Sickle Cell Disease, Trait May Up Risk for Poor COVID Outcomes Sickle Cell Disease, Trait May Up Risk for Poor COVID Outcomes
The risk for hospitalization quadrupled and mortality risk doubled in a cohort of patients with sickle cell disease; excess risk was also seen among carriers, but the magnitude was smaller.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - July 21, 2021 Category: Emergency Medicine Tags: Infectious Diseases News Source Type: news

COVID-19 news from Annals of Internal Medicine
(American College of Physicians) 1. Currently used SARS-CoV-2 vaccines more than 95% effective in preventing confirmed infection ; 2. Having sickle cell disease quadruples risk for COVID-19-related hospitalization and doubles risk for COVID-19-related death. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 20, 2021 Category: Infectious Diseases Source Type: news

Risk Factors ID ’ d for Severe COVID - 19 With Sickle Cell Disease
Hydroxyurea use does not impact development of serious COVID - 19 or need for hospitalization in children or adults (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 14, 2021 Category: Cancer & Oncology Tags: Cardiology, Family Medicine, Infections, Internal Medicine, Critical Care, Emergency Medicine, Nephrology, Oncology, Pediatrics, Pulmonology, Journal, Source Type: news

Risk Factors ID'd for Severe COVID-19 With Sickle Cell Disease
WEDNESDAY, July 14, 2021 -- A history of severe pain episodes and coexisting organ conditions may increase the risk for severe COVID-19 illness and hospitalization in individuals living with sickle cell disease (SCD), according to a study published... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 14, 2021 Category: Pharmaceuticals Source Type: news

Treatment at Infusion Center Beneficial in Sickle Cell Disease
Outcomes significantly better for treatment of vaso - occlusive crises at infusion center versus emergency department (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 7, 2021 Category: Cancer & Oncology Tags: Internal Medicine, Emergency Medicine, Nursing, Oncology, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news

Treatment at Infusion Center Beneficial in Sickle Cell Disease
WEDNESDAY, July 7, 2021 -- For adults with sickle cell disease (SCD) with uncomplicated vaso-occlusive crises, outcomes are significantly better with treatment at an infusion center (IC) compared with an emergency department (ED), according to a... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 7, 2021 Category: Pharmaceuticals Source Type: news

Certain Sickle Cell Disease Traits Can Raise Odds for Severe COVID
This study tells us that all individuals... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 6, 2021 Category: General Medicine Source Type: news

Infusion Centers May Best EDs for Treating Sickle Cell Crises Infusion Centers May Best EDs for Treating Sickle Cell Crises
At infusion centers, patients with vaso-occlusive crises received pain medication an average of 70 minutes faster compared with patients treated in emergency departments, researchers found.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - July 6, 2021 Category: Cancer & Oncology Tags: Internal Medicine News Source Type: news

Infusion centers associated with substantially better outcomes than the ER for patients with acute pain events and sickle cell disease
(American College of Physicians) A prospective cohort study found that treatment at an infusion center (IC) is associated with substantially better outcomes than treatment in the emergency department (ED) for patients with sickle cell disease (SCD) and uncomplicated vaso-occlusive crises. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

Whole genome sequencing of all UK newborns ‘would have public support’
Consultation shows positivity towards screening programme to spot those at heightened risk of certain health conditionsPlans to sequence the whole genome of every newborn in the UK in order to spot those at heightened risk of certain health conditions have been given a boost, with consultations suggesting the approach could have public support.The potential for genomics to improve health was at theheart of the chief medical officer annual report of 2016, with a group of experts convened by Genomics England – a government-owned genetics service – subsequently recommending a research programme to sequence the who...
Source: Guardian Unlimited Science - July 4, 2021 Category: Science Authors: Nicola Davis Science correspondent Tags: Genetics Science UK news NHS Health Childbirth Sickle cell disease Cystic fibrosis Children's health Source Type: news

Cameroon: World Sickle Cell Day - CERAC Visits Sick Children in Mfou
[Cameroon Tribune] The delegation headed by Anne Ndjodo handed gifts to patients at the Mfou District Hospital yesterday June 29, 2021. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 30, 2021 Category: African Health Source Type: news

