Six-year-old boy who's suffered stroke desperately searches for bone marrow donor 
Ayden Palmer, six, from Prosper, Texas, is battling sickle cell disease, an inherited disorder that causes red blood cells to have a crescent shape, which blocks proper blood flow in vessels. (Source: the Mail online | Health)
Source: the Mail online | Health - February 12, 2019 Category: Consumer Health News Source Type: news

Sickle Cell Pioneer Dr Doris Wethers Dead at 91 Sickle Cell Pioneer Dr Doris Wethers Dead at 91
Along with her research in sickle cell anemia, Wethers was also a trailblazer for African American women in the medical community.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 12, 2019 Category: Consumer Health News Tags: Pediatrics News Source Type: news

Six-year-old boy who's suffered stroke and brain cancer desperately searches for bone marrow donor  
Ayden Palmer, six, from Prosper, Texas, is battling sickle cell disease, an inherited disorder that causes red blood cells to have a crescent shape, which blocks proper blood flow in vessels. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2019 Category: Consumer Health News Source Type: news

Six-year-old boy who's suffered stroke and brain cancer desperately searches for bone marrow donor 
Ayden Palmer, six, from Prosper, Texas, is battling sickle cell disease, an inherited disorder that causes red blood cells to have a crescent shape, which blocks proper blood flow in vessels. (Source: the Mail online | Health)
Source: the Mail online | Health - February 11, 2019 Category: Consumer Health News Source Type: news

Dr. Doris Wethers, 91, on Front Lines Against Sickle Cell, Dies
Breaking racial barriers in New York ’ s medical world, she earned renown for research and advocacy that led to mandatory testing for sickle cell anemia. (Source: NYT Health)
Source: NYT Health - February 7, 2019 Category: Consumer Health News Authors: SAM ROBERTS Tags: Blacks Deaths (Obituaries) Sickle Cell Anemia Yale School of Medicine St Luke's-Roosevelt Hospital Center Francis-McBarnette, Yvette Fay (1926-2016) Wethers, Dr. Doris Source Type: news

The silence of sickle cell disease
(Children's Hospital Los Angeles) Silent strokes are a common symptom of sickle cell disease, though they can be debilitating. John Wood, MD, PhD, of Children's Hospital Los Angeles recently showed that silent strokes may be caused by decreased oxygen delivery to a part of the brain called the white matter. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2019 Category: International Medicine & Public Health Source Type: news

Uganda: Film Production Company Embarks On Fight Against Sickle Cell Disease
[Monitor] Worldwide, the burden of Sickle Cell disease has not been amply addressed. Uganda has the 5th highest burden, a situation aggravated by limited and inaccessible formal social support structures to aid patients and families to cope better with the psychosocial burden of sickle cell. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 4, 2019 Category: African Health Source Type: news

Gene Therapy Shows Promise Against Sickle Cell
Despite promising results, it's unclear if the effects of treatment will last and it's likely to be at least three years before a genetic therapy for sickle cell disease is approved. (Source: WebMD Health)
Source: WebMD Health - January 28, 2019 Category: Consumer Health News Source Type: news

Ghana: Govt Partners Novartis to Accelerate Sickle Cell Treatment
[Ghanaian Times] The government has signed a Memorandum of Understanding with global medicines company, Novartis to create a new public-private partnership designed to improve the diagnoses and accelerate treatment for people with sickle cell disease (SCD). (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 28, 2019 Category: African Health Source Type: news

Gene Therapy Shows Promise Against Sickle Cell Disease
Title: Gene Therapy Shows Promise Against Sickle Cell DiseaseCategory: Health NewsCreated: 1/28/2019 12:00:00 AMLast Editorial Review: 1/28/2019 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - January 28, 2019 Category: Anesthesiology Source Type: news

