How Jennifer Doudna ’s Life Has Changed Since Discovering CRISPR 10 Years Ago
Jennifer Doudna was staring at a computer screen filled with a string of As, Cs, Ts, and Gs—the letters that make up human DNA—and witnessing a debilitating genetic disease being cured right before her eyes. Just a year earlier, in 2012, she and microbiologist Emmanuelle Charpentier had published a landmark paper describing CRISPR-Cas9, a molecular version of autocorrect for DNA, and she was seeing one the first demonstrations of CRISPR’s power to cure a human disease. She was in the lab of Dr. Kiran Musunuru, a Harvard researcher who was eager to show her the results from an experiment he had just finish...
Source: TIME: Health - July 1, 2022 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized feature Genetics healthscienceclimate Source Type: news

Brigham and Women ’s Hospital Announces $16M Grant from Helmsley Charitable Trust to Expand Access to Care for Severe Noncommunicable Diseases in Lower
Grant will scale up integrated services for type 1 diabetes, rheumatic heart disease, and sickle cell disease in eight countries in sub-Saharan Africa and South Asia (Source: BWH News)
Source: BWH News - July 1, 2022 Category: Hospital Management Source Type: news

Brigham Announces $16M Grant from Helmsley Charitable Trust to Expand Access to Care for Severe Noncommunicable Diseases in Lower-Income Countries
Grant will scale up integrated services for type 1 diabetes, rheumatic heart disease, and sickle cell disease in eight countries in sub-Saharan Africa and South Asia (Source: BWH News)
Source: BWH News - July 1, 2022 Category: Hospital Management Source Type: news

Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait, JAMA
Study (n=132,577 [2729 sickle cell trait, SCT]) found SCT linked to increased COVID mortality in African ancestry (OR 1.77;95% CI, 1.13-2.77;P=0.01)& increased rates of acute renal failure 60 days after COVID, supporting its inclusion as an adverse prognostic factor for COVID-19 (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 29, 2022 Category: Consumer Health News Source Type: news

The Many Uses of CRISPR: Scientists Tell All
What do infectious diseases, T-cells, tomatoes, heart failure, sickle cell anemia and sorghum harvests have in common? (Source: NYT Health)
Source: NYT Health - June 27, 2022 Category: Consumer Health News Authors: Oliver Whang Tags: Crispr (DNA) Genetic Engineering Research Tomatoes Sickle Cell Anemia Cancer Heart Cereals Source Type: news

Kidney Failure May Drive COVID Deaths in People With Sickle Cell Trait
(MedPage Today) -- COVID-19 patients with sickle cell trait (SCT) were prone to poor outcomes that appeared to be driven in part by kidney dysfunction, a genetic association study suggested. Among U.S. veterans of African ancestry, SCT was tied... (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - June 27, 2022 Category: Urology & Nephrology Source Type: news

Understanding vaccine responses in individuals with weakened immune systems
Yale researchers will conduct a series of studies on vaccine responses in vulnerable groups, including those with multiple sclerosis and sickle cell disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - June 21, 2022 Category: Universities & Medical Training Source Type: news

Sickle cell campaign
NHS England has launched a campaign to boost public awareness of the genetic disorder which affects thousands across the UK. (Source: NHS Networks)
Source: NHS Networks - June 20, 2022 Category: UK Health Source Type: news

New Therapy May Offer'Functional Cure' for Two Blood Disorders New Therapy May Offer'Functional Cure' for Two Blood Disorders
One infusion of an investigational gene editing therapy could eliminate red blood cell transfusions in beta-thalassemia and severe vaso-occlusive crises in sickle cell disease.Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - June 14, 2022 Category: Transplant Surgery Tags: Hematology-Oncology News Source Type: news

Potential gene therapies bring hope to patients with sickle cell disease
Arecent analysis highlights how potential gene therapies have the potential to dramatically reduce income disparities for patients with sickle cell disease, leading to as much as $21,000 more in average income in the year following gene therapy administration alone. (Source: The Catalyst)
Source: The Catalyst - June 6, 2022 Category: Pharmaceuticals Authors: Katie Koziara Tags: Medicines in Development Health Equity Source Type: news

Changing our DNA: 'The age of human therapeutic gene editing is here'
Advances in gene editing have brought us ever closer to fixing some of the most devastating diseases of our time, such as progeria and sickle cell disease. (Source: CNN.com - Health)
Source: CNN.com - Health - May 31, 2022 Category: Consumer Health News Source Type: news

Episode 2: Are We Any Closer to Intestinal Gene Therapy in Crohn's Disease? Episode 2: Are We Any Closer to Intestinal Gene Therapy in Crohn's Disease?
Drs Peter Higgins and Judy Cho discuss recent success in sickle cell anemia and whether we ' re any closer to using intestinal gene therapy in Crohn ' s disease.Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 24, 2022 Category: Consumer Health News Tags: Gastroenterology InDiscussion Source Type: news

The High Cost of Living With Sickle Cell Disease
MONDAY, May 23, 2022 -- Americans with sickle cell disease who have private insurance face average out-of-pocket costs of $1,300 a year and a lifetime total of $44,000, new research reveals. That means that their out-of-pocket expenses are nearly... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 23, 2022 Category: General Medicine Source Type: news

The High Cost of Living With Sickle Cell Disease
Title: The High Cost of Living With Sickle Cell DiseaseCategory: Health NewsCreated: 5/23/2022 12:00:00 AMLast Editorial Review: 5/23/2022 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - May 23, 2022 Category: Anesthesiology Source Type: news

Kwaku Ohene-Frempong, Expert in Sickle Cell Disease, Dies at 76
When his baby boy was diagnosed with the illness, he made it his mission to combat it. He later took his expertise back to his native Ghana. (Source: NYT Health)
Source: NYT Health - May 19, 2022 Category: Consumer Health News Authors: Gina Kolata Tags: Ohene-Frempong, Kwaku Deaths (Obituaries) Sickle Cell Anemia Research Children ' s Hospital of Philadelphia Ghana Africa Source Type: news