Effect of omega-6 Linoleic Acid on Neurobehavioral Development in Caenorhabditis elegans

Linoleic acid (LA, C18H32O2, 18:2, n-6), which cannot be synthesized by humans, is supplied by vegetable oils such as corn, sunflower, and soybean and peanut oils, and is essential for normal growth and development at 1 to 2% of daily energy requirements [1]. Omega-6 polyunsaturated fatty acids (PUFAs) including LA facilitate the protection of the brain and stabilization of neuronal membrane [2], which is required for normal growth and brain development [3]. Nevertheless, a few correlative clinical reports have revealed that excess LA intake potentiates influence of brain development, as LA is a precursor of oxidized linoleic acid metabolites (OXLAMs) that are produced by auto-oxidation or enzymatically through lipoxygenase (LOX), cyclooxygenase (COX), and cytochrome P450 (CYP450) [3].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Tags: Original research article Source Type: research