These Patients Had Sickle-Cell Disease. Experimental Therapies Might Have Cured Them.
Success against sickle-cell would be “ the first genetic cure of a common genetic disease ” and could free tens of thousands of Americans from agonizing pain. (Source: NYT Health)
Source: NYT Health - January 27, 2019 Category: Consumer Health News Authors: GINA KOLATA Tags: Genetics and Heredity Hemoglobin Crispr (DNA) Blood Pain Sickle Cell Anemia National Institutes of Health Harvard University bluebird bio Inc. Africa Source Type: news

These Patients Had Sickle-Cell Disease. Experimental Therapies May Have Cured Them.
Success against sickle-cell would mark “ the first genetic cure of a common genetic disease ” and could free tens of thousands of Americans from agonizing pain. (Source: NYT Health)
Source: NYT Health - January 27, 2019 Category: Consumer Health News Authors: GINA KOLATA Tags: Genetics and Heredity Hemoglobin Crispr (DNA) Blood Pain Sickle Cell Anemia National Institutes of Health Harvard University bluebird bio Inc. Africa Source Type: news

Ghana: Government of Ghana Partners Novartis to Improve Diagnosis, Treatment of Sickle Cell Disease
[Ghana Presidency] The Government of Ghana, through the Ministry of Health, Ghana Health Service and other allied agencies, has signed a Memorandum of Understanding with global medicines company Novartis to create a new public-private partnership designed to improve the diagnoses and accelerate treatment for people with Sickle Cell Disease (SCD). (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - January 25, 2019 Category: African Health Source Type: news

Stem Cell Transplant a Promising Option in Sickle Cell Anemia Stem Cell Transplant a Promising Option in Sickle Cell Anemia
Matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) is a promising option for children with sickle cell anemia (SCA) requiring chronic transfusion due to elevated transcranial Doppler velocity (TCD), a study from France suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 23, 2019 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Sickle cell: Call The Midwife shines spotlight on disease
Sickle cell carriers took to social media to praise the show's portrayal of the genetic disease. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 21, 2019 Category: Consumer Health News Source Type: news

Hopkins Nursing—No. 1 for Online Education
Hopkins Nursing—No. 1 for Online Education body,#bodyTable,#bodyCell{ height:100% !important; margin:0; padding:0; width:100% !important; } table{ border-collapse:collapse; } img,a img{ border:0; outline:none; text-decoration:none; } h1,h2,h3,h4,h5,h6{ margin:0; padding:0; } p{ margin:1em 0; padding:0; } a{ word-wrap:break-word; } .mcnPreviewText{ display:none !important; } .ReadMsgBody{ width:100%; } .ExternalClass{ width:100%; } .ExternalClass,.ExternalClass p,.ExternalClass span,.ExternalClass font,.ExternalClass td,.Externa...
Source: Johns Hopkins University and Health Systems Archive - January 15, 2019 Category: Nursing Source Type: news

UCLA researchers correct genetic mutation that causes IPEX, a life-threatening autoimmune syndrome
UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX. The gene therapy, which was tested in mice, is similar to the technique Kohn has used to cure patients with another immune disease, severe combined immune deficiency, or SCID, also known as bubble baby disease.The workis described in a study published in the journal Cell Stem Cell.IPEX is caused by a mutation that prevents a gene called FoxP3 from making a protein needed for blood stem cells to produce immune cells called regulatory T ce...
Source: UCLA Newsroom: Health Sciences - January 10, 2019 Category: Universities & Medical Training Source Type: news

Sickle cell disease community is hopeful that genome editing will rechart course of the disease
In the first study of its kind, NHGRI researchers explored patients', parents' and physicians' perspectives on the use of CRISPR-Cas9 gene-editing to reverse sickle cell disease. Study participants expressed overall optimism about participating in human genome editing clinical trials, but were concerned about treatment risks and transparency of the research enterprise, according to the findings published December 24 inGenetics in Medicine. (Source: NHGRI Homepage Highlights)
Source: NHGRI Homepage Highlights - January 3, 2019 Category: Genetics & Stem Cells Source Type: news

