L-Glutamine Benefit Patients With Sickle Cell Disease L-Glutamine Benefit Patients With Sickle Cell Disease
For people with sickle cell disease, oral twice-daily L-glutamine reduces hospitalization and trims the number of sickle cell crises compared with placebo, whether or not they are also receiving hydroxyurea, according to details of the key test that resulted in U.S. approval of the treatment just over a year ago.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

& lt;small & gt;L & lt;/small & gt; - Glutamine Reduces Number of Pain Crises in Sickle Cell Disease
Significantly fewer pain crises, hospitalizations compared with those receiving placebo (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 19, 2018 Category: Cancer & Oncology Tags: Oncology, Pediatrics, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news

L-Glutamine Reduces Number of Pain Crises in Sickle Cell Disease
THURSDAY, July 19, 2018 -- For patients with sickle cell-related pain, those receiving oral therapy with L-glutamine have a lower median number of pain crises, according to a study published in the July 19 issue of the New England Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 19, 2018 Category: Pharmaceuticals Source Type: news

Supplement May Ease the Pain of Sickle Cell Disease
Title: Supplement May Ease the Pain of Sickle Cell DiseaseCategory: Health NewsCreated: 7/18/2018 12:00:00 AMLast Editorial Review: 7/19/2018 12:00:00 AM (Source: MedicineNet Chronic Pain General)
Source: MedicineNet Chronic Pain General - July 19, 2018 Category: Anesthesiology Source Type: news

Balance control is impaired in adults with sickle cell anaemia - Silva PO, Ferreira AS, Lima CMA, Guimar ães FS, Lopes AJ.
BACKGROUND: Musculoskeletal involvement and cerebrovascular disease are common in sickle cell anaemia (SCA). These changes are potentially important factors that modify the control of balance in this population. OBJECTIVE: To assess balance control... (Source: SafetyLit)
Source: SafetyLit - July 19, 2018 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain–focused CRISPR-Cas9–based genetic screen with a newly optimized single-guide RNA scaffold. The screen uncovered the heme-regulated inhibitor HRI (also known as EIF2AK1), an erythroid-specific kinase that controls protein translation, as an HbF repressor. HRI depletion markedly increased HbF production in a specific manner and reduce...
Source: ScienceNOW - July 19, 2018 Category: Science Authors: Grevet, J. D., Lan, X., Hamagami, N., Edwards, C. R., Sankaranarayanan, L., Ji, X., Bhardwaj, S. K., Face, C. J., Posocco, D. F., Abdulmalik, O., Keller, C. A., Giardine, B., Sidoli, S., Garcia, B. A., Chou, S. T., Liebhaber, S. A., Hardison, R. C., Shi, Tags: Medicine, Diseases, Molecular Biology reports Source Type: news

Supplement May Ease Sickle Cell Pain
Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell patients' number of acute pain crises by 25 percent compared with a placebo, researchers have found. (Source: WebMD Health)
Source: WebMD Health - July 18, 2018 Category: Consumer Health News Source Type: news

Endari (L-Glutamine) Supplement May Ease the Pain of Sickle Cell Disease
WEDNESDAY, July 18, 2018 -- An FDA-approved supplement reduces episodes of severe pain in people with sickle cell disease, a new clinical trial shows. Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 18, 2018 Category: General Medicine Source Type: news

Supplement May Ease the Pain of Sickle Cell Disease
WEDNESDAY, July 18, 2018 -- An FDA-approved supplement reduces episodes of severe pain in people with sickle cell disease, a new clinical trial shows. Endari, a medicine-grade version of the dietary supplement L-glutamine, reduced sickle cell... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 18, 2018 Category: General Medicine Source Type: news

It ’s easy to host a blood drive at your business
Every two seconds — that’s how often someone in the U.S. needs blood. And, according to the American Red Cross – Ohio Buckeye Region, approximately 500 donations are needed each day in Central Ohio. Blood is needed for routine surgeries, chemotherapy, the treatment of chronic illnesses like sickle cell disease and in saving lives after a traumatic event— one car accident victim can require as many as 100 pints of blood. But despite advancements made in modern medicine, we can’t manufacture… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - July 1, 2018 Category: Pharmaceuticals Authors: Nationwide Source Type: news

It ’s easy to host a blood drive at your business
Every two seconds — that’s how often someone in the U.S. needs blood. And, according to the American Red Cross – Ohio Buckeye Region, approximately 500 donations are needed each day in Central Ohio. Blood is needed for routine surgeries, chemotherapy, the treatment of chronic illnesses like sickle cell disease and in saving lives after a traumatic event— one car accident victim can require as many as 100 pints of blood. But despite advancements made in modern medicine, we can’t manufacture… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - July 1, 2018 Category: Biotechnology Authors: Nationwide Source Type: news