Nigeria: Country Has Highest Prevalent Rate of Sickle Cell Worldwide, Says Govt
[This Day] Abuja -- The federal government has said Nigeria currently ranks highest in rate of Sickle Cell Disease (SCD) in the whole world ahead of Democratic Republic of Congo and India. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 24, 2021 Category: African Health Source Type: news

Stanford spinout's latest deal looks to unlock new fix for sickle cell disease
The initial Stanford research, studying how to make more bone marrow more receptive to gene therapies and stem cell transplants and less toxic for patients, was backed by nearly $23 million in grants from California's stem cell research funding agency. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 21, 2021 Category: American Health Authors: Ron Leuty Source Type: news

“All of who I am”: Celebrating One Red Crossers’ Story
At two years old, my mother lost two sisters in a home fire. They were eight and four years old, and their names were Mary Sue and Gwen. The year ... The post “All of who I am”: Celebrating One Red... {This is a content summary only. Click the blog post title to continue reading this post, share your comments, browse the blog and more!} (Source: Red Cross Chat)
Source: Red Cross Chat - June 21, 2021 Category: International Medicine & Public Health Authors: American Red Cross Tags: Diversity & Inclusion american red cross diversity and inclusion Pride Month Red Cross Stories sickle cell advocacy Source Type: news

‘All of who I am’: Celebrating One Red Crossers’ Story
At two years old, my mother lost two sisters in a home fire. They were eight and four years old, and their names were Mary Sue and Gwen. The year ... The post ‘All of who I am’:... {This is a content summary only. Click the blog post title to continue reading this post, share your comments, browse the blog and more!} (Source: Red Cross Chat)
Source: Red Cross Chat - June 21, 2021 Category: International Medicine & Public Health Authors: American Red Cross Tags: Diversity & Inclusion american red cross diversity and inclusion Pride Month Red Cross Stories sickle cell advocacy Source Type: news

Nigeria: What You Need to Know About Sickle Cell Disorder
[Premium Times] There's no cure for most people with sickle cell, but treatments can relieve pain and help to prevent complications. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 21, 2021 Category: African Health Source Type: news

Nigeria: World SCD 2021 - Nigeria, Global Epicentre of Sickle Cell, Not Doing Enough to Tackle Disease
[Premium Times] These staggering statistics, according to health experts, has ranked Nigeria as a black sheep among the comity of nations. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2021 Category: African Health Source Type: news

Nigeria: Sickle Cell Day - Author Calls for Awareness, Adequate Information
[Vanguard] Malam Shehu Mohammed, author of the book on sickle cell anaemia titled "I am a survivor," has called on Nigerians to create more awareness and sensitisation exercise to the sickle cell disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2021 Category: African Health Source Type: news

Gambia: Gambia to Observe World Sickle Cell Day
[The Point] The Gambia Sickle Cell Association will on Saturday join the rest of the world to celebrate World Sickle Cell day. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 18, 2021 Category: African Health Source Type: news

Sickle Cell Plagues Many Black Americans, But There's Hope for Better Treatments
FRIDAY, June 18, 2021 -- It's been more than six months since Brandy Compton last landed in a hospital emergency room. That's an amazing medical achievement, brought about by scientific breakthroughs that have been unfortunately overshadowed by the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 18, 2021 Category: General Medicine Source Type: news

< a href= " /news-events/nih-research-matters/fixing-sickle-cell-disease-gene " > Fixing the sickle cell disease gene < /a >
Researchers treated sickle cell disease in mice by directly editing the defective hemoglobin gene that causes the disease. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - June 15, 2021 Category: Consumer Health News Source Type: news

Gene Editing Technique Corrects Sickle Cell Disease in Mice
THURSDAY, June 10, 2021 -- Researchers are using mice to study a potential new treatment that could help patients who have sickle cell disease, without some of the risks and side effects of existing therapies. The investigators reported using... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 10, 2021 Category: General Medicine Source Type: news