New Law Boosts Fight Against Sickle Cell Disease
WEDNESDAY, Dec. 19, 2018 -- A sickle cell disease prevention and treatment program in the United States has been reauthorized to receive nearly $5 million each year over the next five years. The measure was included in a bipartisan bill that aims to... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 19, 2018 Category: Pharmaceuticals Source Type: news

New Law Boosts Fight Against Sickle Cell Disease
Title: New Law Boosts Fight Against Sickle Cell DiseaseCategory: Health NewsCreated: 12/18/2018 12:00:00 AMLast Editorial Review: 12/19/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - December 19, 2018 Category: Anesthesiology Source Type: news

Gates Foundation gives $1.5M to Children's for sickle cell research
The Bill& Melinda Gates Foundation has donated $1.5 million to Boston Children ’s Hospital to develop a gene therapy for sickle cell disease, with the goal of making the drug technology more widely available in regions of the world with high rates of the condition. Gene therapy holds promise to treat the more than 275,000 infants who are born annually with sickle cell disea se. But such drugs are complicated — and costly — to produce. Blood stem cells are removed from the body, treated with… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - December 19, 2018 Category: Pharmaceuticals Authors: Jessica Bartlett Source Type: news

Gates Foundation gives $1.5M to Children's for sickle cell research
The Bill& Melinda Gates Foundation has donated $1.5 million to Boston Children ’s Hospital to develop a gene therapy for sickle cell disease, with the goal of making the drug technology more widely available in regions of the world with high rates of the condition. Gene therapy holds promise to treat the more than 275,000 infants who are born annually with sickle cell disea se. But such drugs are complicated — and costly — to produce. Blood stem cells are removed from the body, treated with… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 19, 2018 Category: Biotechnology Authors: Jessica Bartlett Source Type: news

Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions! Spotlight Blast off! The National Network of Libraries of Medicine is getting into Summer Reading! A Universe of Stories is coming to public libraries this summer in celebration of the 50th anniversary of the first moon landing. Explore DNA and family history, make stardust, discover astronaut food, and more with our science programs for kids, teens, and adults. Check out the NNLM Summer Reading Manual for program guides created in partnership with the Collaborative Summer Library Program. National Safe Toys and Giving Month: Decembe...
Source: NN/LM Middle Atlantic Region Blog - December 14, 2018 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news

Africa: In Africa, Sickle Cell Patients Endure Pain, Discrimination
[VOA] Africans who have the blood disorder sickle cell anemia met this week in the northern Cameroon town of Garoua to step up an awareness campaign. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 13, 2018 Category: African Health Source Type: news

New Sickle Cell Test Can Transform Screening New Sickle Cell Test Can Transform Screening
The HemoTypeSC test, which is cheap, highly accurate, and easy to use in settings with few resource, can change the dynamics of sickle cell disease screening.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 10, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Measles Vaccination; Sickle Cell and Hydroxyurea: It's PodMed Double T! (with audio)
(MedPage Today) -- This week's topics also include U.S. mortality data and the acute flaccid myelitis situation (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - December 8, 2018 Category: Pediatrics Source Type: news

Gene Therapy for Sickle Cell Takes Another Step Forward
Title: Gene Therapy for Sickle Cell Takes Another Step ForwardCategory: Health NewsCreated: 12/4/2018 12:00:00 AMLast Editorial Review: 12/5/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - December 5, 2018 Category: Anesthesiology Source Type: news

Sickle Cell Gene Therapy Makes Another Advance
The therapy targets the genetic flaw that causes sickle cell. In a small group of patients, researchers said the therapy appears safe and effective enough to keep moving forward into larger trials. (Source: WebMD Health)
Source: WebMD Health - December 4, 2018 Category: Consumer Health News Source Type: news

Gene therapy treatment reverses sickle cell anemia, early trial results show
A new gene therapy for sickle cell anemia has shown promise in early clinical trials after reversing the condition's symptoms in two adults, researchers report. (Source: Health News - UPI.com)
Source: Health News - UPI.com - December 4, 2018 Category: Consumer Health News Source Type: news