Family travels 7,500 miles to save son ’s life with treatment developed at UCLA
When he was born in September 2015, Hussein El Kerdi looked like a healthy baby boy. No one knew that his immune cells lacked an important enzyme. But the absence of that enzyme would profoundly change the El Kerdi family ’s life, sending them on a journey from their small hometown in Lebanon to UCLA. Their one goal: to save Hussein’s life.When Hussein was three months old, a physician in Beirut diagnosed Hussein with a life-threatening immune disorder called adenosine deaminase-deficient severe combined immunodeficiency, also known as ADA-SCID or bubble baby disease.The disorder is caused by a genetic mutation...
Source: UCLA Newsroom: Health Sciences - June 28, 2018 Category: Universities & Medical Training Source Type: news

GBT's drug meets trial goal, investors skeptical of speedy approval
(Reuters) - Global Blood Therapeutics Inc's sickle cell disease treatment met the main goal of a late-stage trial, but scepticism over whether the drug would get an accelerated review from health regulators pushed its shares down 12 percent. (Source: Reuters: Health)
Source: Reuters: Health - June 27, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Global Blood Therapeutics' sickle cell disease drug succeeds in trial
(Reuters) - Global Blood Therapeutics Inc said on Wednesday its experimental drug met the main goal of a late-stage trial testing it in patients with sickle cell disease. (Source: Reuters: Health)
Source: Reuters: Health - June 27, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Cameroon:World Sickle Cell Day - CERAC Communes With Patients
[Cameroon Tribune] This was during an event to donate gifts to patients at the Chantal Biya Foundation yesterday in Yaounde. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 21, 2018 Category: African Health Source Type: news

Uganda:Sickle Cell Disease - "Break the Silence, Let's Care"
[Observer] On June 19, Uganda joined the rest of the world to commemorate the World Sickle Cell Day under the theme "Break the Silence, Let's Care". (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:World Sickle Cell Day - Know the Facts
[Guardian] In Nigeria, over 150,000 children are born annually with symptomatic sickle cell anaemia, 1-in-4 people are healthy carriers of the disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:Sickle Cell - Emir of Gwandu Calls for Test Before Marriage
[Leadership] The emir of Gwandu in Kebbi and chairman Kebbi State council of chiefs, Alhaji Muhammadu Iliyasu Bashar has called on couples to go for blood screening in order to know their genotype before marriage . (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:Sickle Cell Day - Governor Urges Speedy Deployment of Improved Disease Management Options
[This Day] Edo State Governor, Mr. Godwin Obaseki, has called for increased sensitisation on the choices that lead to the increased cases of sickle cell incidence in society, noting that his government would continue to support sufferers of the health condition by creating the right environment for management of the genetic disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

Nigeria:World Sickle Cell Day - Why Disease Remains Endemic in Nigeria
[Premium Times] As Nigeria joins the rest of the world today to celebrate World Sickle Cell Awareness Day, thousands of the country's citizens are still under the clutches of the deadly disease. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 20, 2018 Category: African Health Source Type: news

AHA: New Insights Into Sickle Cell and Stroke Risk
TUESDAY, June 19, 2018 (American Heart Association) -- Sickle cell disease increases the risk of stroke for African Americans -- but recent research shows carrying the genetic trait for sickle cell doesn't. It's a new layer on the study and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - June 19, 2018 Category: General Medicine Source Type: news

New Drugs Promise Hope This World Sickle Cell Day
This year brings a bit of good news regarding the drug pipeline for sickle cell disease, but pain management is a growing problem. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - June 19, 2018 Category: Pharmaceuticals Authors: Judy Stone, Contributor Source Type: news

Uganda:Home Care for Children With Sickle Cell Disease
[Monitor] Being in and out of hospital is one of the worst experiences parents of children with sickle cell suffer. However, parents should never tire from being in hospital because any slight laziness can lead to death. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 18, 2018 Category: African Health Source Type: news

Study finds music therapy brings effective pain relief for sickle cell patients
(University Hospitals Cleveland Medical Center) In a randomized controlled trial, patients with sickle cell disease were assigned to one of three 20-minute conditions: a session with a music therapist, an iPod to listen to pre-selected music themselves, or no music at all. While passively listening to music improved mood, music therapy had a significantly stronger impact on aiding in pain management for patients actively engaged with a music therapist. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 13, 2018 Category: Cancer & Oncology Source Type: news

Cameroon:Labelled Sorcerers, Children With Sickle-Cell Disease Face Death
[Thomson Reuters Foundation] Douala -"I killed my child because he was going to die anyway. Before, he was suffering greatly. Now he is at peace." (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - June 1, 2018 Category: African Health Source Type: news

