Phospholipase A2 enzymes differently impact PUFA release and oxylipin formation ex vivo in rat hearts
Phospholipase A2 (PLA2) is a superfamily of enzymes involved in the hydrolysis of membrane phospholipids [1,2]. The polyunsaturated fatty acids (PUFA) released by PLA2 can then be converted by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes into oxylipins. These bioactive lipid mediators are involved in important physiological and pathophysiological cardiovascular functions, such as regulation of vascular tone, inflammation, cardiac function, and blood coagulation [3 –11].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Anne Manson, Tanja Winter, Harold M. Aukema Tags: Original research article Source Type: research