Gene Editing Technique Corrects Sickle Cell Disease in Mice
Title: Gene Editing Technique Corrects Sickle Cell Disease in MiceCategory: Health NewsCreated: 6/10/2021 12:00:00 AMLast Editorial Review: 6/10/2021 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - June 10, 2021 Category: Anesthesiology Source Type: news

7T MRI visualizes sickle cell disease's effect on the brain
In a new study, 7-tesla MRI shows the often severe effects that sickle cel...Read more on AuntMinnie.comRelated Reading: Using fMRI to plan brain tumor resection boosts patient outcomes Cardiac MRI boosts myocarditis detection in college athletes 7-fold Bad hair day? Powdered hair products may pose problem for MRI Is mpMRI equally available to all men at risk of prostate cancer? AI enables noninvasive tumor pathology mapping on brain MRI (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 4, 2021 Category: Radiology Source Type: news

Genetic base editing treats sickle cell disease in mice
(Broad Institute of MIT and Harvard) Sickle cell disease leads to chronic pain, organ failure, and early death in patients worldwide. A team led by Broad Institute of MIT and Harvard and St. Jude Children's Research Hospital has demonstrated a gene editing approach that efficiently corrects the mutation underlying SCD in patient blood stem cells and in mice. This treatment rescued disease symptoms in animal models, enabling long-lasting production of healthy blood cells, and could inspire a therapeutic strategy for SCD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 3, 2021 Category: International Medicine & Public Health Source Type: news

Using advanced imaging to study sickle cell disease
(University of Pittsburgh) Researchers from the University of Pittsburgh used a whole-body 7-Tesla MRI scanner alongside their optimized Tic-Tac-Toe RF head coil system to study sickle cell disease's impact on the brain. They discovered that SCD can have a severe effect on specific subfields of the hippocampus - a highly complex part of the human brain that controls learning and memory and is very susceptible to injury or disorders. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 3, 2021 Category: Biology Source Type: news

Sickle Cell Disease: Shift in Cause of Bacterial Infections Sickle Cell Disease: Shift in Cause of Bacterial Infections
Salmonella is now the leading cause of invasive bacterial infection among children with sickle cell disease who have not undergone hematopoietic stem cell transplant, according to a new study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 2, 2021 Category: Cancer & Oncology Tags: Pediatrics News Source Type: news

Researchers develop proof-of-concept treatment that elevates adult and fetal hemoglobin
(Children's Hospital of Philadelphia) Researchers at Children's Hospital of Philadelphia (CHOP) have developed a proof-of-concept treatment for blood disorders like sickle cell disease and beta-thalassemia that could raise hemoglobin levels by activating production of both fetal and adult hemoglobin. Using a viral vector engineered to reactivate fetal hemoglobin production, suppress mutant hemoglobin, and supply functional adult hemoglobin, the researchers developed an approach that could produce more hemoglobin through a single vector. The results were published in Haematologica. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 1, 2021 Category: International Medicine & Public Health Source Type: news

‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain
Cures for a disease that mostly afflicts Black people seem near, but may come too late for Lisa Craig, who lives with an agony like knives stabbing her bones. (Source: NYT Health)
Source: NYT Health - May 30, 2021 Category: Consumer Health News Authors: John Eligon and William DeShazer Tags: Sickle Cell Anemia Pain-Relieving Drugs Chronic Condition (Health) Addiction (Psychology) Opioids and Opiates Race and Ethnicity Doctors Blood Black People Vanderbilt University Medical Center Source Type: news

Finding New Optimism In Those Pandemic Babies
Well hello! I’m so glad you’re here. A version of this article also appeared in theIt’s Not Just You newsletter.Sign up here to receive a new edition every Sunday. As always, you can send comments to me at: Susanna@Time.com. A slew of beloved friends have been having babies lately. I’m embarrassingly emotional about their arrival, or even just the news that they’re on their way. Knowing that this new crop of young ones will uncover delight in this bruised world is one of those ancient wonders. [time-brightcove not-tgx=”true”] It’s been a fractious and scary year, but these p...
Source: TIME: Health - May 30, 2021 Category: Consumer Health News Authors: Susanna Schrobsdorff Tags: Uncategorized It's Not Just You Source Type: news