FDA halts Vertex, CRISPR sickle-cell trial
CRISPR Therapeutics and Vertex Pharmaceuticals announced that the U.S. FDA has placed a clinical hold on the new-drug application for a drug used for the treatment of sickle-cell disease. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - June 1, 2018 Category: Pharmaceuticals Source Type: news

CRISPR, Vertex say FDA puts brakes on upcoming gene editing trial
Cambridge startup CRISPR Therapeutics and Boston-based Vertex Pharmaceuticals said on Wednesday that the FDA has put on hold a highly anticipated upcoming trial of their experimental gene editing drug for sickle cell disease. CRISPR (Nasdaq: CRISPR) and Vertex (Nasdaq: VRTX) announced after markets closed on Wednesday that the FDA had halted the upcoming trial, which hasn't started yet. The companies sought approval in April to begin the early-stage study in humans; it would be one of the first… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - May 31, 2018 Category: American Health Authors: Max Stendahl Source Type: news

CRISPR, Vertex say FDA puts brakes on upcoming gene editing trial
Cambridge startup CRISPR Therapeutics and Boston-based Vertex Pharmaceuticals said on Wednesday that the FDA has put on hold a highly anticipated upcoming trial of their experimental gene editing drug for sickle cell disease. CRISPR (Nasdaq: CRISPR) and Vertex (Nasdaq: VRTX) announced after markets closed on Wednesday that the FDA had halted the upcoming trial, which hasn't started yet. The companies sought approval in April to begin the early-stage study in humans; it would be one of the first… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 31, 2018 Category: Biotechnology Authors: Max Stendahl Source Type: news

Research, for Whom?
We presented this finding to the health minister, who praised our work and announced that the government would set up a tribal medical research centre in Gadchiroli. Eventually, though, the centre was set up in Pune (where there are no tribals) because researchers and doctors did not want to come to Gadchiroli.Disappointed, we approached the tribal leaders in the villages and requested them to put some pressure on the government to bring the centre to Gadchiroli. Their response took us unawares: “Doctor, this is your disease, not ours,” they said. “Did we ever tell you that we need help for this?” t...
Source: IPS Inter Press Service - Health - May 16, 2018 Category: International Medicine & Public Health Authors: Abhay Bang Tags: Asia-Pacific Development & Aid Headlines Health Poverty & SDGs Source Type: news

Uganda:Church to Subject Couples to Mandatory Sickle Cell Testing
[Monitor] Masaka -In a bid to end the sickle cell disease burden in families, West Buganda Diocese has made it a requirement for couples intending to marry in Church to be subjected to mandatory sickle cell tests. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - May 14, 2018 Category: African Health Source Type: news

St. Jude to combat ‘unacceptable’ sickle cell death rate
Because she is a physician, Dr. Glenda Newell-Harris, national president of The Links Foundation Inc. and The Links Inc. said the organization's $1 million award to St. Jude Children's Research Hospital for sickle cell research was even more special to her. "Health is my passion," the Oakland, California-based internist said. "So to be able to be a part of an organization that is willing to acknowledge and recognize the importance of us continuing to be at the forefront of helping to promote research,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 4, 2018 Category: Pharmaceuticals Authors: Elle Perry Source Type: news

Debut novelist reveals how sickle cell disease inspired her book
Debut novelist Adebayo Ayobami reveals how sickle cell disease inspired her book. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - April 30, 2018 Category: Consumer Health News Source Type: news

Sickle Cell Trait Not Linked to Stroke in African - Americans
Meta - analysis of four cohorts shows sickle cell trait not linked to incidence of ischemic stroke (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 27, 2018 Category: Cancer & Oncology Tags: Cardiology, Neurology, Oncology, Pathology, Journal, Source Type: news

Sickle Cell Trait Not Linked to Stroke in African-Americans
FRIDAY, April 27, 2018 -- For African-Americans, sickle cell trait (SCT) seems not to be associated with the incidence of ischemic stroke, according to a meta-analysis published online April 23 in JAMA Neurology. Hyacinth I. Hyacinth, M.D., Ph.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 27, 2018 Category: Pharmaceuticals Source Type: news

New Insights on Pain and Opioid Use in People With Sickle Cell Disease After Hematopoietic Stem Cell Transplant
NIH-funded study offers new information on pain in sickle cell disease, the use of opioids for this pain, and psychological and quality-of-life challenges faced by people with this disease. (Source: NCCAM Featured Content)
Source: NCCAM Featured Content - April 24, 2018 Category: Complementary Medicine Authors: NCCIH Source Type: news

'Incompatible' donor stem cells cure adult sickle cell patients
(University of Illinois at Chicago) Doctors at the University of Illinois Hospital have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be incompatible, thanks to a new transplant treatment protocol. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 24, 2018 Category: International Medicine & Public Health Source Type: news