$2 Test Could Transform Sickle Cell Dx in Africa
(MedPage Today) -- May have applications in high-income countries as well (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 4, 2018 Category: American Health Source Type: news

Gene Therapy for Sickle Cell Takes Another Step Forward
TUESDAY, Dec. 4, 2018 -- A new gene therapy shows early promise against sickle cell anemia, researchers say. The therapy targets the genetic flaw that causes sickle cell. In a small group of patients, researchers said the therapy appears safe and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 4, 2018 Category: General Medicine Source Type: news

NIH researcher presents encouraging results for gene therapy for severe sickle cell disease
This study is part of decades of research on sickle cell disease that have opened the door to novel genetic approaches to curative therapies. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - December 4, 2018 Category: American Health Source Type: news

ASH Offers Early Look at Updated SCD Guidelines
(MedPage Today) -- Experts formulated>50 recommendations on sickle cell disease (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - December 4, 2018 Category: Hematology Source Type: news

Early clinical trial data show gene therapy reversing sickle cell anemia
(Cincinnati Children's Hospital Medical Center) After over a decade of preclinical research and development, a new gene therapy treatment for Sickle Cell Anemia (SCA) is reversing disease symptoms in two adults and showing early potential for transportability to resource-challenged parts of the world where SCA is most common. Preliminary data from a pilot Phase 1-2 clinical trial testing the gene-addition therapy were presented Dec. 3 at the American Society of Hematology's (ASH) annual meeting in San Diego. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 3, 2018 Category: International Medicine & Public Health Source Type: news

Global Health: ‘ From Nothing to Gangbusters ’ : A Treatment for Sickle-Cell Disease Proves Effective in Africa
Already used in Western countries, hydroxyurea eased painful episodes in African children with the condition. It also reduced the risk of malaria infection. (Source: NYT Health)
Source: NYT Health - December 1, 2018 Category: Consumer Health News Authors: DONALD G. McNEIL Jr. Tags: Children and Childhood Sickle Cell Anemia Malaria Transfusions Africa New England Journal of Medicine Hydroxyurea Source Type: news

Sickle cell anemia treatment safely lowers disease burden in African children
(Cincinnati Children's Hospital Medical Center) A daily hydroxyurea pill may bring relief for children living with the painful and deadly blood disease sickle cell anemia (SCA) in resource-challenged sub-Saharan Africa, where the disease is prevalent and health care is suboptimal. This is what a multinational clinical trial called REACH discovered when it tested daily hydroxyurea treatment in 606 children between the ages of 1 and 10 years old. Study data are published in the New England Journal of Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2018 Category: International Medicine & Public Health Source Type: news

Sneak Peak at Practice-Changing Research From ASH 2018
(MedPage Today) -- " Big trials, big results, " plus sickle cell disease and CAR T-cell therapies (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 30, 2018 Category: Hematology Source Type: news

Sneak Peek at Practice-Changing Research From ASH 2018
(MedPage Today) -- " Big trials, big results, " plus sickle cell disease and CAR T-cell therapies (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - November 30, 2018 Category: Hematology Source Type: news

St. Jude research into leukemia, sickle cell and other blood disorders presented at ASH
(St. Jude Children's Research Hospital) The 60th Annual Meeting of the American Society of Hematology will feature research from St. Jude Children's Research Hospital on topics ranging from the genomic basis and vulnerabilities of leukemia to an update on gene therapy for hemophilia B to advances in sickle cell disease and beta-thalassemia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 30, 2018 Category: Cancer & Oncology Source Type: news

Call for nursing courses to include sickle cell and thalassaemia
The blood conditions sickle cell disease and thalassaemia “lack representation” in pre-registration nurse and midwife education, MPs have warned. (Source: Nursing Times)
Source: Nursing Times - November 27, 2018 Category: Nursing Source Type: news

