients EHA and TIF on How COVID-19 Affects Thalassemia and SCD Patients
In a webinar, three experts on thalassemia and sickle cell disease (SCD) provided information from physicians who were dealing with the height of the crisis in their countries.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - April 21, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Clarification on Pain Management Recommendations for Cancer and Sickle Cell Disease
Representatives from multiple organizations convened to address the perceived variance among clinical practice guidelines for disease management in patients with cancer and patients with sickle cell disease. (Source: CancerNetwork)
Source: CancerNetwork - April 11, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

New kind of CRISPR technology to target RNA, including RNA viruses like coronavirus
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases. However, these genetic screens are limited in scope: They can only edit or target DNA. For many regions of the human genome, targeting DNA may not be effective, and other organisms, such as RNA viruses like coronavirus or flu, cannot be targeted at all with existing DNA-targeting CRISPR screens. (Source: World Pharma News)
Source: World Pharma News - March 16, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

A simple blood test could now be used to diagnose sickle cell disease in unborn babies
Until now, the debilitating inherited condition - which causes those with it to produce unusually shaped red blood cells - could only be picked up during an invasive procedure known as amniocentesis. (Source: the Mail online | Health)
Source: the Mail online | Health - March 15, 2020 Category: Consumer Health News Source Type: news

New therapies for sickle cell disease
(Source: ScienceNOW)
Source: ScienceNOW - March 12, 2020 Category: Science Authors: Alderton, G. Tags: twis Source Type: news

Treating sickle cell anemia
(Source: ScienceNOW)
Source: ScienceNOW - March 12, 2020 Category: Science Authors: Tisdale, J. F., Thein, S. L., Eaton, W. A. Tags: Genetics, Medicine, Diseases perspective Source Type: news

From Malaria To Sickle Cell Disease: How Gene Editing Technology May Change Healthcare
Gene editing technology may significantly impact public health and clinical medicine. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - March 6, 2020 Category: Pharmaceuticals Authors: Sai Balasubramanian, J.D., Contributor Source Type: news

SCT screening data
Public Health England has published screening data for the NHS sickle cell and thalassaemia (SCT) screening programme for the financial year 1 April 2017 to 31 March 2018. (Source: NHS Networks)
Source: NHS Networks - March 2, 2020 Category: UK Health Source Type: news

COVID-19 Pandemic and Haemoglobin Disorders
Source: Thalassaemia International Federation (TIF). Published: 3/2020. This 16-page document is an informational leaflet about COVID-19, with a special focus on the challenges it presents for patients affected by thalassaemia and sickle cell disease (SCD). (Text) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - March 1, 2020 Category: International Medicine & Public Health Source Type: news

Haematopoietic cell transplant saves costs in sickle cell disease
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - March 1, 2020 Category: Drugs & Pharmacology Source Type: news

FDA D.I.S.C.O.: L-glutamine for sickle cell disease
. FDA medical oncologists discuss the July 7, 2017, approval of l-glutamine to reduce the acute complications of sickle cell disease. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 28, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news

NIH announces $1 million prize competition to target global disease diagnostics
(NIH/National Institute of Biomedical Imaging& Bioengineering) NIH has launched a $1 million Technology Accelerator Challenge (TAC) to spur the design and development of non-invasive, handheld, digital technologies to detect, diagnose and guide therapies for diseases with high global and public health impact. The Challenge is focused on sickle cell disease, malaria and anemia and is led by NIH's National Institute of Biomedical Imaging and Bioengineering. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 26, 2020 Category: Infectious Diseases Source Type: news