Kenya: Kisumu Sets Up Centre to Tackle Sickle Cell Disease
[Nation] A total of 21 out of 100 children in Kisumu are born with the sickle cell trait, new statistics show. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 26, 2021 Category: African Health Source Type: news

These Sisters With Sickle Cell Had Devastating, and Preventable, Strokes
Kyra and Kami never got a simple test that could have protected them. Their story exemplifies the failure to care for people with the disease, most of whom are Black. (Source: NYT Health)
Source: NYT Health - May 24, 2021 Category: Consumer Health News Authors: Gina Kolata and Ilana Panich-Linsman Tags: Stroke Tests (Medical) Preventive Medicine Ultrasonic Imaging and Sonograms Genetics and Heredity Transfusions Sickle Cell Anemia Black People Children and Childhood Race and Ethnicity Doctors National Institutes of Health Source Type: news

How Sickle Cell Trait in Black People Can Give the Police Cover
Sickle cell trait has been cited in dozens of police custody deaths ruled accidental or natural, even though the condition is benign on its own, a Times investigation found. (Source: NYT Health)
Source: NYT Health - May 15, 2021 Category: Consumer Health News Authors: Michael LaForgia and Jennifer Valentino-DeVries Tags: Black Lives Matter Movement Black People George Floyd Protests (2020) Police Brutality, Misconduct and Shootings Autopsies Prison Guards and Corrections Officers Genetics and Heredity Sickle Cell Anemia Sickle Cell Trait United States Source Type: news

Chiesi Global Rare Diseases Announces FDA Approval of Ferriprox (deferiprone) for Treatment of Transfusional Iron Overload due to Sickle Cell Disease
May 1, 2021 Approval is based on demonstrated reduction in liver iron concentration Expanded indications for patients with sickle cell disease or other anemias, as well as thalassemia - BOSTON, May 1, 2021 /PRNewswire/ -- Chiesi Global Rare... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - May 1, 2021 Category: Drugs & Pharmacology Source Type: news

Bypassing broken genes
(Penn State) A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases. The method involves inserting a new, fully functional copy of the gene that displaces the mutated gene. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 21, 2021 Category: International Medicine & Public Health Source Type: news

Ghana: Sickle Cell Disease - the Place of Hydroxyurea in Treatment
[Ghanaian Times] I saw this vignette in the New England Journal of Medicine (NEJM). What follows by way of intervention, I believe, is still relevant. An 18-year-old woman with sickle cell anemia has had increasing symptoms, with painful crises and episodes of the acute chest syndrome. She was hospitalized three times in the past year. She was started on hydroxyurea therapy.(Orah S. PlattHydroxyurea for the Treatment of Sickle Cell Anemia.N Engl J Med 2008;358:1362-9). (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - April 16, 2021 Category: African Health Source Type: news

New study examines promising approach to treating attention and working memory difficulties in child
(Children's National Hospital) An adaptive cognitive training program could help treat attention and working memory difficulties in children with sickle cell disease (SCD), a new study published in the of Journal of Pediatric Psychology shows. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 7, 2021 Category: Biology Source Type: news

CRISPR-SNP-chip enables amplification-free electronic detection of single point mutations
(Keck Graduate Institute) Keck Graduate Institute (KGI) Assistant Professor and University of California, Berkeley Visiting Scientist Dr. Kiana Aran first introduced the CRISPR-Chip technology in 2019. Now just two years later, she has expanded on its application to develop CRISPR-SNP-Chip, which enables detection of single point mutations without amplification in Sickle Cell Disease and Amyotrophic lateral sclerosis (ALS). (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 5, 2021 Category: Biology Source Type: news

UC group launches clinical trial using CRISPR to correct sickle cell disease gene defect
Scientists at UCLA, UC San Francisco and UC Berkeley have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patients ’ own blood-forming stem cells.The trial will combine CRISPR technology developed at the Innovative Genomics Institute — a UC Berkeley–UCSF initiative founded by Berkeley’s Nobel Prize–winning scientist Jennifer Doudna — with UCLA’s expertise in genetic analysis and cell manufacturing, and the decades-long expertise at U...
Source: UCLA Newsroom: Health Sciences - March 30, 2021 Category: Universities & Medical Training Source Type: news