Sickle Cell Trait May Not Contribute to Stroke Risk (CME/CE)
(MedPage Today) -- Genetic variant not an independent predictor among African Americans (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 23, 2018 Category: American Health Source Type: news

Novo Nordisk buys blood drug licence to boost anaemic biopharma business
COPENHAGEN (Reuters) - Danish drugmaker Novo Nordisk has secured the global licence for U.S. biotech company EpiDestiny's sickle cell disease (SCD) program in a bid to offset declining sales in its biopharmaceutical business. (Source: Reuters: Health)
Source: Reuters: Health - April 5, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Alberta woman 1st adult in Canada to be 'cured' of sickle cell anemia through stem cell transplant
An Alberta woman is the first adult in Canada to be cured of sickle cell anemia with the help of a sister's love — and a stem cell transplant. (Source: CBC | Health)
Source: CBC | Health - April 4, 2018 Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news

Healthy red blood cells owe their shape to muscle-like structures
(Scripps Research Institute) The findings could shed light on sickle cell diseases and other disorders where red blood cells are deformed. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 4, 2018 Category: International Medicine & Public Health Source Type: news

Gene mutation finding may lead to treatment for sickle cell, other blood disorders
Researchers have found a way to introduce natural mutations into blood cells that could lead to new therapies for sickle cell anemia and other blood disorders. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 2, 2018 Category: Consumer Health News Source Type: news

EMedHome's Clinical Pearl: Three Things You Should Know about Sickle Cell Disease
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - April 1, 2018 Category: Emergency Medicine Tags: EMedHome's Clinical Pearl Source Type: news

Nigeria:Edo Sickle Cell Centre Gets Medical Supply From Presco/Ubth Committee
[Guardian] Benin City -Management of PRESCO Plc and the University of Benin Teaching Hospital (UBTH) Sickle Cell Awareness Golf Tournament Fund Management Committee yesterday donated medical equipment worth millions of naira to the Edo State Sickle Cell Board as part of effort to alleviate the suffering of sickle cell-challenged persons in the state. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 23, 2018 Category: African Health Source Type: news

Nigeria:Medical Students Donate 500 Pints of Blood for Sickle Cell Children At Luth
[Guardian] Worried by the challenge of blood transfusion for children with cancer and sickle cell, the Association of Medical Student University of Lagos (AMSUL) has organised a blood drive exercise to generate pints of blood from the university students. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - March 19, 2018 Category: African Health Source Type: news

Weekly Postings
See something of interest? Please share our postings with colleagues in your institutions! Spotlight Funding Available Now! NNLM MAR Members can apply by 11:00 PM ET on April 13 for projects starting May 15, 2018. Need more information? Review our new Requests for Proposals Register for MAR Funding Office Hours to ask specific questions about your proposal Keep up with Weekly Funding Tips – this week: Funding Tip 5- check out previously funded projects Contact us to set up a consultation! Check out the Winter 2018 edition of The MAReport! This quarter, Elaina Vitale is highlighting “Citizen Science and the Na...
Source: NN/LM Middle Atlantic Region Blog - March 16, 2018 Category: Databases & Libraries Authors: Hannah Sinemus Tags: Weekly Postings Source Type: news

Potential New Treatment Option for Adults with Sickle Cell Disease
A new blood stem-cell transplant regimen that uses a low dose of radiation combined with two immunosuppressive drugs reversed sickle cell disease in adults. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Specific dosage of sickle cell drug increases survival rate
(Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news

Director & #39;s Update, Fall 2017
Content on advances in sickle cell disease research, congressional testimony on type 1 diabetes research, type 1 diabetes and aging, and Dr. Tracy Rankin. (Source: NIDDK Directors Update)
Source: NIDDK Directors Update - March 8, 2018 Category: Endocrinology Source Type: news

Director's Update, Fall 2017
Content on advances in sickle cell disease research, congressional testimony on type 1 diabetes research, type 1 diabetes and aging, and Dr. Tracy Rankin. (Source: NIDDK Directors Update)
Source: NIDDK Directors Update - March 8, 2018 Category: Endocrinology Source Type: news

Matter: How One Child ’ s Sickle Cell Mutation Helped Protect the World From Malaria
The genetic mutation arose 7,300 years ago in just one person in West Africa, scientists reported on Thursday. Its purpose: a shield against rampant malaria. (Source: NYT Health)
Source: NYT Health - March 8, 2018 Category: Consumer Health News Authors: CARL ZIMMER Tags: Genetics and Heredity Sickle Cell Anemia Malaria Blacks Hemoglobin DNA (Deoxyribonucleic Acid) American Journal of Human Genetics National Institutes of Health Rotimi, Charles N Africa Source Type: news