Cincinnati Children ’s inks biggest commercialization deal ever
Cincinnati Children ’s officials disclosed today that research on gene therapy for sickle cell disease has resulted in the hospital’s biggest commercialization deal ever. The hospital and Roivant Sciences launched as a joint venture a biopharmaceutical company called Aruvant Sciences, which will focus on developin g innovative gene therapies for hematological conditions such as sickle cell and beta thalassemia. Financial terms weren’t disclosed, but the deal includes “a very large upfront… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 26, 2018 Category: Biotechnology Authors: Barrett J. Brunsman Source Type: news

Moths and magnets could save lives
(Rice University) Rice University bioengineers have combined a virus that infects moths with magnetic nanoparticles to create a potential new therapy for inherited genetic diseases like muscular dystrophy, sickle cell, cystic fibrosis, spinal muscular atrophy and some forms of cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 13, 2018 Category: Cancer & Oncology Source Type: news

Eyeing faster path for sickle cell drug, Peninsula biotech plots expansion — for a higher price
Less than a year after moving into one of South San Francisco's new biotech real estate developments, Global Blood Therapeutics Inc. will be moving again, nearly tripling its space as it shifts operations just a few yards away. Like any biotech company looking to move digs in a tight real estate market, Global Blood will pay top dollar to do so. Even as real estate developers add millions of square feet in South San Francisco alone, it is being snatched up quickly by large pharmaceutical companies… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 8, 2018 Category: American Health Authors: Ron Leuty Source Type: news

Eyeing faster path for sickle cell drug, Peninsula biotech plots expansion — for a higher price
Less than a year after moving into one of South San Francisco's new biotech real estate developments, Global Blood Therapeutics Inc. will be moving again, nearly tripling its space as it shifts operations just a few yards away. Like any biotech company looking to move digs in a tight real estate market, Global Blood will pay top dollar to do so. Even as real estate developers add millions of square feet in South San Francisco alone, it is being snatched up quickly by large pharmaceutical companies… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - November 8, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

Sickle Cell Trait Linked to Venous, Renal Complications Sickle Cell Trait Linked to Venous, Renal Complications
People who carry sickle cell trait (SCT) are at increased risk of pulmonary embolism (PE) and chronic kidney disease (CKD), according to the first-ever systematic review to look at clinical outcomes associated with the trait.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - November 1, 2018 Category: Intensive Care Tags: Hematology-Oncology News Source Type: news

Systematic review study supports that sickle cell trait increases risk for some health conditions
(Source: NHGRI Homepage Highlights)
Source: NHGRI Homepage Highlights - October 30, 2018 Category: Genetics & Stem Cells Source Type: news

FDA Approves New DNA-Based Test to Verify Blood Compatibility
FRIDAY, Oct. 12, 2018 -- The U.S. Food and Drug Administration has approved the ID CORE XT DNA-based test to help doctors verify blood compatibility before a transfusion. Patients who need repeated transfusions, such as those with sickle cell... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 12, 2018 Category: Pharmaceuticals Source Type: news

New DNA-Based Test Approved to Help Verify Blood Compatibility
FRIDAY, Oct. 12, 2018 -- The U.S. Food and Drug Administration has approved the ID CORE XT DNA-based test to help doctors verify blood compatibility before a transfusion. People who need repeated transfusions, such as those with sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 12, 2018 Category: General Medicine Source Type: news

FDA lifts hold on CRISPR, Vertex sickle cell trial
CRISPR Therapeutics and Vertex Pharmaceuticals announced that the U.S. FDA has lifted the clinical hold and accepted the Investigational New Drug application for a new treatment for sickle cell disease. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - October 11, 2018 Category: Pharmaceuticals Source Type: news

NHS calls on 40,000 black people to sign up as blood and organ donors
Davinia Caballero, 33, from Brixton in London, needed a transplant after her kidneys were damaged by sickle cell disease. She said she was 'lucky' her brother was able to donate his kidney. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2018 Category: Consumer Health News Source Type: news