UC consortium launches first clinical trial using CRISPR to correct sickle cell gene
(University of California - San Francisco) Scientists at UC San Francisco, UC Berkeley and UCLA have received U.S. Food and Drug Administration approval to jointly launch an early phase, first-in-human clinical trial of a CRISPR gene correction therapy in patients with sickle cell disease using the patient's own blood-forming stem cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 30, 2021 Category: International Medicine & Public Health Source Type: news

Small Business, Big Mission: Biotech company brings it all together
With early funding from California's Oakland-based stem cell research funding agency for its academic founders, the Stanford University spinout is tapping the CRISPR gene-editing technology out of UC Berkeley to push an experimental gene therapy for sickle cell disease into an early-stage clinical trial and pursue fixes for rare genetic diseases. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 26, 2021 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

A better treatment for sickle cell disease
(Texas A&M University) Sickle cell disease is the most prevalent inherited blood disorder in the world, affecting 70,000 to 100,000 Americans. However, it is considered an orphan disease, meaning it impacts less than 200,000 people nationally, and is therefore underrepresented in therapeutic research. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 24, 2021 Category: International Medicine & Public Health Source Type: news

New findings about immune system reaction to malaria and sickle cell disease
(University of Exeter) The researchers discovered that sugars called mannoses are expressed on the surfaces of both red blood cells infected with malarial parasites and also affected by sickle cell disease. The mannoses cause both infected cells and sickle cells to be eaten in the spleen.The team hope the findings will eventually help inform new treatments for malaria. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 19, 2021 Category: Infectious Diseases Source Type: news

With one sickle cell drug approved, Peninsula drug maker licenses two more
As potential one-shot-and-done gene therapies beckon for sickle cell disease patients, this South San Francisco pioneer is adding to its portfolio of tablets and pills. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - March 16, 2021 Category: Biotechnology Source Type: news

With one sickle cell drug approved, Peninsula drug maker licenses two more
As potential one-shot-and-done gene therapies beckon for sickle cell disease patients, this South San Francisco pioneer is adding to its portfolio of tablets and pills. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 16, 2021 Category: Pharmaceuticals Source Type: news

< a href= " /news-events/nih-research-matters/mitochondrial-dna-involved-sickle-cell-disease " > Mitochondrial DNA involved in sickle cell disease < /a >
People with sickle cell disease have high levels of mitochondrial DNA in their blood, which may help trigger damaging inflammation. (Source: NIH Research Matters from the National Institutes of Health (NIH))
Source: NIH Research Matters from the National Institutes of Health (NIH) - March 16, 2021 Category: Consumer Health News Source Type: news

Stanford gene-editing startup raises $150M for sickle cell clinical trial, expansion into rare diseases
The South San Francisco company's early work at Stanford — as well as the work of a critical partner — was backed by grants from California's stem cell research funding agency CIRM. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - March 15, 2021 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Gene Therapy for Sickle Cell Did Not Cause Patient's Leukemia
THURSDAY, March 11, 2021 -- There is no evidence that a promising gene therapy for sickle cell disease triggered leukemia in a patient, according to the company testing the experimental treatment. Bluebird Bio announced a few weeks ago that a sickle... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 11, 2021 Category: Pharmaceuticals Source Type: news

Gene Therapy for Sickle Cell Not Linked to Cancer, Bluebird Finds
Clinical trials were halted after DNA from the treatment's vector that ferries in the healthy genetic sequence was identified in the genome of a patient's cancer cells. (Source: The Scientist)
Source: The Scientist - March 11, 2021 Category: Science Tags: News & Opinion Source Type: news

Severe COVID-19 With ARDS in a Sickle Cell Disease Patient Severe COVID-19 With ARDS in a Sickle Cell Disease Patient
This case of ARDS caused by COVID-19 in a man with sickle cell disease helps further our understanding of how COVID-19 impacts these patients.BMC Pulmonary Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 11, 2021 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news